Doctor Mark Temple

Doctor Mark Temple

Academic Course Advisor, Medical Science,
Medical Science

Senior Lecturer,
Medical Science

Biography

Dr Mark Temple is a lecturer in Molecular Biology in the School of Science and Health at the Western SydneyUniversity (WSU). During his PhD Mark studied chromatin structure (nucleosome positioning and transcription factor binding) during gene expression and cell cycle progression. In addition he studied the interaction of anti-cancer drugs (including cisplatin and some novel analogues) with DNA in human cells. As a post-doctoral research fellow with Profressor Ian Dawes in the School of Biotechnology and Biomolecular Sciences at University of New South Wales (UNSW), Mark studied ageing and oxidative stress using bakers yeast as a model organism. During the past few years he has become increasingly interested in cell biology, functional genomics and the development of bioinformatics tools for genome-wide dataset analysis. 

I have recently buits a website that demonstrates the potential use of audio for biological sequence analyses (http://dnasonification.org/)

This information has been contributed by Doctor Temple.

Qualifications

  • PhD University of New South Wales

Interests

  • Bioinformatics
  • Molecular Biology
  • Sonification

Organisational Unit (School / Division)

  • Medical Science
  • Medical Science

Contact

Email: M.Temple@westernsydney.edu.au
Phone: (02) 4620 3329
Mobile:
Location: 21.1.09
Campbelltown

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Publications

Chapters in Books

  • Temple, M., Gelling, C., Kornfeld, G. and Dawes, I. (2013), 'Microarrays and gene regulation networks in yeast', Madame Curie Bioscience Database, Landes Bioscience 9781498713733.

Journal Articles

  • Temple, M. (2018), 'A website to identify shared genes in Saccharomyces cerevisiae homozygous deletion library screens', BMC Bioinformatics, vol 19, no 1 .
  • Johnson, B., Burgess, M., Murray, V., Aldrich-Wright, J. and Temple, M. (2018), 'The interactions of novel mononuclear platinum-based complexes with DNA', BMC Cancer, vol 18 .
  • Temple, M. (2017), 'An auditory display tool for DNA sequence analysis', BMC Bioinformatics, vol 18, no 221 .
  • Johnson, B., Murray, V. and Temple, M. (2016), 'Characterisation of the DNA sequence specificity, cellular toxicity and cross-linking properties of novel bispyridine-based dinuclear platinum complexes', BMC Cancer, vol 16, no 1 .
  • Temple, M. (2015), 'Twenty years later, the evolution of origami DNA', Trends in Biochemical Sciences, vol 40, no 6 , pp 293 - 295.
  • Akand, E., Bain, M. and Temple, M. (2010), 'Learning with gene ontology annotation using feature selection and construction', Applied Artificial Intelligence, vol 24, no 40575 , pp 5 - 38.
  • Fong, C., Temple, M., Alic, N., Chiu, J., Durchdewald, M., Thorpe, G., Higgins, V. and Dawes, I. (2008), 'Oxidant-induced cell-cycle delay in Saccaromyces cerevisiae : the involvement of the SWI6 transcription factor', FEMS Yeast Research, vol 8, no 3 , pp 386 - 399.
  • Drakulic, T., Temple, M., Guido, R., Jarolim, S., Breitenbach, M., Attfield, P. and Dawes, I. (2005), 'Involvement of oxidative stress response genes in redox homeostasis, the level of reactive oxygen species, and ageing in Saccharomyces cerevisiae', FEMS Yeast Extract, vol 5, no 12 , pp 1215 - 1228.
  • Temple, M. and Murray, V. (2005), 'Footprinting the 'essential regulatory region' of the retinoblastoma gene promoter in intact human cells', International Journal of Biochemistry and Cell Biology, vol 37, no 3 , pp 665 - 678.
  • Temple, M., Perrone, G. and Dawes, I. (2005), 'Complex cellular responses to reactive oxygen species', Trends in Cell Biology, vol 15, no 6 , pp 319 - 326.
  • Alic, N., Felder, T., Temple, M., Gloeckner, C., Higgins, V. and Dawes, I. (2004), 'Genome-wide transcriptional responses to a lipid hydroperoxide: adaptation occurs without induction of oxidant defenses', Free Radical Biology & Medicine, vol 37, no 1 , pp 23 - 35.
  • Temple, M., Freebody, J. and Murray, V. (2004), 'Genomic and phylogenetic footprinting at the epsilon-globin silencer region in intact human cells', Biochimica et Biophysica Acta - Gene Structure and Expression, vol 1678, no 2-3 , pp 126 - 134.

Conference Papers

  • Akand, E., Bain, M. and Temple, M. (2010), 'A visual analytics approach to augmenting formal concepts with relational background knowledge in a biological domain', Australasian Ontology Workshop, Adelaide, S.A..
  • Akand, E., Bain, M. and Temple, M. (2010), 'Learning responsive cellular networks by integrating genomics and proteomics data', ILP (Conference), Belgium.
  • Akand, E., Bain, M. and Temple, M. (2007), 'Learning from ontological annotation : an application of formal concept analysis to feature construction in the gene ontology', Australasian Ontology Workshop, Gold Coast, Qld..
  • Ahsan, N., Bain, M., Potter, J., Gaeta, B., Temple, M. and Dawes, I. (2006), 'Learning causal networks from microarray data', Workshop on Intelligent Systems for Bioinformatics, Hobart, Tas..
  • Ratnakumar, A., Dawes, I. and Temple, M. (2005), 'Web-based tools for the visualisation of over-represented components of the genetic regulatory network in microarray datasets', Australian Undergraduate Students' Computing Conference, Australian National University, Canberra.

Previous Projects

Title: Discovery and prediction of transcriptional regulatory networks important in the cellular responses to oxidative stress.
Funder:
  • University of Western Sydney
Western Researchers: Mark Temple
Years: 2008-09-24 - 2010-03-31
ID: P00016348

Supervision

Doctor Temple is available to be a principal supervisor for doctoral projects

Current Supervision

Thesis Title: The Formation of DNA Adducts Caused by Cisplatin and other Closely Related Platinum-Based Drugs
Field of Research:
Thesis Title: Geonome-wide Functional Ananlysis of Saccharomyces cerevisiae after peroxynitrite exposure
Field of Research:
Thesis Title: Characterisation of the Formation and Biological Impacts of DNA-Addicts caused by the Anti-Cancer Drug Cisplatin and other Clinically Important Platinum-Based Drugs
Field of Research:

Previous Supervision

Thesis Title: Analysis of High Dimensionality Yeast Gene Expression Data using Data Mining
Field of Research: Computer Science
Thesis Title: Characterisation of the interactions and biological impacts of cisplatin analogues and metallo-drug complexes with DNA
Field of Research: Biological Sciences Not Elsewhere Classified
Thesis Title: The Formation of DNA Adducts Caused by Cisplatin and other Closely Related Platinum-Based Drugs
Field of Research: Chemical Sciences Not Elsewhere Classified; Biological Sciences Not Elsewhere Classified; Other Natural And Physical Sciences

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