Doctor Wei Chua

Journal Articles

• Ooi, L., Ho, V., Zhu, J., Lim, S., Chung, L., Abubakar, A., Rutland, T., Chua, W., Ng, W., Lee, M., Morgan, M., Mackenzie, S. and Lee, C. (2024), 'p21 as a predictor and prognostic indicator of clinical outcome in rectal cancer patients', International Journal of Molecular Sciences, vol 25, no 2 .
• Nindra, U., Childs, S., Yoon, R., Haider, S., Hong, M., Roohullah, A., Cooper, A., Wilkinson, K., Pal, A. and Chua, W. (2024), '[In Press] Survival outcomes in older adults undergoing early phase clinical trials', Journal of Geriatric Oncology, .
• Nindra, U., Hong, J., Balakrishnar, B., Pal, A. and Chua, W. (2023), 'Review of toxicities of PARP inhibitors in metastatic castrate resistant prostate cancer', Clinical Genitourinary Cancer, vol 21, no 1 , pp 183 - 193.
• Ho, V., Chung, L., Wilkinson, K., Lea, V., Lim, S., Abubakar, A., Ng, W., Lee, M., Roberts, T., Chua, W. and Lee, C. (2023), 'Prognostic significance of MRE11 overexpression in colorectal cancer patients', Cancers, vol 15, no 9 .
• Chuan, A., Hatty, M., Shelley, M., Lan, A., Chow, H., Dai, E., Haider, S., Bogdanovych, A. and Chua, W. (2023), 'Feasibility of virtual reality-delivered pain psychology therapy for cancer-related neuropathic pain : a pilot randomised controlled trial', Anaesthesia, vol 78, no 4 , pp 449 - 457.
• Lim, S., Chua, W., Ng, W., Ip, E., Marques, T., Tran, N., Gama-Carvalho, M., Asghari, R., Henderson, C., Ma, Y., Souza, P. and Spring, K. (2023), 'Circulating tumour cell associated microRNA profiles change during chemoradiation and are predictive of response in locally advanced rectal cancer', Cancers, vol 15, no 16 .
• Nindra, U., Pal, A., Bray, V., Yip, P., Tognela, A., Roberts, T., Becker, T., Williamson, J., Farzin, M., Li, J., Lea, V., Hagelamin, A., Ng, W., Wang, B., Lee, C. and Chua, W. (2023), '[In Press] Utility of multigene panel next-generation sequencing in routine clinical practice for identifying genomic alterations in newly diagnosed metastatic nonsmall cell lung cancer', Internal Medicine Journal, .
• Nindra, U., Pal, A., Lea, V., Lim, S., Wilkinson, K., Asghari, R., Roberts, T., Becker, T., Farzin, M., Rutland, T., Lee, M., MacKenzie, S., Ng, W., Wang, B., Lee, C. and Chua, W. (2023), 'Multigene panel next generation sequencing in metastatic colorectal cancer in an Australian population', PLoS ONE, vol 18, no 10 .
• Yoon, R., Wilkinson, K., Gabriel, G., Kadaan, N., Roberts, T., Lim, S., Asghari, R., Lee, C., Chua, W. and Ng, W. (2023), '[In Press] Real-world tolerance and outcomes of oxaliplatin-based adjuvant chemotherapy for stage III colon cancer : does dose intensity matter?', Asia-Pacific Journal of Clinical Oncology, .
• Nindra, U., Shivasabesan, G., Childs, S., Yoon, R., Haider, S., Hong, M., Cooper, A., Roohullah, A., Wilkinson, K., Pal, A. and Chua, W. (2023), 'Time toxicity associated with early phase clinical trial participation', ESMO Open, vol 8, no 6 .
• Habashy, P., Lea, V., Wilkinson, K., Wang, B., Wu, X., Roberts, T., Ng, W., Rutland, T., Po, J., Becker, T., Descallar, J., Lee, M., Mackenzie, S., Gupta, R., Cooper, W., Lim, S., Chua, W. and Lee, C. (2023), 'KRAS and BRAF mutation rates and survival outcomes in colorectal cancer in an ethnically diverse patient cohort', International Journal of Molecular Sciences, vol 24, no 24 .
• Ho, V., Chung, L., Lim, S., Ma, Y., Wang, B., Lea, V., Abubakar, A., Ng, W., Lee, M., Roberts, T., Chua, W. and Lee, C. (2022), 'Prognostic impact of TP53 mutations and tumor mutational load in colorectal cancer', Gastrointestinal Disorders, vol 4, no 3 , pp 165 - 179.
• Khan, T., Becker, T., Scott, K., Descallar, J., Souza, P., Chua, W. and Ma, Y. (2022), 'Prognostic and predictive value of liquid biopsy-derived androgen receptor variant 7 (AR-V7) in prostate cancer : a systematic review and meta-analysis', Frontiers in Oncology, vol 12 .
• Khan, T., Lock, J., Ma, Y., Harman, D., Souza, P., Chua, W., Balakrishnar, B., Scott, K. and Becker, T. (2022), 'Choice of antibody is critical for specific and sensitive detection of androgen receptor splice variant-7 in circulating tumor cells', Scientific Reports, vol 12, no 1 .
• Young, F., Becker, T., Nimir, M., Opperman, T., Chua, W., Balakrishnar, B., Souza, P. and Ma, Y. (2022), 'Biomarkers of castrate resistance in prostate cancer : androgen receptor amplification and T877A mutation detection by multiplex droplet digital PCR', Journal of Clinical Medicine, vol 11, no 1 .
• Adam, T., Becker, T., Chua, W., Bray, V. and Roberts, T. (2021), 'The multiple potential biomarkers for predicting immunotherapy response : finding the needle in the haystack', Cancers, vol 13, no 2 .
• Ding, P., Roberts, T., Chua, W., Becker, T., Caixeiro, N., Souza, P., Gao, B., Lee, C., Itchins, M., Westman, H., Clarke, S., Blinman, P., Kao, S., John, T., Leal, J. and Bray, V. (2021), 'Plasma pre-treatment T790M relative allelic frequency in patients with advanced EGFR-mutated non-small cell lung cancer predicts treatment response to subsequent-line osimertinib', Translational Lung Cancer Research, vol 10, no 4 , pp 1623 - 1634.
• Chow, H., Hon, J., Chua, W. and Chuan, A. (2021), 'Effect of virtual reality therapy in reducing pain and anxiety for cancer-related medical procedures : a systematic narrative review', Journal of Pain and Symptom Management, vol 61, no 2 , pp 384 - 394.
• Wilkinson, K., Ng, W., Roberts, T., Becker, T., Lim, S., Chua, W. and Lee, C. (2021), 'Tumour immune microenvironment biomarkers predicting cytotoxic chemotherapy efficacy in colorectal cancer', Journal of Clinical Pathology, vol 74, no 10 , pp 625 - 634.
• Yang, E., Chua, W., Ng, W. and Roberts, T. (2021), 'Peripheral cytokine levels as a prognostic indicator in gastric cancer : a review of existing literature', Biomedicines, vol 9, no 12 .
• Hofman, M., Emmett, L., Sandhu, S., Iravani, A., Joshua, A., Goh, J., Pattison, D., Tan, T., Kirkwood, I., Ng, S., Francis, R., Gedye, C., Rutherford, N., Weickhardt, A., Scott, A., Lee, S., Kwan, E., Azad, A., Ramdave, S., Redfern, A., Macdonald, W., Guminski, A., Hsiao, E., Chua, W., Lin, P., Zhang, A., McJannett, M., Stockler, M., Violet, J., Williams, S., Martin, A. and Davis, I. (2021), '[177Lu]Lu-PSMA-617 versus cabazitaxel in patients with metastatic castration-resistant prostate cancer (TheraP) : a randomised, open-label, phase 2 trial', The Lancet, vol 397, no 10276 , pp 797 - 804.
• Kang, S., Wilkinson, K., Brungs, D., Chua, W., Ng, W., Chen, J., Nasser, E., Lee, M., Wong, K., Bokey, L., Winn, R., Putnis, S., Lee, C. and Lim, S. (2021), 'Rectal cancer treatment and outcomes in elderly patients treated with curative intent', Molecular and Clinical Oncology, vol 15, no 6 .
• Ho, V., Chung, L., Singh, A., Lea, V., Abubakar, A., Lim, S., Chua, W., Ng, W., Lee, M., Roberts, T., Souza, P. and Lee, C. (2020), 'Aberrant expression of RAD52, its prognostic impact in rectal cancer and association with poor survival of patients', International Journal of Molecular Sciences, vol 21, no 5 .
• Fernando, S., Lin, M., Pham, T., Chong, S., Ip, E., Wong, K., Chua, W., Ng, W., Lin, P. and Lim, S. (2020), 'Prognostic utility of serial 18F-FDG-PET/CT in patients with locally advanced rectal cancer who underwent tri-modality treatment', British Journal of Radiology, vol 93, no 1105 .
• Naher, S., Padinharakam, S., Balakrishnar, B., Chua, W., Descallar, J., Adams, D., Souza, P., Harrison, M. and Lim, S. (2019), 'Patterns of presentation and treatment outcomes of non-clear-cell renal cell carcinoma and sarcomatoid renal cell carcinoma patients in 2 tertiary referral centers in Sydney, Australia', Clinical Genitourinary Cancer, vol 17, no 3 , pp 565 - 569.
• Nimir, M., Ma, Y., Je?reys, S., Opperman, T., Young, F., Khan, T., Ding, P., Chua, W., Balakrishnar, B., Cooper, A., Souza, P. and Becker, T. (2019), 'Detection of AR-V7 in liquid biopsies of castrate resistant prostate cancer patients : a comparison of AR-V7 analysis in circulating tumor cells, circulating tumor RNA and exosomes', Cells, vol 8, no 7 .
• Ding, P., Becker, T., Bray, V., Chua, W., Ma, Y., Lynch, D., Po, J., Luk, A., Caixeiro, N., Souza, P. and Roberts, T. (2019), 'The predictive and prognostic significance of liquid biopsy in advanced epidermal growth factor receptor-mutated non-small cell lung cancer : a prospective study', Lung Cancer, vol 134 , pp 187 - 193.
• Ding, P., Becker, T., Bray, V., Chua, W., Ma, Y., Xu, B., Lynch, D., Souza, P. and Roberts, T. (2019), 'Plasma next generation sequencing and droplet digital PCR-based detection of epidermal growth factor receptor (EGFR) mutations in patients with advanced lung cancer treated with subsequent-line osimertinib', Thoracic Cancer, vol 10, no 10 , pp 1879 - 1884.
• Lim, S., Ip, E., Ng, W., Chua, W., Asghari, R., Roohullah, A., Descallar, J., Henderson, C., Spring, K., Souza, P. and King, M. (2019), 'Health-related quality of life during chemoradiation in locally advanced rectal cancer : impacts and ethnic disparities', Cancers, vol 11, no 9 .
• Ding, P., Ma, Y., Roberts, T., Chua, W., Bray, V., Lynch, D., Burke, D., Souza, P. and Becker, T. (2018), 'Droplet digital PCR based detection of EGFR mutations in advanced lung cancer patient liquid biopsies : a comparison of circulating tumour DNA extraction kits', Journal of Molecular Biomarkers and Diagnosis, vol 9, no 4 .
• Brungs, D., Aghmesheh, M., de Souza, P., Ng, W., Chua, W., Carolan, M., Clingan, P., Healey, E., Rose, J., Tubaro, T. and Ranson, M. (2017), 'Sidedness is prognostic in locoregional colon cancer : an analysis of 9509 Australian patients', BMC Cancer, vol 17 .
• Luk, A., Ma, Y., Ding, P., Young, F., Chua, W., Balakrishnar, B., Dransfield, D., de Souza, P. and Becker, T. (2017), 'CTC-mRNA (AR-V7) analysis from blood samples : impact of blood collection tube and storage time', International Journal of Molecular Sciences, vol 18, no 5 .
• Ding, P., Roberts, T., Chua, W., Becker, T., Descallar, J., Yip, P. and Bray, V. (2017), 'Clinical outcomes in patients with advanced epidermal growth factor receptor-mutated non-small-cell lung cancer in South Western Sydney Local Health District', Internal Medicine Journal, vol 47, no 12 , pp 1405 - 1411.
• Fizazi, K., Tran, N., Fein, L., Matsubara, N., Rodriguez-Antolin, A., Alekseev, B., Ozguroglu, M., Ye, D., Feyerabend, S., Protheroe, A., De Porre, P., Kheoh, T., Park, Y., Todd, M., Chi, K., Korbenfeld, E., Metrebian, S., Kaen, L., Staneloni, E., Batagelj, E., Tan, H., Hovey, E., Woo, H., Frydenberg, M., Chua, W. and et al, .. (2017), 'Abiraterone plus prednisone in metastatic, castration-sensitive prostate cancer', New England Journal of Medicine, vol 377, no 4 , pp 352 - 360.
• Toh, J., de Souza, P., Lim, S., Singh, P., Chua, W., Ng, W. and Spring, K. (2016), 'The potential value of immunotherapy in colorectal cancers : review of the evidence for programmed death-1 (PD-1) inhibitor therapy', Clinical Colorectal Cancer, vol 15, no 4 , pp 285 - 291.
• Ma, Y., Luk, A., Young, F., Lynch, D., Chua, W., Balakrishnar, B., de Souza, P. and Becker, T. (2016), 'Droplet digital PCR based androgen receptor variant 7 (AR-V7) detection from prostate cancer patient blood biopsies', International Journal of Molecular Sciences, vol 17, no 8 .
• Ho, V., Chung, L., Revoltar, M., Lim, S., Tut, T., Abubakar, A., Henderson, C., Chua, W., Ng, W., Lee, M., de Souza, P., Morgan, M., Lee, S. and Shin, J. (2016), 'MRE11 and ATM expression levels predict rectal cancer survival and their association with radiotherapy response', PLoS One, vol 11, no 12 .
• Revoltar, M., Shin, J., Lim, S., Tut, T., Dissanayake, I., Descallar, J., Ho, V., Chua, W., Ng, W., Lee, M., Henderson, C., de Souza, P., Morgan, M. and Lee, S. (2016), 'Early marker of DNA damage response, ATM, as a predictor of clinical outcome following radiotherapy in rectal cancer patients', Pathology, vol 48, no Supplement 1 , pp 153 - 153.
• Tognela, A., Spring, K., Becker, T., Caixeiro, N., Bray, V., Yip, P., Chua, W., Lim, S. and de Souza, P. (2015), 'Predictive and prognostic value of circulating tumor cell detection in lung cancer : a clinician's perspective', Critical Reviews in Oncology/Hematology, vol 93, no 2 , pp 90 - 102.
• Tut, T., Lim, S., Dissanayake, I., Descallar, J., Chua, W., Ng, W., de Souza, P., Shin, J. and Lee, S. (2015), 'Upregulated polo-like kinase 1 expression correlates with inferior survival outcomes in rectal cancer', PLoS One, vol 10, no 6 .
• Lim, S., Chua, W., Henderson, C., Ng, W., Shin, J., Chantrill, L., Asghari, R., Lee, S., Spring, K. and de Souza, P. (2015), 'Predictive and prognostic biomarkers for neoadjuvant chemoradiotherapy in locally advanced rectal cancer', Critical Reviews in Oncology/Hematology, vol 96, no 1 , pp 67 - 80.
• Wilkinson, K., Chua, W., Ng, W. and Roohullah, A. (2015), 'Management of asymptonmatic primary tumours in stage IV colorectal cancer : review of outcomes', World Journal of Gastrointestinal Oncology, vol 7, no 12 , pp 513 - 523.
• Roohullah, A., Wong, H., Sjoquist, K., Gibbs, P., Field, K., Tran, B., Shapiro, J., Mckendrick, J., Yip, D., Nott, L., Gebski, V., Ng, W., Chua, W., Price, T., Tebbutt, N. and Chantrill, L. (2015), 'Gastrointestinal perforation in metastatic colorectal cancer patients with peritoneal metastases receiving bevacizumab', World Journal of Gastroenterology, vol 21, no 17 , pp 5352 - 5358.
• Lim, S., Becker, T., Chua, W., Ng, W., de Souza, P. and Spring, K. (2014), 'Circulating tumour cells and the epithelial mesenchymal transition in colorectal cancer', Journal of Clinical Pathology, vol 67, no 10 , pp 848 - 853.
• Lim, S., Chua, W., Cheng, C., Descallar, J., Ng, W., Solomon, M., Bokey, E., Wong, K., Lee, M., de Souza, P., Shin, J. and Lee, S. (2014), 'Effect of neoadjuvant chemoradiation on tumor-infiltrating/associated lymphocytes in locally advanced rectal cancers', Anticancer Research, vol 34, no 11 , pp 6505 - 6513.
• Lim, S., Becker, T., Chua, W., Caixeiro, N., Ng, W., Kienzle, N., Tognela, A., Lumba, S., Rasko, J., de Souza, P. and Spring, K. (2014), 'Circulating tumour cells and circulating free nucleic acid as prognostic and predictive biomarkers in colorectal cancer', Cancer Letters, vol 346, no 1 , pp 24 - 33.
• Beer, T., Armstrong, A., Rathkopf, D., Loriot, Y., Sternberg, C., Higano, C., Iversen, P., Bhattacharya, S., Carles, J., Chowdhury, S., Davis, I., De Bono, J., Evans, C., Fizazi, K., Joshua, A., Kim, C., Kimura, G., Mainwaring, P., Mansbach, H., Miller, K., Noonberg, S., Perabo, F., Phung, D., Saad, F., Scher, H., Taplin, M., Venner, P., Tombal, B., Begbie, S., Bonaventura, A., Boyce, A., Chua, W., Souza, P. and et al, .. (2014), 'Enzalutamide in metastatic prostate cancer before chemotherapy', New England Journal of Medicine, vol 371, no 5 , pp 424 - 433.
• Chua, W., Horvath, L., Beale, P. and Clarke, S. (2012), 'Reporting clinical trial information : colorectal cancer trials at Sydney Cancer Centre', Internal Medicine Journal, vol 42, no 4 , pp 416 - 421.
• Chua, W., Clarke, S. and Charles, K. (2012), 'Systemic inflammation and prediction of chemotherapy outcomes in patients receiving docetaxel for advanced cancer', Supportive Care in Cancer, vol 20, no 8 , pp 1869 - 1874.
• Coupe, N., Harrison, M., Chua, W. and Souza, P. (2012), 'Biomarkers for tyrosine kinase inhibitors in renal cell cancer', Translational Andrology and Urology, vol 1, no 4 , pp 216 - 222.
• Chua, W., Charles, K., Baracos, V. and Clarke, S. (2011), 'Neutrophil/lymphocyte ratio predicts chemotherapy outcomes in patients with advanced colorectal cancer', British Journal of Cancer, vol 104, no 8 , pp 1288 - 1295.
• Chua, W., Kho, P., Moore, M., Charles, K. and Clarke, S. (2011), 'Clinical, laboratory and molecular factors predicting chemotherapy efficacy and toxicity in colorectal cancer', Critical Reviews in Oncology/Hematology, vol 79, no 3 , pp 224 - 250.
• Clarke, S., Chua, W., Moore, M., Kao, S., Phan, V., Tan, C., Charles, K. and McMillan, D. (2011), 'Use of inflammatory markers to guide cancer treatment', Clinical Pharmacology and Therapeutics, vol 90, no 3 , pp 475 - 478.