Doctor Christopher Jones

Doctor Christopher Jones

Dap - Bmedsc & Bmedsc (adv),
Medical Science (sosh)

Lecturer Biochemistry,
Science (sosh)

Biography

Qualifications

  • PhD University of Queensland

Organisational Unit (School / Division)

  • Medical Science (sosh)
  • Science (sosh)

Contact

Email: C.Jones@westernsydney.edu.au
Phone: (02) 9685 9908
Mobile:
Location: EHA.1.07
Parramatta
Website:

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Publications

Chapters in Books

  • Badrick, A. and Jones, C. (2010), 'Metal-minded : use, control and metallic interplay of copper in the brain', Horizons in Neuroscience Research. Volume 2, Nova Science Publishers 9781608768769.

Journal Articles

  • Tran, K., Jayawardena, B., Elphick, M. and Jones, C. (2019), 'A gonadotropin-releasing hormone type neuropeptide with a high affinity binding site for copper(II) and nickel(II)', Metallomics, vol 11, no 2 , pp 404 - 414.
  • Jayawardena, B., Jones, M., Hong, Y. and Jones, C. (2019), '[In Press] Copper ions trigger disassembly of neurokinin B functional amyloid and inhibit de novo assembly', Journal of Structural Biology, .
  • Gul, A., Tran, K. and Jones, C. (2018), 'Neurokinin B and serum albumin limit copper binding to mammalian gonadotropin releasing hormone', Biochemical and Biophysical Research Communications, vol 497, no 1 , pp 1 - 6.
  • Christofides, K., Menon, R. and Jones, C. (2018), 'Endocytosis of G protein-coupled receptors and their ligands : is there a role in metal trafficking?', Cell Biochemistry and Biophysics, vol 76, no 3 , pp 329 - 337.
  • Sediqi, H., Wray, A., Jones, C. and Jones, M. (2018), 'Application of Spectral Phasor analysis to sodium microenvironments in myoblast progenitor cells', PLoS One, vol 13, no 10 .
  • Zhang, L., Reddy, N., Khoo, C., Koyyalamudi, S. and Jones, C. (2018), 'Antioxidant and immunomodulatory activities and structural characterization of polysaccharides isolated from Lobelia chinensis Lour', Pharmacologia, vol 9, no 4 , pp 157 - 168.
  • Jones, C. and Berliner, L. (2017), 'Nitroxide spin-labelling and its role in elucidating cuproprotein structure and function', Cell Biochemistry and Biophysics, vol 75, no 2 , pp 195 - 202.
  • Jones, C., Zandawala, M., Semmens, D., Anderson, S., Hanson, G., Janies, D. and Elphick, M. (2016), 'Identification of a neuropeptide precursor protein that gives rise to a "cocktail" of peptides that bind Cu(II) and generate metal-linked dimers', Biochimica et Biophysica Acta: General Subjects, vol 1860, no 1, Part A , pp 57 - 66.
  • Shahzad, R., Jones, M., Viles, J. and Jones, C. (2016), 'Endocytosis of the tachykinin neuropeptide, neurokinin B, in astrocytes and its role in cellular copper uptake', Journal of Inorganic Biochemistry, vol 162 , pp 319 - 325.
  • Ng, N., Wu, M., Jones, C. and Aldrich-Wright, J. (2016), 'The antimicrobial efficacy and DNA binding activity of the copper(II) complexes of 3,4,7,8-tetramethyl-1,10-phenanthroline, 4,7-diphenyl-1,10-phenanthroline and 1,2-diaminocyclohexane', Journal of Inorganic Biochemistry, vol 162 , pp 62 - 72.
  • Otara, C., Jones, C., Younan, N., Viles, J. and Elphick, M. (2014), 'Structural analysis of the starfish SALMFamide neuropeptides S1 and S2 : the N-terminal region of S2 facilitates self-association', Biochimica et Biophysica Acta. Proteins and Proteomics, vol 1844, no 2 , pp 358 - 365.
  • Grosas, A., Kalimuthu, P., Smith, A., Williams, P., Millar, T., Bernhardt, P. and Jones, C. (2014), 'The tachykinin peptide neurokinin B binds copper(I) and silver(I) and undergoes quasi-reversible electrochemistry : towards a new function for the peptide in the brain', Neurochemistry International, vol 70, no 1 , pp 1 - 9.
  • Jones, C., Otara, C., Younan, N., Viles, J. and Elphick, M. (2014), 'Bioactivity and structural properties of chimeric analogs of the starfish SALMFamide neuropeptides S1 and S2', Biochimica et Biophysica Acta. Proteins and Proteomics, vol 1844, no 10 , pp 1842 - 1850.
  • Jen, F., Jones, C., Wilson, J., Schulz, B. and Jennings, M. (2013), 'Substrate recognition of a structure motif for phosphorylcholine post-translational modification in Neisseria meningitidis', Biochemical and Biophysical Research Communications, vol 431, no 4 , pp 808 - 814.
  • Schulz, B., Jen, F., Power, P., Jones, C., Fox, K., Ku, S., Blanchfield, J. and Jennings, M. (2013), 'Identification of bacterial protein O-Oligosaccharyltransferases and their glycoprotein substrates', PLoS ONE, vol 8, no 5 , pp 1 - 11.
  • Russino, D., McDonald, E., Hejazi, L., Hanson, G. and Jones, C. (2013), 'The tachykinin peptide neurokinin B binds copper forming an unusual [CuII(NKB)2] complex and inhibits copper uptake into 1321N1 astrocytoma cells', ACS Chemical Neuroscience, vol 4, no 10 , pp 1371 - 1381.
  • Jones, C. (2012), 'The emerging role of astrocytes in metal homeostasis in the brain', International Journal of Inorganic Chemistry, vol 3, no 4 .
  • Badrick, A. and Jones, C. (2011), 'Reorganizing metals: the use of chelating compounds as potential therapies for metal-related neurodegenerative disease.', Current Topics in Medicinal Chemistry, vol 11 , pp 543 - 552.
  • Zalucki, Y., Jones, C., Ng, P., Schulz, B. and Jennings, M. (2010), 'Signal sequence non-optimal codons are required for the correct folding of mature maltose binding protein', BBA Biomembranes, vol 1798, no 6 , pp 1244 - 1249.
  • O'Sullivan, D., Jones, C., Abdelraheim, S., Brazier, M., Toms, H., Brown, D. and Viles, J. (2009), 'Dynamics of a truncated prion protein, PrP(113-231) from 15N NMR relaxation : order parameters calculated and slow conformational fluctuations localized to a distinct region', Protein Science, vol 18, no 2 , pp 410 - 423.
  • Badrick, A. and Jones, C. (2009), 'The amyloidogenic region of the human Prion protein contains a high affinity (His)2(Met)2 Cu(I) binding site', Journal of Inorganic Biochemistry, vol 103, no 8 , pp 1169 - 1175.
  • Badrick, A., Hanson, G. and Jones, C. (2009), 'Chaperoning the immunosuppressant Mycophenolic acid through the gastrointestinal tract : a role for copper', Applied Magnetic Resonance, vol 36, no 40635 , pp 231 - 236.
  • Lim, K., Jones, C., Vanden Hoven, R., Edwards, J., Falsetta, M., Apicella, M., Jennings, M. and Mcewan, A. (2008), 'Metal binding specificity of the MntABC permease of Neisseria gonorrhoeae and its influence on bacterial growth and interaction with cervical epithelial cells', Infection and Immunity, vol 76, no 8 , pp 3569 - 3576.
  • O'Sullivan, D., Jones, C., Abdelraheim, S., Thompsett, A., Brazier, M., Toms, H., Brown, D. and Viles, J. (2007), 'NMR characterization of the pH4 beta intermediate of the Prion protein: The N-terminal half of the protein remains unstructured and retains a high degree of flexibility', Biochemical Journal, vol 401, no 2 , pp 533 - 540.
  • Jones, C., Underwood, C., Coulson, E. and Taylor, P. (2007), 'Copper induced oxidation of serotonin: analysis of products and toxicity', Journal of Neurochemistry, vol 102, no 4 , pp 1035 - 1043.
  • Badrick, A., Hamilton, A., Bernhardt, P., Jones, C., Kappler, U., Jennings, M. and Mcewan, A. (2007), 'PrrC, a Sco homologue from Rhodobacter sphaeroides, possesses thiol-disulfide oxidoreductase activity.', FEBS Letters, vol 581, no 24 , pp 4663 - 4667.
  • Badrick, A. and Jones, C. (2007), 'The immunosuppressive drug Mycophenolic Acid does not bind iron(II) under conditions mimicking the upper gastrointestinal environment.', Transplantation, vol 84, no 6 , pp 799 - 800.
  • Garnett, A., Jones, C. and Viles, J. (2006), 'A survey of diamagnetic probes for copper2+ binding to the prion protein. 1H NMR solution structure of the palladium2+ bound single octarepeat', Dalton Transactions, , no 3 , pp 509 - 518.
  • Jones, C., Taylor, P., McEwan, A. and Hanson, G. (2006), 'Spectroscopic characterization of copper(II) binding to the immunosuppressive drug mycophenolic acid', Journal of the American Chemical Society, vol 128, no 29 , pp 9378 - 9386.
  • Jones, C., Klewpatinond, M., Abdelraheim, S., Brown, D. and Viles, J. (2005), 'Probing copper2+ binding to the prion protein using diamagnetic nickel2+ and 1H NMR : the unstructured N terminus facilitates the coordination of six Cu2+ ions at physiological concentrations', Journal of Molecular Biology, vol 346, no 5 , pp 1393 - 1407.
  • Jones, C., Abdelraheim, S., Brown, D. and Viles, J. (2004), 'Preferential copper2+ coordination by His96 and His111 induces ?-sheet formation in the unstructured amyloidogenic region of the prion protein', Journal of Biological Chemistry, vol 279, no 31 , pp 32018 - 32027.

Conference Papers

  • Holdsworth, J., Semple, A., Meier, P., Jones, C., Smith, E., Trede, F., Casson-Medhurst, D. and Chuck, J. (2018), 'Assuring quality in WIL : is the devil in the detail?', Australian Collaborative Education Network. National Conference, Brisbane, Qld..
  • Jones, C., Millar, T. and Chuck, J. (2018), 'Development of a WIL rubric to facilitate identification and mapping of WIL activities in science courses', Australian Collaborative Education Network. National Conference, Brisbane, Qld..
  • Jones, C. (2009), 'Characterization of copper(II) binding to membrane associated PrP(91-124), part of the putative 'transmembrane' domain of the prion protein.', International Conference on Biological Inorganic Chemistry, .
  • Badrick, A. and Jones, C. (2009), 'The power of prions: towards a role for PrP in the synapse', International Conference on Biological Inorganic Chemistry, .
  • Jones, C., Underwood, C., Coulson, E. and Taylor, P. (2007), 'Copper induced oxidation of serotonin: analysis of products and toxicity', International Conference on Biological Inorganic Chemistry, .

Current Projects

Title: Determining the intracellular trafficking pathways of tachkinin-copper(II)-receptor complexes and elucidation of the fate of copper
Funder:
  • Australian Rotary Health (non ACRG)
Western Researchers: Christopher Jones, Mark Jones and Jo-Anne Chuck
Years: 2018-04-27 - 2020-04-27
ID: P00025027

Previous Projects

Title: Providing WIL across complex interconnected science degrees
Funder:
  • Office of the Chief Scientist
Western Researchers: Jo-Anne Chuck, Christopher Jones and Thomas Millar
Years: 2016-02-19 - 2017-07-18
ID: P00023479

Supervision

Current Supervision

Thesis Title: Determining the intracellular trafficking pathway of tachykinin-copper(II)-receptor complexes and elucidating the intracellular fate of copper
Field of Research:
Thesis Title: Identifying and Characterizing Differences in Aggregation and Membrane Interaction of Functional and Toxic Amyloids
Field of Research:

Previous Supervision

Thesis Title: Investigating Metallio-Peptides as Antibacterial Agents
Field of Research: Other Information Technology
Thesis Title: A neuropeptide-copper complex contributes to nuclear copper uptake via a receptor-mediated endocytosis pathway.
Field of Research: Natural And Physical Sciences

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