Doctor Graham Jones

Doctor Graham Jones

DAP - BMedSc & BMedSc, Adv,
Medical Science

Associate Dean, Learning and Teaching,
Dean's Unit, School of Science

Snr Lecturer - Human Molecular Bio,
Medical Sciences

Biography

Qualifications

  • PhDS University of Sydney
  • BSc University of Sydney

Organisational Unit (School / Division)

  • Medical Science
  • Dean's Unit, School of Science
  • Medical Sciences

Contact

Email: graham.jones@westernsydney.edu.au
Phone: (02) 9685 9988
Mobile:
Location: EHA.1.06
Parramatta

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Teaching

Previous Teaching Areas

  • 300547 Human Genetics, 2012
  • 300549 Human Molecular Biology, 2012

Publications

Journal Articles

  • Demenais, F., Margaritte-Jeannin, P., Barnes, K., Cookson, W., Altmuller, J., Ang, W., Barr, R., Beaty, T., Becker, A., Beilby, J., Bisgaard, H., Bjornsdottir, U., Bleecker, E., Bonnelykke, K., Boomsma, D., Bouzigon, E., Brightling, C., Brossard, M., Brusselle, G., Burchard, E., Burkart, K., Bush, A., Chan-Yeung, M., Chung, K., Couto Alves, A., Curtin, J., Custovic, A., Daley, D., De Jongste, J., Del-Rio-Navarro, B., Donohue, K., Duijts, L., Eng, C., Eriksson, J., Farrall, M., Fedorova, Y., Feenstra, B., Ferreira, M., Freidin, M., Gajdos, Z., Gauderman, J., Gehring, U., Geller, F., Genuneit, J., Gharib, S., Gilliland, F., Granell, R., Graves, P., Gudbjartsson, D., Haahtela, T., Heckbert, S., Heederik, D., Heinrich, J., Heliovaara, M., Henderson, J., Himes, B., Hirose, H., Hirschhorn, J., Hofman, A., Holt, P., Hottenga, J., Hudson, T., Hui, J., Imboden, M., Ivanov, V., Jaddoe, V., James, A., Janson, C., Jarvelin, M., Jarvis, D., Jones, G., Jonsdottir, I., Jousilahti, P., Kabesch, M., Kahonen, M., Kantor, D., Karunas, A., Khusnutdinova, E., Koppelman, G., Kozyrskyj, A., Kreiner, E., Kubo, M., Kumar, R., Kumar, A., Kuokkanen, M., Lahousse, L., Laitinen, T., Laprise, C., Lathrop, M., Lau, S., Lee, Y., Lehtimaki, T., Letort, S., Levin, A., Li, G., Liang, L., Loehr, L., London, S., Loth, D., Manichaikul, A., Marenholz, I., Martinez, F., Matheson, M., Mathias, R., Matsumoto, K., Mbarek, H., McArdle, W., Melbye, M., Melen, E., Meyers, D., Michel, S., Mohamdi, H., Musk, A., Myers, R., Nieuwenhuis, M., Noguchi, E., O'Connor, G., Ogorodova, L., Palmer, C., Palotie, A., Park, J., Pennell, C., Pershagen, G., Polonikov, A., Postma, D., Probst-Hensch, N., Puzyrev, V., Raby, B., Raitakari, O., Ramasamy, A., Rich, S., Robertson, C., Romieu, I., Salam, M., Salomaa, V., Schlunssen, V., Scott, R., Selivanova, P., Sigsgaard, T., Simpson, A., Siroux, V., Smith, L., Solodilova, M., Standl, M., Stefansson, K., Strachan, D., Stricker, B., Takahashi, A., Thompson, P., Thorleifsson, G., Thorsteinsdottir, U., Tiesler, C., Torgerson, D., Tsunoda, T., Uitterlinden, A., Van der Valk, R., Vaysse, A., Vedantam, S., Von Berg, A., Von Mutius, E., Vonk, J., Waage, J., Wareham, N., Weiss, S., White, W., Wickman, M., Widen, E., Willemsen, G., Williams, L., Wouters, I., Yang, J., Zhao, J., Moffatt, M., Ober, C. and Nicolae, D. (2018), 'Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks', Nature Genetics, vol 50, no 1 , pp 42 - 53.
  • Garden, F., Toelle, B., Mihrshahi, S., Webb, K., Almqvist, C., Tovey, E., Brew, B., Ayer, J., Skilton, M., Jones, G., Ferreira, M., Cowie, C., Weber-Chrysochoou, C., Britton, W., Celermajer, D., Leeder, S., Peat, J. and Marks, G. (2018), 'Cohort profile : the Childhood Asthma Prevention Study (CAPS)', International Journal of Epidemiology, vol 47, no 6 , pp 1736 - 1736.
  • Skilton, M., Nakhla, S., Ayer, J., Harmer, J., Toelle, B., Leeder, S., Jones, G., Marks, G. and Celermajer, D. (2016), 'Telomere length in early childhood : early life risk factors and association with carotid intima-media thickness in later childhood', European Journal of Preventive Cardiology, vol 23, no 10 , pp 1086 - 1092.
  • Muscat, P., Mercado, K., Payne, K., Chahal, H. and Jones, G. (2015), 'PHF11 expression and cellular distribution is regulated by the toll-like receptor 3 ligand polyinosinic : polycytidylic acid in HaCaT keratinocytes', BMC Immunology, vol 16 .
  • Bonnelykke, K., Matheson, M., Pers, T., Granell, R., Strachan, D., Alves, A., Linneberg, A., Curtin, J., Warrington, N., Standl, M., Kerkhof, M., Jonsdottir, I., Bukvic, B., Kaakinen, M., Sleimann, P., Thorleifsson, G., Thorsteinsdottir, U., Schramm, K., Baltic, S., Kreiner-M?ller, E., Simpson, A., St Pourcain, B., Coin, L., Hui, J., Walters, E., Tiesler, C., Duffy, D., Jones, G., Ring, S., McArdle, W., Price, L., Robertson, C., Pekkanen, J., Tang, C., Thiering, E., Montgomery, G., Hartikainen, A., Dharmage, S., Husemoen, L., Herder, C., Kemp, J., Elliot, P., James, A., Waldenberger, M., Abramson, M., Fairfax, B., Knight, J., Gupta, R., Thompson, P., Holt, P., Sly, P., Hirschhorn, J., Blekic, M., Weidinger, S., Hakonarsson, H., Stefansson, K., Heinrich, J., Postma, D., Custovic, A., Pennell, C., Jarvelin, M., Koppelman, G., Timpson, N., Ferreira, M., Bisgaard, H. and Henderson, A. (2013), 'Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization', Nature Genetics, vol 45, no 8 , pp 902 - 906.
  • Ferreira, M., Matheson, M., Duffy, D., Marks, G., Hui, J., Souef, P., Danoy, P., Baltic, S., Nyholt, D., Jenkins, M., Hayden, C., Willemsen, G., Ang, W., Kuojjanen, M., Beilby, J., Cheah, F., de Geus, E., Ramasamy, A., Vedantam, S., Salomaa, V., Madden, P., Heath, A., Hopper, J., Visscher, P., Musk, B., Leeder, S., Jarvelin, M., Pennell, C., Boomsma, D., Hirschhorn, J., Walters, H., Martin, N., James, A., Jones, G., Abramson, M., Robertson, C., Dharmage, S., Brown, M., Montgomery, G. and Thompson, P. (2011), 'Identification of IL6R and chromosome 11q13.5 as risk loci for asthma', The Lancet, vol 378, no 9795 , pp 1006 - 1014.
  • Ferreira, M., Matheson, M., Duffy, D., Marks, G., Hui, J., Souef, P., Danoy, P., Baltic, S., Nyholt, D., Jenkins, M., Hayden, C., Willemsen, G., Ang, W., Kuojjanen, M., Beilby, J., Cheah, F., de Geus, E., Ramasamy, A., Vedantam, S., Salomaa, V., Madden, P., Heath, A., Hopper, J., Visscher, P., Musk, B., Leeder, S., Jarvelin, M., Pennell, C., Boomsma, D., Hirschhorn, J., Walters, H., Martin, N., James, A., Jones, G., Abramson, M., Robertson, C., Dharmage, S., Brown, M., Montgomery, G. and Thompson, P. (2011), 'Identification of IL6R and chromosome 11q13.5 as risk loci for asthma', The Lancet, vol 378, no 9795 , pp 1006 - 1014.
  • Rahman, N., Stewart, G. and Jones, G. (2010), 'A role for the atopyassociated gene PHF11 in Tcell activation and viability', Immunology and Cell Biology, vol 88 , pp 817 - 824.
  • Jones, G. and Stewart, G. (2010), 'Association of PHF11 polymorphisms with asthma and allergy', Thorax, vol 65, no 7 , pp 659 - 660.
  • Boulay, J., Ionescu, M., Sivasankaran, B., Labuhn, M., Dolder-Schlienger, B., Taylor, E., Morin, P., Hemmings, B., Lino, M., Jones, G., Maier, D. and Merlo, A. (2009), 'The 10q25.3-26.1 G protein-coupled receptor geneGPR26 is epigenetically silenced in human gliomas', International Journal of Oncology, vol 35, no 5 , pp 1123 - 1131.
  • Clarke, E., Rahman, N., Page, N., Rolph, M., Stewart, G. and Jones, G. (2008), 'Functional characterization of the atopy-associated gene PHF11', Journal of Allergy and Clinical Immunology, vol 121, no 5 , pp 1148 - 1154000.
  • Jones, G. (2007), 'Susceptibility to asthma and eczema from mucosal and epidermal expression of distinctive genes', Current Allergy and Asthma Reports, vol 7, no 1 , pp 11 - 17.
  • Page, N., Jones, G. and Stewart, G. (2006), 'Genetic association studies between the T cell immunoglobulin mucin (TIM) gene locus and childhood atopic dermatitis', International Archives of Allergy and Immunology, vol 141, no 4 , pp 331 - 336.
  • Berglund, L., Jones, G., Murali, R. and Fulcher, D. (2006), 'TACI mutation with invasive polyclonal CD8+ T-cell lymphoproliferation in a patient with common variable immunodeficiency', Journal of Allergy and Clinical Immunology, vol 117, no 4 , pp 870 - 877.
  • Jones, G., Wu, S., Jang, N., Hogan, P., Fulcher, D. and Stewart, G. (2006), 'Polymorphisms within the CTLA-4 gene are associated with infant atopic dermatitis', British Journal of Dermatology, vol 154, no 3 , pp 467 - 671.
  • Jang, N., Stewart, G. and Jones, G. (2005), 'Polymorphisms within the PHF11 gene at chromosome 13q14 are associated with childhood atopic dermatitis', Biochemical and Biophysical Research Communications, vol 6, no 3 , pp 262 - 264.
  • Jones, G. and Stewart, G. (2004), 'Nuclear import of N-terminal FAK by activation of the FceRI receptor in RBL-2H3 cells', Biochemical and Biophysical Research Communications, vol 314, no 1 , pp 39 - 45.
  • Jones, G., Machado, J., Tolnay, M. and Merlo, A. (2001), 'PTEN-independent induction of caspase-mediated cell death and reduced invasion by the focal adhesion targeting domain (FAT) in human astrocytic brain tumors which highly express focal adhesion kinase (FAK)', Cancer Research, vol 61, no 15 , pp 5688 - 5691.
  • Jones, G., Machado, J. and Merlo, A. (2001), 'Loss of FAK inhibits EGFR-dependant migration and induces aggregation of N-terminal FAK in the nuclei of apoptotic glioblastoma cells', Cancer Research, vol 61, no 13 , pp 4978 - 4981.
  • Labuhn, M., Jones, G., Speel, E., Maier, D., Zweifel, C., Gratzl, O., Van Meir, E., Hegi, M. and Merlo, A. (2001), 'Quantitative real-time PCR does not show selective targeting of p14ARF but concomitant inactivation of both p16INK4A and p14ARF in 105 human primary gliomas', Oncogene, vol 20, no 9 , pp 1103 - 1109.

Our laboratory is interested in understanding the biological significance of genetic variants that have been identified as being asociated with allergic eczema (atopic dermatitis) and asthma. Until recently, the immune system was the focus of research into the genetic basis of allergic diseases. However, recent work has now shown that genetic variants can also affect the development and integrity of the epidermal barrier. The epidermal barrier is the impermeable outer layer of skin that prevents water loss and protects the body against invasion from infectious agents and environmental irritants. We have has a long-standing interest in identifying genetic variants that modulate the activation of gene expression. We are currently using an in vitro model of keratinocyte growth and differentiation to understand the regulation and function of several genes identified in genetic asociation studies of allergic disease that we believe play an important role in epidermal barrier homeostasis.

This information has been contributed by Doctor Jones.

Previous Projects

Title: Predicting susceptibility to Invasive Aspergillosis through the characterisation of the immune regulatory response of monocytes during iteraction with the fungus Aspergillus fumigatus.
Funder:
  • University of Western Sydney
Western Researchers: Oliver Morton and Graham Jones
Years: 2013-12-09 - 2015-06-30
ID: P00021837
Title: Tritrichomonas foetus - Epithelial Interactions: dissecting the Roles of Attachment, Cytotoxicity and Host Factors in the Infection Process.
Funder:
  • University of Western Sydney
Western Researchers: Colin Stack, Jens Coorssen and Graham Jones
Years: 2012-11-15 - 2013-12-15
ID: P00021251

Western Sydney University

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