Professor Murray Killingsworth
Adjunct Appointment,
Dean's Unit - School of Medicine
Biography
Murray Killingsworth received his PhD in 1989 from UNSW Medicine based on collaborative studies in macular degeneration of the human retina. His research interests are in the pathobiology of chronic inflammation, particularly of retinal disease, renal disease and cancer. He uses the techniques of cryogenic fixation, live cell imaging, histochemistry and electron microscopy to study disease pathogenesis. Digital image analysis is used to generate quantitative data and nanoparticles are employed in immunocytochemistry and correlative microscopy. He is currently investigating new approaches for visualisation of molecular probes at nanometre resolution. In 2010 Murray was made a Founding Fellow of the Faculty of Science in the Royal College of Pathologists of Australasia (RCPA). In 2018 he was awarded the Lady Mary Fairfax Distinguished Researcher Award.
This information has been contributed by Professor Killingsworth.
Organisational Unit (School / Division)
- Dean's Unit - School of Medicine
Contact
| Email: | M.Killingsworth@westernsydney.edu.au |
|---|---|
| Phone: | (02) 9772 6860 |
| Mobile: | |
| Location: | Off Campus |
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Publications
Journal Articles
- Sinha, A., Stanwell, P., Killingsworth, M. and Bhaskar, S. (2023), 'Prognostic accuracy and impact of cerebral collateral status on clinical and safety outcomes in acute ischemic stroke patients receiving reperfusion therapy : a systematic meta-analysis', Acta Radiologica, vol 64, no 2 , pp 698 - 718.
- Evers, C., Chen, L., Messinger, J., Killingsworth, M., Freund, K. and Curcio, C. (2023), 'Histology, dimensions, and fluorescein staining characteristics of nodular and cuticular drusen in age-related macular degeneration', Retina, vol 43, no 10 , pp 1708 - 1716.
- Shi, C., Killingsworth, M. and Bhaskar, S. (2022), 'Prognostic capacity of hyperdense middle cerebral artery sign in anterior circulation acute ischaemic stroke patients receiving reperfusion therapy : a systematic review and meta-analysis', Acta Neurologica Belgica, vol 122, no 2 , pp 423 - 435.
- Huang, J., Killingsworth, M. and Bhaskar, S. (2022), 'Is composition of brain clot retrieved by mechanical thrombectomy associated with stroke aetiology and clinical outcomes in acute ischemic stroke? : a systematic review and meta-analysis', Neurology International, vol 14, no 4 , pp 748 - 770.
- Katyal, A., Calic, Z., Killingsworth, M. and Bhaskar, S. (2021), 'Diagnostic and prognostic utility of computed tomography perfusion imaging in posterior circulation acute ischemic stroke : a systematic review and meta-analysis', European Journal of Neurology, vol 28, no 8 , pp 2657 - 2668.
- Sinha, A., Stanwell, P., Beran, R., Beran, R., Calic, Z., Killingsworth, M. and Bhaskar, S. (2021), 'Stroke aetiology and collateral status in acute ischemic stroke patients receiving reperfusion therapy : a meta-analysis', Neurology International, vol 13, no 4 , pp 608 - 621.
- Ravindran, A., Killingsworth, M. and Bhaskar, S. (2021), 'Cerebral collaterals in acute ischaemia : implications for acute ischaemic stroke patients receiving reperfusion therapy', European Journal of Neuroscience, vol 53, no 4 , pp 1238 - 1261.
- Cohen-Hyams, T., Mam, K. and Killingsworth, M. (2020), 'Scanning electron microscopy as a new tool for diagnostic pathology and cell biology', Micron, vol 130 .
- Bhaskar, S., Saab, J., Cappelen-Smith, C., Killingsworth, M., Wu, X., Cheung, A., Manning, N., Aouad, P., McDougall, A., Hodgkinson, S. and Cordato, D. (2019), 'Clot histopathology in ischemic stroke with infective endocarditis', Canadian Journal of Neurological Sciences, vol 46, no 3 , pp 331 - 336.
- Santos, L., Gune, S., Killingsworth, M., Cohen-Hyams, T., Wuhrer, R., Harvey, M., McNamara, N., Nguyen, L., Sabapathy, S., Evangelista, C. and Yong, J. (2019), 'Determining and characterizing if deer placenta stem cells are present in commercial food supplement capsules : utilizing microscopy, elemental analysis, cytology, histology, immunohistochemistry and flow cytometry', Microscopy and Microanalysis, vol 25, no Suppl. 2 , pp 1098 - 1099.
- Cohen-Hyams, T. and Killingsworth, M. (2019), 'Scanning electron microscopy as a new tool for diagnostics in pathology', Microscopy and Microanalysis, vol 25, no Suppl. 2 , pp 1118 - 1119.
- Balaratnasingam, C., Cherepanoff, S., Dolz-Marco, R., Killingsworth, M., Chen, F., Mendis, R., Mrejen, S., Too, L., Gal-Or, O., Curcio, C., Freund, K. and Yannuzzi, L. (2018), 'Cuticular drusen : clinical phenotypes and natural history defined using multimodal imaging', Ophthalmology, vol 125, no 1 , pp 100 - 118.
- Lai, K., Matthews, S., Wilmott, J., Killingsworth, M., Yong, J., Caixeiro, N., Wykes, J., Samakeh, A., Forstner, D., Lee, M., McGuiness, J., Niles, N., Hong, A., Ebrahimi, A. and Lee, C. (2018), 'Differences in LC3B expression and prognostic implications in oropharyngeal and oral cavity squamous cell carcinoma patients', BMC Cancer, vol 18 .
- Chistiakov, D., Killingsworth, M., Myasoedova, V., Orekhov, A. and Bobryshev, Y. (2017), 'CD68/macrosialin : not just a histochemical marker', Laboratory Investigation, vol 97, no 1 , pp 4 - 13.
- Lai, K., Killingsworth, M., Matthews, S., Caixeiro, N., Evangelista, C., Wu, X., Wykes, J., Samakeh, A., Forstner, D., Niles, N., Hong, A. and Lee, S. (2017), 'Differences in survival outcome between oropharyngeal and oral cavity squamous cell carcinoma in relation to HPV status', Journal of Oral Pathology and Medicine, vol 46, no 8 , pp 574 - 582.
- Lai, K., Killingsworth, M., Yong, J., Matthews, S., Ebrahimi, A., McGuinness, J., Ngo, Q., Caixeiro, N., Hong, A. and Lee, S. (2017), 'Specific localization of LC3B in autophagosome : a correlative labelling study with nanoparticle in oral squamous cell carcinoma', Experimental and Molecular Pathology, vol 102, no 3 , pp 422 - 427.
- Makris, A., Yeung, K., Lim, S., Sunderland, N., Heffernan, S., Thompson, J., Iliopoulos, J., Killingsworth, M., Yong, J., Xu, B., Ogle, R., Thadhani, R., Karumanchi, S. and Hennessy, A. (2016), 'Placental growth factor reduces blood pressure in a uteroplacental ischemia model of preeclampsia in nonhuman primates', Hypertension, vol 67, no 6 , pp 1263 - 1272.
- Makris, A., Yeung, K., Lim, S., Sunderland, N., Heffernan, S., Thompson, J., Iliopoulos, J., Killingsworth, M., Yong, J., Xu, B., Ogle, R., Thadhani, R., Karumanchi, S. and Hennessy, A. (2016), 'Placental growth factor reduces blood pressure in a uteroplacental ischemia model of preeclampsia in nonhuman primates', Hypertension, vol 67, no 6 , pp 1263 - 1272.
- Nikesitch, N., Tao, C., Lai, K., Killingsworth, M., Bae, S., Wang, M., Harrison, S., Roberts, T. and Ling, S. (2016), 'Predicting the response of multiple myeloma to the proteasome inhibitor Bortezomib by evaluation of the unfolded protein response', Blood Cancer Journal, vol 6 .
- Killingsworth, M. and Bobryshev, Y. (2016), 'Correlative light- and electron microscopy using quantum dot nanoparticles', Journal of Visualized Experiments, vol 114 .
- Lai, K., Killingsworth, M. and Lee, S. (2015), 'Gene of the month : PIK3CA', Journal of Clinical Pathology, vol 68, no 4 , pp 253 - 257.
- Abbineni, P., Wright, E., Rogasevskaia, T., Killingsworth, M., Malladi, C. and Coorssen, J. (2014), 'The sea urchin egg and cortical vesicles as model systems to dissect the fast, Ca2+-triggered steps of regulated exocytosis', Neuromethods, vol 83 , pp 221 - 241.
- Yong, J. and Killingsworth, M. (2014), 'Ultrastructural study of electron dense deposits in renal tubular basement membrane : prevalence and relationship to epithelial atrophy', Ultrastructural Pathology, vol 38, no 4 , pp 273 - 280.
- Lai, K., Killingsworth, M. and Lee, S. (2014), 'The significance of autophagy in colorectal cancer pathogenesis and implications for therapy', Journal of Clinical Pathology, vol 67, no 10 , pp 854 - 858.
- Killingsworth, M., Lai, K., Wu, X., Yong, J. and Lee, S. (2012), 'Quantum dot immunocytochemical localization of somatostatin in somatostatinoma by widefield epifluorescence, super-resolution light, and immunoelectron micrsocopy', Journal of Histochemistry and Cytochemistry, vol 60, no 11 , pp 832 - 843.
- Killingsworth, M. and Wu, X. (2011), 'Vascular pericyte density and angiogenesis associated with adenocarcinoma of the prostate', Pathobiology, vol 78, no 1 , pp 24 - 34.
- Yong, J., Killingsworth, M., Spicer, S. and Wu, X. (2010), 'Fibronectin non-amyloid glomerulopathy', International Journal of Clinical and Experimental, vol 3, no 2 , pp 210 - 216.
- Pissuwan, D., Valenzuela, S., Miller, C., Killingsworth, M. and Cotie, M. (2009), 'Destruction and control of Toxoplasma gondii tachyzoites using gold nanosphere/antibody conjugates', Small, vol 5, no 9 , pp 1030 - 1034.
- Bobryshev, Y., Killingsworth, M., Tran, D. and Lord, R. (2008), 'Amalgamation of Chlamydia pneumoniae inclusions with lipid droplets in foam cells in human atherosclerotic plaque', Virchows Archiv, vol 453, no 1 , pp 69 - 77.
- Bobryshev, Y., Killingsworth, M. and Lord, R. (2008), 'Spatial distribution of osteoblast-specific transcription factor Cbfa1 and bone formation in atherosclerotic arteries', Cell and Tissue Research, vol 333, no 2 , pp 225 - 235.
- Bobryshev, Y., Killingsworth, M., Lord, R. and Grabs, A. (2008), 'Matrix vesicles in the fibrous cap of atherosclerotic plaque: Possible contribution to plaque rupture', Journal of Cellular and Molecular Medicine, vol 12, no 5B , pp 2073 - 2082.
- Bobryshev, Y., Killingsworth, M., Huynh, T., Lord, R., Grabs, A. and Valenzuela, S. (2007), 'Are calcifying matrix vesicles in atherosclerotic lesions of cellular origin', Basic Research in Cardiology, vol 102, no 2 , pp 133 - 143.