Doctor Neville Ng

Doctor Neville Ng

Adjunct Fellow,
Dean's Unit, School of Science

Biography

Obtained BSc at the University of Sydney, MSc (Hons) and PhD at Western Sydney University. Research interests in experimental and translational therapies for terminal degenerative diseases, including neurological disorders and cancer. Rapid cell differentiation, cell-based assay methods and mitochondrial therapies.

This information has been contributed by Doctor Ng.

Qualifications

  • PhD Western Sydney University
  • MSc(Hons) University of Western Sydney
  • BS University of Sydney

Awards

  • Australian Postgraduate Award with Top-up 2013-01-01
  • IHMRI Young Investigator Grant 2019-10-01
  • MAWA Project Grant 2021-08-01

Interests

  • Cell Biology
  • Small molecule drug development

Organisational Unit (School / Division)

  • Dean's Unit, School of Science

Contact

Email: N.Ng@westernsydney.edu.au
Phone:

Mobile:
Location:

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Teaching

Previous Teaching Areas

  • 300324 Pharmacological Chemistry, 2011
  • 300550 Medicinal Chemistry, 2014
  • 300554 Principles of Chemistry, 2012
  • 300800 Essential Chemistry 1, 2012
  • 300808 Introductory Chemistry, 2013
  • 301267 Cell Form and Function, 2020

Publications

Chapters in Books

  • Harper, B., Li, F., Beard, R., Garbutcheon-Singh, K., Ng, N. and Aldrich-Wright, J. (2013), 'Biomolecular ineractions of platinum complexes', Supramolecular Systems in Biomedical Fields, Royal Society of Chemistry 9781849736589.

Journal Articles

  • Ng, N., Newbery, M., Touffu, A., Maksour, S., Chung, J., Carroll, L., Zaw, T., Wu, Y. and Ooi, L. (2023), 'Edaravone and mitochondrial transfer as potential therapeutics for vanishing white matter disease astrocyte dysfunction', CNS Neuroscience and Therapeutics, vol 29, no 9 , pp 2481 - 2497.
  • Antony, A., Ng, N., Lauto, A., Coorssen, J. and Myers, S. (2022), 'Calcium-mediated calpain activation and microtubule dissociation in cell model of hereditary sensory neuropathy type-1 expressing V144D SPTLC1 mutation', DNA and Cell Biology, vol 41, no 2 , pp 225 - 234.
  • Ng, N., Maksour, S., Lum, J., Newbery, M., Shephard, V. and Ooi, L. (2022), 'An optimized direct lysis gene expression microplate assay and applications for disease, differentiation, and pharmacological cell-based studies', Biosensors, vol 12, no 6 .
  • Ng, N., Newbery, M., Maksour, S., Dottori, M., Sluyter, R. and Ooi, L. (2022), 'Transgene and chemical transdifferentiation of somatic cells for rapid and efficient neurological disease cell models', Frontiers in Cellular Neuroscience, vol 16 .
  • Ng, N. and Ooi, L. (2021), 'A simple microplate assay for reactive oxygen species generation and rapid cellular protein normalization', Bio-protocol, vol 11, no 1 .
  • Ng, N., Gately, R. and Ooi, L. (2021), 'Automated liquid handling for microplate assays : a simplified user interface for the Hamilton Microlab STAR', Journal of Applied Bioanalysis, vol 7, no 1 , pp 11 - 18.
  • Ng, N., Cabral-da-Silva, M., Maksour, S., Berg, T., Engel, M., Silva, D., Do-Ha, D., Lum, J., Sanz Munoz, S., Suarez-Bosche, N., Stevens, C. and Ooi, L. (2020), 'Identification of repurposable cytoprotective drugs in vanishing white matter disease patient-derived cells', Translational Medicine Communications, vol 5 .
  • Ng, N., Wu, M. and Aldrich-Wright, J. (2018), 'The cytotoxicity of some phenanthroline-based antimicrobial copper(II) and ruthenium(II) complexes', Journal of Inorganic Biochemistry, vol 180 , pp 61 - 68.
  • Ng, N., Wu, M., Myers, S. and Aldrich-Wright, J. (2018), 'The in vitro renal cell toxicity of some unconventional anticancer phenanthroline-based platinum(II) complexes', Journal of Inorganic Biochemistry, vol 179 , pp 97 - 106.
  • Ng, N., Wu, M., Jones, C. and Aldrich-Wright, J. (2016), 'The antimicrobial efficacy and DNA binding activity of the copper(II) complexes of 3,4,7,8-tetramethyl-1,10-phenanthroline, 4,7-diphenyl-1,10-phenanthroline and 1,2-diaminocyclohexane', Journal of Inorganic Biochemistry, vol 162 , pp 62 - 72.
  • Ng, N., Leverett, P., Hibbs, D., Yang, Q., Bulanadi, J., Wu, M. and Aldrich-Wright, J. (2013), 'The antimicrobial properties of some copper(II) and platinum(II) 1,10-phenanthroline complexes', Dalton Transactions, vol 42, no 9 , pp 3196 - 3209.
  • Garbutcheon-Singh, K., Myers, S., Harper, B., Ng, N., Dong, Q., Xie, C. and Aldrich-Wright, J. (2013), 'The effects of 56MESS on mitochondrial and cytoskeletal proteins and the cell cycle in MDCK cells', Metallomics, vol 5, no 8 , pp 1061 - 1067.

Experimental and translational therapies toward terminal degenerative diseases, including neurological disorders and cancer

Development and implementation of rapid cell differentiation, cell-based assay methods and mitochondrial therapies

This information has been contributed by Doctor Ng.

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