Doctor Karren Beattie

Doctor Karren Beattie

Adjunct Fellow,
Dean's Unit, School of Science

Biography

Karren Beattie is a Research Fellow at the School of Science and Health and the National Institute of Complementary Medicine at Western Sydney University. She has previously held positions as a Postdoctoral Research Fellow at The Eskitis Institute for Drug Discovery and the School of Pharmacy at Griffith University. She has extensive capability in the development of chromatographic methods for the separation and isolation of compounds from plant extracts and essential oils. She also has extensive experience in the discovery and characterisation of biologically active compounds (against antioxidant, anti-inflammatory, cytotoxic, antibacterial and insecticidal targets) from plants and fungi.

She is an inventor on 1 international patent for a series of novel anti-inflammatory compounds and has more than 20 refereed journal articles in the fields of: plant chemistry; natural products drug discovery; molecular biology; pharmacology; and complementary medicine.

She is currently supervising 2 PhD and 1 Research MSc students in the areas of: phytochemistry, biopesticides, pharmacology, ethnobotany and natural products drug discovery.

This information has been contributed by Doctor Beattie.

Qualifications

  • PhD Southern Cross University (Aust)
  • BSc (Hons) University of Melbourne

Professional Memberships

  • MRACI, CChem (2012 - 2016)

Interests

  • Botanical insecticides
  • Safety and efficacy of traditional herbal medicines
  • bioactive secondary metabolites
  • large-scale purification of natural products for clinical trials
  • natural products drug discovery
  • structure elucidation, mass spectrometry and NMR spectroscopy of natural products

Organisational Unit (School / Division)

  • Dean's Unit, School of Science

Contact

Email: K.Beattie@westernsydney.edu.au
Phone: (02) 4620 3508
Mobile:
Location: 18.G.07
CampbelltownHawkesbury

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Publications

Journal Articles

  • Tietjen, I., Cassel, J., Register, E., Zhou, X., Messick, T., Keeney, F., Lu, L., Beattie, K., Rali, T., Tebas, P., Ertl, H., Salvino, J., Davis, R. and Montaner, L. (2021), 'The natural stilbenoid (-)-hopeaphenol inhibits cellular entry of SARS-CoV-2 USA-WA1/2020, B.1.1.7, and B.1.351 variants', Antimicrobial Agents and Chemotherapy, vol 65, no 12 .
  • Puigvert, M., Sole, M., Lopez-Garcia, B., Coll, N., Beattie, K., Davis, R., Elofsson, M. and Valls, M. (2019), 'Type III secretion inhibitors for the management of bacterial plant diseases', Molecular Plant Pathology, vol 20, no 1 , pp 20 - 32.
  • Herath, H., Preston, S., Jabbar, A., Garcia-Bustos, J., Taki, A., Addison, R., Hayes, S., Beattie, K., McGee, S., Martin, S., Ekins, M., Hooper, J., Chang, B., Hofmann, A., Davis, R. and Gasser, R. (2019), 'Identification of fromiamycalin and halaminol A from Australian marine sponge extracts with anthelmintic activity against haemonchus contortus', Marine Drugs, vol 17, no 11 .
  • Akhtar, M., Raju, R., Beattie, K., Bodkin, F. and Muench, G. (2016), 'Medicinal plants of the Australian Aboriginal Dharawal people exhibiting anti-inflammatory activity', Evidence-Based Complementary and Alternative Medicine, vol 2016 .
  • Schwartz, B., Skinner-Adams, T., Andrews, K., Coster, M., Edstein, M., MacKenzie, D., Charman, S., Koltun, M., Blundell, S., Campbell, A., Pouwer, R., Quinn, R., Beattie, K., Healya, P. and Davis, R. (2015), 'Synthesis and antimalarial evaluation of amide and urea derivatives based on the thiaplakortone A natural product scaffold', Organic and Biomolecular Chemistry, vol 13, no 5 , pp 1558 - 1570.
  • Schwartz, B., Skinner-Adams, T., Andrews, K., Coster, M., Edstein, M., MacKenzie, D., Charman, S., Koltun, M., Blundell, S., Campbell, A., Pouwer, R., Quinn, R., Beattie, K., Healya, P. and Davis, R. (2015), 'Synthesis and antimalarial evaluation of amide and urea derivatives based on the thiaplakortone A natural product scaffold', Organic and Biomolecular Chemistry, vol 13, no 5 , pp 1558 - 1570.
  • Choomuenwai, V., Beattie, K., Healy, P., Andrews, K., Fechner, N. and Davis, R. (2015), 'Entonalactams A-C : isoindolinone derivatives from an Australian rainforest fungus belonging to the genus Entonaema', Phytochemistry, vol 117, no 1 , pp 10 - 16.
  • Beattie, K., Ellwood, N., Kumar, R., Yang, X., Healy, P., Choomuenwai, V., Quinn, R., Elliott, A., Huang, J., Chitty, J., Fraser, J., Cooper, M. and Davis, R. (2015), 'Antibacterial and antifungal screening of natural products sourced from Australian fungi and characterisation of pestalactams D-F', Phytochemistry, vol 124 , pp 79 - 85.
  • Khokhar, S., Feng, Y., Campitelli, M., Ekins, M., HoopeR, J., Beattie, K., Sadowski, M., Nelson, C. and Davis, R. (2014), 'Isolation, structure determination and cytotoxicity studies of tryptophan alkaloids from an Australian marine sponge Hyrtios sp.', Bioorganic & Medicinal Chemistry Letters, vol 24, no 15 , pp 3329 - 3332.
  • Davis, R., Beattie, K., Xu, M., Yang, X., Yin, S., Holla, H., Healy,, P., Sykes, M., Shelper, T., Avery, V., Elofsson, M., Sundin, C. and Quinn, R. (2014), 'Solving the supply of resveratrol tetramers from Papua New Guinean rainforest Anisoptera species that inhibit bacterial type III secretion systems', Journal of Natural Products, vol 77, no 12 , pp 2633 - 2640.
  • Levrier, C., Balastrier, M., Beattie, K., Carroll, A., Martin, F., Choomuenwai, V. and Davis, R. (2013), 'Pyridocoumarin, aristolactam and aporphine alkaloids from the Australian rainforest plant Goniothalamus australis', Phytochemistry, vol 86 , pp 121 - 126.
  • Choomuenwai, V., Schwartz, B., Beattie, K., Andrews, K., Khokhar, S. and Davis, R. (2013), 'The discovery, synthesis and antimalarial evaluation of natural product-based polyamine alkaloids', Tetrahedron Letters, vol 54, no 38 , pp 5188 - 5191.
  • Beattie, K., Bhadbhade, M., Craig, D. and Leach, D. (2012), '(3R,4S,5S,8S,10R,13R)-3-Hydroxykaura-9(11),16-dien-18-oic acid', Acta Crystallographica: Section E, vol 68, no 2 , pp 526 - 527.
  • Beattie, K., Waterman, P., Forster, P., Thompson, D. and Leach, D. (2011), 'Chemical composition and cytotoxicity of oils and eremophilanes derived from various parts of Eremophila mitchellii Benth. (Myoporaceae)', Phytochemistry: The International Journal of Plant Chemistry, Plant Biochemistry and Molecular Biology, vol 72, no 4-5 , pp 400 - 408.
  • Beattie, K., Ulrich, R., Grice, I., Uddin, S., Blake, T., Wood, K., Steele, J., Iu, F., May, T. and Tiralongo, E. (2011), 'Ethanolic and aqueous extracts derived from Australian fungi inhibit cancer cell growth in vitro', Mycologia, vol 103, no 3 , pp 458 - 465.
  • Uddin, S., Jason, T., Beattie, K., Grice, I. and Tiralongo, E. (2011), '(2S, 3S)-Sulfated Pterosin C, a cytotoxic Sesquiterpene from the Bangladeshi Mangrove Fern Acrostichum aureum', Journal of Natural Products, vol 74, no 9 , pp 2010 - 2013.
  • Beattie, K., Thompson, D., Tiralongo, E., Ratkowsky, D., May, T. and Gill, M. (2011), 'Austrocolorone B and austrocolorin B1, cytotoxic anthracenone dimers from the Tasmanian mushroom Cortinarius vinosipes Gasparini', Tetrahedron Letters, vol 52, no 42 , pp 5448 - 5451.
  • Beattie, K., Rouf, R., Gander, L., May, T., Ratkowsky, D., Donner, C., Gill, M., Grice, I. and Tiralongo, E. (2010), 'Antibacterial metabolites from Australian macrofungi from the genus Cortinarius', Phytochemistry, vol 71, no 8-9 , pp 948 - 955.
  • Beattie, K., Elsworth, C., Gill, M., Milanovic, N., Prima-Putra, D. and Raudies, E. (2004), 'Austrocolorins A1 and B1 : atropisomeric 10,10'-linked dihydroanthracenones from an Australian Dermocybe sp.', Phytochemistry, vol 65, no 8 , pp 1033 - 1038.

Conference Papers

  • Leach, D., Spooner-Hart, R. and Beattie, K. (2016), 'Pharmacognosy of Centipeda cunninghamii, an endemic Australian traditional medicinal plant', International Horticultural Congress, Brisbane, Qld..

Supervision

Doctor Beattie is available to be a principal supervisor for doctoral projects

Previous Supervision

Thesis Title: Elucidating Novel Biopesticide Modes of Action in Insects: Physiological, Cellular and Molecular Approaches
Field of Research: Pest And Weed Control

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