Doctor Michelle Moffitt

Doctor Michelle Moffitt

Senior Lecturer,
Medical Science (SoSH)

SENIOR LECTURER,
Medical Science (SoSH)

Biography

Qualifications

  • PhD University of New South Wales
  • BSc University of New South Wales

Organisational Unit (School / Division)

  • Medical Science (SoSH)
  • Medical Science (SoSH)

Contact

Email: M.Moffitt@westernsydney.edu.au
Phone: (02) 4620 3521
Mobile:
Location: 21.1.06
Campbelltown
Website:

PLEASE NOTE: obtaining information from this Directory must be for the legitimate purposes of doing business with and within Western Sydney University, and must not be used for unsolicited bulk e-mailing (spamming) or similar purposes.

Publications

Chapters in Books

  • D'Agostino, P., Moffitt, M. and Neilan, B. (2014), 'Current knowledge of paralytic shellfish toxin biosynthesis, molecular detection and evolution', Toxins and Biologically Active Compounds from Microalgae. Vol. 1, Origin, Chemistry and Detection, CRC Press 9781482210682.
  • Neilan, B., Pearson, L., Moffitt, M., Kaebernick, M., Mihali, T. and Kellmann, R. (2008), 'The genetics and genomics of cyanobacterial toxicity', Cyanobacterial harmful Algal Blooms: State of the Science and Research Needs, Springer New York 9780387758640.

Journal Articles

  • D'Agostino, P., Song, X., Neilan, B. and Moffitt, M. (2016), 'Proteogenomics of a saxitoxin-producing and non-toxic strain of Anabaena circinalis (cyanobacteria) in response to extracellular NaCl and phosphate depletion', Environmental Microbiology, vol 18, no 2 , pp 461 - 476.
  • D'Agostino, P., Woodhouse, J., Makower, A., Yeung, A., Ongley, S., Micallef, M., Moffitt, M. and Neilan, B. (2016), 'Advances in genomics, transcriptomics and proteomics of toxin-producing cyanobacteria', Environmental Microbiology Reports, vol 8, no 1 , pp 3 - 13.
  • Micallef, M., D'Agostino, P., Sharma, D., Viswanathan, R. and Moffitt, M. (2015), 'Genome mining for natural product biosynthetic gene clusters in the Subsection V cyanobacteria', BMC Genomics, vol 16, no 1 .
  • Cronin, L., Moffitt, M., Mawad, D., Morton, O., Lauto, A. and Stack, C. (2014), 'An in vitro study of the photodynamic effect of rose bengal on Trichophyton rubrum.', Journal of Biophotonics, vol 7, no 6 , pp 410 - 417.
  • Cronin, L., Mildern, R., Moffitt, M., Lauto, A., Morton, O. and Stack, C. (2014), 'An investigation into the inhibitory effect of ultraviolet radiation on Trichophyton rubrum', Lasers in Medical Science, vol 29, no 1 , pp 157 - 163.
  • D'Agostino, P., Song, X., Neilan, B. and Moffitt, M. (2014), 'Comparative proteomics reveals that a saxitoxin-producing and a nontoxic strain of Anabaena circinalis are two different ecotypes', Journal of Proteome Research, vol 13, no 3 , pp 1474 - 1484.
  • Belshaw, D., Moffitt, M. and Truman, G. (2014), 'Cyanobacteria : health and research possibilities', NSW Public Health Bulletin, vol 24, no 4 , pp 178 - 179.
  • Micallef, M., Sharma, D., Bunn, B., Gerwick, L., Viswanathan, R. and Moffitt, M. (2014), 'Comparative analysis of hapalindole, ambiguine and welwitindolinone gene clusters and reconstitution of indole-isonitrile biosynthesis from cyanobacteria', BMC Microbiology, vol 14, no 213 .
  • Wu, M., Bak, T., O'Doherty, P., Moffitt, M., Nowotny, J., Bailey, T. and Kersaitis, C. (2014), 'Photocatalysis of titanium dioxide for water disinfection : challenges and future perspectives', International Journal of Photochemistry, vol 2014 .
  • Micallef, M., D'Agostino, P., Al-Sinawi, B., Neilan, B. and Moffitt, M. (2014), 'Exploring cyanobacterial genomes for natural product biosynthesis pathways', Marine Genomics, .
  • Neilan, B., Pearson, L., Muenchhoff, J., Moffitt, M. and Dittmann, E. (2013), 'Environmental conditions that influence toxin biosynthesis in cyanobacteria', Environmental Microbiology, vol 15, no 5 , pp 1239 - 1253.
  • Gehringer, M., Adler, L., Roberts, A., Moffitt, M., Mihali, T., Mills, T., Fieker, C. and Neilan, B. (2012), 'Nodularin, a cyanobacterial toxin, is synthesized in planta by symbiotic Nostoc sp.', ISME journal, vol 6, no 10 , pp 1834 - 1847.
  • Pearson, L., Mihali, T., Moffitt, M., Kellmann, R. and Neilan, B. (2010), 'On the chemistry, toxicology and genetics of the cyanobacterial toxins, microcystin, nodularin, saxitoxin and cylindrospermopsin', Marine Drugs, vol 8, no 5 , pp 1650 - 1680.
  • Wiese, M., D'Agostino, P., Mihali, T., Moffitt, M. and Neilan, B. (2010), 'Neurotoxic alkaloids : saxitoxin and its analogs', Marine Drugs, vol 8, no 7 , pp 2185 - 2211.
  • Pearson, L., Moffitt, M., Ginn, H. and Neilan, B. (2008), 'The molecular genetics and regulation of cyanobacterial peptide hepatotoxin biosynthesis', Critical Reviews in Toxicology, vol 38, no 10 , pp 847 - 856.
  • Winter, J., Moffitt, M., Zazopoulos, E., Mcalpine, J., Dorrestein, P. and Moore, B. (2007), 'Molecular basis for chloronium-mediated meroterpene cyclization: cloning, sequencing, and heterologous expression of the napyradiomycin biosynthetic gene cluster', Journal of Biological Chemistry, vol 282, no 22 , pp 16362 - 16368.
  • Moffitt, M., Louie, G., Bowman, M., Pence, J., Noel, J. and Moore, B. (2007), 'Discovery of two cyanobacterial phenylalanine ammonia lyases: kinetic and structural characterization.', Biochemistry-US, vol 46, no 4 , pp 1004 - 1012.
  • Hicks, L., Moffitt, M., Beer, L., Moore, B. and Kelleher, N. (2006), 'Structural characterization of in vitro and in vivo intermediates on the loading module of microcystin synthetase', A C S Chemical Biology, vol 1, no 2 , pp 93 - 102.
  • Louie, G., Bowman, M., Moffitt, M., Baiga, T., Moore, B. and Noel, J. (2006), 'Structural determinants and modulation of substrate specificity in phenylalanine-tyrosine ammonia-lyases', Chemistry and Biology, vol 13, no 12 , pp 1327 - 1338.
  • Burns, B., Saker, M., Moffitt, M. and Neilan, B. (2004), 'Molecular detection of genes responsible for cyanobacterial toxin production in the genera Microcystis, Nodularia, and Cylindrospermopsis', Methods in Molecular Biology, vol 268 , pp 213 - 222.
  • Pomati, F., Moffitt, M., Cavaliere, R. and Neilan, B. (2004), 'Evidence for differences in the metabolism of saxitoxin and C1+2 toxins in the freshwater cyanobacterium Cylindrospermopsis raciborskii T3', Biochimica et Biophysica Acta - General subjects, vol 1674, no 1 , pp 60 - 67.
  • Toh, M., Moffitt, M., Henrichsen, L., Raferty, M., Barrow, K., Cox, J., Marquis, C. and Neilan, B. (2004), 'Cereulide, the emetic toxin of Bacillus cereus, is putatively a product of nonribosomal peptide synthesis', Journal of Applied Microbiology, vol 97, no 5 , pp 992 - 1000.
  • Moffitt, M. and Neilan, B. (2004), 'Characterization of the nodularin synthetase gene cluster and proposed theory of the evolution of cyanobacterial hepatotoxins', Applied and Environmental Microbiology, vol 70, no 11 , pp 6353 - 6362.
  • Moffitt, M. and Neilan, B. (2003), 'Evolutionary affiliations within the superfamily of ketosynthases reflect complex pathway associations', Journal of Molecular Evolution, vol 56, no 4 , pp 446 - 457.
  • Feitz, A., Lukondeh, T., Moffitt, M., Burns, B., Naidoo, D., Della Vedova, J., Gooden, J. and Neilan, B. (2002), 'Absence of detectable levels of the cyanobacterial toxin (microcystin-LR) carry-over into milk', Toxicon, vol 40, no 8 , pp 1173 - 1180.
  • Moffitt, M., Blackburn, S. and Neilan, B. (2001), 'rRNA sequences reflect the ecophysiology and define the toxic cyanobacteria of the genus Nodularia', International Journal of Systematic and Evolutionary Microbiology, vol 51, no 2 , pp 505 - 512.
  • Moffitt, M. and Neilan, B. (2001), 'On the presence of peptide synthetase and polyketide synthase genes in the cyanobacterial genus Nodularia', FEMS Microbiology Letters, vol 196, no 2 , pp 207 - 214.

Research

Previous Projects

Title: Natural product genes in cyanobacteria: From microbial genetics to biotechnological applications
Years: 2007-12-10 - 2009-06-30
ID: P0015934
Western Researchers: Michelle Moffitt
Funding:
  • University of Western Sydney
Title: Characterising Genes For The Biosynthesis Of Isoprenoid-Isonitrile Alkaloids In Microorganisms
Years: 2006-09-30 - 2007-11-15
ID: P0015261
Western Researchers: Michelle Moffitt
Funding:
  • University of Western Sydney
Title: Polyketides as the conserved basis for diverse marine toxin biosyntheses [via UNSW]
Years: 2008-02-11 - 2011-02-10
ID: P0015529
Western Researchers: Michelle Moffitt
Funding:
  • Australian Research Council (ACRG)
Title: Establishment of a mass spectrometer facility for natural products and proteomics research and teaching at the College of Health and Science within the University of Western Sydney, Campbelltown campus
Years: 2008-09-24 - 2010-09-15
ID: P00016326
Western Researchers: Jens Coorssen, Bill Price, Gerald Muench, Andrew Shalliker, Dennis Chang, Sabine Piller, Simon Myers, Colin Stack and Michelle Moffitt
Funding:
  • University of Western Sydney
Title: Dispersal of rodents and their role in transmission of bacterial pathogens between piggeries
Years: 2008-07-01 - 2008-12-31
ID: P00016469
Western Researchers: Michelle Moffitt and Colin Stack
Funding:
  • Pork CRC Ltd

Supervision

Doctor Moffitt is available to be a principal supervisor for doctoral projects

Current Supervision

Title: Characterisation of Biosynthetic Gene Clusters within Cyanobacteria
Field of Research:

Western Sydney University

Locked Bag 1797
Penrith NSW 2751

Tel: +61 2 9852 5222

ABN 53 014 069 881
CRICOS Provider No: 00917k

Visit our mobile site