- Group Member Profiles
- Research Candidates
- Biomedical Magnetic Resonance Facility
- Research Projects
- Image Gallery
- NODG Engagement
- 9th (biennial) Western Sydney University & Inaugural Asian Symposium on NMR, MRI & Diffusion
Prof. Janice Aldrich-Wright
|Professor Janice Aldrich-Wright||School of Science, School of Medicine, Western Sydney University, Head of the Biologically Active Drugs by Design Group (BADD)|
|Contact Details||Professor Janice R. Aldrich-Wright|
Nanoscale Organisation and Dynamics Group | School of Science
Campbelltown Campus - Building CA 21.G.43
Western Sydney University
Locked Bag 1797, Penrith, NSW, 2751
Phone: [+61 2] 4620 3218
|Key Words||anticancer; metallointercalators; biological activity; NMR; platinum|
Significant contributions have been made to the investigation of metal complex-DNA interactions. Work initiated at WSU has demonstrated by 1H NMR, that both Δ- and -Λ[Ru(2,9-phenMe2)2(dpq/dppz)]2+ bind to the oligonucleotide d(GTCGAC)2 by intercalation within the minor groove. These were the first NMR experiments to do so and this finding, while controversial, is significant because the differences in binding of these simple molecules must be well understood if sequence-selective binding by metal complexes is to be realised. The work has influenced researchers to re-investigate the DNA interactions of metallointercalators with a less prejudiced view about the nature and extent of intercalation. The findings of this research were confirmed by X-ray structure analysis for more than one complex of this type in Nature Chemistry in 2012.
Ongoing research and innovative complex design at WSU has resulted in the discovery of a new class of platinum compounds that differ significantly in their mode of action from current clinically used anticancer platinum compound. Antibacterial agents that are more effective against biofilms, than currently used, have also been identified.
Other research conducted at by Janice's group at Western Sydney University has resulted in the discovery of a new group of platinum-based compounds. This new group of compounds are water-soluble and in preliminary testing against cancer cells lines and are showing a very high level of activity.
Most appear in high profile journals, with more than 3,813 citations from 119 publications (average citations per article 31.7) and an h-index 33 (Scopus: accessed, Jan 2020). ORCID ID: https://orcid.org/0000-0002-6943-6908
Professor Aldrich-Wright has supervised 27 PhD, 15 MSc and 38 Honours students to completion by establishing a dynamic research group. This group is recognised internally at Western Sydney University, and externally both nationally and internationally, as being innovative and extremely productive. All postgraduate students are encouraged to publish as much of their work as possible, before submitting their thesis for examination. In this respect, success has been demonstrated by the number of Published Patents/Book Chapters/Papers (average 4.1) and Conference Papers (average 3.3) per PhD student.
This contribution to graduate research training and supervision has been recognised by the Vice-Chancellor's Excellence Award for Postgraduate Research Training and Supervision in 2009, 2013 and 2020 and the School of Science and Health’s award for Postgraduate Research Training and Supervision 2020.
Aldrich-Wright, J.R. (Ed), 2011. Metallointercalators; Synthesis and Techniques to probe their interactions with Biomolecules. (opens in a new window) Springer Publications ISBN 978-3-211-0942