Professor Kelvin Chan

Journal Articles

• Huang, S., Chen, J., Li, W., Song, S., Li, X., Yu, H., Long, F., Chen, R., Bao, X., Chan, K. and Lu, G. (2023), 'Comparison of volatile compositions among four related Ligusticum chuanxiong herbs by HS-SPME-GC-MS', Processes, vol 11, no 1 .
• Razmovski-Naumovski, V., Kimble, B., Laurenti, D., Nammi, S., Norimoto, H. and Chan, K. (2022), 'Polysaccharide peptide extract from Coriolus versicolor increased Tmax of tamoxifen and maintained biochemical serum parameters, with no change in the metabolism of tamoxifen in the rat', Frontiers in Pharmacology, vol 13 .
• Zhou, X., Razmovski-Naumovski , V., Mendoza, R., Truong, J. and Chan, K. (2022), 'A comparative study of Salvia miltiorrhiza Radix & Rhizoma raw material and granule products using chromatographic analysis and antioxidant activity', Journal of Traditional Chinese Medical Sciences, vol 9, no 3 , pp 311 - 320.
• Du, Y., Zheng, Y., Yu, C., Zhong, L., Li, Y., Wu, B., Hu, W., Zhu, E., Xie, V., Xu, Q., Zhan, X., Huang, Y., Zeng, L., Zhang, Z., Liu, X., Yin, J., Zha, G., Chan, K. and Tsim, K. (2021), 'The mechanisms of Yu Ping Feng San in tracking the cisplatin-resistance by regulating ATP-binding cassette transporter and glutathione S-transferase in lung cancer cells', Frontiers in Pharmacology, vol 12 .
• Gong, G., Huang, J., Yang, Y., Qi, B., Han, G., Zheng, Y., He, H., Chan, K., Tsim, K. and Dong, T. (2020), 'Saussureae Involucratae Herba (snow lotus) : review of chemical compositions and pharmacological properties', Frontiers in Pharmacology, vol 10 .
• Razmovski-Naumovski, V., Zhou, X., Wong, H., Kam, A., Pearson, J. and Chan, K. (2020), 'Chromatographic, chemometric and antioxidant assessment of the equivalence of granules and herbal materials of Angelicae Sinensis Radix', Medicines, vol 7, no 6 .
• Zhou, X., Razmovski-Naumovski, V., Kam, A., Chang, D., Li, C., Chan, K. and Bensoussan, A. (2019), 'Synergistic study of a Danshen (Salvia Miltiorrhizae Radix et Rhizoma) and Sanqi (Notoginseng Radix et Rhizoma) combination on cell survival in EA.hy926 cells', BMC Complementary and Alternative Medicine, vol 19 .
• Gong, A., Duan, R., Wang, H., Kong, X., Dong, T., Tsim, K. and Chan, K. (2018), 'Evaluation of the pharmaceutical properties and value of Astragali Radix', Medicines, vol 5, no 2 .
• Wong, K., Li, G., Li, K., Razmovski-Naumovski, V. and Chan, K. (2017), 'Optimisation of Pueraria isoflavonoids by response surface methodology using ultrasonic-assisted extraction', Food Chemistry, vol 231 , pp 231 - 237.
• Zhou, X., Razmovski-Naumovski, V., Kam, A., Chang, D., Li, C., Bensoussan, A. and Chan, K. (2017), 'Synergistic effects of Danshen (Salvia Miltiorrhizae Radix et Rhizoma) and Sanqi (Notoginseng Radix et Rhizoma) combination in angiogenesis behavior in EAhy 926 cells', Medicines, vol 4, no 4 .
• Zhou, X., Seto, S., Chang, D., Kiat, H., Razmovski-Naumovski, V., Chan, K. and Bensoussan, A. (2016), 'Synergistic effects of Chinese herbal medicine : a comprehensive review of methodology and current research', Frontiers in Pharmacology, vol 7 .
• Zhou, X., Razmovski-Naumovski, V., Chang, D., Li, C., Kam, A., Low, M., Bensoussan, A. and Chan, K. (2016), 'Synergistic effects of Danshen (Salvia Miltiorrhiza Radix et Rhizoma) and Sanqi (Notoginseng Radix et Rhizoma) combination in inhibiting inflammation mediators in RAW264.7 cells', BioMed Research International, vol 2016 .
• Chan, C., Zhang, H., Chan, K. and Lin, Z. (2016), '[In Press] Xiaoke Pill and anti-diabetic drugs : a review on clinical evidence of possible herb-drug interactions', Chinese Journal of Integrative Medicine, .
• Chan, K. (2016), 'The evolutional development of traditional Chinese medicine (TCM) outside the Chinese mainland : challenges, training, practice, research, and future development', World Journal of Traditional Chinese Medicine, vol 2, no 4 , pp 6 - 28.
• Williamson, E., Chan, K., Xu, Q., Nachtergael, A., Bunel, V., Zhang, L., Ouedraogo, M., Nortier, J., Qu, F., Shaw, D., Liu, X., Stevigny, C., Kahumba, J., Pelkonan, O. and Duez, P. (2015), 'Evaluating the safety of herbal medicines : integrated toxicological approaches', Science, vol 347, no 6219 , pp 47 - 49.
• Chan, K., Hu, X., Razmovski-Naumovski, V. and Robinson, N. (2015), 'Challenges and opportunities of integrating traditional Chinese medicine into mainstream medicine : a review of the current situation', European Journal of Integrative Medicine, vol 7, no 1 , pp 67 - 75.
• Chan, K. (2015), 'Understanding interactions between Chinese medicines and pharmaceutical drugs in integrative healthcare', Chinese Journal of Integrative Medicine, vol 21, no 2 , pp 83 - 89.
• Wong, K., Razmovski-Naumovski, V., Li, K., Li, G. and Chan, K. (2015), 'Comparing morphological, chemical and anti-diabetic characteristics of Puerariae Lobatae Radix and Puerariae Thomsonii Radix', Journal of Ethnopharmacology, vol 164 , pp 53 - 63.
• Wong, K., Razmovski-Naumovski, V., Li, K., Li, G. and Chan, K. (2015), 'The quality control of two Pueraria species using Raman spectroscopy coupled with partial least squares analysis', Journal of Raman Spectroscopy, vol 46, no 4 , pp 361 - 368.
• Zhou, X., Razmovski-Naumovski, V. and Chan, K. (2015), 'A multivariate analysis on the comparison of raw notoginseng (Sanqi) and its granule products by thin-layer chromatography and ultra-performance liquid chromatography', Chinese Medicine, vol 10, no 13 .
• Chan, K., Zhang, H. and Lin, Z. (2015), 'An overview on adverse drug reactions to traditional Chinese medicines', British Journal of Clinical Pharmacology, vol 80, no 4 , pp 834 - 843.
• Kam, A., Li, K., Razmovski-Naumovski, V., Nammi, S., Chan, K., Grau, G. and Li, G. (2015), 'Curcumin reduces tumour necrosis factor-enhanced annexin V-positive microparticle release in human vascular endothelial cells', Journal of Pharmacy and Pharmaceutical Sciences, vol 18, no 4 , pp 424 - 433.
• Alqahtani, A., Tongkao-On, W., Li, K., Razmovski-Naumovski, V., Chan, K. and Li, G. (2015), 'Seasonal variation of triterpenes and phenolic compounds in Australian Centella asiatica (L.) Urb', Phytochemical Analysis, vol 26, no 6 , pp 436 - 443.
• Kam, A., Razmovski-Naumovski, V., Zhou, X., Truong, J. and Chan, K. (2015), 'Nucleoside transport inhibition by dipyridamole prevents angiogenesis impairment by homocysteine and adenosine', Journal of Pharmacy and Pharmaceutical Sciences, vol 18, no 5 , pp 871 - 881.
• Kam, A., Li, K., Razmovski-Naumovski, V., Nammi, S., Chan, K. and Li, G. (2014), 'Gallic acid protects against endothelial injury by restoring the depletion of DNA methyltransferase 1 and inhibiting proteasome activities', International Journal of Cardiology, vol 171, no 2 , pp 231 - 242.
• Wang, Q., Wang, C., Shu, Z., Chan, K., Huang, S., Li, Y., Xiao, Y., Wu, L., Kuang, H. and Sun, X. (2014), 'Valeriana amurensis improves Amyloid-beta 1-42 induced cognitive deficit by enhancing cerebral cholinergic function and protecting the brain neurons from apoptosis in mice', Journal of Ethnopharmacology, vol 153, no 2 , pp 318 - 325.
• Wong, K., Razmovski-Naumovski, V., Li, K., Li, G. and Chan, K. (2014), 'Differentiating Puerariae Lobatae Radix and Puerariae Thomsonii Radix using HPTLC coupled with multivariate classification analyses', Journal of Pharmaceutical and Biomedical Analysis, vol 95 , pp 11 - 19.
• Su, Y., Wang, Q., Wang, C., Chan, K., Sun, Y. and Kuang, H. (2014), 'The treatment of Alzheimer's disease using Chinese medicinal plants : from disease models to potential clinical applications', Journal of Ethnopharmacology, vol 152, no 3 , pp 403 - 423.
• Chui, S., Chow, F., Szeto, Y., Chan, K. and Lam, C. (2014), 'A case series of acupuncture treatment for female infertility with some cases supplemented with Chinese medicines', European Journal of Integrative Medicine, vol 6, no 3 , pp 337 - 341.
• Pan, S., Litscher, G., Chan, K., Yu, Z., Chen, H. and Ko, K. (2014), 'Traditional medicines in the world : where to go next?', Evidence-based Complementary and Alternative Medicine, vol 2014 .
• Razmovski-Naumovski, V., Zhou, X., Grace, R., Wong, H., Lee, S. and Chan, K. (2014), 'Similarity and difference in chemical profile and antioxidant activity between Chinese materia medica decoction pieces and their aqueous granules : Danggui, Danshen and Sanqi', European Journal of Integrative Medicine, vol 6, no 1 , pp 127 - 128.
• Truong, J., Razmovski-Naumovski, V., Zhou, X., Khoo, C. and Chan, K. (2014), 'A comparative study on the antioxidant activity of Zingiberis Rhizoma raw herb and granule', European Journal of Integrative Medicine, vol 6, no 6 , pp 733 - 733.
• Kam, A., Li, K., Razmovski-Naumovski, V., Nammi, S., Chan, K. and Li, G. (2013), 'Variability of the polyphenolic content and antioxidant capacity of methanolic extracts of pomegranate peel', Natural Product Communications, vol 8, no 6 , pp 707 - 710.
• Liu, Z., Li, G., Bensoussan, A., Kiat, H., Chan, K. and Liu, J. (2013), 'Chinese herbal medicines for hypertriglyceridaemia : intervention review', Cochrane Database of Systematic Reviews, vol 2013, no 6 .
• Wong, K., Razmovski-Naumovski, V., Li, K., Li, G. and Chan, K. (2013), 'Differentiation of Pueraria lobata and Pueraria thomsonii using partial least square discriminant analysis (PLS-DA)', Journal of Pharmaceutical and Biomedical Analysis, vol 84 , pp 5 - 13.
• Kim, E., Chen, Y., Huang, J., Li, K., Razmovski-Naumovski, V., Poon, J., Chan, K., Roufogalis, B., McLachlan, A., Mo, S., Yang, D., Yao, M., Liu, Z., Liu, J. and Li, G. (2013), 'Evidence-based toxicity evaluation and scheduling of Chinese herbal medicines', Journal of Ethnopharmacology, vol 146, no 1 , pp 40 - 61.
• Wang, Q., Kuang, H., Su, Y., Sun, Y., Feng, J., Guo, R. and Chan, K. (2013), 'Naturally derived anti-inflammatory compounds from Chinese medicinal plants', Journal of Ethnopharmacology, vol 146, no 1 , pp 9 - 39.
• Chua, M., Hocking, T., Chan, K. and Baldwin, T. (2013), 'Temporal and spatial regulation of glucomannan deposition and mobilization in corms of Amorphophallus konjac (Araceae)', American Journal of Botany, vol 100, no 2 , pp 337 - 345.
• Chong, C., Zhou, Z., Razmovski-Naumovski, V., Cui, G., Zhang, L., Sa, F., Hoi, P., Chan, K. and Lee, S. (2013), 'Danshensu protects against 6-hydroxydopamine-induced damage of PC12 cells in vitro and dopaminergic neurons in zebrafish', Neuroscience Letters, vol 543 , pp 121 - 125.
• Alqahtani, A., Hamid, K., Kam, A., Wong, K., Abdelhak, Z., Razmovski-Naumovski, V., Chan, K., Li, K., Groundwater, P. and Li, G. (2013), 'The pentacyclic triterpenoids in herbal medicines and their pharmacological activities in diabetes and diabetic complications', Current Medicinal Chemistry, vol 20, no 7 , pp 908 - 931.
• Kam, A., Li, K., Razmovski-Naumovski, V., Nammi, S., Shi, J., Chan, K. and Li, G. (2013), 'A comparative study on the inhibitory effects of different parts and chemical constituents of pomegranate on a-amylase and a-glucosidase', Phytotherapy Research, vol 27, no 11 , pp 1614 - 1620.
• Chua, M., Chan, K., Hocking, T., Williams, P., Perry, C. and Baldwin, T. (2012), 'Methodologies for the extraction and analysis of konjac glucomannan from corms of Amorphophallus konjac K. Koch', Carbohydrate Polymers, vol 87, no 3 , pp 2202 - 2210.
• Lu, A., Jiang, M., Zhang, C. and Chan, K. (2012), 'An integrative approach of linking traditional Chinese medicine pattern classification and biomedicine diagnosis', Journal of Ethnopharmacology, vol 141, no 2 , pp 549 - 556.
• Qu, F., Zhou, J., Bovey, M., Franconi, G., Chan, K., Smith, C., Jiang, D. and Robinson, N. (2012), 'Does acupuncture improve the outcome of in vitro fertilisation? Guidance for future trials', European Journal of Integrative Medicine, vol 4, no 3 , pp 234 - 244.
• Kam, A., Li, K., Razmovski-Naumovski, V., Nammi, S., Chan, K. and Li, G. (2012), 'Combination of TNF-a, homocysteine and adenosine exacerbated cytotoxicity in human cardiovascular and cerebrovascular endothelial cells', Cellular Physiology and Biochemistry, vol 30, no 3 , pp 805 - 814.
• Kam, A., Li, K., Razmovski-Naumovski, V., Nammi, S., Chan, K., Li, Y. and Li, G. (2012), 'The protective effects of natural products on blood-brain barrier breakdown', Current Medicinal Chemistry, vol 19, no 12 , pp 1830 - 1845.
• Fan, T., Deal, G., Koo, H., Rees, D., Sun, H., Chen, S., Dou, J., Makarov, V., Pozharitskaya, O., Shikov, A., Kim, Y., Huang, Y., Chang, Y., Jia, W., Dias, A., Wong, V. and Chan, K. (2012), 'Future development of global regulations of Chinese herbal products', Journal of Ethnopharmacology, vol 140, no 3 , pp 568 - 586.
• Zhang, L., Yan, J., Liu, X., Ye, Z., Yang, X., Meyboom, R., Chan, K., Shaw, D. and Duez, P. (2012), 'Pharmacovigilance practice and risk control of Traditional Chinese Medicine drugs in China : current status and future perspective', Journal of Ethnopharmacology, vol 140, no 3 , pp 519 - 525.
• Pelkonen, O., Pasanen, M., Lindon, J., Chan, K., Zhao, L., Deal, G., Xu, Q. and Fan, T. (2012), 'Omics and its potential impact on R&D and regulation of complex herbal products', Journal of Ethnopharmacology, vol 140, no 3 , pp 587 - 593.
• Jiang, M., Lu, C., Zhang, C., Yang, J., Tan, Y., Lu, A. and Chan, K. (2012), 'Syndrome differentiation in modern research of traditional Chinese medicine', Journal of Ethnopharmacology, vol 140, no 3 , pp 634 - 642.
• Ouedraogo, M., Baudoux, T., Stevigny, C., Nortier, J., Colet, J., Efferth, T., Qu, F., Zhou, J., Chan, K., Shaw, D., Pelkonen, O. and Duez, P. (2012), 'Review of current and 'omics' methods for assessing the toxicity (genotoxicity, teratogenicity and nephrotoxicity) of herbal medicines and mushrooms', Journal of Ethnopharmacology, vol 140, no 3 , pp 492 - 512.
• Shaw, D., Ladds, G., Duez, P., Williamson, E. and Chan, K. (2012), 'Pharmacovigilance of herbal medicine', Journal of Ethnopharmacology, vol 140, no 3 , pp 513 - 518.
• Chan, K., Shaw, D., Simmonds, M., Leon, C., Xu, Q., Lu, A., Sutherland, I., Ignatova, S., Zhu, Y., Verpoorte, R., Williamson, E. and Duez, P. (2012), 'Good practice in reviewing and publishing studies on herbal medicine, with special emphasis on traditional Chinese medicine and Chinese materia medica', Journal of Ethnopharmacology, vol 140, no 3 , pp 469 - 475.
• Hung, M., Zhang, Z., Li, S., Lei, B., Yuan, S., Cui, G., Hoi, P., Chan, K. and Lee, S. (2012), 'From omics to drug metabolism and high content screen of natural product in zebrafish : a new model for discovery of neuroactive compound', Evidence-Based Complementary and Alternative Medicine, , pp 605303 - 605320.
• Zhou, X., Chan, K. and Yeung, J. (2012), 'Herb-drug interactions with Danshen (Salvia miltiorrhiza) : a review on the role of cytochrome P450 enzymes', Drug Metabolism and Drug Interactions, vol 27, no 1 , pp 9 - 18.
• Yeh, J., Cindrova-Davis, T., Belleri, M., Morbidelli, L., Miller, N., Cho, C., Chan, K., Wang, Y., Luo, G., Ziche, M., Charnock-Jones, D. and Fan, T. (2011), 'The natural compound n-butylidenephthalide derived from the volatile oil of Radix Angelica sinesis inhibits angiogenesis in vitro and in vivo', Journal of Angiogenesis Research, vol 14, no 2 , pp 187 - 197.
• Jiang, M., Zhang, C., Cao, H., Chan, K. and Lu, A. (2011), 'The role of Cinese medicine in the treatment of chronic diseases in China', Planta Medica, vol 77 , pp 873 - 881.
• Jiang, M., Zhang, C., Cao, H., Chan, K. and Lu, A. (2011), 'The role of Cinese medicine in the treatment of chronic diseases in China', Planta Medica, vol 77 , pp 873 - 881.
• Poon, S., Poon, J., Mcgrane, M., Zhou, X., Kwan, P., Zhang, R., Liu, B., Gao, J., Loy, C., Chan, K. and Sze, D. (2011), 'A novel approach in discovering significant interactions from TCM patient prescription data', International Journal of Data Mining and Bioinformatics, vol 5, no 4 , pp 353 - 368.
• Poon, S., Poon, J., Mcgrane, M., Zhou, X., Kwan, P., Zhang, R., Liu, B., Gao, J., Loy, C., Chan, K. and Sze, D. (2011), 'A novel approach in discovering significant interactions from TCM patient prescription data', International Journal of Data Mining and Bioinformatics, vol 5, no 4 , pp 353 - 368.
• Wong, K., Li, G., Li, K., Naumovski, V. and Chan, K. (2011), 'Kudzu root: traditional uses and potential medicinal benefits in diabetes and cardiovascular diseases', Journal of Ethnopharmacology, vol 134, no 3 , pp 584 - 604.
• Wong, K., Li, G., Li, K., Naumovski, V. and Chan, K. (2011), 'Kudzu root: traditional uses and potential medicinal benefits in diabetes and cardiovascular diseases', Journal of Ethnopharmacology, vol 134, no 3 , pp 584 - 604.
• Wong, K., Li, G., Li, K., Naumovski, V. and Chan, K. (2010), 'Kudzu root: Traditional uses and potential medicinal benefits in diabetes and cardiovascular diseases', Journal of Ethnopharmacology, vol 134, no 3 , pp 584 - 607.
• Omar, E., Kam, A., Alqahtani, A., Li, K., Naumovski, V., Nammi, S., Chan, K., Roufogalis, B. and Li, G. (2010), 'Herbal medicines and nutraceuticals for diabetic vascular complications : mechanisms of action and bioactive phytochemicals', Current Pharmaceutical Design, vol 16, no 34 , pp 3776 - 3807.
• Zhao, Z., Liang, Z., Chan, K., Lu, G., Lee, E., Chen, H. and Li, L. (2010), 'A unique issue in the standardization of Chinese materia medica : processing', Planta Medica, vol 76, no 17 , pp 1975 - 1986.
• Jiang, M., Yang, J., Zhang, C., Liu, B., Chan, K., Cao, H. and Lu, A. (2010), 'Clinical studies with traditional Chinese medicine in the past decade and future research and development', Planta Medica, vol 76, no 17 , pp 2048 - 2064.
• Liang, Y., Xie, P. and Chan, K. (2010), 'Perspective of chemical fingerprinting of Chinese herbs', Planta Medica, vol 76, no 17 , pp 1997 - 2003.
• Sun, S., Chen, J., Zhou, Q., Lu, G. and Chan, K. (2010), 'Application of mid-infrared spectroscopy in the quality control of traditional Chinese medicines', Planta Medica, vol 76, no 17 , pp 1987 - 1996.
• Singh, S., Singh, V., Kar, N. and Chan, K. (2010), 'Efficacy of antidepressants in treating the negative symptoms of chronic schizophrenia : meta-analysis', British Journal of Psychiatry, vol 197, no 3 , pp 174 - 179.
• Chua, M., Baldwin, T., Hocking, T. and Chan, K. (2010), 'Traditional uses and potential health benefits of Amorphophallus konjac K.Koch ex N.E.Br', Journal of Ethnopharmacology, vol 128, no 2 , pp 268 - 278.
• Chui, S., Shek, S., Fong, M., Szeto, Y. and Chan, K. (2010), 'A panel study to evaluate the quality of life assessments in patients suffering from allergic rhinitis after treatment with a Chinese herbal nasal drop', Phytotherapy Research, vol 24, no 4 , pp 609 - 613.
• Liang, Y., Xie, P. and Chan, K. (2010), 'Chromatographic fingerprinting and metabolomics for quality control of TCM', Combinatorial Chemistry and High Throughput Screening, vol 13, no 10 , pp 943 - 953.
• Lv, G., Cheng, S., Chan, K., Leung, K. and Zhao, Z. (2010), 'Determination of free ferulic acid and total ferulic acid in Chuanxiong by high-performance liquid chromatography for quality assessment', Zhongguo Zhongyao Zazhi, vol 35, no 2 , pp 194 - 198.
• Singh, V., Singh, S. and Chan, K. (2009), 'Review and meta-analysis of usage of Ginkgo as an adjunct therapy in chronic schizophrenia', The International Journal of Neuropsychopharmacology, vol 13, no 2 , pp 257 - 271.
• Chan, K., Leung, K. and Zhao, S. (2009), 'Harmonization of monographic standards is needed to ensure the quality of Chinese medicinal materials', Chinese Medicine, vol 4, no 18 , pp 18 - .
• Wang, J., Van Der Heijden, R., Spruit, S., Hankermeier, T., Chan, K., Van Der Greef, J., Xu, G. and Wang, M. (2009), 'Quality and safety of Chinese medicine herbal medicines guided by a systems biology perspective', Journal of Ethnopharmacology, vol 126, no 1 , pp 31 - 41.
• Yu, H., Li, W., Cheung, M., Zuo, Z., Carlier, P., Gu, Z., Chan, K. and Huang, M. (2009), 'Development and validation of an HPLC-DAD method for bis(12)-hupyridone and its application to a pharmacokinetic study', Journal of Pharmaceutical and Biomedical Analysis, vol 49, no 2 , pp 410 - 414.
• Lee, N., Nehmeh, S., Schoder, H., Fury, M., Chan, K., Ling, C. and Humm, J. (2009), 'Prospective Trial Incorporating Pre-/Mid-Treatment [18F]-Misonidazole Positron Emission Tomography for Head-and-Neck Cancer Patients Undergoing Concurrent Chemoradiotherapy', International Journal of Radiation Oncology, Biology, Physics, vol 75, no 1 , pp 101 - 108.
• Zhao, L., Leung, K., Liu, F., Chen, J. and Chan, K. (2008), 'Responsiveness of the Chinese quality of life instrument in patients with congestive heart failure', Chinese Journal of Integrative Medicine, vol 14, no 3 , pp 173 - 179.
• Cui, L., Chan, W., Wu, J., Jiang, Z., Chan, K. and Cai, Z. (2008), 'High performance liquid chromatography-mass spectrometry analysis for rat metabolism and pharmacokinetic studies of lithospermic acid B from danshen', Talanta, vol 75, no 4 , pp 1002 - 1007.
• Chui, S., Chow, F., Chan, K., Fu, S. and Szeto, Y. (2008), 'Slimpid may boost plasma IGF-1 level and improve the quality of life in patients with risk of developing metabolic syndrome', Journal of Complementary and Integrative Medicine, vol 5, no 1 .
• Chan, K. (2008), 'An overview on safety issues of interactions between traditional herbal medicines and pharmaceutical medicines', Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas, vol 7 , pp 311 - 330.
• Yu, H., Kan, K., Ho, J., Li, W., Carlier, P., Pang, Y., Gu, Z., Chan, K., Wang, Y. and Han, Y. (2008), 'The physicochemical properties and the in vivo AChE inhibition of two potential anti-Alzheimer agents, bis(12)-hupyridone and bis(7)-tacrine', Journal of Pharmaceutical and Biomedical Analysis, vol 46, no 1 , pp 75 - 81.
• Zhang, L., Yu, H., Li, W., Cheung, M., Pang, Y., Gu, Z., Chan, K., Wang, Y., Zuo, Z. and Han, Y. (2008), 'Preclinical characterization of intestinal absorption and metabolism of promising anti-Alzheimer's dimer bis(7)-tacrine', International Journal of Pharmaceutics, vol 357, no 40575 , pp 85 - 94.
• Leung, K., Chan, K., Bensoussan, A. and Munroe, M. (2007), 'Application of atmospheric pressure chemical ionisation mass spectrometry in the identification and differentiation of the Panax species', Phytochemical Analysis, vol 18, no 2 , pp 146 - 150.
• Yu, H., Li, W., Kan, K., Chan, K., Wang, Y. and Han, Y. (2007), 'An overview on the progress of pharmacokinetics of anti-Alzheimer drugs', Chinese Pharmaceutical Journal, vol 42 , pp 1121 - 1125.
• Tin, M., Cho, C., Chan, K., James, A. and Ko, J. (2007), 'Astragalus saponins induce growth inhibition and apoptosis in human colon cancer cells and tumor xenograft', Carcinogenesis, vol 28, no 6 , pp 1347 - 1355.
• Yi, T., Leung, K., Lu, G., Zhang, H. and Chan, K. (2007), 'Identification and determination of the major constituents in traditional Chinese medicinal plant polygonum multiflorum Thunb by HPLC coupled with PAD and ESI/MS', Phytochemical Analysis, vol 18, no 3 , pp 181 - 187.
• Lu, G., Cheng, S., Leung, K., Ma, J., Chan, K. and Zhao, Z. (2007), 'Determination of free and total available ferulic acid in different types of Chinese Angelica by high performance liquid chromatography', Journal of Food and Drug Analysis, vol 15, no 4 , pp 438 - 446.
• Zhao, L., Leung, K. and Chan, K. (2007), 'The Chinese quality of life instrument: Reliability and validity of the Hong Kong Chinese version (ChQOL-HK)', Hong Kong Practitioner, vol 29, no 6 , pp 220 - 232.
• Yu, H., Ho, J., Kan, K., Cheng, B., Li, W., Lin, G., Pang, Y., Gu, Z., Chan, K., Wang, Y. and Han, Y. (2007), 'Development of a high performance liquid chromatography-tandem mass method for determination of bis(7)-tacrine, a promising anti-Alzheimer's dimer, in rat blood', Journal of Pharmaceutical and Biomedical Analysis, vol 44 , pp 1133 - 1138.
• Liu, H., Sun, S., Lu, G. and Chan, K. (2006), 'Study on Angelica and its different extracts by Fourier transform infrared spectroscopy and two-dimensional correlation IR spectroscopy', Spectrochimica acta part A, vol 64, no 2 , pp 321 - 326.
• Qing, L., Zhang, H., Lu, G., Chan, K., Leung, K. and Chen, C. (2006), 'Determination of oleanolic acid in Caulis Clematidis armadii by HPLC', West China Journal of Pharmacy Science, vol 21 , pp 273 - 274.
• Yi, T., Leung, K., Lu, G., Chan, K. and Zhang, H. (2006), 'Simultaneous qualitative and quantitative analyses of the major constituents in the rhizome of Ligusticum chuanxiong using HPLC-DAD-MS', Chemical and Pharmaceutical Bulletin, vol 54, no 2 , pp 255 - 259.
• Fang, K., Liang, Y., Yin, X., Chan, K. and Lu, G. (2006), 'Critical value determination on similarity of fingerprints', Chemometrics and Intelligent Laboratory Systems, vol 82, no 1-2 SPEC. ISS , pp 236 - 240.
• Chan, K., Liu, Z., Jiang, Z., Zhou, H., Wong, Y., Xu, H. and Liu, L. (2006), 'The effects of sinomenine on intestinal absorption of paeoniflorin by the everted rat gut sac model', Journal of Ethnopharmacology, vol 103, no 3 , pp 425 - 432.
• Ha, W., Lau, C., Yue, P., Hung, K., Chan, K., Chui, S., Chui, A., Yam, W. and Wong, R. (2006), 'Simultaneous detection of precore/basal core promoter mutations in hepatitis B virus using arrayed primer extension', Molecular Diagnosis and Therapy, vol 10, no 2 , pp 125 - 134.
• Cheung, T., Xue, C., Leung, K., Chan, K. and Li, C. (2006), 'Aristolochic acids detected in some raw Chinese medicinal herbs and manufactured herbal products - A consequence of inappropriate nomenclature and imprecise labelling?', Clinical Toxicology, vol 44, no 4 , pp 371 - 378.
• Zhao, L., Liu, F., Leung, K., Chan, K. and Fang, J. (2006), 'Reliability and validity of the Chinese Quality of Life Instrument', Chinese Journal of Clinical Rehabilitation, vol 10, no 8 , pp 1 - 3.
• Leung, K., Cheng, Y., Mak, N., Chan, K., David Fan, T. and Wong, R. (2006), 'Signaling pathway of ginsenoside-Rg1 leading to nitric oxide production in endothelial cells', FEBS Letters, vol 580, no 13 , pp 3211 - 3216.
• Zhao, L., Chan, K., Leung, K., Liu, F., Lang, J. and Fang, J. (2005), 'The Chinese quality of life instrument: Development of a new health-related quality of life using factor analysis and structural equation modelling', Journal of Complementary and Integrative Medicine, vol 2 , pp 1 - 22.
• Zhao, L., Chan, K., Leung, K., Liu, F. and Fang, J. (2005), 'The conceptual structure of the Chinese Quality of Life (ChQOL) Instrument', Annals of Traditional Chinese Medicine, Chinese Medicine - Modern Practice, vol 1 , pp 187 - 195.
• Yi, T., Leung, K., Lu, G., Zhang, H. and Chan, K. (2005), 'Identification and comparative determination of senkyunolide A in traditional Chinese medicinal plants Ligusticum chuanxiong and Angelica sinensis by HPLC coupled with DAD and ESI-MS', Chemical and Pharmaceutical Bulletin, vol 53, no 11 , pp 1480 - 1483.
• Lu, G., Chan, K., Leung, K., Chan, C., Zhao, Z. and Jiang, Z. (2005), 'Assay of free ferulic acid and total ferulic acid for quality assessment of Angelica sinensis', Journal of Chromatography A, vol 1068, no 2 , pp 209 - 219.
• Liu, Z., Chan, K., Zhou, H., Jiang, Z., Wong, Y., Xu, H. and Liu, L. (2005), 'The pharmacokinetics and tissue distribution of sinomenine in rats and its protein binding ability in vitro', Life Sciences, vol 77, no 25 , pp 3197 - 3209.
• Liu, Z., Zhou, H., Liu, L., Jiang, Z., Wong, Y., Xie, Y., Cai, X., Xu, H. and Chan, K. (2005), 'Influence of co-administrated sinomenine on pharmacokinetic fate of paeoniflorin in unrestrained conscious rats', Journal of Ethnopharmacology, vol 99, no 1 , pp 61 - 67.
• Leung, K., Chan, K., Lau, A. and Lu, G. (2005), 'Measurement uncertainty for total ash and acid-insoluble ash determination of Chinese materia medica', Accreditation and Quality Assurance, vol 10, no 6 , pp 289 - 294.
• Yue, P., Wong, D., Ha, W., Fung, M., Mak, N., Yeung, H., Leung, H., Chan, K., Liu, L., Fan, T. and Wong, R. (2005), 'Elucidation of the mechanisms underlying the angiogenic effects of ginsenoside Rg1 in vivo and in vitro', Angiogenesis, vol 8, no 3 , pp 205 - 216.
• Zhong, Q., Zhi, H., Chan, K., Zhou, H., Yuen, F., Zhao, X., Hong, X. and Liu, L. (2005), 'Pharmacokinetic interaction of paeoniflorin and sinomenine: Pharmacokinetic parameters and tissue distribution characteristics in rats and protein binding ability in vitro', Journal of Pharmacological Sciences, vol 99, no 4 , pp 381 - 391.
• Leung, K., Liu, F., Zhao, L., Fang, J., Chan, K. and Lin, L. (2005), 'Development and validation of the Chinese Quality of Life Instrument', Health and Quality of Life Outcomes, vol 3 .
• Zhao, L. and Chan, K. (2005), 'Building a bridge for integrating Chinese medicine into conventional healthcare: Observations drawn from the development of the Chinese quality of life instrument', American Journal of Chinese Medicine, vol 33, no 6 , pp 897 - 902.
• Lu, G., Chan, K., Laing, Y., Leung, K., Chan, C., Jian, Z. and Zhao, Z. (2005), 'Development of high-performance liquid chromatographic fingerprints for distinguishing Chinese Angelica from related umbelliferae herbs', Journal of Chromatography A, vol 1073, no 40575 , pp 383 - 392.
• Chui, S., Chan, K., Chui, A., Shek, L. and Wong, R. (2005), 'The effects of a Chinese medicinal suppository (Vitalliver) on insulin-like growth factor 1 and homocysteine in patients with hepatitis B infection', Phytotherapy Research, vol 19, no 8 , pp 674 - 678.
• Leung, K., Chan, K., Chan, C. and Lu, G. (2005), 'Systematic evaluation of organochlorine pesticide residues in Chinese materia medica', Phytotherapy Research, vol 19, no 6 , pp 514 - 518.
• Leung, K. and Chan, K. (2004), 'Regulatory System of Proprietary Chinese Medicine in Hong Kong', Journal of Complementary and Integrative Medicine, vol 1 .
• Zhao, L., Liu, F., Leung, K., Fang, J., Lin, L. and Chan, K. (2004), 'Discussion on the theory and structure model of the Chinese quality of life instrument', Chinese Journal of Clinical Rehabilitation, vol 8 , pp 3132 - 3134.
• Liu, F., Zhao, L., Leung, K., Fang, J., Lin, L. and Chan, K. (2004), 'Discussing the probability and steps of setting up the system of instruments used for assessment of clinical effectiveness of traditional Chinese medicine', Chinese Journal of Clinical Rehabilitation, vol 8 , pp 164 - 165.
• Zhao, L., Chan, K., Leung, K., Liu, F. and Fang, J. (2004), 'Application of factor analysis in development and validation of a new questionnaire for quality of life', Chinese Journal of Integrated Traditional and Western Medicine, vol 24 , pp 965 - 968.
• Lu, G., Chan, K., Chan, C., Leung, K., Jiang, Z. and Zhao, Z. (2004), 'Quantification of ligustilides in the roots of Angelica sinensis and related umbelliferous medicinal plants by high-performance liquid chromatography and liquid chromatography-mass spectrometry', Journal of Chromatography A, vol 1046, no 1-Feb , pp 101 - 107.
• Chui, S., Chan, K., Wong, R. and Chen, K. (2004), 'A panel study on the effects of a Chinese medicinal suppository, Vigconic VI-28, on insulin-like growth factor 1 and homocysteine in healthy men', Methods and Findings in Experimental and Clinical Pharmacology, vol 26, no 5 , pp 349 - 355.
• Chan, K., Chui, S., Wong, D., Ha, W., Chan, C. and Wong, R. (2004), 'Protective effects of Danshensu from the aqueous extract of Salvia miltiorrhiza (Danshen) against homocysteine induced endothelial dysfunction', Life Sciences, vol 75 , pp 3157 - 3171.
• Hu, S., Zhang, H., Chan, K. and Mei, Q. (2004), 'Studies on the toxicity of Aristolochia manshuriensis (Guanmuton)', Toxicology, vol 198 , pp 195 - 201.
• Lu, G., Sun, S., Leung, H. and Chan, K. (2004), 'Study on the identification of Dangguitou and Dangguiwei by Two-Dimensional infrared correlation spectroscopy', Spectroscopy and Spectral Analysis, vol 24 , pp 311 - 314.
• Hu, S., Zhang, H., Chan, K. and Mei, Q. (2003), 'Preliminary studies on the toxicity of Guang Fang Ji', Zhong Yao Cai (Chinese Materia Medica), vol 26 , pp 274 - 277.
• Zhao, L. and Chan, K. (2003), 'The health concept in Chinese medicine', Medicine and Philosophy, vol 24 , pp 58 - 59.
• Zhao, L. and Chan, K. (2003), 'Quality of life assessment: An outcome estimation of Chinese medical treatment', Chinese Journal of Integrative Medicine, vol 9 , pp 299 - 301.
• Di, X., Chan, K., Leung, H. and Huie, C. (2003), 'Fingerprint profiling of acid hydrolyzates of polysaccharide extracted from the fruiting bodies and spores of Lingzhi by high-performance thin-layer chromatography', Journal Chromatography A, vol 1018 , pp 85 - 95.
• Choi, M., Chan, K., Leung, H. and Chiu, C. (2003), 'Pressurised liquid extraction of active ingredients (ginsenosides) from medicinal plants using non-ionic surfactant solutions', Journal Chromatography A, vol 983 , pp 153 - 162.
• Song, Z., Bi, K., Luo, X. and Chan, K. (2002), 'The isolation, identification and determination of dehydrotumulosic acid in Poria cocos', Analytical Sciences, vol 18, no 5 , pp 529 - 531.
• Liu, X., Zakaria, M., Islam, M., Radhakrishnan, R., Ismail, A., Chen, H., Chan, K. and Al-Attas, A. (2001), 'Anti-inflammatory and anti-ulcer activity of Calligonum comosum in rats', Fitoterapia, vol 72 , pp 487 - 491.
• Zakaria, M., Islam, M., Radhakrishnana, R., Chen, H., Kamil, M., Al-gifri, M., Chan, K. and Al-Attas, A. (2001), 'Anti-nociceptive and anti-inflammatory properties of Caralluma Arabica', Journal of Ethnopharmacology, vol 76 , pp 155 - 158.
• Radhakrishnan, R., Zakaria, M., Islam, M., Chen, H., Kamil, M., Chan, K. and Al-Attas, A. (2001), 'Neuropharmacological actions of Portulaca oleraceae L v. sativa (Hawk)', Journal of Ethnopharmacology, vol 76 , pp 171 - 176.
• Chan, K. (2001), 'Generating fingerprinting from analytical techniques alone is not enough in the assurance for quality, efficacy and safety of Chinese medicinal herbs and herbal products.', Analytical Sciences, vol 17 (suppl) , pp 409 - 412.