Professor Soon Lee

Professor Soon Lee

Chair of Pathology,
School of Medicine

Biography

Professor C. Soon Lee, MBBS (Melb), MD (Melb), FRCPA, FRCPath (UK), MIAC, AFRACMA

 Prof Lee is the Foundation Professor and Chair of Pathology at Western Sydney University. He is also Clinical Professor at University of Sydney, Conjoint Professor at University of New South Wales, and Senior Pathologist at Liverpool Hospital and Royal Prince Alfred Hospital.

Prof Lee is a certified pathologist for genomics testing and heads the Molecular Pathology Service at Liverpool Hospital that provides diagnostic molecular testing for patients from Sydney South West Local Health District, St George and Wollongong Hospitals.

Prof Lee’s research interests include genomics and biomarkers of colorectal, lung and head and neck cancers. He heads the Cancer Pathology and Cell Biology Laboratory, Ingham Institute. His research group has made significant contributions that have influenced and led to changes in the clinical practice of pathology including the detection of EGFR and HPV in head and neck cancers, detection of the human herpes virus 8 in the diagnosis of early stage Kaposi’s sarcoma, and the use of the EWS/FLI1 fusion transcript in the diagnosis of Ewing’s sarcoma.

He has published over 210 original research articles in international peer-reviewed journals with over 8,400 citations for his publications; and an H-index of 53. Professor Lee has mentored and graduated over 20 higher degree students, many of whom have gone on to forge successful careers as Professors, Associate Professors and Heads of Departments.

Prof Lee was the recipient of the 2017 Lady Mary Fairfax Distinguished Researcher Award and the 2018 Distinguished Pathologist Award of the International Academy of Pathology. He was previous Editor of the journal, Pathology (2000-2009) and Editor-in-Chief of the Journal of Clinical Pathology (2010-2016). He holds international appointments as the Distinguished Visiting Scholar at the Graduate Medical School, Duke University-National University of Singapore (since 2015) and Visiting Professor and International Advisor at Sunway University in Malaysia (since 2017).

This information has been contributed by Professor Lee.

Qualifications

  • PhD University of Melbourne
  • MBBS University of Melbourne

Interests

  • Breast Cancer
  • Cancer Pathology
  • Colorectal Cancer
  • Cytology
  • Head and Neck Cancer
  • Pancreatic Cancer
  • Prostate Cancer
  • Surgical Pathology

Organisational Unit (School / Division)

  • School of Medicine

Contact

Email: soon.lee@westernsydney.edu.au
Phone: (02) 9772 6858
Mobile:
Location: Off Campus

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Publications

Journal Articles

  • Ooi, L., Ho, V., Zhu, J., Lim, S., Chung, L., Abubakar, A., Rutland, T., Chua, W., Ng, W., Lee, M., Morgan, M., Mackenzie, S. and Lee, C. (2024), 'p21 as a predictor and prognostic indicator of clinical outcome in rectal cancer patients', International Journal of Molecular Sciences, vol 25, no 2 .
  • Li, J. and Lee, C. (2024), 'The role of the AT-rich interaction domain 1A gene (ARID1A) in human carcinogenesis', Genes, vol 15, no 1 .
  • Ho, V., Chung, L., Wilkinson, K., Lea, V., Lim, S., Abubakar, A., Ng, W., Lee, M., Roberts, T., Chua, W. and Lee, C. (2023), 'Prognostic significance of MRE11 overexpression in colorectal cancer patients', Cancers, vol 15, no 9 .
  • Tadi, S., Cheung, V., Lee, C., Nguyen, K., Luk, P., Low, T., Palme, C., Clark, J. and Gupta, R. (2023), 'MYB RNA detection by in situ hybridisation has high sensitivity and specificity for the diagnosis of adenoid cystic carcinoma', Pathology, vol 55, no 4 , pp 456 - 465.
  • Nindra, U., Pal, A., Bray, V., Yip, P., Tognela, A., Roberts, T., Becker, T., Williamson, J., Farzin, M., Li, J., Lea, V., Hagelamin, A., Ng, W., Wang, B., Lee, C. and Chua, W. (2023), '[In Press] Utility of multigene panel next-generation sequencing in routine clinical practice for identifying genomic alterations in newly diagnosed metastatic nonsmall cell lung cancer', Internal Medicine Journal, .
  • Nindra, U., Pal, A., Lea, V., Lim, S., Wilkinson, K., Asghari, R., Roberts, T., Becker, T., Farzin, M., Rutland, T., Lee, M., MacKenzie, S., Ng, W., Wang, B., Lee, C. and Chua, W. (2023), 'Multigene panel next generation sequencing in metastatic colorectal cancer in an Australian population', PLoS ONE, vol 18, no 10 .
  • Yoon, R., Wilkinson, K., Gabriel, G., Kadaan, N., Roberts, T., Lim, S., Asghari, R., Lee, C., Chua, W. and Ng, W. (2023), '[In Press] Real-world tolerance and outcomes of oxaliplatin-based adjuvant chemotherapy for stage III colon cancer : does dose intensity matter?', Asia-Pacific Journal of Clinical Oncology, .
  • Tune, B., Sareen, H., Powter, B., Kahana-Edwin, S., Cooper, A., Koh, E., Lee, C., Po, J., McCowage, G., Dexter, M., Cain, L., O?Neill, G., Prior, V., Karpelowsky, J., Tsoli, M., Baumbusch, L., Ziegler, D., Roberts, T., Souza, P., Becker, T. and Ma, Y. (2023), 'From pediatric to adult brain cancer : exploring histone H3 mutations in Australian brain cancer patients', Biomedicines, vol 11, no 11 .
  • Habashy, P., Lea, V., Wilkinson, K., Wang, B., Wu, X., Roberts, T., Ng, W., Rutland, T., Po, J., Becker, T., Descallar, J., Lee, M., Mackenzie, S., Gupta, R., Cooper, W., Lim, S., Chua, W. and Lee, C. (2023), 'KRAS and BRAF mutation rates and survival outcomes in colorectal cancer in an ethnically diverse patient cohort', International Journal of Molecular Sciences, vol 24, no 24 .
  • Ho, V., Chung, L., Lim, S., Ma, Y., Wang, B., Lea, V., Abubakar, A., Ng, W., Lee, M., Roberts, T., Chua, W. and Lee, C. (2022), 'Prognostic impact of TP53 mutations and tumor mutational load in colorectal cancer', Gastrointestinal Disorders, vol 4, no 3 , pp 165 - 179.
  • Fan, X., Yuan, Z., Zhao, Y., Xiong, W., Hsiao, H., Pare, R., Ding, J., Almosa, A., Sun, K., Zhang, S., Jordan, R., Lee, C., An, Z. and Zhang, N. (2022), 'Impairment of IgG Fc functions promotes tumor progression and suppresses NK cell antitumor actions', Communications Biology, vol 5, no 1 .
  • Nikesitch, N., Rebeiro, P., Ho, L., Pothula, S., Wang, X., Khong, T., Quek, H., Spencer, A., Lee, C., Roberts, T. and Ling, S. (2021), 'The role of chaperone-mediated autophagy in bortezomib resistant multiple myeloma', Cells, vol 10 .
  • Singh, A., Ham, J., Po, J., Niles, N., Roberts, T. and Lee, C. (2021), 'The genomic landscape of thyroid cancer tumourigenesis and implications for immunotherapy', Cells, vol 10, no 5 .
  • Ham, J., Wang, B., Po, J., Singh, A., Niles, N. and Lee, C. (2021), 'Cancer-associated fibroblasts (CAFs) in thyroid papillary carcinoma : molecular networks and interactions', Journal of Clinical Pathology, vol 74, no 12 , pp 759 - 765.
  • Wilkinson, K., Ng, W., Roberts, T., Becker, T., Lim, S., Chua, W. and Lee, C. (2021), 'Tumour immune microenvironment biomarkers predicting cytotoxic chemotherapy efficacy in colorectal cancer', Journal of Clinical Pathology, vol 74, no 10 , pp 625 - 634.
  • Lin, P., Min, M., Lai, K., Lee, M., Holloway, L., Xuan, W., Bray, V., Fowler, A., Lee, C. and Yong, J. (2021), 'Mid-treatment fluorodeoxyglucose positron emission tomography in human papillomavirus-related oropharyngeal squamous cell carcinoma treated with primary radiotherapy : nodal metabolic response rate can predict treatment outcomes', Clinical Oncology, .
  • Kang, S., Wilkinson, K., Brungs, D., Chua, W., Ng, W., Chen, J., Nasser, E., Lee, M., Wong, K., Bokey, L., Winn, R., Putnis, S., Lee, C. and Lim, S. (2021), 'Rectal cancer treatment and outcomes in elderly patients treated with curative intent', Molecular and Clinical Oncology, vol 15, no 6 .
  • Ho, V., Chung, L., Singh, A., Lea, V., Abubakar, A., Lim, S., Chua, W., Ng, W., Lee, M., Roberts, T., Souza, P. and Lee, C. (2020), 'Aberrant expression of RAD52, its prognostic impact in rectal cancer and association with poor survival of patients', International Journal of Molecular Sciences, vol 21, no 5 .
  • Mueller, S., Gauthier, M., Blackburn, J., Grady, J., Kraitsek, S., Hajdu, E., Dettmer, M., Dahlstrom, J., Lee, C., Luk, P., Yu, B., Giger, R., Kummerfeld, S., Clark, J., Gupta, R. and Cowley, M. (2020), 'Molecular patterns in salivary duct carcinoma identify prognostic subgroups', Modern Pathology, vol 33, no 10 , pp 1896 - 1909.
  • Situ, Y., Chung, L., Lee, C. and Ho, V. (2019), 'MRN (MRE11-RAD50-NBS1) complex in human cancer and prognostic implications in colorectal cancer', International Journal of Molecular Sciences, vol 20, no 4 .
  • Pare, R., Soon, P., Shah, A. and Lee, C. (2019), 'Differential expression of senescence tumour markers and its implications on survival outcomes of breast cancer patients', PLoS One, vol 14, no 4 .
  • Ferreira, M., Gamazon, E., Al-Ejeh, F., Aittomaki, K., Andrulis, I., Anton-Culver, H., Arason, A., Arndt, V., Aronson, K., Arun, B., Asseryanis, E., Azzollini, J., Balma?a, J., Barnes, D., Barrowdale, D., Beckmann, M., Behrens, S., Benitez, J., Bermisheva, M., Bialkowska, K., Blomqvist, C., Bogdanova, N., Bojesen, S., Bolla, M., Borg, A., Brauch, H., Brenner, H., Broeks, A., Burwinkel, B., Caldes, T., Caligo, M., Campa, D., Campbell, I., Canzian, F., Carter, J., Carter, B., Castelao, J., Chang-Claude, J., Chanock, S., Christiansen, H., Chung, W., Claes, K., Clarke, C., Adlard, J., Ahmed, M., Barwell, J., Brady, A., Brewer, C., Cook, J., Davidson, R., Donaldson, A., Eason, J., Eeles, R., Evans, D., Gregory, H., Hanson, H., Henderson, A., Hodgson, S., Izatt, L., Kennedy, M., Lalloo, F., Miller, C., Morrison, P., Ong, K., Perkins, J., Porteous, M., Rogers, M., Side, L., Snape, K., Walker, L., Harrington, P., Arnold, N., Auber, B., Bogdanova-Markov, N., Borde, J., Caliebe, A., Ditsch, N., Dworniczak, B., Engert, S., Faust, U., Gehrig, A., Hahnen, E., Hauke, J., Hentschel, J., Herold, N., Honisch, E., Just, W., Kast, K., Larsen, M., Lemke, J., Nguyen, H., Niederacher, D., Ott, C., Platzer, K., Pohl-Rescigno, E., Ramser, J., Rhiem, K., Steinemann, D., Sutter, C., Varon-Mateeva, R., Wang-Gohrke, S., Weber, B., Prieur, F., Pujol, P., Sagne, C., Sevenet, N., Sobol, H., Sokolowska, J., Stoppa-Lyonnet, D., Venat-Bouvet, L., Couch, F., Cox, A., Cross, S., Czene, K., Daly, M., De la Hoya, M., Dennis, J., Devilee, P., Diez, O., Dork, T., Dunning, A., Dwek, M., Eccles, D., Ejlertsen, B., Ellberg, C., Engel, C., Eriksson, M., Fasching, P., Fletcher, O., Flyger, H., Friedman, E., Frost, D., Gabrielson, M., Gago-Dominguez, M., Ganz, P., Gapstur, S., Garber, J., Garcia-Closas, M., Garcia-Saenz, J., Gaudet, M., Giles, G., Glendon, G., Godwin, A., Goldberg, M., Goldgar, D., Gonzalez-Neira, A., Greene, M., Gronwald, J., Guenel, P., Haiman, C., Hall, P., Hamann, U., He, W., Heyworth, J., Hogervorst, F., Hollestelle, A., Hoover, R., Hopper, J., Hulick, P., Humphreys, K., Imyanitov, E., Balleine, R., Baxter, R., Braye, S., Carpenter, J., Dahlstrom, J., Forbes, J., Lee, C. and et al, .. (2019), 'Genome-wide association and transcriptome studies identify target genes and risk loci for breast cancer', Nature Communications, vol 10, no 1 .
  • Lee, S., Liu, F., Riordan, S., Lee, C. and Zhang, L. (2019), 'Global investigations of Fusobacterium nucleatum in human colorectal cancer', Frontiers in Oncology, vol 9 .
  • Pham, T., Stait-Gardner, T., Lee, C., Barton, M., Graham, P., Liney, G., Wong, K. and Price, W. (2019), 'Correlation of ultra-high field MRI with histopathology for evaluation of rectal cancer heterogeneity', Scientific Reports, vol 9, no 1 .
  • Ho, U., Luff, J., James, A., Lee, C., Quek, H., Lai, H., Apte, S., Lim, Y., Lavin, M. and Roberts, T. (2019), 'SMG1 heterozygosity exacerbates haematopoietic cancer development in Atm null mice by increasing persistent DNA damage and oxidative stress', Journal of Cellular and Molecular Medicine, vol 23, no 12 , pp 8151 - 8160.
  • Nasir, N., Ng, C., Rajasegaran, V., Wong, S., Liu, W., Ng, X., Lee, J., Guan, P., Lim, J., Thike, A., Koh, C., Loke, B., Chang, T., Gudi, M., Lian, W., Madhukumar, P., Tan, K., Tan, K., Wong, C., Yong, W., Ho, H., Ong, K., Tan, P., Teh, B., Tan, P., Rahman, N., Khodeza Nahar Begum, S., Cheah, P., Chen, C., Dela Fuente, D., Han, A., Harada, O., Kanomata, N., Lee, C. and Lee, J. (2019), 'Genomic characterisation of breast fibroepithelial lesions in an international cohort', Journal of Pathology, vol 249, no 4 , pp 447 - 460.
  • Figlioli, G., Bogliolo, M., Catucci, I., Caleca, L., Lasheras, S., Pujol, R., Kiiski, J., Muranen, T., Barnes, D., Dennis, J., Michailidou, K., Bolla, M., Leslie, G., Aalfs, C., Balleine, R., Baxter, R., Braye, S., Carpenter, J., Dahlstrom, J., Forbes, J., Lee, C. and et, a. (2019), 'The FANCM:p.Arg658* truncating variant is associated with risk of triple-negative breast cancer', npj Breast Cancer, vol 5, no 1 .
  • Dork, T., Peterlongo, P., Mannermaa, A., Bolla, M., Wang, Q., Dennis, J., Ahearn, T., Andrulis, I., Anton-Culver, H., Arndt, V., Aronson, K., Augustinsson, A., Freeman, L., Beckmann, M., Beeghly-Fadiel, A., Behrens, S., Bermisheva, M., Blomqvist, C., Bogdanova, N., Bojesen, S., Brauch, H., Brenner, H., Burwinkel, B., Canzian, F., Chan, T., Chang-Claude, J., Chanock, S., Choi, J., Christiansen, H., Clarke, C., Couch, F., Czene, K., Daly, M., dos-Santos-Silva, I., Dwek, M., Eccles, D., Ekici, A., Eriksson, M., Evans, D., Fasching, P., Figueroa, J., Flyger, H., Fritschi, L., Gabrielson, M., Gago-Dominguez, M., Gao, C., Gapstur, S., Garcia-Closas, M., Garcia-Saenz, J., Gaudet, M., Giles, G., Goldberg, M., Goldgar, D., Guenel, P., Haeberle, L., Haiman, C., Hakansson, N., Hall, P., Hamann, U., Hartman, M., Hauke, J., Hein, A., Hillemanns, P., Hogervorst, F., Hooning, M., Hopper, J., Howell, T., Huo, D., Ito, H., Iwasaki, M., Jakubowska, A., Janni, W., John, E., Jung, A., Kaaks, R., Kang, D., Kapoor, P., Khusnutdinova, E., Kim, S., Kitahara, C., Koutros, S., Kraft, P., Kristensen, V., Kwong, A., Lambrechts, D., Marchand, L., Li, J., Lindstrom, S., Linet, M., Lo, W., Long, J., Lophatananon, A., Lubinski, J., Manoochehri, M., Manoukian, S., Margolin, S., Martinez, E., Matsuo, K., Mavroudis, D., Meindl, A., Menon, U., Milne, R., Taib, N., Muir, K., Mulligan, A., Neuhausen, S., Nevanlinna, H., Neven, P., Newman, W., Offit, K., Olopade, O., Olshan, A., Olson, J., Olsson, H., Park, S., Park-Simon, T., Peto, J., Plaseska-Karanfilska, D., Pohl-Rescigno, E., Presneau, N., Rack, B., Radice, P., Rashid, M., Rennert, G., Rennert, H., Romero, A., Ruebner, M., Saloustros, E., Schmidt, M., Schmutzler, R., Schneider, M., Schoemaker, M., Scott, C., Shen, C., Shu, X., Simard, J., Slager, S., Smichkoska, S., Southey, M., Spinelli, J., Stone, J., Surowy, H., Swerdlow, A., Tamimi, R., Tapper, W., Teo, S., Terry, M., Toland, A., Tollenaar, R., Torres, D., Torres-Mejia, G., Troester, M., Truong, T., Tsugane, S., Untch, M., Vachon, C., Van Den Ouweland, A., Van Veen, E., Vijai, J., Wendt, C., Wolk, A., Yu, J., Zheng, W., Ziogas, A., Ziv, E., Balleine, R., Baxter, R., Braye, S., Carpenter, J., Dahlstrom, J., Forbes, J., Lee, C. and et al, .. (2019), 'Two truncating variants in FANCC and breast cancer risk', Scientific Reports, vol 9, no 1 .
  • Loke, B., Nasir, N., Thike, A., Lee, J., Lee, S., Teh, B. and Tan, P. (2018), 'Genetics and genomics of breast fibroadenomas', Journal of Clinical Pathology, vol 71, no 5 , pp 381 - 387.
  • Lai, K., Matthews, S., Wilmott, J., Killingsworth, M., Yong, J., Caixeiro, N., Wykes, J., Samakeh, A., Forstner, D., Lee, M., McGuiness, J., Niles, N., Hong, A., Ebrahimi, A. and Lee, C. (2018), 'Differences in LC3B expression and prognostic implications in oropharyngeal and oral cavity squamous cell carcinoma patients', BMC Cancer, vol 18 .
  • Ho, V., Chung, L., Singh, A., Lea, V., Abubakar, A., Lim, S., Ng, W., Lee, M., Souza, P., Shin, J. and Lee, C. (2018), 'Overexpression of the MRE11-RAD50-NBS1 (MRN) complex in rectal cancer correlates with poor response to neoadjuvant radiotherapy and prognosis', BMC Cancer, vol 18, no 1 .
  • Pham, T., Stait-Gardner, T., Lee, C., Barton, M., Liney, G., Wong, K. and Price, W. (2018), 'Ultra-high field MRI for evaluation of rectal cancer stroma ex vivo : correlation with histopathology', Radiotherapy and Oncology, vol 127, no Suppl. 1 , pp 541 - 542.
  • Lai, K., Killingsworth, M., Matthews, S., Caixeiro, N., Evangelista, C., Wu, X., Wykes, J., Samakeh, A., Forstner, D., Niles, N., Hong, A. and Lee, S. (2017), 'Differences in survival outcome between oropharyngeal and oral cavity squamous cell carcinoma in relation to HPV status', Journal of Oral Pathology and Medicine, vol 46, no 8 , pp 574 - 582.
  • Manoharan, V., Lee, S., Chong, S., Yap, J., Coupe, N., Wilson, R., Merrett, N., Ng, W. and Lin, M. (2017), 'Serial imaging using [18F]fluorodeoxyglucose positron emission tomography and histopathologic assessment in predicting survival in a population of surgically resectable distal oesophageal and gastric adenocarcinoma following neoadjuvant therapy', Annals of Nuclear Medicine, vol 31, no 4 , pp 315 - 323.
  • Pang, J., Savas, P., Fellowes, A., Arnau, G., Kader, T., Vedururu, R., Hewitt, C., Takano, E., Byrne, D., Choong, D., Millar, E., Lee, S., O'Toole, S., Lakhani, S., Cummings, M., Mann, G., Campbell, I., Dobrovic, A., Loi, S., Gorringe, K. and Fox, S. (2017), 'Breast ductal carcinoma in situ carry mutational driver events representative of invasive breast cancer', Modern Pathology, vol 30 , pp 952 - 963.
  • Quek, H., Luff, J., Cheung, K., Kozlov, S., Gatei, M., Lee, S., Bellingham, M., Noakes, P., Lim, Y., Barnett, N., Dingwall, S., Wolvetang, E., Moshimo, T., Roberts, T. and Lavin, M. (2017), 'A rat model of ataxia-telangiectasia : evidence for a neurodegenerative phenotype', Human Molecular Genetics, vol 26, no 1 , pp 109 - 123.
  • Quek, H., Luff, J., Cheung, K., Kozlov, S., Gatei, M., Lee, S., Bellingham, M., Noakes, P., Lim, Y., Barnett, N., Dingwall, S., Wolvetang, E., Mashimo, T., Roberts, T. and Lavin, M. (2017), 'Rats with a missense mutation in Atm display neuroinflammation and neurodegeneration subsequent to accumulation of cytosolic DNA following unrepaired DNA damage', Journal of Leukocyte Biology, vol 101, no 4 , pp 927 - 947.
  • Ng, T., Shin, J., Wang, B. and Lee, S. (2017), 'Exploration of mutation and DNA methylation of polo-like kinase 1 (PLK1) in colorectal cancer', Open Journal of Pathology, vol 7, no 3 , pp 45 - 57.
  • Lai, K., Killingsworth, M., Yong, J., Matthews, S., Ebrahimi, A., McGuinness, J., Ngo, Q., Caixeiro, N., Hong, A. and Lee, S. (2017), 'Specific localization of LC3B in autophagosome : a correlative labelling study with nanoparticle in oral squamous cell carcinoma', Experimental and Molecular Pathology, vol 102, no 3 , pp 422 - 427.
  • Pang, J., Molania, R., Chand, A., Knower, K., Takano, E., Byrne, D., Mikeska, T., Millar, E., Lee, S., O'Toole, S., Clyne, C., Gorringe, K., Dobrovic, A. and Fox, S. (2017), 'LRH-1 expression patterns in breast cancer tissues are associated with tumour aggressiveness', Oncotarget, vol 8, no 48 , pp 83626 - 83636.
  • Ho, V., Chung, L., Singh, A., Lea, V., Revoltar, M., Lim, S., Tut, T., Ng, W., Lee, M., de Souza, P., Shin, J. and Lee, S. (2017), 'Early postoperative low expression of RAD50 in rectal cancer patients associates with disease-free survival', Cancers, vol 9, no 12 .
  • Rajendra, S., Yang, T., Xuan, W., Sharma, P., Pavey, D., Lee, C., Le, S., Collins, J. and Wang, B. (2017), 'Active human papillomavirus involvement in Barrett's dysplasia and oesophageal adenocarcinoma is characterized by wild-type p53 and aberrations of the retinoblastoma protein pathway', International Journal of Cancer, vol 141, no 10 , pp 2037 - 2049.
  • Kalinowski, D., Stefani, C., Toyokuni, S., Ganz, T., Anderson, G., Subramaniam, N., Trinder, D., Olynyk, J., Chua, A., Jansson, P., Sahni, S., Lane, D., Merlot, A., Kovacevic, Z., Huang, M., Lee, C. and Richardson, D. (2016), 'Redox cycling metals : pedaling their roles in metabolism and their use in the development of novel therapeutics', Biochimica et Biophysica Acta, vol 1863, no 4 , pp 727 - 748.
  • Kalinowski, D., Stefani, C., Toyokuni, S., Ganz, T., Anderson, G., Subramaniam, N., Trinder, D., Olynyk, J., Chua, A., Jansson, P., Sahni, S., Lane, D., Merlot, A., Kovacevic, Z., Huang, M., Lee, C. and Richardson, D. (2016), 'Redox cycling metals : pedaling their roles in metabolism and their use in the development of novel therapeutics', Biochimica et Biophysica Acta, vol 1863, no 4 , pp 727 - 748.
  • Zhang, X., Gee, H., Rose, B., Lee, S., Clark, J., Elliott, M., Gamble, J., Cairns, M., Harris, A., Khoury, S. and Tran, N. (2016), 'Regulation of the tumour suppressor PDCD4 by miR-499 and miR-21 in oropharyngeal cancers', BMC Cancer, vol 16, no 1 .
  • Caixeiro, N., Lai, K. and Lee, S. (2016), 'Quality assessment and preservation of RNA from biobank tissue specimens : a systematic review', Journal of Clinical Pathology, vol 69, no 3 , pp 260 - 265.
  • Ng, T., Shin, J., Roberts, T., Wang, B. and Lee, S. (2016), 'Molecular interactions of polo-like kinase 1 in human cancers', Journal of Clinical Pathology, vol 69, no 7 , pp 557 - 562.
  • Caixeiro, N., Byun, H., Descallar, J., Levesque, J., de Souza, P. and Lee, S. (2016), 'Health professionals' opinions on supporting a cancer biobank : identification of barriers to combat biobanking pitfalls', European Journal of Human Genetics, vol 24, no 5 , pp 626 - 632.
  • Pare, R., Shin, J. and Lee, S. (2016), 'Increased expression of senescence markers P14ARF and p16 INK4a in breast cancer is associated with increased risk of disease recurrence and poor survival outcome', Histopathology, vol 69, no 3 , pp 479 - 491.
  • Hong, A., Lee, S., Jones, D., Veillard, A., Zhang, M., Zhang, X., Smee, R., Corry, J., Porceddu, S., Milross, C., Elliott, M., Clark, J. and Rose, B. (2016), 'Rising prevalence of human papillomavirus-related oropharyngeal cancer in Australia over the last 2 decades', Head & Neck, vol 38, no 5 , pp 743 - 750.
  • Chng, T., Lee, J., Lee, S., Li, H., Tan, M. and Tan, P. (2016), 'Validation of the Singapore nomogram for outcome prediction in breast phyllodes tumours : an Australian cohort', Journal of Clinical Pathology, vol 69 , pp 1124 - 1126.
  • Shen, K., Xi, Z., Xie, J., Wang, H., Xie, C., Lee, S., Fahey, P., Dong, Q. and Xu, H. (2016), 'Guttiferone K suppresses cell motility and metastasis of hepatocellular carcinoma by restoring aberrantly reduced profilin 1', Oncotarget, vol 7, no 35 , pp 56650 - 56663.
  • Hong, A., Vilain, R., Romanes, S., Yang, J., Smith, E., Jones, D., Scolyer, R., Lee, S., Zhang, M. and Rose, B. (2016), 'PD-L1 expression in tonsillar cancer is associated with human papillomavirus positivity and improved survival : implications for anti-PD1 clinical trials', Oncotarget, vol 7, no 47 , pp 77010 - 77020.
  • Ho, V., Chung, L., Revoltar, M., Lim, S., Tut, T., Abubakar, A., Henderson, C., Chua, W., Ng, W., Lee, M., de Souza, P., Morgan, M., Lee, S. and Shin, J. (2016), 'MRE11 and ATM expression levels predict rectal cancer survival and their association with radiotherapy response', PLoS One, vol 11, no 12 .
  • Revoltar, M., Shin, J., Lim, S., Tut, T., Dissanayake, I., Descallar, J., Ho, V., Chua, W., Ng, W., Lee, M., Henderson, C., de Souza, P., Morgan, M. and Lee, S. (2016), 'Early marker of DNA damage response, ATM, as a predictor of clinical outcome following radiotherapy in rectal cancer patients', Pathology, vol 48, no Supplement 1 , pp 153 - 153.
  • Hong, A., Zhang, X., Jones, D., Zhang, M., Lee, C., Lyons, J., Veillard, A. and Rose, B. (2016), 'E6 viral protein ratio correlates with outcomes in human papillomavirus related oropharyngeal cancer', Cancer Biology and Therapy, vol 17, no 2 , pp 181 - 187.
  • Rajendra, S., Wang, B., Pavey, D., Sharma, P., Yang, T., Lee, S., Gupta, N., Ball, M., Gill, R. and Wu, X. (2015), 'Persistence of human papillomavirus, overexpression of p53 and outcomes of patients after endoscopic ablation of Barrett's esophagus', Clinical Gastroenterology and Hepatology, vol 13, no 7 , pp 1364 - 1368.
  • Lai, K., Killingsworth, M. and Lee, S. (2015), 'Gene of the month : PIK3CA', Journal of Clinical Pathology, vol 68, no 4 , pp 253 - 257.
  • Tut, T., Lim, S., Dissanayake, I., Descallar, J., Chua, W., Ng, W., de Souza, P., Shin, J. and Lee, S. (2015), 'Upregulated polo-like kinase 1 expression correlates with inferior survival outcomes in rectal cancer', PLoS One, vol 10, no 6 .
  • Lim, S., Chua, W., Henderson, C., Ng, W., Shin, J., Chantrill, L., Asghari, R., Lee, S., Spring, K. and de Souza, P. (2015), 'Predictive and prognostic biomarkers for neoadjuvant chemoradiotherapy in locally advanced rectal cancer', Critical Reviews in Oncology/Hematology, vol 96, no 1 , pp 67 - 80.
  • Liu, J., Zhang, M., Rose, B., Veillard, A., Jones, D., Zhang, X., Lee, S., Milross, C. and Hong, A. (2015), 'Ki67 expression has prognostic significance in relation to human papillomavirus status in oropharyngeal squamous cell carcinoma', Annals of Surgical Oncology, vol 22, no 6 , pp 1893 - 1900.
  • Caixeiro, N., Aghmesheh, M., Souza, P. and Lee, S. (2015), 'The Centre for Oncology Education and Research Translation (CONCERT) Biobank', Open Journal of Bioresources, vol 2 .
  • Zhang, M., Rose, B., Lee, S. and Hong, A. (2015), 'In vitro 3-dimensional tumor model for radiosensitivity of HPV positive OSCC cell lines', Cancer Biology & Therapy, vol 16, no 8 , pp 1231 - 1240.
  • Moon, H., Lee, S., Inder, K., Sharma, S., Choi, E., Black, D., Le Cao, K., Winterford, C., Coward, J., Ling, M., Craik, D., Parton, R., Russell, P. and Hill, M. (2014), 'PTRF/cavin-1 neutralizes non-caveolar caveolin-1 microdomains in prostate cancer', Oncogene, vol 33, no 27 , pp 3561 - 3570.
  • Shin, J., Tut, T., Ho, V. and Lee, S. (2014), 'Predictive markers of radiotherapy-induced rectal cancer regression', Journal of Clinical Pathology, vol 67, no 10 , pp 859 - 864.
  • Lai, K., Killingsworth, M. and Lee, S. (2014), 'The significance of autophagy in colorectal cancer pathogenesis and implications for therapy', Journal of Clinical Pathology, vol 67, no 10 , pp 854 - 858.
  • Lim, S., Chua, W., Cheng, C., Descallar, J., Ng, W., Solomon, M., Bokey, E., Wong, K., Lee, M., de Souza, P., Shin, J. and Lee, S. (2014), 'Effect of neoadjuvant chemoradiation on tumor-infiltrating/associated lymphocytes in locally advanced rectal cancers', Anticancer Research, vol 34, no 11 , pp 6505 - 6513.
  • Hong, A., Martin, A., Armstrong, B., Lee, S., Jones, D., Chatfield, M., Zhang, M., Harnett, G., Clark, J., Elliott, M., Milross, C., Smee, R., Corry, J., Liu, C., Porceddu, S., Vaska, K., Veness, M., Morgan, G., Fogarty, G., Veivers, D., Rees, G. and Rose, B. (2013), 'Human papillomavirus modifies the prognostic significance of T stage and possibly N stage in tonsillar cancer', Annals of Oncology, vol 24, no 1 , pp 215 - 219.
  • Roberts, T., Ho, U., Luff, J., Lee, S., Apte, S., MacDonald, K., Raggat, L., Pettit, A., Morrow, C., Waters, M., Chen, P., Woods, R., Thomas, G., Pierre, L., Farah, C., Clarke, R., Brown, J. and Lavin, M. (2013), 'Smg1 haploinsufficiency predisposes to tumor formation and inflammation', Proceedings of the National Academy of Sciences of the United States of America, vol 110, no 4 , pp 285 - 294.
  • Pare, R., Yang, T., Shin, J., Tan, P. and Lee, S. (2013), 'Breast cancer precursors : diagnostic issues and current understanding on their pathogenesis', Pathology, vol 45, no 3 , pp 209 - 213.
  • Pare, R., Yang, T., Shin, J. and Lee, S. (2013), 'The significance of the senescence pathway in breast cancer progression', Journal of Clinical Pathology, vol 66, no 6 , pp 491 - 495.
  • Shin, J., Tut, T., Yang, T. and Lee, S. (2013), 'Radiotherapy response in microsatellite instability related rectal cancer', Korean Journal of Pathology, vol 47, no 1 , pp 1 - 8.
  • Karim, R., O'Toole, S., Scolyer, R., Cooper, C., Chan, B., Selinger, C., Yu, B., Carmalt, H., Mak, C., Tse, G., Tan, P., Putti, T. and Lee, S. (2013), 'Recent insights into the molecular pathogenesis of mammary phyllodes tumours', Journal of Clinical Pathology, vol 66, no 6 , pp 496 - 505.
  • Cooper, C., Karim, R., Selinger, C., Carmalt, H., Lee, S. and O'Toole, S. (2013), 'Molecular alterations in metaplastic breast carcinoma', Journal of Clinical Pathology, vol 66, no 6 , pp 522 - 528.
  • Lee, M., Lee, S. and Tan, P. (2013), 'Hormone receptor expression in breast cancer : postanalytical issues', Journal of Clinical Pathology, vol 66, no 6 , pp 478 - 484.
  • Zhang, M., Boughton, P., Rose, B., Lee, S. and Hong, A. (2013), 'The use of porous scaffold as a tumor model', International Journal of Biomaterials, vol 2013, no 396056 .
  • Harris, J., Richards, R., Chow, C., Lee, S., Kim, M., Buck, M., Teng, L., Clarke, R., Gardiner, R. and Lavin, M. (2013), 'BMCC1 Is an AP-2 associated endosomal protein in prostate cancer cells', PLoS One, vol 8, no 9 .
  • Bae, D., Jansson, P., Huang, M., Kovacevic, Z., Kalinowski, D., Lee, S., Sahni, S. and Richardson, D. (2013), 'The role of NDRG1 in the pathology and potential treatment of human cancers', Journal of Clinical Pathology, vol 66, no 11 , pp 911 - 917.
  • Hong, A., Jones, D., Chatfield, M., Lee, S., Zhang, M., Clark, J., Elliott, M., Harnett, G., Milross, C. and Rose, B. (2013), 'HPV status of oropharyngeal cancer by combination HPV DNA/p16 testing : biological relevance of discordant results', Annals of Surgical Oncology, vol 20, no 3 , pp 450 - 458.
  • Chetty, R., Gill, P., Govender, D., Bateman, A., Chang, H., Deshpande, V., Driman, D., Gomez, M., Greywoode, G., Jaynes, E., Lee, S., Locketz, M., Rowsell, C., Rullier, A., Serra, S., Shepherd, N., Szentgyorgyi, E., Vajpeyi, R., Wang, L. and Bateman, A. (2012), 'International study group on rectal cancer regression grading : interobserver variability with commonly used regression grading systems', Human Pathology, vol 43, no 11 , pp 1917 - 1923.
  • Chetty, R., Gill, P., Govender, D., Bateman, A., Chang, H., Driman, D., Duthie, F., Gomez, M., Jaynes, E., Lee, S., Locketz, M., Mescoli, C., Rowsell, C., Rullier, A., Serra, S., Shepherd, N., Szentgyorgyi, E., Vajpeyi, R. and Wang, L. (2012), 'A multi-centre pathologist survey on pathological processing and regression grading of colorectal cancer resection specimens treated by neoadjuvant chemoradiation', Virchows Archiv, vol 460, no 2 , pp 151 - 155.
  • Killingsworth, M., Lai, K., Wu, X., Yong, J. and Lee, S. (2012), 'Quantum dot immunocytochemical localization of somatostatin in somatostatinoma by widefield epifluorescence, super-resolution light, and immunoelectron micrsocopy', Journal of Histochemistry and Cytochemistry, vol 60, no 11 , pp 832 - 843.
  • Tsang, J., Mendoza, P., Putti, T., Karim, R., Scolyer, R., Lee, S., Pang, A. and Tse, G. (2012), 'E-caherin expression in the epithelial components of mammary phyllodes tumors', Human Pathology, vol 43, no 12 , pp 2117 - 2123.
  • Clarke, R., Lee, S. and Eapen, V. (2012), 'Pathogenetic model for Tourette syndrome delineates overlap with related neurodevelopmental disorders including autism', Translational Psychiatry, vol 2 , pp 158 - .
  • Tsang, J., Mendoza, P., Lam, C., Yu, A., Putti, T., Karim, R., Scolyer, R., Lee, S., Tan, P. and Tse, G. (2012), 'Involvement of a- and ?-catenins and E-cadherin in the development of mammary phyllodes tumours', Histopathology, vol 61, no 4 , pp 667 - 674.
  • Rizvi, S., Allen, B., Lee, S., Bruchertseifer, F., Apostolidis, C., Morgenstern, A. and Clarke, R. (2012), 'Orthotopic administration of 213Bi-bevacizumab inhibits progression of PC3 xenografts in the prostate', Immunotherapy, vol 4, no 5 , pp 549 - 554.
  • Sasani, S., Quin, J., Henderson, C., Lee, S. and Shin, J. (2012), 'An unsuspected case of cerebral toxoplasmosis : case report and literature review', Pathology, vol 44, no SUPP. 1 , pp 94 - 94.
  • Hong, A., Dobbins, T., Lee, S., Jones, D., Fei, J., Clark, J., Armstrong, B., Harnett, G., Milross, C., Tran, N., Peculis, L., Ng, C., Milne, A., Loo, C., Hughes, L., Forstner, D., O'Brien, C. and Rose, B. (2011), 'Use of cyclin D1 in conjunction with human papillomavirus status to predict outcome in oropharyngeal cancer', International Journal of Cancer, vol 128, no 7 , pp 1532 - 1545.
  • Yip, P., Kench, J., Rasiah, K., Benito, R., Lee, S., Stricker, P., Henshall, S., Sutherland, R. and Horvath, L. (2011), 'Low AZGP1 expression predicts for recurrence in margin-positive, localized prostate cancer', Prostate, vol 71, no 15 , pp 1638 - 1645.
  • Hollingsworth, J., Cooper, W., Nicolls, K., Wills, E., Thiruvilangam, V., Lee, S. and Scolyer, R. (2011), 'Follicular dendritic cell sarcoma of the lung: a report of two cases highlighting its pathological features and diagnostic pitfalls', Pathology, vol 43, no 1 , pp 67 - 70.
  • Shin, J., Jalaludin, B., Solomon, M., Hong, A. and Lee, S. (2011), 'Histopathological regression grading versus staging of rectal cancer following radiotherapy', Pathology, vol 43, no 1 , pp 24 - 30.
  • Murphy, N., Biankin, A., Millar, E., Mcneil, C., O'Toole, S., Segara, D., Crea, P., Olayioye, M., Lee, S., Fox, S., Morey, A., Christie, M., Musgrove, E., Daly, R., Linderman, G., Henshall, S., Visvader, J. and Sutherland, R. (2010), 'Loss of STARD10 expression identifies a group of poor prognosis breast cancers independent of HER2/Neu and triple negative status', International Journal of Cancer, vol 126, no 6 , pp 1445 - 1453.
  • Hong, A., Dobbins, T., Lee, S., Jones, D., Jackson, E., Clark, J., Armstrong, B., Harnett, G., Milross, C., O'Brien, C. and Rose, B. (2010), 'Relationships between epidermal growth factor receptor expression and human papillomavirus status as markers of prognosis in oropharyngeal cancer', European Journal of Cancer, vol 46, no 11 , pp 2088 - 2096.
  • Huang, K., Dobrovic, A., Yan, M., Karim, R., Lee, S., Lakhani, S. and Fox, S. (2010), 'DNA methylation profiling of phyllodes and fibroadenoma tumours of the breast', Breast Cancer Research and Treatment, vol 124, no 2 , pp 555 - 565.
  • Hong, A., Grulich, A., Jones, D., Lee, S., Garland, S., Dobbins, T., Clark, J., Harnett, G., Milross, C., O'Brien, C. and Rose, B. (2010), 'Squamous cell carcinoma of the oropharynx in Australian males induced by human papillomavirus vaccine targets', Vaccine, vol 28 , pp 3269 - 3272.
  • Karim, R., Gerega, S., Yang, Y., Spillane, A., Carmalt, H., Scolyer, R. and Lee, S. (2010), 'p16 and pRb immunohistochemical expression increases with increasing tumour grade in mammary phyllodes tumours', Histopathology, vol 56, no 7 , pp 868 - 875.
  • Hong, A., Dobbins, T., Lee, S., Jones, D., Harnett, G., Armstrong, B., Clark, J., Milross, C., Kim, J., O'Brien, C. and Rose, B. (2010), 'Human papillomavirus predicts outcomes in oropharyngeal cancer in patients treated with surgery or radiation therapy', British Journal of Cancer, vol 103, no 10 , pp 1510 - 1517.
  • Sharma, S., Shin, J., Grimshaw, M., Clarke, R. and Lee, S. (2010), 'The senescence pathway in prostatic carcinogenesis', Pathology, vol 42, no 6 , pp 507 - 511.
  • Hong, A. and Lee, S. (2010), 'Australian data show increase', British Medical Journal, vol 340 , pp 1048 - 1048.
  • Zardawi, S., Zardawi, I., Mcneil, C., Millar, E., Mcleod, D., Morey, A., Crea, P., Murphy, N., Pinese, M., Lopez-Knowles, E., Oakes, S., Ormandy, C., Qiu, M., Hamilton, A., Spillane, A., Lee, S., Sutherland, R., Musgrove, E. and O'Toole, S. (2010), 'High Notch1 protein expression is an early event in breast cancer development and is associated with the HER-2 molecular subtype', Histopathology, vol 56, no 3 , pp 286 - 296.
  • Lee, S. (2009), 'Pathology: the story so far', Pathology, vol 41, no 2 , pp 101 - 102.
  • Karim, R., Scolyer, R., Tse, G., Tan, P., Putti, T. and Lee, S. (2009), 'Pathogenic mechanisms in the initiation and progression of mammary phyllodes tumour', Pathology, vol 41, no 2 , pp 105 - 117.
  • Yu, D., Ajami, K., Gall, M., Park, J., Lee, S., Evans, K., McLaughlin, E., Pitman, M., Abbott, C., McCaughan, G. and Gorrell, M. (2009), 'The in vivo expression of dipeptidyl peptidases 8 and 9', Journal of Histochemistry & Cytochemistry, vol 57, no 11 , pp 1025 - 1040.
  • Fei, J., Hong, A., Dobbins, T., Jones, D., Lee, S., Loo, C., Al-Ghamdi, M., Harnett, G., Clarke, J., O'Brien, C. and Rose, B. (2009), 'Prognostic significance of vascular endothelial growth factor in squamous cell carcinomas of the tonsil in relation to human papillomavirus status and epidermal growth factor receptor', Annals of Surgical Oncology, vol 16, no 10 , pp 2908 - 2917.
  • Bennett, N., Hooper, J., Lee, S. and Gobe, G. (2009), 'Androgen receptor and caveolin-1 in prostate cancer', IUBMB LIFE, vol 61, no 10 , pp 961 - 970.
  • Karim, R., Gerega, S., Yang, Y., Spillane, A., Carmalt, H., Scolyer, R. and Lee, S. (2009), 'Phyllodes tumours of the breast : a clinicopathological analysis of 65 cases from a single institution', The Breast, vol 18, no 3 , pp 165 - 170.
  • Cooper, W., Kohonen-Corish, M., Mccaughan, B., Kennedy, C., Sutherland, R. and Lee, S. (2009), 'Expression and prognostic significance of cyclin B1 and cyclin A in non-small cell lung cancer', Histopathology, vol 55, no 1 , pp 28 - 36.
  • Karim, R., Gerega, S., Yang, Y., Horvath, L., Spilane, A., Carmalt, H., Scolyer, R. and Lee, S. (2009), 'Proteins from the Wnt pathway are involved in the pathogenesis and progression of mammary phyllodes tumours', Journal of Clinical Pathology, vol 62, no 11 , pp 1016 - 1020.
  • Wong, M., Dobbins, T., Tseung, J., Tran, N., Lee, S., O'Brien, C. and Clark, J. (2009), 'Oestrogen receptor B expression in pleomorphic adenomas of the parotid gland', Journal of Clinical Pathology, vol 62, no 0 , pp 789 - 793.
  • Zhuang, L., Scolyer, R., Lee, S., Mccarthy, S., Cooper, W., Zhang, X., Thompson, J. and Hersey, P. (2009), 'Expression of glucose-regulated stress protein GRP78 is related to progression of melanoma', Histopathology, vol 54, no 4 , pp 462 - 470.
  • Tse, G., Lui, P., Vong, J., Lau, K., Putti, T., Karim, R., Scolyer, R., Lee, S., Yu, A., Ng, D., Tse, A. and Tan, P. (2009), 'Increased epidermal growth factor receptor (EGFR) expression in malignant mammay phyllodes tumors', Breast Cancer Research and Treatment, vol 114 , pp 441 - 448.
  • Biankin, A., Kench, J., Colvin, E., Segara, D., Scarlett, C., Nguyen, N., Chang, D., Morey, A., Lee, S., Pinese, M., Kuo, S., Susanto, J., Cosman, P., Lindemann, G., Visvader, J., Nguyen, T., Merrett, N., Warusavitarne, J., Musgrove, E., Henshall, S. and Sutherland, R. (2009), 'Expression of S100A2 Calcium-Binding Protein Predicts Response to Pancreatectomy for Pancreatic Cancer', Gastroenterology, vol 137, no 2 , pp 558 - 568.
  • Lee, S. (2008), 'Pathology in its fortieth year', Pathology, vol 40, no 1 , pp 1 - 2.
  • Doubrovsky, A., Scolyer, R., Murali, R., Mckenzie, P., Watson, G., Lee, C., McLeod, D., McCarthy, W., Uren, R., Stretch, J., Saw, R. and Thompson, J. (2008), 'Diagnostic Accuracy of Fine Needle Biopsy for Metastatic Melanoma and Its Implications for Patient Management', Annals of Surgical Oncology, vol 15, no 1 , pp 323 - 332.
  • Seng, T., Currey, N., Cooper, W., Lee, C., Chan, C., Horvath, L., Sutherland, R., Kennedy, C., McCaughan, B. and Kohonen-Corish, M. (2008), 'DLEC1 and MLH1 promoter methylation are associated with poor prognosis in non-small cell lung carcinoma', British Journal of Cancer, vol 99 , pp 375 - 382.
  • Murali, R., Sharma, R., Thompson, J., Stretch, J., Lee, S., Mccarthy, S. and Scolyer, R. (2008), 'Sentinel Lymph Node Biopsy in Histologically Ambiguous Melanocytic Tumors With Spitzoid Features (So-Called Atypical Spitzoid Tumors)', Annals of Surgical Oncology, vol 15, no 1 , pp 302 - 309.
  • Cooper, W., Kohonen-Corish, M., Chan, C., Kwun, S., Mccaughan, B., Kennedy, C., Sutherland, R. and Lee, S. (2008), 'Prognostic significance of DNA repair proteins MLH1, MSH2 and MGMT expression in non-small-cell lung cancer and precursor lesions', Histopathology, vol 52, no 5 , pp 613 - 622.
  • Murphy, N., Scarlett, C., Kench, J., Sum, E., Segara, D., Colvin, E., Susanto, J., Cosman, P., Lee, C., Musgrove, E., Sutherland, R., Lindeman, G., Henshall, S., Visvader, J. and Biankin, A. (2008), 'Expression of LMO4 and outcome in pancreatic ductal adenocarcinoma', British Journal of Cancer, vol 98, no 3 , pp 537 - 541.
  • Murphy, N., Scarlett, C., Kench, J., Sum, E., Segara, D., Colvin, E., Susanto, J., Cosman, P., Lee, C., Musgrove, E., Sutherland, R., Lindeman, G., Henshall, S., Visvader, J. and Biankin, A. (2008), 'Expression of LMO4 and outcome in pancreatic ductal adenocarcinoma', British Journal of Cancer, vol 98, no 3 , pp 537 - 541.
  • Cooper, W., Kohonen-Corish, M., Zhuang, L., Mccaughan, B., Kennedy, C., Screaton, G., Sutherland, R. and Lee, S. (2008), 'Role and prognostic significance of tumor necrosis factor-related apoptosis-inducing ligand death receptor DR5 in nonsmall-cell lung cancer and precursor lesions', Cancer, vol 113, no 1 , pp 135 - 142.
  • Zhuang, L., Lee, S., Scolyer, R., Mccarthy, S., Zhang, X., Thompson, J. and Hesey, P. (2007), 'Mcl-1, Bcl-XL and Stat3 expression are associated with progression of melanoma whereas Bcl-2, AP-2 and MITF levels decrease during progression of melanoma', Modern Pathology, vol 20, no 4 , pp 416 - 426.
  • Horvath, L., Lelliott, J., Kench, J., Lee, S., Williams, E., Saunders, D., Grygiel, J. and Sutherland, R. (2007), 'Secreted Frizzled-Related Protein 4 Inhibits Proliferation and Metastatic Potential in Prostate Cancer', The Prostate, vol 67, no 10 , pp 1081 - 1090.
  • Patel, R., Rose, B., Bawdon, H., Hong, A., Lee, S., Fredericks, S., Gao, K. and O'Brien, C. (2007), 'Cyclin D1 and p16 expression in pleomorphic adenoma and carcinoma ex pleomorphic adenoma of the parotid gland', Histopathology, vol 51, no 5 , pp 691 - 696.
  • Murali, R., Doubrovsky, A., Watson, G., Mckenzie, P., Lee, S., Mcleod, D., Uren, R. and Stretch, J. (2007), 'Diagnosis of Metastatic Melanoma by Fine-Needle Biopsy: Analysis of 2,204 Cases', American Journal of Clinical Pathology, vol 127, no 3 , pp 385 - 397.
  • Tse, G., Chaiwun, B., Lau, K., Scolyer, R., Lee, S., Karim, R., Putti, T. and Law, B. (2007), 'Endothelin-1 expression correlates with atypical histological features in mammary phyllodes tumours', Journal of Clinical Pathology, vol 60, no 9 , pp 1051 - 1056.
  • Patel, R., Hughes, C., Fredericks, S., Lee, S., Rose, B., Gao, K., Smith, G. and Hong, A. (2007), 'Cyclin A expression and its diagnostic value in pleomorphic adenoma and carcinoma expleomorphic adenoma of the parotid gland', Histopathology, vol 51, no 1 , pp 21 - 25.
  • Li, W., Tran, N., Lee, S., O'Brien, C., Tse, G., Scolyer, R., Hong, A. and Milross, C. (2007), 'New evidence of geographic variation in the role of human papillomavirus in tonsillar carcinogenesis', Pathology, vol 39, no 2 , pp 217 - 222.
  • Kaufman, A., Storey, D., Lee, S. and Murali, R. (2007), 'Mucinous cyst exhibiting severe dysplasia in gastric heterotophic pancreasw associated with gastrointestinal stromal tumour', World Journal of Gastroenterology, vol 13, no 43 , pp 5781 - 5782.
  • Cooper, C., Joshua, D., Lee, S., Eyers, A. and Cooper, W. (2007), 'Extranodal plasmablastic lymphoma arising in mantle cell lymphoma [6]', Histopathology, vol 51, no 6 , pp 856 - 859.
  • Shin, J., Hong, A., Solomon, M. and Lee, S. (2006), 'The role of telomeres and telomerase in the pathology of human cancer and ageing', Pathology, vol 38, no 2 , pp 103 - 113.
  • Zhuang, L., Lee, S., Scolyer, R., Mccarthy, S., Zhang, X., Thompson, J., Screaton, G. and Hersey, P. (2006), 'Progression in melanoma is associated with decreased expression of death receptors for tumor necrosis factor-related apoptosis-inducing ligand', Human Pathology, vol 37, no 10 , pp 1286 - 1294.
  • Rasiah, K., Kench, J., Gardiner-Garden, M., Biankin, A., Golovsky, D., Brenner, P., Kooner, R. and Lee, S. (2006), 'Aberrant Neuropeptide Y and Macrophage Inhibitory Cytokine-1 Expression Are Early Events in Prostate Cancer Development and Are Associated with Poor Prognosis', Cancer Epidemiol Biomarkers & Prevention, vol 15, no 4 , pp 711 - 716.
  • Ellmark, P., Belov, L., Huang, P., Lee, S., Solomon, M., Morgan, D. and Christopherson, R. (2006), 'Multiplex detection of surface molecules on colorectal cancers', Proteomics, vol 6 , pp 1791 - 1802.
  • Li, W., Sanki, A., Karim, R., Thompson, J., Lee, S., Zhuang, L., Mccarthy, S. and Scolyer, R. (2006), 'The role of cell cycle regulatory proteins in the pathogenesis of melanoma', Pathology, vol 38, no 4 , pp 287 - 301.
  • Seddiki, N., Santner-Nanan, B., Tangye, S., Alexander, S., Solomon, M., Lee, S., Nanan, R. and Fazekas De Saint Groth, B. (2006), 'Persistence of naive CD43RA+regulatory T cells in adult life', Blood, vol 107, no 7 , pp 2830 - 2838.
  • Kirkham, B., Lassere, M., Edmonds, J., Juhasz, K., Bird, P., Lee, S., Shnier, R. and Portek, I. (2006), 'Synovial Membrane Cytokine Expression Is Predictive of Joint Damage Progression in Rheumatoid Arthritis. A Two-Year Prospective Study (the DAMAGE Study Cohort)', Arthritis & Rheumatism, vol 54, no 4 , pp 1122 - 1131.
  • Zhuang, L., Lee, S., Scolyer, R., Mccarthy, S., Palmer, A., Zhang, X., Thompson, J. and Bron, L. (2005), 'Activation of the extracellular signal regulated kinase (ERK) pathway in human melanoma', Journal of Clinical Pathology, vol 58, no 11 , pp 1163 - 1169.
  • Murphy, N., Millar, E. and Lee, S. (2005), 'Gene expression profiling in breast cancer: towards individualising patient management', Pathology, vol 37, no 4 , pp 271 - 277.
  • Lee, S. (2005), 'Breast cancer pathology', Pathology, vol 37, no 5 , pp 339 - 340.
  • Tse, G., Wong, F., Tsang, A., Lee, S., Lui, P., Lo, A., Law, B. and Scolyer, R. (2005), 'Stromal nitric oxide synthase (NOS) expression correlates with the grade of mammary phyllodes tumour', Journal of Clinical Pathology, vol 58, no 6 , pp 600 - 604.
  • Tse, G., Tsang, A., Putti, T., Scolyer, R., Lui, P., Law, B., Karim, R. and Lee, S. (2005), 'Stromal CD10 expression in mammary fibroadenomas and phyllodes tumours', Journal of Clinical Pathology, vol 58, no 2 , pp 185 - 189.
  • Horvath, L., Henshall, S., Lee, S., Kench, J., Golovsky, D., Brenner, P., O'Neill, G., Kooner, R., Stricker, P., Grygiel, J. and Sutherland, R. (2005), 'Lower levels of Nuclear Beta-Catenin Predict for a Poorer Prognosis in Localized Prostate Cancer', Internal Journal of Cancer, vol 113 , pp 415 - 422.
  • Clarke, R., Fang, Z., Lee, S., Sarris, M., Murrell, D. and Kearsley, J. (2002), 'Multiple sclerosis in a radiosensitive family with low levels of the ATM protein', Australasian Radiology, vol 46, no 3 , pp 267 - 274.
  • Ren, Z., Pang, G., Clancy, R., Li, L., Lee, S., Batey, R., Borody, T. and Dunkley, M. (2001), 'Shift of the gastric T-cell response in gastric carcinoma', Journal of Gastroenterology and Hepatology, vol 16, no 2 , pp 142 - 148.

Conference Papers

  • Ng, W., Shin, J., Wang, B. and Lee, S. (2016), 'Overexpression of Polo-like kinase 1 (PLK1) in colorectal cancer (CRC) is independent of gene mutation and epigenetic alteration', Australasian Division of the International Academy of Pathology. Annual Scientific Meeting, Brisbane, Qld..
  • Ng, W., Shin, J., Yang, T., Roberts, T., Wang, B., Begg, J. and Lee, S. (2016), 'Inhibition of polo-like kinase 1 (PLK1) additively improves the outcome of ionising irradiation (IR) in colorectal cancer (CRC)', Australasian Division of the International Academy of Pathology. Annual Scientific Meeting, Brisbane, Qld..
  • Lim, S., Lee, S., Shin, J., Chua, W., Ng, W., Solomon, M. and Cheng, C. (2013), 'Tumour infiltrating lymphocytes as a predictive and prognostic biomarker in rectal cancers treated with neoadjuvant chemoradiotherapy', Medical Oncology Group of Australia Incorporated. Annual Scientific Meeting, Melbourne, Vic..
  • Shin, J., Zhou, J., Belov, L., Zhang, M., Hong, A., Solomon, M., Christopherson, R. and Lee, S. (2009), 'Comparison of Radiosensitivity and Cell Membrane Proteome between Microsatellite stable and unstable colorectal cancers - an In Vitro study with A 122 antibody microarray', RCPA Pathology Update, Sydney.

Previous Projects

Title: Translational Cancer Research Clinical Fellowship [via Ingham Institute]
Funder:
  • Cancer Institute NSW
Western Researchers: Soon Lee
Years: 2013-02-01 - 2014-06-30
ID: P00021286
Title: Optimising molecular profiling for prostate cancer detection and diagnosis
Funder:
  • University of Western Sydney
Western Researchers: Raymond Clarke and Soon Lee
Years: 2012-11-15 - 2014-09-30
ID: P00021212
Title: Clinical significance of molecular alterations in thyroid cancers
Funder:
  • Covidien Pty Limited
Western Researchers: Navin Niles, Faryal Zehra, Tao Yang and Soon Lee
Years: 2015-08-24 - 2017-08-24
ID: P00023034
Title: Evaluation of Chinese herbal medicine in preventing prostate cancer progression in patients under active surveillance
Funder:
  • University of Western Sydney
  • Actel Medicine International Pty Ltd
Western Researchers: Qihan Dong, Paul De Souza, Soon Lee and Alan Bensoussan
Years: 2016-03-29 - 2017-03-28
ID: P00022994
Title: Cancer and Inflammation
Funder:
  • Centre for Oncology Education & Research Translation (Cancer Institute NSW)
Western Researchers: Tara Roberts and Soon Lee
Years: 2019-07-01 - 2020-06-30
ID: P00025841
Title: Cell and Protein Analysis Unit
Funder:
  • University of Western Sydney
Western Researchers: Simon Myers, Jens Coorssen, Sabine Piller, Annemarie Hennessy, Janice Aldrich-Wright, Soon Lee and Gerald Muench
Years: 2009-09-22 - 2010-09-21
ID: P00017371
Title: Analysis for differentially expressed proteins in radiation sensitive and resistant rectal cancer cells [via SSWAHS]
Funder:
  • Cancer Institute NSW
Western Researchers: Soon Lee
Years: 2010-01-01 - 2011-12-31
ID: P00017457
Title: International Efforts in Translational Medicine
Funder:
  • University of Western Sydney
Western Researchers: Jens Coorssen, Annemarie Hennessy, Bradley Frankum, Gerald Muench, Lind, Simon Myers and Soon Lee
Years: 2009-10-28 - 2010-10-27
ID: P00017596
Title: Brm and Brg-1 protect from ultraviolet radiation-induced skin and ocular damage [via USYD]
Funder:
  • National Health and Medical Research Council (ACRG)
Western Researchers: Soon Lee
Years: 2010-01-01 - 2013-12-31
ID: P00017780
Title: Breast Cancer Tissue Bank - data collection and management infrastructure [via USYD]
Funder:
  • Cancer Institute NSW
Western Researchers: Soon Lee
Years: 2009-07-01 - 2012-06-30
ID: P00017458
Title: PALM Microbeam Laser Microdissection (LM) Microscope for the Multi-User Sydney Cancer Gene Expression Facility [via Bosch Institute, USYD]
Funder:
  • Cancer Institute NSW
Western Researchers: Soon Lee
Years: 2009-07-01 - 2012-06-30
ID: P00017459
Title: Evaluation of antibody targeted a-therapy for prostate cancer in a new mouse model
Funder:
  • University of Western Sydney
Western Researchers: Raymond Clarke and Soon Lee
Years: 2010-11-30 - 2012-02-29
ID: P00019600
Title: Optimised Pharmacological Targeting of Novel Thlosemicarbazones for Advanced and REsistant Breast Cancer (via USyd)
Funder:
  • National Breast Cancer Foundation (ACGR)
Western Researchers: Soon Lee
Years: 2019-01-01 - 2020-12-31
ID: P00025463
Title: Investigation of biomarkers for the diagnosis and prognosis of common cancers in the community such as breast, colorectal, prostate and head and neck cancers
Funder:
  • Cancer Institute NSW
Western Researchers: Soon Lee and Yi Qiu Sun
Years: 2011-01-01 - 2012-12-31
ID: P00018651
Title: Modulating cholesterol-dependent lipid rafts and caveolin in prostate cancer therapy [via University of Qld]
Funder:
  • Association for International Cancer Research
Western Researchers: Soon Lee
Years: 2010-10-01 - 2013-09-30
ID: P00018511
Title: Management of asymptomatic primary tumours in stage IV colocrectal cancer
Funder:
  • South Western Sydney Local Health District
Western Researchers: Soon Lee
Years: 2019-01-01 - 2021-01-31
ID: P00025786
Title: Centre for Oncology Education and Research Translation (CONCERT) [via UNSW]
Funder:
  • University of Western Sydney
  • Cancer Institute NSW
  • Cancer Institute NSW
  • University of Western Sydney
  • South Western Sydney Local Health District
Western Researchers: Paul De Souza, Soon Lee and Les Bokey
Years: 2014-06-06 - 2022-12-31
ID: P00021956
Title: Improving treatment options for rare breast cancers - identifying therapeutic targets in malignant phyllodes tumours [via The Garvan Institute of Medical Research]
Funder:
  • National Breast Cancer Foundation (ACGR)
Western Researchers: Soon Lee
Years: 2019-01-01 - 2020-12-31
ID: P00025462
Title: Identification of the specific structure-activity relationships of thiosemicarbazones to overcome multidrug resistance by exploiting lysosomal drug pumps in breast cancer [via USYD]
Funder:
  • National Breast Cancer Foundation (non ACRG)
Western Researchers: Soon Lee
Years: 2016-01-01 - 2017-12-31
ID: P00023137
Title: Molecular Cancer Pathology Scholarship [via Ingham Institute for Applied Medical Research]
Funder:
  • Cancer Institute NSW
Western Researchers: Soon Lee
Years: 2011-10-17 - 2016-03-05
ID: P00020992
Title: South West Sydney Translational Cancer Research Unit [via Ingham Institute for Applied Medical Research]
Funder:
  • Cancer Institute NSW
Western Researchers: Paul De Souza, Soon Lee and Les Bokey
Years: 2012-02-27 - 2013-02-26
ID: P00020939

Supervision

Professor Lee is available to be a principal supervisor for doctoral projects

Current Supervision

Thesis Title: Regulation of Gene Expression in Progression of Prostate Cancer to Help Improve Understanding of Early Detection, Improved Prognosis and Targeted Therapy
Field of Research:
Thesis Title: Morphological Assessment of Biomarkers of Cellular Senescence in the Prognostication of Colorectal Cancer.
Field of Research:
Thesis Title: Differential Expressions of Markers of Cellular Senescence in the Assessment of Breast Cancer Development
Field of Research:
Thesis Title: Morphological Analysis of Differentially Expressed Biomarkers that are Predictive of Vascular Invasion and Lever Metastases in Colonic Carcinoma Using Tissue Microarrays.
Field of Research:
Thesis Title: Differential Expressions of Cellular Senescence Markers in the Assessment of Breast Cancer Development
Field of Research: Mathematical Sciences, N.e.c.; Other Health; Health
Thesis Title: Adenocaricinoma of the Prostate: Morphological, Immunocytochemical and Ultrastructural
Field of Research:
Thesis Title: Biomarkers of Radiation Sensitivity in Rectal Cancer
Field of Research:
Thesis Title: Differential Expression of Markers of Cellular Senescence in the Assessment of Prognosis in Prostate Carcinomas
Field of Research:

Previous Supervision

Thesis Title: The Development of Computer Processes that Aid in Streamlining Tumour Bank Workflow
Field of Research: Medical Studies, N.e.c.
Thesis Title: Molecular Interactions of Polo-Like Kinase 1 (PLK1) in Colorectal Cancer
Field of Research: Medical Science; Other Health; Biochemistry And Cell Biology

Western Sydney University

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