Senior Lecturer, School of Medicine, Western Sydney University
Originally from Winnipeg, Manitoba in Canada, Scott completed his master’s degree is Biological Sciences at the University of Manitoba. Following the emergence of West Nile virus in North America, Scott’s master’s focused on gaining a molecular understanding of virus:pathogen protein interactions in mosquitoes; the vector for West Nile virus, and an annoying pest throughout Winnipeg summers.
Scott travelled to Sydney, Australia in 2009 to undertake a PhD at the Storr Liver Centre at the Westmead Institute for Medical Research, University of Sydney. Scott’s PhD focused on understanding the molecular basis of hepatitis C virus treatment failure and its association with insulin resistance. Under Drs. Mark Douglas and Jacob George, Scott demonstrated that PPARα agonists sensitized hepatocytes to interferons by modulating negative regulators of interferon signaling, including the receptor tyrosine kinase, AXL.
Following the identification of polymorphisms in the interferon lambda 3/4 gene locus by the Storr Liver group and others, Scott became deeply interested in interferon lambda biology. Following his PhD, Scott moved into a post-doctoral position in the liver immunology group of Dr. Golo Ahlenstiel at Storr Liver Centre. As a Senior Lecturer at Western Sydney University, Scott is now focused on understanding how genetic and environmental factors drive inflammation and fibrosis in hepatic and gastrointestinal tissues.
- Hepatology and gastroenterology
- Gut:liver axis
- NAFLD and NASH
- Cirrhosis and peritonitis
- Chronic viral infection
- Innate Immunity
- Kupffer cells and macrophages
- Interferon biology
- In vitro models of disease
Research & Publications
View my publications page (opens in a new window)
|Location||Westmead Institute for Medical Research, 176 Hawkesbury Rd, Westmead 2145|