Professor Janice Aldrich-Wright

Professor Janice Aldrich-Wright

Associate Dean, HDR,
Dean's Unit School of Science

Professor,
Dean's Unit School of Science

Biography

Janice Aldrich-Wright obtained her BAppSc (Hons) from University of Technology, Sydney and PhD from Macquarie University, Sydney. Subsequently she was awarded the Cornforth Medal, for the best PhD in Chemistry in Australia (1993). From 1993- till present she has been an associate lecturer, Lecture, Senior Lecture, Associate Professors and now a Professor in Chemistry at the University of Western Sydney. She is a fellow of the Royal Australian Chemical Institute and a Fellow of the Royal Society of Chemistry. She began with teaching in chemistry but quickly established a strong foundation in research and in this capacity, student mentorship. Her work is internationally recognised in the field of anticancer chemistry and pharmacology and she has published widely. Innovative bioinorganic molecular design, elegant synthesis, comprehensive characterisation (including X-ray analysis at the synchrotron) and the biophysical analysis of the interactions of these compounds with DNA using, for example synchrotron radiation circular Dichroism (SRCD – Aarhus, Denmark), exemplify her research while creating a vibrant, productive and collaborative environment for her research students.

This information has been contributed by Professor Aldrich-Wright.

Qualifications

  • PhD Macquarie University
  • BAppSc NSW Institute of Technology

Professional Memberships

  • FRSC (2015)
  • RACI (1993 - 2015)

Organisational Unit (School / Division)

  • Dean's Unit School of Science
  • Dean's Unit School of Science

Contact

Email: J.Aldrich-Wright@westernsydney.edu.au
Phone: (02) 4620 3218
Mobile:
Location: 21.G.43
Campbelltown

PLEASE NOTE: obtaining information from this Directory must be for the legitimate purposes of doing business with and within Western Sydney University, and must not be used for unsolicited bulk e-mailing (spamming) or similar purposes.

Teaching

Previous Teaching Areas

  • 300324 Pharmacological Chemistry, 2015
  • 300412 Science, Technology and Environment Honours Project, 2015

Publications

Chapters in Books

  • Harper, B., Li, F., Beard, R., Garbutcheon-Singh, K., Ng, N. and Aldrich-Wright, J. (2013), 'Biomolecular ineractions of platinum complexes', Supramolecular Systems in Biomedical Fields, Royal Society of Chemistry 9781849736589.
  • Hicks, M., Orkey, N., Pisani, M., Collins, J., Wheate, N. and Aldrich-Wright, J. (2012), 'Using spectroscopic techniques to examine drug-DNA interactions', Methods for Studying Nucleic Acid/Drug Interactions, CRC Press 9781439839737.
  • Van Holst, M., Grant, M. and Aldrich-Wright, J. (2011), 'Target Biological Structures: The Cell, Organelles, DNA and RNA', Metallointercalators: Synthesis and Techniques to Probe Their Interactions with Biomolecules, Springer 9783211094273.
  • Orkey, N., Wormell, P. and Aldrich-Wright, J. (2011), 'Ruthenium Polypyridyl Metallointercalators', Metallointercalators: Synthesis and Techniques to Probe Their Interactions with Biomolecules, Springer 9783211094273.
  • Krause-Heuer, A., Manohar, M., Garbutcheon-Singh, K., Fisher, D. and Aldrich-Wright, J. (2011), 'The Synthesis of Platinum(II) Intercalators', Metallointercalators: Synthesis and Techniques to Probe Their Interactions with Biomolecules, Springer 9783211094273.
  • Harper, B., Van Holst, M. and Aldrich-Wright, J. (2011), 'Platinum(II) Intercalating Complexes Based on 2,2':6',2"-Terpyridine', Metallointercalators: Synthesis and Techniques to Probe Their Interactions with Biomolecules, Springer 9783211094273.
  • Salih, A., Wormell, P., Garbutcheon-Singh, K., Harper, B., Myers, S., Geny, D., Hammang, C. and Aldrich-Wright, J. (2011), 'Applications of Fluorescence Spectroscopy and Confocal Microscopy.', Metallointercalators: Synthesis and Techniques to Probe Their Interactions with Biomolecules, Springer 9783211094273.

Journal Articles

  • Ang, D., Kelso, C., Beck, J., Ralph, S., Harman, D. and Aldrich-Wright, J. (2020), 'A study of Pt(II)-phenanthroline complex interactions with double-stranded and G-quadruplex DNA by ESI-MS, circular dichroism, and computational docking', Journal of Biological Inorganic Chemistry, vol 25 , pp 429 - 440.
  • Dankers, C., Tadros, J., Harman, D., Aldrich-Wright, J., Nguyen, T. and Gordon, C. (2020), 'Immobilized carbodiimide assisted flow combinatorial protocol to facilitate amide coupling and lactamization', ACS Combinatorial Science, vol 22, no 5 , pp 255 - 267.
  • Bjelosevic, A., Sakoff, J., Gilbert, J., Zhang, Y., Gordon, C. and Aldrich-Wright, J. (2020), '[In Press] Synthesis, characterisation, and biological activity of the ruthenium complexes of the N4-Tetradentate (N4-TL), 1,6-Di(2'-pyridyl)-2,5-dimethyl-2,5-diazahexane (picenMe2)', Australian Journal of Chemistry, .
  • Khoury, A., Deo, K. and Aldrich-Wright, J. (2020), 'Recent advances in platinum-based chemotherapeutics that exhibit inhibitory and targeted mechanisms of action', Journal of Inorganic Biochemistry, vol 207 .
  • Kostrhunova, H., Zajac, J., Novohradsky, V., Kasparkova, J., Malina, J., Aldrich-Wright, J., Petruzzella, E., Sirota, R., Gibson, D. and Brabec, V. (2019), 'A subset of new platinum antitumor agents kills cells by a multimodal mechanism of action also involving changes in the organization of the microtubule cytoskeleton', Journal of Medicinal Chemistry, vol 62, no 10 , pp 5176 - 5190.
  • Li, L., Craze, A., Mustonen, O., Zenno, H., Whittaker, J., Hayami, S., Lindoy, L., Marjo, C., Clegg, J., Aldrich-Wright, J. and Li, F. (2019), 'A mixed-spin spin-crossover thiozolylimine [Fe4L6]8+ cage', Dalton Transactions, vol 48, no 27 , pp 9935 - 9938.
  • Spare, L., Menti, M., Harman, D., Aldrich-Wright, J. and Gordon, C. (2019), 'A continuous flow protocol to generate, regenerate, load, and recycle chlorotrityl functionalised resins', Reaction Chemistry and Engineering, vol 4, no 7 , pp 1309 - 1317.
  • McGhie, B., Sakoff, J., Gilbert, J. and Aldrich-Wright, J. (2019), 'Synthesis and characterisation of platinum(IV) polypyridyl complexes with halide axial ligands', Inorganica Chimica Acta, vol 495 .
  • Deo, K., Sakoff, J., Gilbert, J., Zhang, Y. and Aldrich-Wright, J. (2019), 'Synthesis, characterisation and potent cytotoxicity of unconventional platinum(iv) complexes with modified lipophilicity', Dalton Transactions, vol 48, no 46 , pp 17217 - 17227.
  • Deo, K., Sakoff, J., Gilbert, J., Zhang, Y. and Aldrich-Wright, J. (2019), 'Synthesis, characterisation and influence of lipophilicity on cellular accumulation and cytotoxicity of unconventional platinum(iv) prodrugs as potent anticancer agents', Dalton Transactions, vol 48, no 46 , pp 17228 - 17240.
  • Pages, B., Sakoff, J., Gilbert, J., Zhang, Y., Kelly, S., Hoeschele, J. and Aldrich-Wright, J. (2018), 'Combining the platinum(II) drug candidate kiteplatin with 1,10-phenanthroline analogues', Dalton Transactions, vol 47, no 7 , pp 2156 - 2163.
  • Ng, N., Wu, M. and Aldrich-Wright, J. (2018), 'The cytotoxicity of some phenanthroline-based antimicrobial copper(II) and ruthenium(II) complexes', Journal of Inorganic Biochemistry, vol 180 , pp 61 - 68.
  • Deo, K., Ang, D., McGhie, B., Rajamanickam, A., Dhiman, A., Khoury, A., Holland, J., Bjelosevic, A., Pages, B., Gordon, C. and Aldrich-Wright, J. (2018), 'Platinum coordination compounds with potent anticancer activity', Coordination Chemistry Reviews, vol 375 , pp 148 - 163.
  • Ng, N., Wu, M., Myers, S. and Aldrich-Wright, J. (2018), 'The in vitro renal cell toxicity of some unconventional anticancer phenanthroline-based platinum(II) complexes', Journal of Inorganic Biochemistry, vol 179 , pp 97 - 106.
  • Spare, L., Harman, D., Aldrich-Wright, J., Nguyen, T. and Gordon, C. (2018), 'Chemoselective flow hydrogenation approaches to diversify the cytotoxic tetrahydroepoxyisoindole carboxamide scaffold', Advanced Synthesis and Catalysis, vol 360, no 6 , pp 1209 - 1217.
  • Li, L., Craze, A., Akiyoshi, R., Tsukiashi, A., Hayami, S., Mustonen, O., Bhadbhade, M., Bhattacharyya, S., Marjo, C., Wang, Y., Lindoy, L., Aldrich-Wright, J. and Li, F. (2018), 'Direct monitoring of spin transitions in a dinuclear triple-stranded helicate iron(II) complex through X-ray photoelectron spectroscopy', Dalton Transactions, vol 47, no 8 , pp 2543 - 2548.
  • Johnson, B., Burgess, M., Murray, V., Aldrich-Wright, J. and Temple, M. (2018), 'The interactions of novel mononuclear platinum-based complexes with DNA', BMC Cancer, vol 18 .
  • Spare, L., Laude, V., Harman, D., Aldrich-Wright, J. and Gordon, C. (2018), 'An optimised approach for continuous-flow solid-phase peptide synthesis utilising a rudimentary flow reactor', Reaction Chemistry and Engineering, vol 3, no 6 , pp 875 - 882.
  • Li, L., Craze, A., Fanna, D., Brock, A., Clegg, J., Lindoy, L., Aldrich-Wright, J., Reynolds, J. and Li, F. (2017), 'Synthesis and characterization of two Cu(I) metalloligands based on tetradentate tripodal ligands', Polyhedron, vol 125 , pp 44 - 49.
  • Spare, L., Falsetta, P., Gilbert, J., Harman, D., Baker, M., Li, F., McCluskey, A., Clegg, J., Sakoff, J., Aldrich-Wright, J. and Gordon, C. (2017), 'Cytotoxicity of a series of norcantharidin-inspired tetrahydroepoxyisoindole carboxamides', ChemMedChem, vol 12, no 2 , pp 130 - 145.
  • Pages, B., Garbutcheon-Singh, K. and Aldrich-Wright, J. (2017), 'Platinum intercalators of DNA as anticancer agents', European Journal of Inorganic Chemistry, vol 2017, no 12 , pp 1613 - 1624.
  • Harper, B., Friedman-Ezra, A., Sirota, R., Petruzzella, E., Aldrich-Wright, J. and Gibson, D. (2017), 'Probing the interactions of cytotoxic [Pt(1S,2S-DACH)(5,6-dimethyl-1,10-phenanthroline)] and its PtIV derivatives with human serum', ChemMedChem, vol 12, no 7 , pp 510 - 519.
  • Klenner, M., Pascali, G., Zhang, B., Sia, T., Spare, L., Krause-Heuer, A., Aldrich-Wright, J., Greguric, I., Guastella, A., Massi, M. and Fraser, B. (2017), 'A fluorine-18 radiolabeling method enabled by Rhenium(I) complexation circumvents the requirement of anhydrous conditions', Chemistry: A European Journal, vol 23, no 27 , pp 6499 - 6503.
  • Li, L., Neville, S., Craze, A., Clegg, J., Sciortino, N., Arachchige, K., Mustonen, O., Marjo, C., McRae, C., Kepert, C., Lindoy, L., Aldrich-Wright, J. and Li, F. (2017), 'Spin-state patterning in an iron(II) tripodal spin-crossover complex', ACS Omega, vol 2, no 7 , pp 3349 - 3353.
  • Petruzzella, E., Braude, J., Aldrich-Wright, J., Gandin, V. and Gibson, D. (2017), 'A quadruple-action platinum (IV) prodrug with anticancer activity against KRAS mutated cancer cell lines', Angewandte Chemie (International Edition), vol 56, no 38 , pp 11539 - 11544.
  • Harper, B., Petruzzella, E., Sirota, R., Faccioli, F., Aldrich-Wright, J., Gandin, V. and Gibson, D. (2017), 'Synthesis, characterization and in vitro and in vivo anticancer activity of Pt(iv) derivatives of [Pt(1S,2S-DACH)(5,6-dimethyl-1,10-phenanthroline)]', Dalton Transactions, vol 46, no 21 , pp 7005 - 7019.
  • Bjelosevic, A., Pages, B., Spare, L., Deo, K., Ang, D. and Aldrich-Wright, J. (2017), 'Exposing "bright" metals : promising advances in photoactivated anticancer transition metal complexes', Current Medicinal Chemistry, vol 24 , pp 1 - 15.
  • Callari, M., Wong, S., Lu, H., Aldrich-Wright, J., de Souza, P. and Stenzel, M. (2017), 'Drug induced self-assembly of triblock copolymers into polymersomes for the synergistic dual-drug delivery of platinum drugs and paclitaxel', Polymer Chemistry, vol 8, no 40 , pp 6289 - 6299.
  • Fanna, D., Zhang, Y., Li, L., Karatchevtseva, I., Shepherd, N., Azim, A., Price, J., Aldrich-Wright, J., Reynolds, J. and Li, F. (2016), '3d transition metal complexes with a julolidine-quinoline based ligand : structures, spectroscopy and optical properties', Inorganic Chemistry Frontiers, vol 3, no 2 , pp 286 - 295.
  • Ang, D., Harper, B., Cubo, L., Mendoza, O., Vilar, R. and Aldrich-Wright, J. (2016), 'Quadruplex DNA-stabilising dinuclear platinum(II) terpyridine complexes with flexible linkers', Chemistry: A European Journal, vol 22, no 7 , pp 2317 - 2325.
  • Garbutcheon-Singh, K., Galanski, M., Keppler, B. and Aldrich-Wright, J. (2016), 'Synthesis, characterisation and cytotoxicity of [(1,10-phenanthroline)(1R,2R,4R/1S,2S,4S)-4-methyl-1,2-cyclohexanediamine)platinum(II)]2+ (PHEN-4-MeDACH)', Inorganica Chimica Acta, vol 441 , pp 152 - 156.
  • Taha, .., Siddiqui, K., Campanaro, S., Najnin, T., Deshpande, N., Williams, T., Aldrich-Wright, J., Wilkins, M., Curmi, P. and Cavicchioli, R. (2016), 'Single TRAM domain RNA-binding proteins in Archaea : functional insight from Ctr3 from the Antarctic methanogen Methanococcoides burtonii', Environmental Microbiology, vol 18 , pp 2810 - 2824.
  • Pages, B., Sakoff, J., Gilbert, J., Zhang, Y., Li, F., Preston, D., Crowley, J. and Aldrich-Wright, J. (2016), 'Investigating the cytotoxicity of platinum(II) complexes incorporating bidentate pyridyl-1,2,3-triazole 'click' ligands', Journal of Inorganic Biochemistry, vol 165 , pp 92 - 99.
  • Harper, B., Morris, T., Gailer, J. and Aldrich-Wright, J. (2016), 'Probing the interaction of bisintercalating (2,2':6',2''-terpyridine)platinum(II) complexes with glutathione and rabbit plasma', Journal of Inorganic Biochemistry, vol 163 , pp 95 - 102.
  • Ng, N., Wu, M., Jones, C. and Aldrich-Wright, J. (2016), 'The antimicrobial efficacy and DNA binding activity of the copper(II) complexes of 3,4,7,8-tetramethyl-1,10-phenanthroline, 4,7-diphenyl-1,10-phenanthroline and 1,2-diaminocyclohexane', Journal of Inorganic Biochemistry, vol 162 , pp 62 - 72.
  • Li, L., Zhang, Y., Avdeev, M., Lindoy, L., Harman, D., Zheng, R., Cheng, Z., Aldrich-Wright, J. and Li, F. (2016), 'Self-assembly of a unique 3d/4f heterometallic square prismatic box-like coordination cage', Dalton Transactions, vol 45, no 23 , pp 9407 - 9411.
  • Pages, B., Sakoff, J., Gilbert, J., Rodger, A., Chmel, N., Jones, N., Kelly, S., Ang, D. and Aldrich-Wright, J. (2016), 'Multifaceted studies of the DNA interactions and in vitro cytotoxicity of anticancer polyaromatic platinum(II) complexes', Chemistry: A European Journal, vol 22, no 26 , pp 8943 - 8954.
  • Deo, K., Pages, B., Ang, D., Gordon, C. and Aldrich-Wright, J. (2016), 'Transition metal intercalators as anticancer agents : recent advances', International Journal of Molecular Sciences, vol 17, no 11 .
  • Ertanab, H., Cassela, C., Verma, A., Poljakc, A., Charlton, T., Aldrich-Wright, J., Omara, S., Siddiqui, K. and Cavicchioli, R. (2015), 'A new broad specificity alkaline metalloprotease from a Pseudomonas sp. isolated from refrigerated milk : role of calcium in improving enzyme productivity', Journal of Molecular Catalysis B: Enzymatic, vol 113 , pp 1 - 8.
  • Pages, B., Ang, D., Wright, E. and Aldrich-Wright, J. (2015), 'Metal complex interactions with DNA', Dalton Transactions, vol 44, no 8 , pp 3505 - 3526.
  • Harper, B. and Aldrich-Wright, J. (2015), 'The synthesis, characterisation and cytotoxicity of bisintercalating (2,2':6',2''-terpyridine)platinum(II) complexes', Dalton Transactions, vol 44, no 1 , pp 87 - 96.
  • Ang, D., Jones, N., Stootman, F., Ghadirian, B. and Aldrich-Wright, J. (2015), 'Improved DNA equilibrium binding affinity determinations of platinum(II) complexes using synchrotron radiation circular dichroism', Analyst, vol 140, no 12 , pp 4162 - 4169.
  • Li, L., Saigo, N., Zhang, Y., Fanna, D., Shepherd, N., Clegg, J., Zheng, R., Hayami, S., Lindoy, L., Aldrich-Wright, J., Li, C., Reynolds, J., Harman, D. and Li, F. (2015), 'A large spin-crossover [Fe4L4]8+ tetrahedral cage', Journal of Materials Chemistry C, vol 3, no 30 , pp 7878 - 7882.
  • Pages, B., Zhang, Y., Li, F., Sakoff, J., Gilbert, J. and Aldrich-Wright, J. (2015), 'Cytotoxicity and structural analyses of 2,2'-Bipyridine-,4,4'-Dimethyl-2,2'-bipyridine- and 2-(2'-Pyridyl)-quinoxalineplatinum(II) complexes', European Journal of Inorganic Chemistry, vol 2015, no 25 , pp 4167 - 4175.
  • Macias, F., Deo, K., Pages, B., Wormell, P., Clegg, J., Zhang, Y., Li, F., Zheng, G., Sakoff, J., Gilbert, J. and Aldrich-Wright, J. (2015), 'Synthesis and analysis of the structure, diffusion and cytotoxicity of heterocyclic platinum(IV) complexes', Chemistry: A European Journal, vol 21, no 47 , pp 16990 - 17001.
  • Macias, F., Deo, K., Pages, B., Wormell, P., Clegg, J., Zhang, Y., Li, F., Zheng, G., Sakoff, J., Gilbert, J. and Aldrich-Wright, J. (2015), 'Synthesis and analysis of the structure, diffusion and cytotoxicity of heterocyclic platinum(IV) complexes', Chemistry: A European Journal, vol 21, no 47 , pp 16990 - 17001.
  • Reichel, F., Clegg, J., Gloe, K., Gloe, K., Weigand, J., Reynolds, J., Li, C., Aldrich-Wright, J., Kepert, C., Lindoy, L., Yao, H. and Li, F. (2014), 'Self-assembly of an imidazolate-bridged FeIII/CuII heterometallic cage', Inorganic Chemistry, vol 53, no 2 , pp 688 - 690.
  • Garbutcheon-Singh, K., Harper, B., Myers, S. and Aldrich-Wright, J. (2014), 'Combination studies of platinum(II)-based metallointercalators with buthionine-S,R-sulfoximine, 3-bromopyruvate, cisplatin or carboplatin', Metallomics, vol 6, no 1 , pp 126 - 131.
  • Beeton, M., Aldrich-Wright, J. and Bolhuis, A. (2014), 'The antimicrobial and antibiofilm activities of copper(II) complexes', Journal of Inorganic Biochemistry, vol 140 , pp 167 - 172.
  • Callari, M., Aldrich-Wright, J., de Souza, P. and Stenzel, M. (2014), 'Polymers with platinum drugs and other macromolecular metal complexes for cancer treatment', Progress in Polymer Science, vol 39, no 9 , pp 1614 - 1643.
  • Millington, C., Sonego, S., Karunaweera, N., Rangel, A., Aldrich-Wright, J., Campbell, I., Gyengesi, E. and Muench, G. (2014), 'Chronic neuroinflammation in Alzheimer's disease : new perspectives on animal models and promising candidate drugs', BioMed Research International, vol 2014 .
  • Bolhuis, A. and Aldrich-Wright, J. (2014), 'DNA as a target for antimicrobials', Bioorganic Chemistry, vol 55 , pp 51 - 59.
  • Pages, B., Li, F., Wormell, P., Ang, D., Clegg, J., Kepert, C., Spare, L., Danchaiwijit, S. and Aldrich-Wright, J. (2014), 'Synthesis and analysis of the anticancer activity of platinum(II) complexes incorporating dipyridoquinoxaline variants', Dalton Transactions, vol 43, no 41 , pp 15566 - 15575.
  • Wright, E., Padula, M., Higgins, V., Aldrich-Wright, J. and Coorssen, J. (2014), 'A systems biology approach to understanding the mechanisms of action of an alternative anticancer compound in comparison to cisplatin', Proteomes, vol 2, no 4 , pp 501 - 526.
  • Ng, N., Leverett, P., Hibbs, D., Yang, Q., Bulanadi, J., Wu, M. and Aldrich-Wright, J. (2013), 'The antimicrobial properties of some copper(II) and platinum(II) 1,10-phenanthroline complexes', Dalton Transactions, vol 42, no 9 , pp 3196 - 3209.
  • Garbutcheon-Singh, K., Leverett, P., Myers, S. and Aldrich-Wright, J. (2013), 'Cytotoxic platinum(II) intercalators that incorporate 1R,2R-diaminocyclopentane', Dalton Transactions, vol 42, no 4 , pp 918 - 926.
  • Petitjean, H., Guiglion, P., In, M., Aldrich-Wright, J., Castignolles, P., Ganachaud, F. and Gaborieau, M. (2013), 'Supramolecular organization of protonated aminosilicones in water', Journal of Colloid and Interface Science, vol 408 , pp 87 - 93.
  • Garbutcheon-Singh, K., Myers, S., Harper, B., Ng, N., Dong, Q., Xie, C. and Aldrich-Wright, J. (2013), 'The effects of 56MESS on mitochondrial and cytoskeletal proteins and the cell cycle in MDCK cells', Metallomics, vol 5, no 8 , pp 1061 - 1067.
  • Maniego, A., Ang, D., Guillaneuf, Y., Lefay, C., Gigmes, D., Aldrich-Wright, J., Gaborieau, M. and Castignolles, P. (2013), 'Separation of poly(acrylic acid) salts according to topology using capillary electrophoresis in the critical conditions', Analytical and Bioanalytical Chemistry, vol 405, no 28 , pp 9009 - 9020.
  • Orkey, N., Taleb, R. and Aldrich-Wright, J. (2012), 'Synthesis and characterisation of metallopolyamide complexes', Inorganica Chimica Acta, vol 393 , pp 187 - 197.
  • Krause-Heuer, A., Price, W. and Aldrich-Wright, J. (2012), 'Spectroscopic investigations on the interactions of potent platinum(II) anticancer agents with bovine serum albumin', Journal of Chemical Biology, vol 5, no 3 , pp 105 - 113.
  • Davis, K., Carrall, J., Lai, B., Aldrich-Wright, J., Ralph, S. and Dillon, C. (2012), 'Does cytotoxicity of metallointercalators correlate with cellular uptake or DNA affinity?', Dalton Transactions, vol 41, no 31 , pp 9417 - 9426.
  • Krause-Heuer, A., Leverett, P., Bolhuis, A. and Aldrich-Wright, J. (2012), 'Copper(ii) and palladium(ii) complexes with cytotoxic and antibacterial activity', Australian Journal of Chemistry, vol 65, no 7 , pp 860 - 873.
  • Wang, S., Wu, M., Higgins, V. and Aldrich-Wright, J. (2012), 'Comparative analyses of cytotoxicity and molecular mechanisms between platinum metallointercalators and cisplatin', Metallomics, vol 4, no 9 , pp 950 - 959.
  • Wang, S., Higgins, V., Aldrich-Wright, J. and Wu, M. (2012), 'Identification of the molecular mechanisms underlying the cytotoxic action of a potent platinum metallointercalator', Journal of Chemical Biology, vol 5, no 2 , pp 51 - 61.
  • Aldrich-Wright, J. (2012), 'Metallo-helical complexes resolutely pure helices', Nature Chemistry, vol 4, no 1 , pp 10 - 11.
  • Garbutcheon-Singh, K., Grant, M., Harper, B., Manohar, M., Krause-Heuer, A., Orkey, N. and Aldrich-Wright, J. (2011), 'Transition metal based anticancer drugs', Current Topics in Medicinal Chemistry, vol 11, no 5 , pp 521 - 542.
  • Bolhuis, A., Hand, L., Marshall, J., Richards, A., Rodger, A. and Aldrich-Wright, J. (2011), 'Antimicrobial activity of ruthenium-based intercalators', European Journal of Pharmaceutical Sciences, vol 42, no 4 , pp 313 - 317.
  • Moretto, J., Chauffert, B., Ghiringhelli, F., Aldrich-Wright, J. and Bouyer, F. (2011), 'Discrepancy between in vitro and in vivo antitumor effect of a new platinum(II) metallointercalator', Investigational New Drugs, vol 29, no 6 , pp 1164 - 1176.
  • Harper, B., Krause-Heuer, A., Grant, M., Manohar, M., Garbutcheon-Singh, K. and Aldrich-Wright, J. (2010), 'Advances in platinum chemotherapeutics', Chemistry: A European Journal, vol 16, no 24 , pp 7064 - 7077.
  • Talib, J., Harman, D., Dillon, C., Aldrich-Wright, J., Beck, J. and Ralph, S. (2009), 'Does the metal influence non-covalent binding of complexes to DNA', Dalton Transactions, vol 38, no 3 , pp 504 - 513.
  • Grant, M., Wheate, N. and Aldrich-Wright, J. (2009), 'Diffusion coefficient of curcurbit[n]urils (n=6 or 7) at various concentrations, temperature and pH', Journal of Chemical & Engineering Data, vol 54, no 2 , pp 323 - 326.
  • Pisani, M., Wheate, N., Keene, F., Aldrich-Wright, J. and Collins, J. (2009), 'Anionic PAMAM dendrimers as drug delivery vehicles for transition metal-based anticancer drugs', Journal of Inorganic Biochemistry, vol 103, no 3 , pp 373 - 380.
  • Jones, D., Van Host, M., Yano, S., Tanase, T. and Aldrich-Wright, J. (2009), 'N-Glycoside Complexes of Nickel(II); Probing Carbohydrate-Transition Metal Interactions', Australian Journal of Chemistry, vol 62, no 3 , pp 265 - 268.
  • Krause-Heuer, A., Wheate, N., Price, W. and Aldrich-Wright, J. (2009), 'Diffusion-based studies on the self-stacking and nanorod formation of platinum(II) intercalators', Chemical Communications, vol 10 , pp 1210 - 1212.
  • Krause-Heuer, A., Grnert, R., Khne, S., Buczkowska, M., Wheate, N., Le Pevelen, D., Boag, L., Fisher, D., Kasparkova, J., Malina, J., Bednarski, P., Brabec, V. and Aldrich-Wright, J. (2009), 'Studies of the Mechanism of Action of Platinum (II) complexes with Potent Cytotoxicity in Human Cander Cells', Journal of Medicinal Chemistry, vol 52, no 17 , pp 5474 - 5484.
  • Talib, J., Beck, J., Urathamakul, T., Nguyen, C., Aldrich-Wright, J., Mackay, J. and Ralph, S. (2009), 'A mass spectrometric investigation of the ability of metal complexes to modulate transcription factor activity', Chemical Communications, , no 37 , pp 5546 - 5548.
  • Amon, M., Ali, M., Bender, V., Hall, K., Aguilar, M., Aldrich-Wright, J. and Manolios, N. (2008), 'Kinetic and conformational properties of a novel T-cell antigen receptor transmembrane peptide in model membranes', Journal of Peptide Science, vol 14, no 6 , pp 714 - 724.
  • Urathamakul, T., Waller, D., Beck, J., Aldrich-Wright, J. and Ralph, S. (2008), 'Comparison of Mass Spectrometry and Other Techniques for Probing Interactions Between Metal Complexes and DNA', Inorganic Chemistry, vol 47, no 15 , pp 6621 - 6632.
  • Krause-Heuer, A., Wheate, N., Tilby, M., Pearson, G., Ottley, C. and Aldrich-Wright, J. (2008), 'Substituted B Cyclodextrin and Calix[4]arene as Encapsulatory Vehicles for Platinum(II)-Based DNA Intercalators', Inorganic Chemistry, vol 47, no 15 , pp 6880 - 6888.
  • Kemp, S., Wheate, N., Pisani, M. and Aldrich-Wright, J. (2008), 'Degredation of Bidentate-Coordinated Platinum(II) Based DNA Intercalators by Reduced L-Glutathione', Journal of Medicinal Chemistry, vol 51, no 9 , pp 2787 - 2794.
  • Wheate, N., Payyadi Govardhan, A., Torres, A., Aldrich-Wright, J. and Price, W. (2008), 'Examination of cucurbit[7]uril and its host-guest complexes by diffusion nuclear magnetic resonance', Journal of Physical Chemistry B, vol 112, no 8 , pp 2311 - 2314.
  • Talib, J., Green, C., Davis, K., Beck, J., Urathamakul, T., Aldrich-Wright, J. and Ralph, S. (2008), 'A comparison of the binding of metal complexes to duplex and quadruplex DNA', Journal of the Chemical Society, Dalton Transactions, vol 8 , pp 1018 - 1026.
  • Van Holst, M., Le Pevelen, D. and Aldrich-Wright, J. (2008), 'Terpyridineplatinum (II) Incorporation in N-Methylpyrrole-Based Polyamides by Solid Phase Techniques', European Journal of Inorganic Chemistry, vol 29 , pp 4608 - 4615.
  • Krause-Heuer, A., Grant, M., Orkey, N. and Aldrich-Wright, J. (2008), 'Drug Delivery Devices and Targeting Agents for Platinum (II) Anticancer Complexes', Australian Journal of Chemistry, vol 61, no 9 , pp 675 - 681.
  • Fisher, D., Fenton, R. and Aldrich-Wright, J. (2008), 'In vivo studies of platinum (II) metallointercalators', Chemical Communications, vol 43 , pp 5613 - 5615.
  • Yousouf, S., Brodie, C., Wheate, N. and Aldrich-Wright, J. (2007), 'Synthesis of a heterodinuclear ruthenium(II)-platinum(II) complex linked by L-cysteine methyl ester', Polyhedron, vol 26, no 2 , pp 318 - 328.
  • Still, B., Payyadi Govardhan, A., Aldrich-Wright, J. and Price, W. (2007), '195Pt NMR-theory and application', Chemical Society Reviews, vol 36 , pp 665 - 686.
  • Taleb, R., Jaramillo, D., Wheate, N. and Aldrich-Wright, J. (2007), 'Synthesis of DNA-sequence-selective hairpin polyamide platinum complexes', Chemistry: A European Journal, vol 13, no 11 , pp 3177 - 3186.
  • Fisher, D., Bednarski, P., Grunert, R., Turner, P., Fenton, R. and Aldrich-Wright, J. (2007), 'Chiral platinum(II) metallointercalators with potent in vitro cytotoxic activity', ChemMedChem, vol 2, no 4 , pp 488 - 495.
  • Wheate, N., Brodie, C., Collins, G., Kemp, S. and Aldrich-Wright, J. (2007), 'DNA intercalators in cancer therapy: Organic and inorganic drugs and their spectroscopic tools of analysis', Mini Reviews in Medicinal Chemistry, vol 7, no 6 , pp 627 - 648.
  • Kemp, S., Wheate, N., Buck, D., Nikac, M., Collins, J. and Aldrich-Wright, J. (2007), 'The effect of ancillary ligand chirality and phenanthroline functional group substitution on the cytotoxicity of platinum(II)-based metallointercalators', Journal of Inorganic Biochemistry, vol 101, no 7 , pp 1049 - 1058.
  • Aldrich-Wright, J., Fenton, R., Leverett, P., Stephens, F., Williams, P. and Vagg, R. (2007), 'The synthesis and structural analysis of cis-beta-{(1,6-di(2'-pyridyl)(2,5-dibenzyl-2,5-diazahexane)(1,2-diazahexane)(1,2-benzoquinone diimine)ruthenium(II)} and related complexes', Journal of Coordination Chemistry, vol 60, no 17-19 , pp 2015 - 2034.
  • Kemp, S., Wheate, N., Stootman, F. and Aldrich-Wright, J. (2007), 'The host-guest chemistry of proflavine with cucurbit[6,7,8]urils', Supramolecular Chemistry, vol 19, no 7 , pp 475 - 484.
  • Wheate, N., Taleb, R., Krause-Heuer, A., Cook, R., Higgins, V., Aldrich-Wright, J. and Wang, S. (2007), 'Novel platinum(II)-based anticancer complexes and molecular hosts as their drug delivery vehicles', Journal of the Chemical Society, Dalton Transactions, , pp 5055 - 5064.
  • Brodie, C. and Aldrich-Wright, J. (2007), 'Synthesis of Flexible Bis-Intercalating Ruthenium (II) Complexes', European Journal of Inorganic Chemistry, vol 30 , pp 4781 - 4793.
  • Kemp, S., Wheate, N., Wang, S., Collins, G., Higgins, V., Aldrich-Wright, J., Ralph, S. and Day, A. (2007), 'Encapsulation of platinum(II)-based DNA intercalators within cucurbit[6,7,8]urils', Journal of Biological Inorganic Chemistry, vol 12, no 7 , pp 969 - 979.
  • Jaramillo, D., Junk, P., Brodie, C. and Aldrich-Wright, J. (2006), 'chloro(dimehtylsulfoxide-kS)[(1R,3S)-1,2,2-trimethylcyclopentane-1,3-diamine-k2N,N']platinum(II) trichloro(dimethyl sulfoxide-kS)platinum(II)', Acta Crystallographica E, vol E62 , pp 3377 - 3379.
  • Stootman, F., Fisher, D., Rodger, A. and Aldrich-Wright, J. (2006), 'Improved curve fitting procedures to determine equilibrium binding constants', The Analyst, vol 131, no 10 , pp 1145 - 1151.
  • Brodie, C., Turner, P., Wheate, N. and Aldrich-Wright, J. (2006), '(4,7-dimethyl-1,10-phenanthroline)ethylenediamine)platinum(II) dichloride tris(deuterium oxide) solvate', Acta Crystallographica. Section E: Structure Reports Online, vol E62 , pp 3137 - 3139.
  • Jaramillo, D., Buck, D., Collins, J., Wheate, N., Stootman, F., Aldrich-Wright, J. and Fenton, R. (2006), 'Synthesis, characterisation and biological activity of chiral platinum(II) complexes', European Journal of Inorganic Chemistry, vol 4 , pp 839 - 849.
  • Jaramillo, D., Wheate, N., Ralph, S., Howard, W., Tor, Y. and Aldrich-Wright, J. (2006), 'Polyamide platinum anticancer complexes designed to target specific DNA sequences', Inorganic Chemistry, vol 45, no 15 , pp 6004 - 6013.
  • Jaramillo, D., Liu, Q., Aldrich-Wright, J. and Yitzhak, T. (2004), 'Synthesis of N-Methylpyrrole and N-Methylimidaqzole Amino Acids Suitable for Solid-Phase Synthesis', Journal of Organic Chemistry, vol 69 , pp 8151 - 8153.
  • Brodie, C., Collins, J. and Aldrich-Wright, J. (2004), 'DNA binding and biological activity of some platinum(II) intercalating compounds containing methyl-substituted 1,10-phenanthrolines', Dalton Transactions, , pp 1145 - 1152.
  • Urathamakul, T., Beck, J., Sheil, M., Aldrich-Wright, J. and Ralph, S. (2004), 'A mass spectrometric investigation of non-covalent interactions between ruthenium complexes and DNA', Dalton Transactions, , pp 2683 - 2690.
  • Gupta, R., Beck, J., Ralph, S., Sheil, M. and Aldrich-Wright, J. (2004), 'Comparison of the Binding Stoichiometries of Positively Charged DNA-Binding Drugs using positive and negative ion electrospray ionization mass spectrometry', American Society for Mass Spectronomy Journal, vol 15 , pp 1382 - 1391.
  • Aldrich-Wright, J., Brodie, C., Glazer, E., Luedtke, N., Elson-Schwab, L. and Tor, Y. (2004), 'Symmetrical dinuclear complexes with high DNA affinity based on [Ru(dpq)2(phen)]2+', Chemical Communications, , pp 1018 - 1019.
  • Pellegrini, P. and Aldrich-Wright, J. (2003), 'Evidence for chiral discrimination of ruthenium(II) polypyridyl complexes by DNA', Dalton Transactions, , pp 176 - 183.
  • Aldrich-Wright, J., Vagg, J. and Williams, P. (2003), 'HPLC separation of diasteromeric metal complexes of the form Delta, Lambda-[Ru(diimine)2(S-aminoacidate)].', Australian Journal of Chemistry, , pp 1193 - 1200.
  • Aldrich-Wright, J. and Howard, W. (2003), 'DNA binding studies of ruthenium (II) dipyridotetrahydrophenazine complexes', Journal of Inorganic Biochemistry, , pp 152 - 152.
  • Aldrich-Wright, J., Jaramillo, D., Collins, G. and Junk, P. (2003), 'The structure-Activity relationship of Chiral Square-Planar Platinum(II) Metallointercalators', Journal of Inorganic Biochemistry, , pp 159 - 159.
  • Aldrich-Wright, J., Ralph, S., Gupta, R., Urathamakul, T., Sheil, M. and Beck, J. (2003), 'Probing the DNA selectivity of Ruthenium Metallointercalators usin ESI Mass Spectometry', Journal of Inorganic Biochemistry, , pp 214 - 214.
  • Aldrich-Wright, J., Yousouf, S. and Brodie, C. (2003), 'Synthesis of Ruthenuym-Platinum Di- and Tri- nuclear Complexes', Journal of Inorganic Biochemistry, , pp 259 - 259.
  • Aldrich-Wright, J., Collins, G. and Keene, R. (2003), 'Dinuclear Ruthenium Complexes as Sequence- and Structure-Selective binding agents for DNA', Journal of Inorganic Biochemistry, , pp 90 - 90.
  • Aldrich-Wright, J., Brodie, C., Glazer, E., Luedtke, N. and Tor, Y. (2003), 'Synthesis and DNA binding of bisintercalating complexes of the type [(dpq)(2)Ru(phen-n-SOS-n-phen)Ru(dpq)(2)](4+)', Journal of Inorganic Biochemistry, , pp 105 - 105.
  • Aldrich-Wright, J., Fenton, R. and Fisher, D. (2003), 'Platinum(II) Intercalators as potential Anti-Cancer Agents', Journal of Inorganic Biochemistry, , pp 106 - 106.
  • Aldrich-Wright, J., Hinds, F., Leverett, P. and Hazell, S. (2003), 'Synthesis, characterisation and anti bacterial testing of Bismuth maltol', Journal of Inorganic Biochemistry, , pp 144 - 144.
  • Aldrich-Wright, J., van Holst, M. and Jaramillo, D. (2003), 'The Synthesis of 2,3-Diamino-2,3-dideoxy-a-D-glucose, 3,4-Diamino-6-hydroxymethyl-tetrahydro-pyran-2,5-diol and their Chiral Platinum Compounds', Journal of Inorganic Biochemistry, , pp 151 - 151.
  • Back, J., Gupta, R., Urathamakul, T., Williamson, N., Sheil, M., Aldrich-Wright, J. and Ralph, S. (2003), 'Probing DNA selectivity of ruthenium metallointercalators using ESI mass spectrometry', Chemical Communications, vol 9, no 5 , pp 626 - 627.
  • Greguric, A., Greguric, I., Hambley, T., Aldrich-Wright, J. and Collins, G. (2002), 'Minor Groove Intercalation of D-[Ru(Me2phen)2dppz]2+ to the Hexanucleotide d(GTCGAC)2', Journal of the Chemical Society, Dalton Transactions, vol 6 , pp 849 - 855.
  • Hinds, F., Harris, A., Campbell, M., Aldrich-Wright, J. and Hazell, S. (2002), 'Iron transport systems are necessary to Helicobacter pylori, providing a level of protection against bismuth activity.', Gut, .
  • Aldrich-Wright, J., Fenton, R., Greguric, I., Hambley, T. and Williams, P. (2002), 'The stereospecific synthesis of Lambda-alpha-{dipyrido[3,2-a:2'3'-c](6,7,8,9-tetrahydro)phenazine[N,N'-di(2-picolyl)-2,5-dimethyl-2S,5S-diaminocyclohexane]ruthenium(II)} and related beta isomers', Journal of the Chemical Society, Dalton Transactions, , pp 4666 - 4671.

Conference Papers

  • Aldrich-Wright, J., Wheate, N. and Taleb, R. (2007), 'Novel platinum(II) based anticancer drugs; metallointercalators and DNA sequence specific agents', 13th International Conference on Biological Inorganic Chemistry, Vienna, Austria.
  • Aldrich-Wright, J., Wheate, N., Wright, E., Dawes, I. and Higgins, V. (2007), 'Molecular mechanisms involved in the Saccharomyces cerevisiae response to the novel anticance platinum compond 56MESS', 13th International Conference on Biological Inorganic Chemistry, Vienna, Austria.
  • Aldrich-Wright, J., Wheate, N. and Krause-Heuer, A. (2007), 'Use of molecular hosts in the drug delivery of platinum(II) based DNA intercalating agents', 13th International Conference on Biological Inorganic Chemistry, Vienna, Austria.
  • Wang, S., Cook, R., Aldrich-Wright, J. and Higgins, V. (2007), 'Structure-cytotoxicity relationships of novel platinum anticancer drugs in cancer cells and Saccharomyces cerevisiae', XXIIIrd International Conference of Yeast Genetics and Molecular Biology, Melbourne, Australia.
  • Wright, E., Aldrich-Wright, J., Wheate, N., Dawes, I. and Higgins, V. (2007), 'The use of a Saccharomyces cerevisiae deletion mutant library to elucidate the molecular mechanisms involved in the eukaryote response to the novel platinum anticancer compound 56MESS', XXIIIrd International Conference of Yeast Genetics and Molecular Biology, Melbourne, Australia.
  • Miyoshi, E., Price, W. and Aldrich-Wright, J. (2005), 'Multinuclear NMR and in vivo studies of platinum-based anti-cancer drugs.', College of Science, Technology and Environment Innovation Conference 2005, Werrington South, NSW, Australia.
  • Apps, M., Price, W. and Aldrich-Wright, J. (2005), 'NMR and optical studies of the association of biomolecules', College of Science, Technology and Environment Innovation Conference 2005, Werrington South, NSW, Australia.

Other Publications

  • 2002, 'Metal Complexes and Therapeutic uses thereof', Patent
  • 2002, 'Selective Compounds', Patent

Understanding how molecules find a unique binding position on a segment of DNA ranks among the most fascinating and important current chemical and/or biochemical questions because it is absolutely essential for determining how biological systems work. The rational design of therapeutic drugs design requires an understanding of the physical and chemical principles involved in DNA and RNA recognition and for improved design this information is essential. My research objective has been to significantly extend our understanding of the principles involved in sequence-specific recognition of biological molecules like DNA by carrying out investigations of the binding of metal complexes. The result of this work has far-reaching consequences on the rational design of DNA-based chemotherapeutic agents, effective DNA probes and DNA-sequencing agents. To achieve these objectives a number of metal complexes have been designed, synthesised, resolved and characterised in order to aid our understand of how DNA discriminates between simple molecules by determining their binding affinity and biological activity.

Octahedral metallointercalators are a class of compounds which have been extensively used as probes for DNA recognition. There has been considerable interest, and controversy, in determining their precise mode of DNA binding. Our studies were able to unambiguously demonstrate that these metal complexes could intercalate from the minor groove.

Platinum compounds that are in clinical use, such as cisplatin and its analogues, exhibit their activity by binding covalently to DNA in the cancerous cell thus preventing cell division. The potent compounds we investigate interact in an entirely different way with DNA, through non-covalent interactions. They are highly soluble in water, show very high level of activity in cell lines suggesting they are likely to demonstrate high clinical activity and effectiveness at low dosage and exhibit a high level of activity against cisplatin resistant cell lines.

Microbial biofilm infections play a significant role in chronic infections within the healthcare system due mainly to their resistance to antibiotic treatments. We have determined that our copper complexes exhibit antibacterial activity against the biofilms of Staphylococcus aureus and yeast Candida krusei.

This information has been contributed by Professor Aldrich-Wright.

Previous Projects

Title: Sequence selective platinum drugs for DNA
Funder:
  • University of Western Sydney
Western Researchers: Janice Aldrich-Wright
Years: 2004-02-16 - 2005-02-15
ID: P0011764
Title: The Synthesis of Bis-intercalating Metal Complexes with Sequence-Specific Recognition in the Minor Groove of DNA
Funder:
  • University of Western Sydney
Western Researchers: Janice Aldrich-Wright
Years: 2001-01-01 - 2001-12-31
ID: P0011868
Title: The Biological Evaluation of Bis-intercalating Metal Complexes
Funder:
  • University of Western Sydney
Western Researchers: Janice Aldrich-Wright
Years: 2002-01-01 - 2002-12-31
ID: P0011534
Title: The Synthesis of Sequence-Selective Platinum Drugs
Funder:
  • University of Western Sydney
Western Researchers: Janice Aldrich-Wright
Years: 2003-01-04 - 2004-01-31
ID: P0011686
Title: Newbio Pre-establishment Project
Funder:
  • Newbio Limited
Western Researchers: Janice Aldrich-Wright
Years: 2005-03-01 - 2006-02-22
ID: P0014710
Title: Vibrational Spectroscopy /Microprobe/FESEM/AFM Imaging Cells, Tissues and Materials [via USYD]
Funder:
  • Australian Research Council (Other Research Grants)
Western Researchers: Janice Aldrich-Wright
Years: 2005-04-04 - 2006-04-04
ID: P0014725
Title: Anti Cancer - Intercalating Metal Complexes (Project 2)
Funder:
  • Newbio Limited
Western Researchers: Janice Aldrich-Wright
Years: 2005-05-10 - 2006-08-17
ID: P0014745
Title: Anti Cancer - Sequence Selective Compounds (Project 3)
Funder:
  • Newbio Limited
Western Researchers: Janice Aldrich-Wright
Years: 2005-05-11 - 2006-02-22
ID: P0014746
Title: Platinum (II) Anticancer Drugs
Funder:
  • University of Western Sydney
Western Researchers: Janice Aldrich-Wright
Years: 2005-12-21 - 2006-02-28
ID: P0014990
Title: Investigations into Metallodrugs Mechanisms of Action
Funder:
  • University of Western Sydney
Western Researchers: Janice Aldrich-Wright
Years: 2007-06-05 - 2008-06-04
ID: P0015647
Title: Developing comprehensive methods for bimolecular analysis using NMR, Circular Dichroism (CD) and Linear Dichroism (LD) to understand of the mechanisms of intermolecular interactions
Funder:
  • University of Western Sydney
Western Researchers: Janice Aldrich-Wright and Bill Price
Years: 2007-08-06 - 2012-09-30
ID: P0015753
Title: Are Linked Bisintercalating Platinum (II) Compounds Effective as Anticancer Agents?
Funder:
  • University of Western Sydney
Western Researchers: Janice Aldrich-Wright
Years: 2007-12-10 - 2008-12-09
ID: P0015919
Title: Using Circular and Linear Dichromism to Understand the Binding Interactions of Platinum (II) Intercalculators with Biomolecules
Funder:
  • University of Western Sydney
Western Researchers: Janice Aldrich-Wright
Years: 2006-06-08 - 2007-06-07
ID: P0015163
Title: Programmable Peltier Temperature Controller
Funder:
  • Ramaciotti Australia Foundation
Western Researchers: Janice Aldrich-Wright, Bill Price, Vincent Higgins and Frank Stootman
Years: 2006-11-15 - 2006-12-31
ID: P0015270
Title: Anionic dendrimers for improved delivery of platinum anticancer drugs
Funder:
  • University of Western Sydney
Western Researchers: Janice Aldrich-Wright
Years: 2006-12-20 - 2008-01-03
ID: P0015411
Title: Ultra-high resolution magnetic resonance imaging (MRI) system for physical applications
Funder:
  • University of New England
  • Australian Research Council (Other Research Grants)
  • South Western Sydney Local Health District
  • Surgical Diagnostics Pty Ltd
  • University of Sydney
  • University of Western Australia
  • University of South Australia
  • Ingham Institute for Applied Medical Research
  • University of New South Wales
Western Researchers: Bill Price, Janice Aldrich-Wright, Annemarie Hennessy, Sathaa Sathasivan and Allan Torres
Years: 2014-05-06 - 2015-05-05
ID: P00021626
Title: Synthesising G4-DNA Metallodrugs
Funder:
  • University of Western Sydney
Western Researchers: Janice Aldrich-Wright
Years: 2013-12-09 - 2014-12-09
ID: P00021829
Title: Identifying new cytotoxic agents
Funder:
  • Anonymous Donation
Western Researchers: Janice Aldrich-Wright
Years: 2014-05-13 - 2015-06-22
ID: P00022248
Title: Developing Platinum(IV) prodrugs [no funding to UWS]
Funder:
  • The Lady Davis Fellowship Trust
Western Researchers: Janice Aldrich-Wright
Years: 2014-10-26 - 2015-06-26
ID: P00021884
Title: COST Action CM1105 Management Committee Meeting and Whole Action Meeting
Funder:
  • Department of Industry, Innovation and Science (non ACRG)
Western Researchers: Janice Aldrich-Wright
Years: 2012-09-12 - 2012-09-25
ID: P00021139
Title: Spin - Switch Materials in Molecular Recognition: towards Molecular devices
Funder:
  • University of Western Sydney
Western Researchers: Feng Li and Janice Aldrich-Wright
Years: 2012-11-13 - 2013-11-12
ID: P00021171
Title: Designing multidentate ligands for lanthanide complexes for the visualization of cellular components
Funder:
  • University of Western Sydney
Western Researchers: Janice Aldrich-Wright
Years: 2012-03-02 - 2013-07-31
ID: P00020540
Title: SRCD study of copper metallointercalators and their effect on biomacromolecule
Funder:
  • Australian Synchrotron Company Ltd
Western Researchers: Janice Aldrich-Wright
Years: 2013-09-16 - 2013-09-23
ID: P00021670
Title: Quality assurance and bioavailability of a Chinese herbal proprietary formula
Funder:
  • AusIndustry - Dept Industry Science & Resources
Western Researchers: Alan Bensoussan, Cheang Khoo, Janice Aldrich-Wright, Andrew Shalliker, Kamali Kannangara, Dennis Chang and Mick Wilson
Years: 2002-12-16 - 2004-03-31
ID: P0010628
Title: Isolation and Characterisation of individual components of complex organic mixtures using Liquid Chromatography-Mass Spectrometry (LC-MS/MS)
Funder:
  • University of Western Sydney
Western Researchers: Kamali Kannangara, Andrew Shalliker and Janice Aldrich-Wright
Years: 2005-10-05 - 2006-10-04
ID: P0014808
Title: Dinuclear Ruthenium Complexes as Sequence- and Structure-Selective Binding Agents for DNA - DP0343480 [via James Cook University]
Funder:
  • Australian Research Council (ACRG)
Western Researchers: Janice Aldrich-Wright
Years: 2003-01-01 - 2005-12-31
ID: P0009800
Title: Circular Dichroism - Measuring molecular interactions and dynamics in biological chemistry [via Macquarie Uni]- RIEF: R00107905
Funder:
  • Australian Research Council (ACRG)
Western Researchers: Janice Aldrich-Wright, Stuart Hazell and Jo-Anne Chuck
Years: 2001-01-01 - 2001-12-31
ID: P0013590
Title: Electrochemical Electron Spin Resonance Spectrometer [via University of Wollongong]
Funder:
  • Australian Research Council (Other Research Grants)
Western Researchers: Janice Aldrich-Wright
Years: 2004-01-01 - 2004-12-31
ID: P0013600
Title: The Selective DNA Binding of Chrial Metal Complexes
Funder:
  • University of Western Sydney
Western Researchers: Janice Aldrich-Wright
Years: 1998-01-01 - 1998-12-31
ID: P0011170
Title: The Synthesis and Characterisation of Carbohydrate-Metal Complexes for Interaction with DNA
Funder:
  • University of Western Sydney
Western Researchers: Janice Aldrich-Wright
Years: 1999-01-01 - 1999-12-31
ID: P0011176
Title: Synthsesis and Resolution of Chiral Metal Complexes for Selective DNA Binding
Funder:
  • University of Western Sydney
Western Researchers: Janice Aldrich-Wright
Years: 1999-01-01 - 1999-12-31
ID: P0011180
Title: Chiral Metal Complexes
Funder:
  • University of Western Sydney
Western Researchers: Janice Aldrich-Wright
Years: 2000-01-01 - 2001-12-31
ID: P0011192
Title: Design and Synthesis of Dinuclear Metal Complexes with Sequences-Specific Recognition in the DNA Minor Grove
Funder:
  • University of Western Sydney
Western Researchers: Janice Aldrich-Wright
Years: 2000-01-01 - 2000-12-31
ID: P0011212
Title: Purchase of protein Synthesiser for Sequence Selective Drug Design
Funder:
  • University of Western Sydney
Western Researchers: Janice Aldrich-Wright
Years: 2004-07-15 - 2005-07-14
ID: P0014391
Title: A PFG indirect detection nano probe for the spectroscopy of bioactive molecules
Funder:
  • Perpetual Trustees Australia Limited (old)
Western Researchers: Janice Aldrich-Wright
Years: 2000-01-01 - 2000-12-31
ID: P0012786
Title: A PFG indirect nano probe for the spectroscopy of bioactive molecules
Funder:
  • Perpetual Trustees Australia Limited (old)
Western Researchers: Janice Aldrich-Wright and Mark Williams
Years: 1999-11-16 - 2001-12-31
ID: P0012790
Title: Mathematical modelling of biomolecular association processes at the Nanoscale
Funder:
  • University of Western Sydney
Western Researchers: Bill Price and Janice Aldrich-Wright
Years: 2004-09-06 - 2005-09-05
ID: P0013684
Title: Characterisation and commercialisation of Bioactives in medical mushrooms
Funder:
  • University of Western Sydney
Western Researchers: John Cairney, Mick Wilson, Kai Yip Cho, Kamali Kannangara, Gary Dennis and Janice Aldrich-Wright
Years: 2005-01-01 - 2007-12-31
ID: P0014445
Title: Characterisation and commercialisation of bioactives in medical mushrooms
Funder:
  • University of Western Sydney
Western Researchers: Mick Wilson, Kai Yip Cho, Kamali Kannangara, Gary Dennis and Janice Aldrich-Wright
Years: 2004-06-21 - 2007-06-20
ID: P0011412
Title: Access to the Single Crystal Beamlines for ANSTO Researchers and Collaborators in Molecular Structural Sciences
Funder:
  • Australian Synchrotron Company Ltd
Western Researchers: Janice Aldrich-Wright
Years: 2018-08-21 - 2019-01-16
ID: P00025070
Title: Novel Platinum(II) Complexes for Stabilising Quadruplex DNA (QDNA)
Funder:
  • Aarhus Universitet
Western Researchers: Janice Aldrich-Wright
Years: 2019-08-19 - 2019-08-26
ID: P00025377
Title: Characterisation of quadruplex DNA motifs by Synchrotron Radiation Circular Dichroism (SRCD)
Funder:
  • Australian Synchrotron Company Ltd
Western Researchers: Janice Aldrich-Wright
Years: 2015-06-15 - 2015-06-22
ID: P00022856
Title: SRCD Characterisation of unusual DNA structures
Funder:
  • Australian Synchrotron Company Ltd
Western Researchers: Janice Aldrich-Wright
Years: 2016-06-27 - 2016-07-04
ID: P00023169
Title: Infrastructure for Developing MRI Contrast Agents for Cancer Imaging that Spans from Contemporary to Future Clinical Field Strengths
Funder:
  • Cancer Institute NSW
Western Researchers: Bill Price, Janice Aldrich-Wright, Timothy Stait-Gardner and Abhishek Gupta
Years: 2016-07-01 - 2017-06-30
ID: P00023484
Title: Ultra-High Resolution NMR Imaging System for Nanotechnology including Nanobiotechnology
Funder:
  • Australian Research Council (Other Research Grants)
  • University of Western Sydney
  • USYD-UOW-UNEW-UNSW-GRIFU-UMELB-UADE
Western Researchers: Bill Price, Mick Wilson, Jann Conroy, Peter Williams, Andrew Shalliker, Janice Aldrich-Wright and Kamali Kannangara
Years: 2005-01-19 - 2006-06-06
ID: P0014448
Title: Characterizing QDNA and the Metal Complexes Interactions that Induce Stabilization
Funder:
  • Australian Synchrotron Company Ltd
Western Researchers: Janice Aldrich-Wright and Brondwyn Mcghie
Years: 2018-08-23 - 2018-08-26
ID: P00025192
Title: Effectively Targeting Anticancer Agents
Funder:
  • University of Western Sydney
Western Researchers: Janice Aldrich-Wright
Years: 2008-12-18 - 2009-12-17
ID: P00016471
Title: CD DNA binding of platinum (II) intercalating compounds [no funding to UWS]
Funder:
  • Aarhus Universitet
Western Researchers: Janice Aldrich-Wright
Years: 2009-07-12 - 2009-07-17
ID: P00016709
Title: Cell and Protein Analysis Unit
Funder:
  • University of Western Sydney
Western Researchers: Simon Myers, Jens Coorssen, Sabine Piller, Annemarie Hennessy, Janice Aldrich-Wright, Soon Lee and Gerald Muench
Years: 2009-09-22 - 2010-09-21
ID: P00017371
Title: Designing Effective Metallodrugs
Funder:
  • University of Western Sydney
Western Researchers: Janice Aldrich-Wright
Years: 2009-10-28 - 2010-10-27
ID: P00017592
Title: Fluorescent and Sequence Selective DNA Antibacterial Agents
Funder:
  • University of Western Sydney
Western Researchers: Janice Aldrich-Wright
Years: 2009-12-04 - 2010-12-03
ID: P00017715
Title: Australian Synchrotron Access Program [via Monash Uni - no funding to UWS]
Funder:
  • Australian Research Council (ACRG)
Western Researchers: Janice Aldrich-Wright
Years: 2012-10-25 - 2016-10-24
ID: P00021033
Title: Metallointercalators as Anticancer and Antibacterial Agents
Funder:
  • Department of Industry, Innovation and Science (ACRG)
Western Researchers: Janice Aldrich-Wright, Bill Price and Vincent Higgins
Years: 2008-10-01 - 2011-07-19
ID: P00016174
Title: Novel Spectroscopic Techniques for The Investigation of Membrane Drug Interactions
Funder:
  • University of Western Sydney
Western Researchers: Janice Aldrich-Wright
Years: 2010-05-28 - 2011-05-27
ID: P00018715
Title: CD DNA binding of platinum (II) intercalating compounds
Funder:
  • Royal Society of Chemistry
Western Researchers: Janice Aldrich-Wright
Years: 2009-06-25 - 2009-07-17
ID: P00016949
Title: CD DNA binding of platinum (II) intercalating compounds
Funder:
  • Australian Synchrotron Company Ltd
Western Researchers: Janice Aldrich-Wright
Years: 2009-07-13 - 2009-07-19
ID: P00016950
Title: Synchrotron CD Study of a alpha-synuclein in the presence of metal complexes
Funder:
  • Australian Synchrotron Company Ltd
Western Researchers: Janice Aldrich-Wright
Years: 2010-07-01 - 2010-07-04
ID: P00018147
Title: The role of redox balance and reactive oxygen species in beer stability using an integrated transcriptomic and metabolomic analysis
Funder:
  • Australian Research Council (ACRG)
  • University of Western Sydney
  • Fosters Australia Limited
Western Researchers: Janice Aldrich-Wright
Years: 2007-07-03 - 2011-09-30
ID: P0015191
Title: Novel Platinum(II) Complexes for Stabilising Quadruplex DNA ( ISP 15565)
Funder:
  • Australian Synchrotron Company Ltd
Western Researchers: Janice Aldrich-Wright
Years: 2019-08-19 - 2020-08-26
ID: P00025952
Title: Metallointercalator Antibacterial Agents
Funder:
  • University of Western Sydney
Western Researchers: Janice Aldrich-Wright
Years: 2010-11-30 - 2012-02-29
ID: P00019675
Title: Cost D39 - Non-covalent metallo-drugs working group 2
Funder:
  • Department of Industry, Innovation and Science (non ACRG)
Western Researchers: Janice Aldrich-Wright
Years: 2011-06-24 - 2011-07-22
ID: P00020030
Title: SRCD study of quadruplex DNA and induced effects of metal complexes
Funder:
  • Australian Synchrotron Company Ltd
Western Researchers: Janice Aldrich-Wright
Years: 2012-06-25 - 2012-07-01
ID: P00020751
Title: Branched degradable polymers for anti-cancer drugs delivery
Funder:
  • University of Western Sydney
Western Researchers: Patrice Castignolles, Janice Aldrich-Wright and Mark Jones
Years: 2011-11-09 - 2012-11-08
ID: P00020491
Title: Cost D39 - Non-covalent metallo-drugs working group 2 - Undertake research at Birmingham University and participate in a Circular and Linear Dichroism workshop at the University of Warwick [via Australian Academy of Science]
Funder:
  • Department of Industry, Innovation and Science (non ACRG)
Western Researchers: Janice Aldrich-Wright
Years: 2011-11-21 - 2011-12-16
ID: P00020468
Title: Synchrotron CD Study of proteins and quadraplex DNA in the presence of metal complexes (no funding to UWS)
Funder:
  • Aarhus Universitet
Western Researchers: Janice Aldrich-Wright
Years: 2011-06-29 - 2011-07-15
ID: P00020064
Title: Characterisation of quadraplex DNA motifs by SRCD [no funding to UWS]
Funder:
  • Aarhus Universitet
Western Researchers: Janice Aldrich-Wright
Years: 2014-06-23 - 2014-07-01
ID: P00021929
Title: Analysis of platinum complex-DNA binding interactions via SRCD spectra and melting profiles [no funding to UWS]
Funder:
  • Aarhus Universitet
Western Researchers: Janice Aldrich-Wright
Years: 2014-06-23 - 2014-07-01
ID: P00021930

Supervision

Professor Aldrich-Wright is available to be a principal supervisor for doctoral projects

Current Supervision

Thesis Title: Protection of platinum (II)-based anti cancer complexes
Field of Research:
Thesis Title: Structural Requirements for Selective Quadruplex DNA Binding
Field of Research:
Thesis Title: Design and Development of Unconventional Platinum (IV) Prodrugs as Potent Anticancer Agents
Field of Research: Medical Science
Thesis Title: Synthesis of Ligands for Anticancer Metallointercallators Using Flow Cytometry
Field of Research:
Thesis Title: Finite Nano-Scale Metallosupramolecular Assemblies: Towards Advanced SUper Molecular Materials
Field of Research:
Thesis Title: Synthesis of Metallointercalators Metallodrugs
Field of Research:
Thesis Title: Characterisation of the Formation and Biological Impacts of DNA-Addicts caused by the Anti-Cancer Drug Cisplatin and other Clinically Important Platinum-Based Drugs
Field of Research:
Thesis Title: Utilising Proteomic Analyses to Investigate the Mechanism of Actions of Platinum(II) DNA-Intercalator Compounds
Field of Research:
Thesis Title: Development of [18F]-Fluorine Radiolabelling Methods for Polypyridine Metal Complexes for Evaluation of Bio-Distribution and Therapeutic `Mechanism of Action? Studies
Field of Research:
Thesis Title: Synthesis and Biophysical Characterisation of Lanthanide Imaging Agents
Field of Research:
Thesis Title: Modification of Copper(II) Complexes and Evaluating Their Anti-Biofilm Potency
Field of Research:
Thesis Title: Developing Total Flow Synthetic Protocols to Produce [18F]-fluorine Labelled Pharmaceuticals and Biological Probes
Field of Research:
Thesis Title: A Study of Different Forms of Quadraplex DNA and Their Affinity for Planar Molecules
Field of Research:
Thesis Title: Conjugated Design Strategies for Pt(IV) Complexes
Field of Research:
Thesis Title: The Investigation of Improved Intercalators
Field of Research:
Thesis Title: Some Studies of the Molecular and Cellular Interaction of Metallointercalators for Potential Application
Field of Research:
Thesis Title: The Synthesis, Characterisation, and Biological Properties of Tetradentate Ligands and Their Ruthenium(II) Complexes
Field of Research: Medical Science

Previous Supervision

Thesis Title: Synthesis and Characterisation of Platinum (II) and Ruthenium (II) Polyamide Conjugates
Field of Research: Biomedical Engineering
Thesis Title: Synthesis and Analysis of Platinum(II) Sequence Selective Complexes
Field of Research: Biomedical Engineering
Thesis Title: Antimicrobial Properties of some Ruthenium(II), Platinum(II), and Copper(II) Metallointercalators
Field of Research: Chemical Sciences
Thesis Title: Silver (I) helicates and Their Biological Activity
Field of Research: Biological Sciences; Biochemistry And Cell Biology; Biological Sciences Not Elsewhere Classified
Thesis Title: Polymer Nanocarriers to Enhance the Efficiency of Platinum Based Chemotherapeutics
Field of Research: Chemical Sciences Not Elsewhere Classified; Biochemistry And Cell Biology; Other Health; Pharmacology
Thesis Title: Characterisation of the interactions and biological impacts of cisplatin analogues and metallo-drug complexes with DNA
Field of Research: Biological Sciences Not Elsewhere Classified
Thesis Title: The Design and Biological Interactions of Terpyridineplatinum(II) Bisintercalators as Potential Anticancer Compounds
Field of Research: Biological Sciences; Chemical Sciences
Thesis Title: The Biology Activity of some Phenanthroline Coordinated Metal Complexes
Field of Research: Natural And Physical Sciences; Inorganic Chemistry; Pharmacology
Thesis Title: Characterisation of Chitosan and its Films for Tissue Engineering
Field of Research: Biochemistry And Cell Biology; Chemical Sciences; Other Society And Culture
Thesis Title: Platinum (II) Metallointercalators as Anticancer Complexes: Synthesis, Biological Testing and Combination Therapy
Field of Research: Biological Sciences Not Elsewhere Classified
Thesis Title: Interactions of Metallointercalators
Field of Research: Chemical Sciences Not Elsewhere Classified; Inorganic Chemistry; Pharmacology
Thesis Title: Polyaromatic Anticancer Platinum Complexes: Synthesis and Analysis of DNA Binding
Field of Research: Chemical Sciences Not Elsewhere Classified; Medical Studies Not Elsewhere Classified; Other Natural And Physical Sciences
Thesis Title: Finite Nano-scale Metallosupramolecular Assemblies: Design, Synthesis and Applications
Field of Research: Natural And Physical Sciences

Media

Title: Academic Lead
Description: Australia Gender Equity (SAGE) initiative

Western Sydney University

Locked Bag 1797
Penrith NSW 2751

Tel: +61 2 9852 5222

ABN 53 014 069 881
CRICOS Provider No: 00917k

Visit our mobile site