Doctor Gang Zheng

Doctor Gang Zheng

Senior Lecturer,
Science

Biography

Dr Gang Zheng started his scientific research career in 2003 while pursuing a MEng degree at HUST (China). His early research interests focused on the development of novel QSPR and QSAR models for predicting the chemical and biological properties of persistent organic pollutants (POPs) by utilising artificial neural networks (ANNs). In 2005, he moved to Sydney to pursue a PhD in nuclear magnetic resonance (NMR) on an IPRS scholarship under the supervision of Prof. William S. Price. He finished his PhD study in three years with four high quality journal publications that have already received more than 120 citations in total. After working as postdoctoral fellow in Price’s group for one and half years, he secured a research lecturer position at Western Sydney University in 2010. Since then, his research has been focusing on the development of novel diffusion NMR techniques and their applications in environmental and food sciences. Recently, he has also developed research interests in the study of proton exchange by NMR saturation transfer. A study on thiol-water proton exchange led by Mr Johnny Chen (Gang’s PhD student) has given birth to some exciting findings, indicating the potential application of a commonly used pharmaceutical drug, n-acetylcysteine (NAC), to the generation of magnetic resonance imaging (MRI) contrast. Up to 2020, Dr Zheng has generated 40 journal papers, 4 book chapters, 2 patent cooperation treaty (PCT) publications, and holds an h-index of 13 (Scopus).

This information has been contributed by Doctor Zheng.

Qualifications

  • PhD University of Western Sydney

Professional Memberships

  • ANZMAG (2009)

Interests

  • Chemometrics
  • Environmental Chemistry
  • Food Chemistry
  • Nuclear Magnetic Resonance - NMR
  • Pulsed Gradient Spin-Echo NMR
  • QSAR
  • Self-diffusion

Organisational Unit (School / Division)

  • Science

Contact

Email: G.Zheng@westernsydney.edu.au
Phone: (02) 4620 3729
Mobile:
Location: 21.1.25
Campbelltown

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Teaching

Current Teaching Areas

  • 300803 Essential Chemistry 2
  • 300849 Physical Chemistry
  • 300912 Molecular Pharmacokinetics

Publications

Chapters in Books

  • Willis, S., Stait-Gardner, T., Torres, A., Zheng, G. and Price, W. (2018), 'NMR versatility', Diffusive Spreading in Nature, Technology and Society, Springer 9783319677972.
  • Willis, S., Stait-Gardner, T., Virk, A., Masuda, R., Zubkov, M., Zheng, G. and Price, W. (2014), 'Diffusion : definition, description and measurement', Modern NMR Techniques for Synthetic Chemistry, CRC Press 9781466592247.
  • Zheng, G. and Price, W. (2013), 'Environmental NMR : diffusion ordered spectroscopy methods', eMagRes, Wiley & Sons 9780470034590.
  • Zheng, G., Krause-Heuer, A. and Price, W. (2011), 'Pulsed Gradient Spin-Echo NMR', Metallointercalators: Synthesis and Techniques to Probe Their Interactions with Biomolecules, Springer 9783211094273.

Journal Articles

  • Kochubei, A., Zhang, Y., Wang, Z., Price, W., Zheng, G. and Huang, J. (2020), 'Structural changes in copper based metal-organic framework catalyst induced by organic solvents', Catalysis Today, vol 351 , pp 2 - 5.
  • Chen, J., Yadav, N., Stait-Gardner, T., Gupta, A., Price, W. and Zheng, G. (2020), 'Thiol-water proton exchange of glutathione, cysteine, and N-acetylcysteine : implications for CEST MRI', NMR in Biomedicine, vol 33, no 1 .
  • Chen, J., Torres, A., Zheng, G. and Price, W. (2020), 'Applications of WaterControl to TOCSY and COSY experiments', Journal of Biomolecular NMR, vol 74 , pp 333 - 340.
  • Wijesekera, N., Stait-Gardner, T., Gupta, A., Chen, J., Zheng, G., Torres, A. and Price, W. (2019), 'A complete derivation of the Karger equations for analyzing NMR diffusion measurements of exchanging systems', Concepts in Magnetic Resonance. Part A, vol 47A, no 2 .
  • Wijesekera, N., Willis, S., Gupta, A., Torres, A., Zheng, G. and Price, W. (2018), 'NMR diffusion and relaxation studies of 2-nitroimidazole and albumin interactions', Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, vol 193 , pp 318 - 323.
  • Brenner, T., Chen, J., Stait-Gardner, T., Zheng, G., Matsukawa, S. and Price, W. (2018), 'Jump-and-return sandwiches : a new family of binomial-like selective inversion sequences with improved performance', Journal of Magnetic Resonance, vol 288 , pp 100 - 108.
  • Stait-Gardner, T., Torres, A., Zubkov, M., Willis, S., Zheng, G. and Price, W. (2018), 'Diffusion NMR : a tool to investigate the dynamics of organic systems', Current Organic Chemistry, vol 22, no 8 , pp 758 - 768.
  • Willis, S., Zheng, G., Torres, A., Stait-Gardner, T. and Price, W. (2018), 'A simple and effective binomial block based pulse sequence capable of suppressing multiple NMR signals', Journal of Physical Chemistry A, vol 122, no 50 , pp 9712 - 9720.
  • Suresh, H., Low, M., Jarouche, M., Zheng, G., Zhang, L., Lee, S., Pearson, J., Power, D., Singh, S., Li, C. and Khoo, C. (2018), 'The chemical and pharmacological variability of key bio-actives present in commercially available Angelica sinensis, Glycyrrhiza uralensis and Rhodiola rosea samples', Pharmaceutica Analytica Acta, vol 9, no 10 .
  • Masuda, R., Gupta, A., Stait-Gardner, T., Zheng, G., Torres, A. and Price, W. (2018), 'Shortening NMR experimental times', Magnetic Resonance in Chemistry, vol 56, no 9 , pp 847 - 851.
  • Zheng, G., Torres, A. and Price, W. (2017), 'WaterControl : self-diffusion based solvent signal suppression enhanced by selective inversion', Magnetic Resonance in Chemistry, vol 55, no 5 , pp 447 - 451.
  • Chen, J., Zheng, G. and Price, W. (2017), 'A new phase modulated binomial-like selective-inversion sequence for solvent signal suppression in NMR', Magnetic Resonance in Chemistry, vol 55, no 2 , pp 115 - 119.
  • Torres, A., Zheng, G. and Price, W. (2017), 'NOESY-watercontrol : a new NOESY sequence for the observation of under-water protein resonances', Journal of Biomolecular NMR, vol 67, no 3 , pp 233 - 241.
  • Willis, S., Dennis, G., Stait-Gardner, T., Zheng, G. and Price, W. (2017), 'Determining a 'diffusion-averaged' characteristic ratio for aligned lyotropic hexagonal phases using PGSE NMR self-diffusion measurements, random walk simulations and obstruction models', Journal of Molecular Liquids, vol 236 , pp 107 - 116.
  • Zubkov, M., Dennis, G., Stait-Gardner, T., Torres, A., Willis, S., Zheng, G. and Price, W. (2017), 'Physical characterization using diffusion NMR spectroscopy', Magnetic Resonance in Chemistry, vol 55, no 5 , pp 414 - 424.
  • Ganbold, B., Zheng, G., Willis, S., Dennis, G. and Price, W. (2015), 'The transport and conductivity properties of the ionic liquid EMIMTCM', Journal of Molecular Liquids, vol 201 , pp 96 - 101.
  • Aryal, A., Sathasivan, A., Heitz, A., Zheng, G., Nikraz, H. and Ginige, M. (2015), 'Combined BAC and MIEX pre-treatment of secondary wastewater effluent to reduce fouling of nanofiltration membranes', Water Research, vol 70 , pp 214 - 223.
  • Macias, F., Deo, K., Pages, B., Wormell, P., Clegg, J., Zhang, Y., Li, F., Zheng, G., Sakoff, J., Gilbert, J. and Aldrich-Wright, J. (2015), 'Synthesis and analysis of the structure, diffusion and cytotoxicity of heterocyclic platinum(IV) complexes', Chemistry: A European Journal, vol 21, no 47 , pp 16990 - 17001.
  • Codling, D., Zheng, G., Stait-Gardner, T. and Price, W. (2014), 'Diffusion studies of phenylenediamine isomers in water-monohydric-alcohol systems', Australian Journal of Chemistry, vol 67, no 6 , pp 922 - 928.
  • Codling, D., Zheng, G., Stait-Gardner, T. and Price, W. (2014), 'Probing solute-solvent interactions using difluorobenzene isomers in water-monohydric-alcohol mixtures', Journal of Molecular Liquids, vol 198 , pp 392 - 397.
  • Willis, S., Dennis, G., Zheng, G. and Price, W. (2013), 'Preparation and physical properties of a macroscopically aligned lyotropic hexagonal phase templated hydrogel', Reactive and Functional Polymers, vol 73, no 7 , pp 911 - 922.
  • Codling, D., Zheng, G., Stait-Gardner, T., Yang, S., Nilsson, M. and Price, W. (2013), 'Diffusion studies of dihydroxybenzene isomers in water-alcohol systems', Journal of Physical Chemistry B, vol 117, no 9 , pp 2734 - 2741.
  • Zheng, G. and Price, W. (2012), 'Direct hydrodynamic radius measurement on dissolved organic matter in natural waters using diffusion NMR', Environmental Science and Technology, vol 46, no 3 , pp 1675 - 1680.
  • Willis, S., Price, W., Eriksson-Scott, K., Zheng, G. and Dennis, G. (2012), 'Influence of polymer architecture on the averaging effects in PGSE NMR attenuations for bimodal solutions of linear and star poly(vinyl acetates)', Journal of Molecular Liquids, vol 167 , pp 110 - 114.
  • Zheng, G., Torres, A., Ali, M., Manolios, N. and Price, W. (2011), 'NMR study of the structure and self-association of core peptide in aqueous solution and DPC micelles', Biopolymers (Pept. Sci.), vol 96, no 2 , pp 177 - 180.
  • Torres, A., Zheng, G. and Price, W. (2010), 'J-compensated PGSE: an improved NMR diffusion experiment with fewer phase distortions', Magnetic Resonance in Chemistry, vol 48, no 2 , pp 129 - 133.
  • Zheng, G. and Price, W. (2010), 'Solvent signal suppression in NMR', Progress in Nuclear Magnetic Resonance Spectroscopy, vol 56, no 3 , pp 267 - 288.
  • Price, W., Stait-Gardner, T., Torres, A. and Zheng, G. (2010), 'Developments in NMR diffusion measurements and q-space imaging', Chinese Journal of Magnetic Resonance, vol 27, no 3 , pp 267 - 288.
  • Willis, S., Dennis, G., Zheng, G. and Price, W. (2010), 'Averaging effects in PGSE NMR attenuations observed in bimodal molecular weight PMMA solutions', Macromolecules, vol 43, no 17 , pp 7351 - 7356.
  • Willis, S., Dennis, G., Zheng, G. and Price, W. (2010), 'Hydrodynamic size and scaling relations for linear and 4 arm star PVAc studied using PGSE NMR', Journal of Molecular Liquids, vol 156, no 1 , pp 45 - 51.
  • Zheng, G., Torres, A. and Price, W. (2009), 'MQ-PGSTE: a new multi-quantum STE-based PGSE NMR sequence', Journal of Magnetic Resonance, vol 198, no 2 , pp 271 - 274.
  • Zheng, G. and Price, W. (2009), 'Simultaneous convection compensation and solvent suppression in biomolecular NMR diffusion experiments', Journal of Biomolecular NMR, vol 45, no 3 , pp 295 - 299.
  • Stait-Gardner, T., Willis, S., Yadav, N., Zheng, G. and Price, W. (2009), 'NMR Diffusion Measurements of Complex Systems', Diffusion Fundamentals, vol 15 , pp 1 - 22.
  • Zheng, G., Stait-Gardner, T., Payyadi Govardhan, A., Torres, A. and Price, W. (2008), 'PGSTE-WATERGATE : An STE-based PGSE NMR sequence with excellent solvent suppression', Journal of Magnetic Resonance, vol 191, no 1 , pp 159 - 163.
  • Zheng, G., Torres, A. and Price, W. (2008), 'Solvent suppression using phase-modulated binomial-like sequences and applications to diffusion measurements', Journal of Magnetic Resonance, vol 194, no 1 , pp 108 - 114.
  • Zheng, G. and Price, W. (2008), 'MAG-PGSTE : A new STE-based PGSE NMR sequence for the determination of diffusion in magnetically inhomogeneous samples', Journal of Magnetic Resonance, vol 195, no 1 , pp 40 - 44.
  • Zheng, G. and Price, W. (2007), 'Suppression of background gradients in (B0 gradient-based) NMR diffusion experiments', Concepts in Magnetic Resonance Part A, vol 30, no 5 , pp 261 - 277.
  • Zheng, G., Xiao, M. and Lu, X. (2007), 'Quantitative structure - activity relationships study on the Ah receptor binding affinities of polybrominated diphenyl ethers using a support vector machine', QSAR & Combinatorial Science, vol 26, no 4 , pp 536 - 541.
  • Xiao, M., Zheng, G., Yu, T. and Lu, X. (2007), 'Structure and activity relationship studies on toxicity of polychlorinated naphthalene using support vector machines', Fenxi Kexue Xuebao, vol 23 , pp 143 - 147.
  • Ai, Z., Zheng, G., Yang, P. and Lu, X. (2006), 'QSPR study on microwave-assisted photocatalytic degradation of chlorophenols', Fenxi Kexue Xuebao, vol 22 , pp 570 - 572.
  • Yuan, S., Xiao, M., Zheng, G., Tian, M. and Lu, X. (2006), 'Quantitative structure-property relationship studies on electrochemical degradation of substituted phenols using a support vector machine', SAR and QSAR in Environmental Research, vol 17, no 5 , pp 473 - 481.
  • Zheng, G., Xiao, M. and Lu, X. (2005), 'QSAR study on the Ah receptor-binding affinities of polyhalogenated dibenzo-p-dioxins using net atomic-charge descriptors and a radial basis neural network', Analytical and Bioanalytical Chemistry, vol 383, no 5 , pp 810 - 816.
  • Zheng, G., Huang, W. and Lu, X. (2003), 'Prediction of n-octanol/water partition coefficients for polychlorinated dibenzo-p-dioxins using a general regression neural network', Analytical and Bioanalytical Chemistry, vol 376, no 5 , pp 680 - 685.

Other Publications

  • 2014, 'Method and Apparatus for Separation of Mixtures', Patent
  • 2014, 'NMR Signal Excitation and Acquisition Methods and System', Patent
  • 2014, 'Method and Apparatus for Separation of Mixtures', Patent

Dr Gang Zheng started his scientific research career in 2003 while pursuing a MEng degree at HUST (China). His early research interests focused on the development of novel QSPR and QSAR models for predicting the chemical and biological properties of persistent organic pollutants (POPs) by utilising artificial neural networks (ANNs). In 2005, he moved to Sydney to pursue a PhD in nuclear magnetic resonance (NMR) on an IPRS scholarship under the supervision of Prof. William S. Price. He finished his PhD study in three years with four high quality journal publications that have already received more than 120 citations in total. After working as postdoctoral fellow in Price’s group for one and half years, he secured a research lecturer position at Western Sydney University in 2010. Since then, his research has been focusing on the development of novel diffusion NMR techniques and their applications in environmental and food sciences. Recently, he has also developed research interests in the study of proton exchange by NMR saturation transfer. A study on thiol-water proton exchange led by Mr Johnny Chen (Gang’s PhD student) has given birth to some exciting findings, indicating the potential application of a commonly used pharmaceutical drug, n-acetylcysteine (NAC), to the generation of magnetic resonance imaging (MRI) contrast. Up to 2020, Dr Zheng has generated 40 journal papers, 4 book chapters, 2 patent cooperation treaty (PCT) publications, and holds an h-index of 13 (Scopus).

MRes students wanted:

1. Nuclear magnetic resonance (NMR) studies on dissolved organic matter (DOM) in Australian natural waters

2. NMR studies on wine: the first step to a wine-tasting machine

3. NMR studies on the physicochemical properties of biochar produced from spent coffee ground

PhD students wanted: 

Development of advanced water signal manipulation techniques and their applications in chemical and medical sciences

This information has been contributed by Doctor Zheng.

Current Projects

Title: Treatment planning for the 21st Century - Electron Density: CT to MRI
Funder:
  • Anonymous Donation
Western Researchers: Bill Price, Timothy Stait-Gardner, Allan Torres and Gang Zheng
Years: 2015-03-01 - 2023-12-31
ID: P00022164

Previous Projects

Title: Development of a NMR Spectroscopy based Biomedical Research Platform Driven by Designing the Next Generation Water Signal Filtering Techniques.
Funder:
  • University of Western Sydney
Western Researchers: Gang Zheng, Bill Price, Allan Torres, Timothy Stait-Gardner and Bahman Ghadirian
Years: 2013-12-09 - 2014-12-09
ID: P00021842
Title: Evaluation of Hypoxia by MRI (i.e., tentative thesis title)
Funder:
  • South Western Sydney Local Health District
Western Researchers: Bill Price, Timothy Stait-Gardner, Allan Torres and Gang Zheng
Years: 2015-01-01 - 2018-06-30
ID: P00022775
Title: Development of high performance NMR diffusion experiments for physiologically relevant applications
Funder:
  • University of Western Sydney
Western Researchers: Gang Zheng
Years: 2009-09-22 - 2010-12-21
ID: P00017387
Title: Post-processing methods for dramatically improving NMR signals and its applications
Funder:
  • University of Western Sydney
Western Researchers: Bill Price, Bahman Ghadirian, Gang Zheng, Timothy Stait-Gardner and Allan Torres
Years: 2012-03-02 - 2013-03-01
ID: P00020582
Title: NMR Diffusography
Funder:
  • University of Western Sydney
Western Researchers: Bill Price, Timothy Stait-Gardner, Allan Torres, Gang Zheng, Andrew Shalliker, Gary Dennis and Marion Gaborieau
Years: 2010-05-28 - 2011-05-27
ID: P00018722
Title: Development of Advanced MRI Techniques for Clinical Imaging
Funder:
  • Anonymous Donation
Western Researchers: Bill Price, Gang Zheng, Timothy Stait-Gardner and Allan Torres
Years: 2010-11-15 - 2015-02-28
ID: P00019301

Supervision

Doctor Zheng is available to be a principal supervisor for doctoral projects

Current Supervision

Thesis Title: Development of Novel Chemical Exchange Saturation Transfer Contrast Techniques for MRI
Field of Research: Biological Sciences; Chemical Sciences; Medical Science
Thesis Title: An Exploratory Metabolomic Analysis of Dealcoholised Wines Through 1H NMR, ICPMS and Chemometrics
Field of Research:

Previous Supervision

Thesis Title: Development of Brownian Ratchets for Solution Phase Chemical Separation
Field of Research: Chemical Sciences
Thesis Title: Development of Novel Magnetic Resonance Imaging Pulse Sequences for Clinical Applications
Field of Research: Other Natural And Physical Sciences
Thesis Title: NMR Studies of Molecular Dynamics of Liquid Electrolytes
Field of Research: Transport Engineering; Chemical Sciences Not Elsewhere Classified; Chemical Engineering
Thesis Title: Beyond the Noise - High Fidelity MR Signal Processing
Field of Research: Other Natural And Physical Sciences
Thesis Title: Characterisation of Liquid Electrolytes by Determination of Physicochemical and Electrochemical Properties using Advanced Nuclear Magnetic Resonance Techniques
Field of Research: Physics; Other Natural And Physical Sciences
Thesis Title: Polyaromatic Anticancer Platinum Complexes: Synthesis and Analysis of DNA Binding
Field of Research: Chemical Sciences Not Elsewhere Classified; Medical Studies Not Elsewhere Classified; Other Natural And Physical Sciences
Thesis Title: Evaluating Hypoxia-Targeting Vectors for MRI Applications
Field of Research: Medical Studies Not Elsewhere Classified; Biochemistry And Cell Biology; Other Health; Organic Chemistry
Thesis Title: Advanced Numerical Modelling of NMR Diffusion Experiments
Field of Research: Chemical Sciences; Natural And Physical Sciences

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