Doctor Mark Temple
Dean's Unit - School of Science and Health
Dr Mark Temple is a lecturer in Molecular Biology in the School of Science and Health at the Western SydneyUniversity (WSU). During his PhD Mark studied chromatin structure (nucleosome positioning and transcription factor binding) during gene expression and cell cycle progression. In addition he studied the interaction of anti-cancer drugs (including cisplatin and some novel analogues) with DNA in human cells. As a post-doctoral research fellow with Profressor Ian Dawes in the School of Biotechnology and Biomolecular Sciences at University of New South Wales (UNSW), Mark studied ageing and oxidative stress using bakers yeast as a model organism. During the past few years he has become increasingly interested in cell biology, functional genomics and the development of bioinformatics tools for genome-wide dataset analysis.
This information has been contributed by Doctor Temple.
- PhD University of New South Wales
Organisational Unit (School / Division)
- Dean's Unit - School of Science and Health
|Phone:||(02) 4620 3329|
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Chapters in Books
- Temple, M., Gelling, C., Kornfeld, G. and Dawes, I. (2013), 'Microarrays and gene regulation networks in yeast', Madame Curie Bioscience Database, Landes Bioscience 9781498713733.
- Temple, M. (2018), 'A website to identify shared genes in Saccharomyces cerevisiae homozygous deletion library screens', BMC Bioinformatics, vol 19, no 1 .
- Johnson, B., Burgess, M., Murray, V., Aldrich-Wright, J. and Temple, M. (2018), 'The interactions of novel mononuclear platinum-based complexes with DNA', BMC Cancer, vol 18 .
- Temple, M. (2017), 'An auditory display tool for DNA sequence analysis', BMC Bioinformatics, vol 18, no 221 .
- Johnson, B., Murray, V. and Temple, M. (2016), 'Characterisation of the DNA sequence specificity, cellular toxicity and cross-linking properties of novel bispyridine-based dinuclear platinum complexes', BMC Cancer, vol 16, no 1 .
- Temple, M. (2015), 'Twenty years later, the evolution of origami DNA', Trends in Biochemical Sciences, vol 40, no 6 , pp 293 - 295.
- Akand, E., Bain, M. and Temple, M. (2010), 'Learning with gene ontology annotation using feature selection and construction', Applied Artificial Intelligence, vol 24, no 40575 , pp 5 - 38.
- Fong, C., Temple, M., Alic, N., Chiu, J., Durchdewald, M., Thorpe, G., Higgins, V. and Dawes, I. (2008), 'Oxidant-induced cell-cycle delay in Saccaromyces cerevisiae : the involvement of the SWI6 transcription factor', FEMS Yeast Research, vol 8, no 3 , pp 386 - 399.
- Drakulic, T., Temple, M., Guido, R., Jarolim, S., Breitenbach, M., Attfield, P. and Dawes, I. (2005), 'Involvement of oxidative stress response genes in redox homeostasis, the level of reactive oxygen species, and ageing in Saccharomyces cerevisiae', FEMS Yeast Extract, vol 5, no 12 , pp 1215 - 1228.
- Temple, M. and Murray, V. (2005), 'Footprinting the 'essential regulatory region' of the retinoblastoma gene promoter in intact human cells', International Journal of Biochemistry and Cell Biology, vol 37, no 3 , pp 665 - 678.
- Temple, M., Perrone, G. and Dawes, I. (2005), 'Complex cellular responses to reactive oxygen species', Trends in Cell Biology, vol 15, no 6 , pp 319 - 326.
- Alic, N., Felder, T., Temple, M., Gloeckner, C., Higgins, V. and Dawes, I. (2004), 'Genome-wide transcriptional responses to a lipid hydroperoxide: adaptation occurs without induction of oxidant defenses', Free Radical Biology & Medicine, vol 37, no 1 , pp 23 - 35.
- Temple, M., Freebody, J. and Murray, V. (2004), 'Genomic and phylogenetic footprinting at the epsilon-globin silencer region in intact human cells', Biochimica et Biophysica Acta - Gene Structure and Expression, vol 1678, no 2-3 , pp 126 - 134.
- Akand, E., Bain, M. and Temple, M. (2010), 'A visual analytics approach to augmenting formal concepts with relational background knowledge in a biological domain', Australasian Ontology Workshop, Adelaide, S.A..
- Akand, E., Bain, M. and Temple, M. (2010), 'Learning responsive cellular networks by integrating genomics and proteomics data', ILP (Conference), Belgium.
- Akand, E., Bain, M. and Temple, M. (2007), 'Learning from ontological annotation : an application of formal concept analysis to feature construction in the gene ontology', Australasian Ontology Workshop, Gold Coast, Qld..
- Ahsan, N., Bain, M., Potter, J., Gaeta, B., Temple, M. and Dawes, I. (2006), 'Learning causal networks from microarray data', Workshop on Intelligent Systems for Bioinformatics, Hobart, Tas..
- Ratnakumar, A., Dawes, I. and Temple, M. (2005), 'Web-based tools for the visualisation of over-represented components of the genetic regulatory network in microarray datasets', Australian Undergraduate Students' Computing Conference, Australian National University, Canberra.
|Title:||Discovery and prediction of transcriptional regulatory networks important in the cellular responses to oxidative stress.|
|Western Researchers:||Mark Temple|
|Years:||2008-09-24 - 2010-03-31|
Doctor Temple is available to be a principal supervisor for doctoral projects
|Thesis Title:||The Formation of DNA Adducts Caused by Cisplatin and other Closely Related Platinum-Based Drugs|
|Field of Research:|