Doctor Patrice Castignolles

Doctor Patrice Castignolles

Biography

I have made significant contributions to the understanding of polymerization kinetics and the separation and characterization of polymers, especially branched polymers, polyelectrolytes, polysaccharides and biobased polymers

In terms of polymerization kinetics, using a combination of theory, simulation and experiment, I showed that certain reactions (viz., transfer) with dead polymer chains play a major role in the (radical) polymerization of alkyl acrylates, widely used industrially (in adhesives, coatings and paints). It was published in several seminal papers, including one on benchmark rate coefficients, under the auspices of IUPAC (the interntional governing body in chemistry).

I have made important contributions to the understanding of the separation of polymers by liquid chromatography (particularly size-exclusion chromatography, SEC, also knonw as GPC). I showed that SEC is generally applied in a limited and too often also incorrect way. I showed how these problems could be corrected by proper use of apparent molar masses (e.g. polystyrene -equivalent or pullulan-equivalent molar masses) determined by SEC  in controlled/living polymerization or for the determination of transfer coefficients in radical polymerization. I derived the first rigorous expression for the signals of multiple detectors in SEC, and showed how such data can be processed correctly for complex polymers. I have applied this theory to the first accurate characterization of branched poly(alkyl acrylates), branched glucans and amphiphilic and double-hydrophilic block copolymers (pH-responsive and thermoresponsive) , studies which give considerable insight into the (bio)syntheses of these important classes of polymers. I showed that the local dispersity can be determined using multiple-detection SEC and used to estimate the accuracy of the molecular weight determined by SEC. In the cases  where the accuracy of the moleclar weight is low (e.g. 100 % error), I have shown that hydrodynamic volume distribution can lead to meaningful and accurate information.

I have proposed free solution capillary electrophoresis as an alternative to liquid chromatography in the critical conditions for the separation and characterization of polyelectrolytes and polysaccharides by their structure such as composition (copolymer) or branching. The method, capillary electorphoresis in the critical condtions, can be used even to characterize soluble fractions in suspensions (no flitration needed) as in the case of gellan gums. it can separate conjugates according tothe functionalization for example chitosan conjugates.

I graduated in Paris, University Pierre and Marie Curie under Prof Jean-Pierre Varion and Prof Bernadette Charleux in 2003. My first post-doc was in the Max Planck Institute for Polymer Reserach, Minaz, in 2004-2005. I was then research Fellows in the Key Centre for Polymer (and) Colloids (KCPC) in the University of Sydney (2005-2006), the Centre for Nutrition and Food Sciences (CNAFS) in the University of Queensland (2006-2008) and the Insitute of Physical Chemistry at the University of Mainz (2009).  In 2010, I joined UWS and the Australian Centre for Research on Separation Science (ACROSS).

This information has been contributed by Doctor Castignolles.

Qualifications

  • PhD (PhyChemMat) University of Paris VI
  • MChemPhyChem University of Paris VI

Professional Memberships

  • French Polymer Group GFP (2001)
  • RACI (Chemistry) (2005)
  • SCF (Chemistry) (2006)
  • ACS (Chemistry) (2008)
  • IUPAC (Chemistry) (2004)

Committees

  • SoSH research seminars on Parramatta campus

Contact

Email: P.Castignolles@westernsydney.edu.au
Phone:
Mobile:
Location: Parramatta

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Teaching

Previous Teaching Areas

  • 300297 Analytical Chemistry 2, 2012
  • 300468 Green Chemistry 2, 2012
  • 300541 Biomolecular Frontiers, 2011
  • 300542 Biomolecular Science Project, 2013
  • 300592 Advanced Science Research Project B, 2012
  • 300747 Advanced Topics and Research Skills, 2015
  • 300800 Essential Chemistry 1, 2015
  • 300803 Essential Chemistry 2, 2015
  • 300808 Introductory Chemistry, 2014
  • 300832 Analytical Chemistry, 2019
  • 300832 Analytical Chemistry, 2020
  • 300843 Forensic and Environmental Analysis, 2015
  • 300892 Medical Science Project, 2015
  • 300910 Advanced Science Project C, 2015
  • 300924 Science Research Project, 2015
  • 300937 Advanced Science Project A, 2015

Publications

Journal Articles

  • Read, E., Lonetti, B., Gineste, S., Sutton, A., Di Cola, E., Castignolles, P., Gaborieau, M., Mingotaud, A., Destarac, M. and Marty, J. (2021), 'Mechanistic insights into the formation of polyion complex aggregates from cationic thermoresponsive diblock copolymers', Journal of Colloid and Interface Science, vol 590 , pp 268 - 276.
  • Van Leeuwen, M., Toutounji, M., Mata, J., Ward, R., Gilbert, E., Castignolles, P. and Gaborieau, M. (2021), 'Assessment of starch branching and lamellar structure in rice flours', Food Structure, vol 29 .
  • Bhullar, K., Meinel, A., Maeder, K., Wuhrer, R., Gaborieau, M. and Castignolles, P. (2021), 'Advanced spectroscopy, microscopy, diffraction and thermal analysis of polyamide adhesives and prediction of their functional properties with solid-state NMR spectroscopy', Polymer Chemistry, vol 12, no 10 , pp 1487 - 1497.
  • Maniego, A., Sutton, A., Guillaneuf, Y., Lefay, C., Destarac, M., Fellows, C., Castignolles, P. and Gaborieau, M. (2019), 'Degree of branching in poly(acrylic acid) prepared by controlled and conventional radical polymerization', Polymer Chemistry, vol 10, no 19 , pp 2469 - 2476.
  • Pintiaux, T., Heuls, M., Vandenbossche, V., Murphy, T., Wuhrer, R., Castignolles, P., Gaborieau, M. and Rouilly, A. (2019), 'Cellulose consolidation under high-pressure and high-temperature uniaxial compression', Cellulose, vol 26, no 5 , pp 2941 - 2954.
  • Xu, H., Wang, Z., Miao, Z., Zhu, Y., Marianov, A., Wang, L., Castignolles, P., Gaborieau, M., Huang, J. and Jiang, Y. (2019), 'Correlation between acidity and catalytic performance of mesoporous zirconium oxophosphate in phenylglyoxal conversion', ACS Sustainable Chemistry and Engineering, vol 7, no 9 , pp 8931 - 8942.
  • Sutton, A., Arrua, R., Gaborieau, M., Castignolles, P. and Hilder, E. (2018), 'Characterization of oligo(acrylic acid)s and their block co-oligomers', Analytica Chimica Acta, vol 1032 , pp 163 - 177.
  • Thevarajah, J., Van Leeuwen, M., Cottet, H., Castignolles, P. and Gaborieau, M. (2017), 'Determination of the distributions of degrees of acetylation of chitosan', International Journal of Biological Macromolecules, vol 95 , pp 40 - 48.
  • Howard-Smith, K., Craze, A., Badbhade, M., Marjo, C., Murphy, T., Castignolles, P., Wuhrer, R. and Li, F. (2017), 'Syntheses and structure investigations of 3d transition metal complexes with a flexible N4O2-donor hexadentate Schiff-base ligand', Australian Journal of Chemistry, vol 70, no 5 , pp 581 - 587.
  • Lena, J., Goroncy, A., Thevarajah, J., Maniego, A., Russell, G., Castignolles, P. and Gaborieau, M. (2017), 'Effect of transfer agent, temperature and initial monomer concentration on branching in poly(acrylic acid) : a study by 13C NMR spectroscopy and capillary electrophoresis', Polymer, vol 114 , pp 209 - 220.
  • Maniego, A., Sutton, A., Gaborieau, M. and Castignolles, P. (2017), 'Assessment of the branching quantification in poly(acrylic acid) : is it as easy as it seems?', Macromolecules, vol 50, no 22 , pp 9032 - 9041.
  • Thevarajah, J., Sutton, A., Maniego, A., Whitty, E., Harrisson, S., Cottet, H., Castignolles, P. and Gaborieau, M. (2016), 'Quantifying the heterogeneity of chemical structures in complex charged polymers through the dispersity of their distributions of electrophoretic mobilities or of compositions', Analytical Chemistry, vol 88, no 3 , pp 1674 - 1681.
  • Thevarajah, J., Bulanadi, J., Wagner, M., Gaborieau, M. and Castignolles, P. (2016), 'Towards a less biased dissolution of chitosan', Analytica Chimica Acta, vol 935 , pp 258 - 268.
  • Rebiere, J., Heuls, M., Castignolles, P., Gaborieau, M., Rouilly, A., Violleau, F. and Durrieu, V. (2016), 'Structural modifications of cellulose samples after dissolution into various solvent systems', Analytical and Bioanalytical Chemistry, vol 408, no 29 , pp 8403 - 8414.
  • Thevarajah, J., O'Connor, M., Castignolles, P. and Gaborieau, M. (2016), 'Capillary electrophoresis to monitor peptide grafting onto chitosan films in real time', Journal of Visualized Experiments, vol 116 .
  • Oliver, J., Sutton, A., Karu, N., Phillips, M., Markham, J., Peiris, P., Hilder, E. and Castignolles, P. (2015), 'Simple and robust monitoring of ethanol fermentations by capillary electrophoresis', Biotechnology and Applied Biochemistry, .
  • Lacik, I., Stach, M., Kasak, P., Semak, V., Uhelska, L., Chovancova, A., Rheinhold, G., Kilz, P., Delaittre, G., Charleux, B., Chaduc, I., D'Agosto, F., Lansalot, M., Gaborieau, M., Castignolles, P., Gilbert, R., Szablan, Z., Barner-Wowollik, C., Hesse, P. and Buback, M. (2015), 'SEC Analysis of poly(acrylic acid) and poly(methacrylic acid)', Macromolecular Chemistry and Physics, vol 216, no 1 , pp 23 - 37.
  • Schmid, T., Himmelsbach, M., Oliver, J., Gaborieau, M., Castignolles, P. and Buchberger, W. (2015), 'Investigation of photochemical reactions of saccharides during direct ultraviolet absorbance detection in capillary electrophoresis', Journal of Chromatography A, vol 1388 , pp 259 - 266.
  • Taylor, D., Thevarajah, J., Narayan, D., Murphy, P., Mangala, M., Lim, S., Wuhrer, R., Lefay, C., O'Connor, M., Gaborieau, M. and Castignolles, P. (2015), 'Real-time monitoring of peptide grafting onto chitosan films using capillary electrophoresis', Analytical and Bioanalytical Chemistry, vol 407, no 9 , pp 2543 - 2555.
  • Toutounji, M., Van Leeuwen, M., Oliver, J., Shrestha, A., Castignolles, P. and Gaborieau, M. (2015), 'Quantification of sugars in breakfast cereals using capillary electrophoresis', Carbohydrate Research, vol 408 , pp 134 - 141.
  • Whitty, E., Maniego, A., Bentwitch, S., Guillaneuf, Y., Jones, M., Gaborieau, M. and Castignolles, P. (2015), 'Cellular response to linear and branched poly(acrylic acid)', Macromolecular Bioscience, vol 15, no 12 , pp 1724 - 1734.
  • Barner-Kowollik, C., Beuermann, S., Buback, M., Castignolles, P., Charleux, B., Coote, M., Hutchinson, R., Junkers, T., Lacik, I., Russell, G., Stach, M. and Herk, A. (2014), 'Critically evaluated rate coefficients in radical polymerization - 7. Secondary-radical propagation rate coefficients for methyl acrylate in bulk', Polymer Chemistry, vol 5 , pp 204 - 212.
  • Oliver, J., Rosser, A., Fellows, C., Guillaneuf, Y., Clement, J., Gaborieau, M. and Castignolles, P. (2014), 'Understanding and improving direct UV detection of monosaccharides and disaccharides in free solution capillary electrophoresis', Analytica Chimica Acta, vol 809 , pp 183 - 193.
  • Oliver, J., Gaborieau, M. and Castignolles, P. (2014), 'Ethanol determination using pressure mobilization and free solution capillary electrophoresis by photo-oxidation assisted ultraviolet detection', Journal of Chromatography A, vol 1348 , pp 150 - 157.
  • Thevarajah, J., Gaborieau, M. and Castignolles, P. (2014), 'Separation and characterization of synthetic polyelectrolytes and polysaccharides with capillary electrophoresis', Advances in Chemistry, vol 798503 .
  • Sutton, A., Read, E., Maniego, A., Thevarajah, J., Marty, J., Destarac, M., Gaborieau, M. and Castignolles, P. (2014), 'Purity of double hydrophilic block copolymers revealed by capillary electrophoresis in the critical conditions', Journal of Chromatography A, vol 1372 , pp 187 - 195.
  • Lefay, C., Guillaneuf, Y., Moreira, G., Thevarajah, J., Castignolles, P., Ziarelli, F., Bloch, E., Major, M., Charles, L., Gaborieau, M., Bertin, D. and Gigmes, D. (2013), 'Heterogeneous modification of chitosan via nitroxide-mediated polymerization', Polymer Chemistry, vol 4, no 2 , pp 322 - 328.
  • Oliver, J., Gaborieau, M., Hilder, E. and Castignolles, P. (2013), 'Simple and robust determination of monosaccharides in plant fibers in complex mixtures by capillary electrophoresis and high performance liquid chromatography', Journal of Chromatography A, vol 1291 , pp 179 - 186.
  • Mnatsakanyan, M., Thevarajah, J., Roi, R., Lauto, A., Gaborieau, M. and Castignolles, P. (2013), 'Separation of chitosan by degree of acetylation using simple free solution capillary electrophoresis', Analytical and Bioanalytical Chemistry, vol 405, no 21 , pp 6873 - 6877.
  • Petitjean, H., Guiglion, P., In, M., Aldrich-Wright, J., Castignolles, P., Ganachaud, F. and Gaborieau, M. (2013), 'Supramolecular organization of protonated aminosilicones in water', Journal of Colloid and Interface Science, vol 408 , pp 87 - 93.
  • Maniego, A., Ang, D., Guillaneuf, Y., Lefay, C., Gigmes, D., Aldrich-Wright, J., Gaborieau, M. and Castignolles, P. (2013), 'Separation of poly(acrylic acid) salts according to topology using capillary electrophoresis in the critical conditions', Analytical and Bioanalytical Chemistry, vol 405, no 28 , pp 9009 - 9020.
  • Castignolles, P. (2012), 'Williams, S. Kim R.; Caldwell, Karin D. (Eds.): Field-flow fractionation in biopolymer analysis', Analytical and Bioanalytical Chemistry, vol 404 , pp 1619 - 1620.
  • Taylor, D., Ferris, C., Maniego, A., Castignolles, P., Panhuis, M. and Gaborieau, M. (2012), 'Characterization of gellan gum by capillary electrophoresis', Australian Journal of Chemistry, vol 65, no 8 , pp 1156 - 1164.
  • Delaittre, G., Save, M., Gaborieau, M., Castignolles, P., Rieger, J. and Charleux, B. (2012), 'Synthesis by nitroxide-mediated aqueous dispersion polymerization, characterization, and physical core-crosslinking of pH- and thermoresponsive dynamic diblock copolymer micelles', Polymer Chemistry, vol 3, no 6 , pp 1526 - 1538.
  • Colombani, O., Langelier, O., Martwong, E. and Castignolles, P. (2011), 'Polymerization kinetics: monitoring monomer conversion using an internal standard - key Role of sample t0', Journal of Chemical Education, vol 88, no 1 , pp 116 - 121.
  • Gaborieau, M. and Castignolles, P. (2011), 'Size-exclusion chromatography (SEC) of branched polymers and polysaccharides', Analytical and Bioanalytical Chemistry, vol 399, no 4 , pp 1413 - 1423.
  • Gaborieau, M., Causon, T., Guillaneuf, Y., Hilder, E. and Castignolles, P. (2010), 'Molecular weight and tacticity of oligoacrylates by capillary electrophoresis - mass spectrometry', Australian Journal of Chemistry, vol 63, no 8 , pp 1219 - 1226.
  • Gaborieau, M., Koo, S., Castignolles, P., Junkers, T. and Barner-Kowollik, C. (2010), 'Reducing the degree of branching in polyacrylates via midchain radical patching: a quantitative melt-state NMR study', Macromolecules, vol 43, no 13 , pp 5492 - 5495.
  • Castignolles, P. and Gaborieau, M. (2010), 'Viscosimetric detection in size-exclusion chromatography (SEC/GPC) : the Goldwasser method and beyond', Journal of Separation Science, vol 33, no 22 , pp 3564 - 3570.
  • Junkers, T., Schneider-Baumann, M., Koo, S., Castignolles, P. and Barner-Kowollik, C. (2010), 'Determination of propagation rate coefficients for methyl and 2-ethylhexyl acrylate via high frequency PLP-SEC under consideration of the impact of chain branching', Macromolecules, vol 43, no 24 , pp 10427 - 10434.
  • Schmitz, S., Dona, A., Castignolles, P., Gilbert, R. and Gaborieau, M. (2009), 'Assessment of the extent of starch dissolution in dimethylsulfoxide by 1H NMR spectroscopy', Macromolecular Bioscience, vol 9 , pp 506 - 514.
  • Gaborieau, M., De Bruyn, H., Mange, S., Castignolles, P., Brockmeyer, A. and Gilbert, R. (2009), 'Synthesis and characterization of synthetic polymer colloids colloidally stabilized by cationized starch oligomers', Journal of Polymer Science A: Polymer Chemistry, vol 47, no 7 , pp 1836 - 1852.
  • David, G., El Asri, Z., Rich, S., Castignolles, P., Guillaneuf, Y., Lacroix-Desmazes, P. and Boutevin, B. (2009), 'Peculiar behavior of degenerative chain transfer polymerization of a phosphonated methacrylate', Macromolecular Chemistry and Physics, vol 210, no 8 , pp 631 - 639.
  • Castignolles, P., Graf, R., Parkinson, M., Wilhelm, M. and Gaborieau, M. (2009), 'Detection and quantification of branching in polyacrylates by size-exclusion chromatography (SEC) and melt-state 13C NMR spectroscopy', Polymer, vol 50, no 11 , pp 2373 - 2383.
  • Castignolles, P. and Gaborieau, M. (2009), 'Caracterisation de l'amidon et de ses materiaux composites', Annales des Falsifications, de l'Expertise Chimique and Toxicologique, vol 971 , pp 23 - 31.
  • Bar-Nes, G., Hall, R., Sharma, V., Gaborieau, M., Lucas, D., Castignolles, P. and Gilbert, R. (2009), 'Controlled/living radical polymerization of isoprene and butadiene in emulsion', European Polymer Journal, vol 45, no 11 , pp 3149 - 3163.
  • Castignolles, P. (2009), 'Transfer to polymer and long-chain branching in PLP-SEC of acrylates', Macromolecular Rapid Communications, vol 23 , pp 1995 - 2001.
  • Guillaneuf, Y. and Castignolles, P. (2008), 'Using apparent molecular weight from SEC in controlled /living polymerization and kinetics of polymerization', Journal of Polymer Science, Part A: Polymer Chemistry, vol 46 , pp 897 - 911.
  • Aungsupravate, O., Lucas, D., Abu Hassan, N., Tonge, M., Castignolles, P., Gaborieau, M., Warrender, G. and Gilbert, R. (2008), 'Water vapour transmission in butadiene-MMA-methacrylic acid latex films', European Polymer Journal, vol 44, no 2 , pp 342 - 356.
  • Gaborieau, M., Nicolas, J., Save, M., Charleux, B., Vairon, J., Gilbert, R. and Castignolles, P. (2008), 'Separation of complex branched polymers by size-exclusion chromatography (SEC) probed with multiple detection', Journal of Chromatography A, vol 1190 , pp 215 - 223.
  • Hoang, N., Landolfi, A., Kravchuk, A., Girard, E., Peate, J., Hernandez, J., Gaborieau, M., Kravchuk, O., Gilbert, R., Guillaneuf, Y. and Castignolles, P. (2008), 'Toward a full characterization of native starch: separation and detection by size-exclusion chromatography', Journal of Chromatography A, vol 1205, no 40575 , pp 60 - 70.
  • Hernandez, J., Gaborieau, M., Castignolles, P., Gidley, M., Myers, A. and Gilbert, R. (2008), 'Mechanistic investigation of a starch-branching enzyme using hydrodynamic volume SEC analysis', Biomacromolecules, vol 9, no 3 , pp 954 - 965.
  • Nejad, E., Castignolles, P., Gilbert, R. and Guillaneuf, Y. (2008), 'Synthesis of methacrylate derivatives oligomers by dithiobenzoate-RAFT- mediated polymerization', Journal of Polymer Science, Part A: Polymer Chemistry, vol 46, no 6 , pp 2277 - 2289.
  • Gaborieau, M., Hernandez, J., Gilbert, R., Gray-Weale, A. and Castignolles, P. (2007), 'Theory of multiple detection of size exclusion chromatography of complex branched polymers', Macromolecular Theory and Simulations, vol 16, no 1 , pp 13 - 28.
  • Demir, M., Castignolles, P., Abkey, U. and Wegner, G. (2007), 'In-situ bulk polymerization of dilute particle/MMA dispersion', Macromolecules, vol 40 , pp 4190 - 4198.
  • Mange, S., Dever, C., De Bruyn, H., Gaborieau, M., Castignolles, P. and Gilbert, R. (2007), 'Grafting of oligosaccharides onto synthetic polymer colloids', Biomacromolecules, vol 8, no 6 , pp 1816 - 1823.
  • Dona, A., Yuen, W., Peate, J., Gilbert, R., Castignolles, P. and Gaborieau, M. (2007), 'A new NMR method for directly monitoring and quantifying the dissolution kinetics of starch in DMSO', Carbohydrate Research, vol 342, no 17 , pp 2604 - 2610.
  • Konkolewicz, D., Taylor, J., Castignolles, P., Gray-Weale, A. and Gilbert, R. (2007), 'Toward a more general solution to the band-broadening problem in size separation of polymers', Macromolecules, vol 40, no 9 , pp 3477 - 3487.
  • Castignolles, P., Nikitin, A., Couvreur, L., Mouraret, G., Charleux, B. and Vairon, J. (2006), 'Pulsed laser polymerization of alkyl acrylates: Potential effects of the oxygen presence and high laser power', Macromolecular Chemistry and Physics, vol 207, no 1 , pp 81 - 89.
  • Castignolles, P., Gaborieau, M., Hilder, E., Sprong, E., Ferguson, C. and Gilbert, R. (2006), 'High-resolution separation of oligo(acrylic acid) by capillary zone electrophoresis', Macromolecular Rapid Communications, vol 27, no 1 , pp 42 - 46.
  • Demir, M., Memesa, M., Castignolles, P. and Wegner, G. (2006), 'PMMA/zinc oxide nanocomposites prepared by in-situ bulk polymerization', Macromolecular Rapid Communications, vol 27, no 10 , pp 763 - 770.
  • Guillaneuf, Y., Bertin, D., Castignolles, P. and Charleux, B. (2005), 'New experimental procedure to determine the recombination rate constants between nitroxides and macroradicals', Macromolecules, vol 38, no 11 , pp 4638 - 4646.
  • Asua, J., Beuermann, S., Buback, M., Castignolles, P., Charleux, B., Gilbert, R., Hutchinson, R. and Leiza, J. (2004), 'Critically evaluated rate coefficients for free-radical polymerization, 5, Propagation rate coefficient for butyl acrylate', Macromolecular Chemistry Physics, vol 16 , pp 2151 - 2160.
  • Nikitin, A., Castignolles, P., Charleux, B. and Vairon, J. (2003), 'Simulation of molecular weight distributions obtained by pulsed laser polymerization (PLP). New analytical expressions including intramolecular transfer to polymer,', Macromolecular Theory and Simulations, vol 12, no na , pp 440 - 448.
  • Nikitin, A., Castignolles, P., Charleux, B. and Vairon, J. (2003), 'Determination of propagation rate coefficients of acrylates by pulsed-laser polymerization in the presence of intramolecular transfer to polymer', Macromolecular Rapid Communications, vol 24 , pp 778 - 782.
  • Couvreur, L., Piteau, G., Castignolles, P., Tonge, M., Coutin, B., Charleux, B. and Vairon, J. (2001), 'Pulsed-laser Radical Polymerization and Propagation Kinetic Parameters of some Alkyl Acrylates', Macromolecular Symposia, vol 174, no nil , pp 197 - 207.

Conference Papers

  • De Bruyn, H., Sprong, E., David, G., Mange, S., Castignolles, P., Gaborieau, M. and Gilbert, R. (2007), 'Copolymers of starch and synthetic monomers', RACI cereal chemistry conference, .

My reseach aims at establishing the relations between the structure of polymers and their synthesis (radical polymerization or biosynthesis) and the structure of polymers and their properties (such cell adhesion, drug binding, drug release etc.). We are developping new separation and characterization methods mainly based on capillary electrophoresis and SEC (as well as solid-state NMR and others).

Together with Dr Marion Gaborieau, Prof Janice Aldrich-Wright and Dr Mark Jones (UWS) and Dr Yohann Guillaneuf (Aix-Marseille University), we are developping new delivery agents for anticancer drugs. We use smart polymers synthesized in Marseille as agents. We characterize these  and their binding to anticancer drugs using capillary electrophoresis in the critical conditions (and other method including solid-state NMR). Alison Maniego complete a first class honours project on this topic and is going further on a PhD in 2013.

Together with Dr Marion Gaborieau and Dr Michael O'Connor, we are developping new substrates for stem cell culture. The synthesis of the substrate is monitored (and optimized) using capillary electrorphoresis. The substrates are then characterized by solid-state NMR as well as Scanning Electron Microscopy in collaboration with Dr Ric Wuehrer.

Together with James Oliver, Dr Marion Gaborieau , Dr Michael Philips, Julie Markham and Dr Paul Peiris (UWS)  and Prof Emiliy Hilder (ACROSS, University of Tasmania), we are developping fast and accurate method to determine sugar compostion in plant fiber or in bioethanol production, comparing capillary electrophoresis and the different possible forms of liquid chromatography (including ion-exchange and HILIC).

Together with Dr Marion Gaborieau, Dr Valentina Naumovski and Prof Kelvin Chan, we are investigating the relation between the structure of glucomans and the health benefit related to their consumption as food.

Together with Dr Marion Gaborieau (UWS), Dr Aurelia Charlot and Prof Etienne Fleury (INSA, Lyon, France), we characterize polysaccharides and their composities for bioplastics.

Together with Dr Marion Gaborieau (UWS) and Prof Mathias Destarac (University Paul Sabatier, Toulouse, France), we characterize new smart block copolymers.

 

This information has been contributed by Doctor Castignolles.

Previous Projects

Title: Two dimensional separation SEC x CE of poly (acrylic acid)
Funder:
  • PSS Polymer Standards Service GmbH (PSS)
Western Researchers: Marion Gaborieau and Patrice Castignolles
Years: 2014-09-02 - 2015-09-01
ID: P00022412
Title: Solid-state NMR spectroscopy to characterise membranes for water purification
Funder:
  • Evoqua Water Technologies Membrane Systems Pty Ltd
  • University of Western Sydney
Western Researchers: Marion Gaborieau and Patrice Castignolles
Years: 2016-07-20 - 2016-12-31
ID: P00023603
Title: Characterisation of poly (N-vinyl pyrroidine) using capillary electrophoresis
Funder:
  • Evoqua Water Technologies Membrane Systems Pty Ltd
Western Researchers: Patrice Castignolles and Marion Gaborieau
Years: 2018-10-01 - 2019-05-09
ID: P00025360
Title: Development and application of alternative polymeric materials for mining and materials handling
Funder:
  • International Materials and Technology Pty Ltd
Western Researchers: Marion Gaborieau, Patrice Castignolles and Richard Wuhrer
Years: 2017-02-23 - 2020-02-23
ID: P00022870
Title: Investigating the architecture of rice starch at the nanoscale using complementary scattering methods to predict digestibility
Funder:
  • Australian Institute of Nuclear Science and Engineering Ltd (non ACRG)
Western Researchers: Marion Gaborieau, Patrice Castignolles and Gerald Muench
Years: 2017-07-01 - 2019-06-30
ID: P00024028
Title: Characterisation of rice startch
Funder:
  • NSW Department of Industries
Western Researchers: Patrice Castignolles and Marion Gaborieau
Years: 2017-07-01 - 2017-12-03
ID: P00024530
Title: Methods to study the chemical resistance of RubbaFIX?
Funder:
  • International Materials and Technology Pty Ltd
  • University of Western Sydney
Western Researchers: Patrice Castignolles and Marion Gaborieau
Years: 2016-09-16 - 2017-09-15
ID: P00023605
Title: Understand and more accurately predict GI with techniques such as capillary electrophoresis and solid-state NMR spectroscopy
Funder:
  • Rural Industries R&D Corporation (non ACRG)
Western Researchers: Marion Gaborieau, Patrice Castignolles and Gerald Muench
Years: 2017-02-01 - 2020-04-03
ID: P00023894
Title: Arnotts_Characterisation of Starchy Food Structure
Funder:
  • Campbell Arnott's
Western Researchers: Patrice Castignolles and Marion Gaborieau
Years: 2017-05-15 - 2017-08-31
ID: P00024137
Title: Branched degradable polymers for anti-cancer drugs delivery
Funder:
  • University of Western Sydney
Western Researchers: Patrice Castignolles, Janice Aldrich-Wright and Mark Jones
Years: 2011-11-09 - 2012-11-08
ID: P00020491

Supervision

Doctor Castignolles is available to be a principal supervisor for doctoral projects

Previous Supervision

Thesis Title: Silver (I) helicates and Their Biological Activity
Field of Research: Biological Sciences; Biological Sciences, N.e.c.; Biochemistry And Cell Biology
Thesis Title: Characterization of Branched poly(acrylic acid) via Capillary Electrophoresis and NMR Spectroscopy for Anticancer Drug Targeting and Delivery
Field of Research: Other Natural And Physical Sciences; Chemical Sciences; Chemical Sciences, N.e.c.; Biochemistry And Cell Biology
Thesis Title: Characterisation of Chitosan and its Films for Tissue Engineering
Field of Research: Other Society And Culture; Chemical Sciences; Biochemistry And Cell Biology
Thesis Title: Investigating and Applying Free Solution Capillary Electrophoresis with Direct UV Detection to Bioethanol Research
Field of Research: Biological Sciences; Other Natural And Physical Sciences; Biochemistry And Cell Biology
Thesis Title: Characterisation of Double Hydrophilic Block Copolymers
Field of Research: Natural And Physical Sciences; Chemical Sciences; Chemical Sciences, N.e.c.
Thesis Title: Molecular Characterisation of Breakfast Cereals and Rice to Understand their Digestibility
Field of Research: Chemical Engineering; Other Natural And Physical Sciences; Chemical Sciences; Chemical Sciences, N.e.c.
Thesis Title: Assessment of the "Smart" Polymer Poly (Acrylic Acid) for Drug Delivery
Field of Research: Other Natural And Physical Sciences
Thesis Title: Relating Starch Structure in Breakfast Cereals and Rice to their Digestibility
Field of Research: Other Health; Other Natural And Physical Sciences; General Medicine; Chemical Sciences, N.e.c.
Thesis Title: Generation of Human Pluripotent Stem Cell-Derived Micro-Lenses to Investigate Lens Development and Lens Toxicity
Field of Research: Biological Sciences; Other Health; Other Natural And Physical Sciences
Thesis Title: Characterisation of Vinylphosphonic Acid-based Block Copolymers
Field of Research: Chemical Sciences, N.e.c.
Thesis Title: Synthesis and Characterisation of New Schiff-Base Metallo-Supramolecular Assemblies
Field of Research: Natural And Physical Sciences
Thesis Title: The Characterisation of Ultrafiltration Membranes used in Water Purification
Field of Research: Natural And Physical Sciences
Thesis Title: Free-solution Capillary Electrophoresis for the Structural Characterization of Proteins
Field of Research: Natural And Physical Sciences

Western Sydney University

Locked Bag 1797
Penrith NSW 2751

ABN 53 014 069 881
CRICOS Provider No: 00917k