Professor Paul De Souza

Professor Paul De Souza

Professor Of Oncology,
Dean'S Unit - School Of Medicine

Foundation Chair, Medical Oncology,
School Of Medicine

Biography

Qualifications

  • PhD University of New South Wales
  • MBBS University of Sydney

Professional Memberships

  • ASCO (1992 - 2022)
  • MOGA (1992 - 2022)
  • SNO (2011 - 2022)
  • AACR (1992 - 2022)

Organisational Unit (School / Division)

  • Dean'S Unit - School Of Medicine
  • School Of Medicine

Contact

Email: P.DeSouza@westernsydney.edu.au
Phone: (02) 8738 9744
Mobile:
Location: Off Campus
Website:

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Publications

Chapters in Books

  • Po, J., Lynch, D., de Souza, P. and Becker, T. (2016), 'Importance and detection of epithelial-to-mesenchymal transition (EMT) phenotype in CTCs', Tumor Metastasis, InTech 9789535126300.
  • Gano, C., Scott, K., Bucci, J., Greenfield, H., Dong, Q. and de Souza, P. (2012), 'Dietary manipulation for therapeutic effect in prostate cancer', Cancer Prevention: From Mechanisms to Translational Benefits, In-Tech 9789535105473.

Journal Articles

  • Tjokrowidjaja, A., Goldstein, D., Hudson, H., Lord, S., Gebski, V., Clarke, S., Souza, P., Motzer, R. and Lee, C. (2020), 'The impact of neutrophil-lymphocyte ratio on risk reclassification of patients with advanced renal cell cancer to guide risk-directed therapy', Acta Oncologica, vol 59, no 1 , pp 20 - 27.
  • Toh, J., Lim, S., MacKenzie, S., Souza, P., Bokey, L., Chapuis, P. and Spring, K. (2020), 'Association between microsatellite instability status and peri-operative release of circulating tumour cells in colorectal cancer', Cells, vol 9, no 2 .
  • Ho, V., Chung, L., Singh, A., Lea, V., Abubakar, A., Lim, S., Chua, W., Ng, W., Lee, M., Roberts, T., Souza, P. and Lee, C. (2020), 'Aberrant expression of RAD52, its prognostic impact in rectal cancer and association with poor survival of patients', International Journal of Molecular Sciences, vol 21, no 5 .
  • Hnit, S., Yao, M., Xie, C., Ge, G., Bi, L., Jin, S., Jiao, L., Xu, L., Long, L., Nie, H., Jin, Y., Rogers, L., Suchowerska, N., Wong, M., Liu, T., Souza, P., Li, Z. and Dong, Q. (2020), 'Transcriptional regulation of G2/M regulatory proteins and perturbation of G2/M Cell cycle transition by a traditional Chinese medicine recipe', Journal of Ethnopharmacology, vol 251 .
  • Bi, L., Xie, C., Jiao, L., Jin, S., Hnit, S., Yao, M., Wang, Y., Wang, Q., Ge, G., Wang, Y., Zhao, X., Shi, X., Kang, Y., Souza, P., Liu, T., Zhou, J., Xu, L. and Dong, Q. (2020), 'CPF impedes cell cycle re-entry of quiescent lung cancer cells through transcriptional suppression of FACT and c-MYC', Journal of Cellular and Molecular Medicine, vol 24, no 3 , pp 2229 - 2239.
  • Po, J., Ma, Y., Balakrishna, B., Brungs, D., Azimi, F., Souza, P. and Becker, T. (2019), 'Immunomagnetic isolation of circulating melanoma cells and detection of PD-L1 status', PLoS One, vol 14, no 2 .
  • Bi, L., Xie, C., Yao, M., Hnit, S., Vignarajan, S., Wang, Y., Wang, Q., Xi, Z., Xu, H., Li, Z., Souza, P., Tee, A., Wong, M., Liu, T., Zhao, X., Zhou, J., Xu, L. and Dong, Q. (2019), 'The histone chaperone complex FACT promotes proliferative switch of G0 cancer cells', International Journal of Cancer, vol 145, no 1 , pp 164 - 178.
  • Clingan, P., Ackland, S., Brungs, D., Souza, P., Aghmesheh, M., Garg, M., Ranson, R., Parker, S., Jokela, R. and Ranson, M. (2019), 'First-in-human phase I study of infusional and bolus schedules of Deflexifol, a novel 5-fluorouracil and leucovorin formulation, after failure of standard treatment', Asia Pacific Journal of Clinical Oncology, vol 15, no 3 , pp 151 - 157.
  • Basch, E., Scholz, M., De Bono, J., Vogelzang, N., Souza, P., Marx, G., Vaishampayan, U., George, S., Schwarz, J., Antonarakis, E., O'Sullivan, J., Kalebasty, A., Chi, K., Dreicer, R., Hutson, T., Dueck, A., Bennett, A., Dayan, E., Mangeshkar, M. and Scher, H. (2019), 'Cabozantinib versus mitoxantrone-prednisone in symptomatic metastatic castration-resistant prostate cancer : a randomized phase 3 trial with a primary pain endpoint', European Urology, vol 75, no 6 , pp 929 - 937.
  • Broom, A., Kirby, E., Kokanovic, R., Woodland, L., Wyld, D., Souza, P., Koh, E. and Lwin, Z. (2019), '[In Press] Individualising difference, negotiating culture : intersections of culture and care', Health, .
  • Naher, S., Padinharakam, S., Balakrishnar, B., Chua, W., Descallar, J., Adams, D., Souza, P., Harrison, M. and Lim, S. (2019), 'Patterns of presentation and treatment outcomes of non-clear-cell renal cell carcinoma and sarcomatoid renal cell carcinoma patients in 2 tertiary referral centers in Sydney, Australia', Clinical Genitourinary Cancer, vol 17, no 3 , pp 565 - 569.
  • Nimir, M., Ma, Y., Je?reys, S., Opperman, T., Young, F., Khan, T., Ding, P., Chua, W., Balakrishnar, B., Cooper, A., Souza, P. and Becker, T. (2019), 'Detection of AR-V7 in liquid biopsies of castrate resistant prostate cancer patients : a comparison of AR-V7 analysis in circulating tumor cells, circulating tumor RNA and exosomes', Cells, vol 8, no 7 .
  • Ding, P., Becker, T., Bray, V., Chua, W., Ma, Y., Lynch, D., Po, J., Luk, A., Caixeiro, N., Souza, P. and Roberts, T. (2019), 'The predictive and prognostic significance of liquid biopsy in advanced epidermal growth factor receptor-mutated non-small cell lung cancer : a prospective study', Lung Cancer, vol 134 , pp 187 - 193.
  • Aghajani, M., Roberts, T., Yang, T., McCafferty, C., Caixeiro, N., Souza, P. and Niles, N. (2019), 'Elevated levels of soluble PD-L1 are associated with reduced recurrence in papillary thyroid cancer', Endocrine Connections, vol 8, no 7 , pp 1040 - 1051.
  • Porter, D., Zhu, X., Bensoussan, A. and Souza, P. (2019), 'Perceptions of breast cancer survivors participating in a Chinese herbal medicine study : an exploratory narrative study', HSOA Journal of Alternative, Complementary and Integrative Medicine, vol 5, no 2 .
  • Ding, P., Becker, T., Bray, V., Chua, W., Ma, Y., Xu, B., Lynch, D., Souza, P. and Roberts, T. (2019), 'Plasma next generation sequencing and droplet digital PCR-based detection of epidermal growth factor receptor (EGFR) mutations in patients with advanced lung cancer treated with subsequent-line osimertinib', Thoracic Cancer, vol 10, no 10 , pp 1879 - 1884.
  • Lim, S., Ip, E., Ng, W., Chua, W., Asghari, R., Roohullah, A., Descallar, J., Henderson, C., Spring, K., Souza, P. and King, M. (2019), 'Health-related quality of life during chemoradiation in locally advanced rectal cancer : impacts and ethnic disparities', Cancers, vol 11, no 9 .
  • Panizza, B., Souza, P., Cooper, A., Roohullah, A., Karapetis, C. and Lickliter, J. (2019), 'Phase I dose-escalation study to determine the safety, tolerability, preliminary efficacy and pharmacokinetics of an intratumoral injection of tigilanol tiglate (EBC-46)', EBioMedicine, vol 50 , pp 433 - 441.
  • Aghajani, M., Cooper, A., McGuire, H., Jeffries, T., Saab, J., Ismail, K., Souza, P., Bray, V., De Saint Groth, F., Niles, N. and Roberts, T. (2019), 'Pembrolizumab for anaplastic thyroid cancer : a case study', Cancer Immunology, Immunotherapy, vol 68 , pp 1921 - 1934.
  • Harris, B., Walsh, J., Neciunaite, R., Manders, P., Cooper, A. and de Souza, P. (2018), 'Ring a ring o'roses, a patient with Kaposi's? : pazopanib, pazopanib, it might go away : Mediterranean (classic) Kaposi sarcoma responds to the tyrosine kinase inhibitor pazopanib after multiple lines of standard therapy', Clinical and Experimental Dermatology, vol 43, no 2 , pp 234 - 236.
  • Brungs, D., Lynch, D., Luk, A., Minaei, E., Ranson, M., Aghmesheh, M., Vine, K., Carolan, M., Jaber, M., de Souza, P. and Becker, T. (2018), 'Cryopreservation for delayed circulating tumor cell isolation is a valid strategy for prognostic association of circulating tumor cells in gastroesophageal cancer', World Journal of Gastroenterology, vol 24, no 7 , pp 810 - 818.
  • Roohullah, A., Cooper, A., Lomax, A., Aung, J., Barge, A., Chow, L., McHale, M., Desai, J., Whittle, J., Tran, B., de Souza, P. and Horvath, L. (2018), 'A phase I trial to determine safety and pharmacokinetics of ASLAN002, an oral MET superfamily kinase inhibitor, in patients with advanced or metastatic solid cancers', Investigational New Drugs, vol 36, no 5 , pp 886 - 894.
  • Campbell, D., Lund, M., Nocon, A., Cozzi, P., Frydenberg, M., Souza, P., Schiller, B., Beebe-Dimmer, J., Ruterbusch, J. and Walsh, B. (2018), 'Detection of glypican-1 (GPC-1) expression in urine cell sediments in prostate cancer', PLoS ONE, vol 13, no 4 .
  • Po, J., Roohullah, A., Lynch, D., DeFazio, A., Harrison, M., Harnett, P., Kennedy, C., Souza, P. and Becker, T. (2018), 'Improved ovarian cancer EMT-CTC isolation by immunomagnetic targeting of epithelial EpCAM and mesenchymal N-cadherin', Journal of Circulating Biomarkers, vol 7 .
  • Aghajani, M., Graham, S., McCafferty, C., Abdel Shaheed, C., Roberts, T., Souza, P., Yang, T. and Niles, N. (2018), 'Clinicopathologic and prognostic significance of programmed cell death ligand 1 expression in patients with non-medullary thyroid cancer : a systematic review and meta-analysis', Thyroid, vol 28, no 3 , pp 349 - 361.
  • Brungs, D., Aghmesheh, M., Souza, P., Carolan, M., Clingan, P., Rose, J. and Ranson, M. (2018), 'Safety and efficacy of oxaliplatin doublet adjuvant chemotherapy in elderly patients with stage III colon cancer', Clinical Colorectal Cancer, vol 17, no 3 , pp 549 - 555.
  • Ho, V., Chung, L., Singh, A., Lea, V., Abubakar, A., Lim, S., Ng, W., Lee, M., Souza, P., Shin, J. and Lee, C. (2018), 'Overexpression of the MRE11-RAD50-NBS1 (MRN) complex in rectal cancer correlates with poor response to neoadjuvant radiotherapy and prognosis', BMC Cancer, vol 18, no 1 .
  • Razdan, A., Souza, P. and Roberts, T. (2018), 'Role of microRNAs in treatment response in prostate cancer', Current Cancer Drug Targets, vol 18, no 10 , pp 929 - 944.
  • Del Re, M., Fogli, S., Derosa, L., Massar, F., de Souza, P., Crucitta, S., Bracarda, S., Santini, D. and Danesi, R. (2017), 'The role of drug-drug interactions in prostate cancer treatment : focus on abiraterone acetate/prednisone and enzalutamide', Cancer Treatment Reviews, vol 55 , pp 71 - 82.
  • Brungs, D., Aghmesheh, M., de Souza, P., Ng, W., Chua, W., Carolan, M., Clingan, P., Healey, E., Rose, J., Tubaro, T. and Ranson, M. (2017), 'Sidedness is prognostic in locoregional colon cancer : an analysis of 9509 Australian patients', BMC Cancer, vol 17 .
  • Bergin, A., Hovey, E., Lloyd, A., Marx, G., Parente, P., Rapke, T. and de Souza, P. (2017), 'Docetaxel-related fatigue in men with metastatic prostate cancer : a descriptive analysis', Supportive Care in Cancer, vol 25, no 9 , pp 2871 - 2879.
  • Luk, A., Ma, Y., Ding, P., Young, F., Chua, W., Balakrishnar, B., Dransfield, D., de Souza, P. and Becker, T. (2017), 'CTC-mRNA (AR-V7) analysis from blood samples : impact of blood collection tube and storage time', International Journal of Molecular Sciences, vol 18, no 5 .
  • Callari, M., de Souza, P., Rawal, A. and Stenzel, M. (2017), 'The effect of drug loading on micelle properties : solid-state NMR as a tool to gain structural insight', Angewandte Chemie (International Edition), vol 56, no 29 , pp 8441 - 8445.
  • Callari, M., Wong, S., Lu, H., Aldrich-Wright, J., de Souza, P. and Stenzel, M. (2017), 'Drug induced self-assembly of triblock copolymers into polymersomes for the synergistic dual-drug delivery of platinum drugs and paclitaxel', Polymer Chemistry, vol 8, no 40 , pp 6289 - 6299.
  • Ho, V., Chung, L., Singh, A., Lea, V., Revoltar, M., Lim, S., Tut, T., Ng, W., Lee, M., de Souza, P., Shin, J. and Lee, S. (2017), 'Early postoperative low expression of RAD50 in rectal cancer patients associates with disease-free survival', Cancers, vol 9, no 12 .
  • Caixeiro, N., Byun, H., Descallar, J., Levesque, J., de Souza, P. and Lee, S. (2016), 'Health professionals' opinions on supporting a cancer biobank : identification of barriers to combat biobanking pitfalls', European Journal of Human Genetics, vol 24, no 5 , pp 626 - 632.
  • Lee, C., Davies, L., Gebski, V., Lord, S., Di Leo, A., Johnston, S., Geyer, C., Cameron, D., Press, M., Ellis, C., Loi, S., Marschner, I., Simes, J. and de Souza, P. (2016), 'Serum human epidermal growth factor 2 extracellular domain as a predictive biomarker for lapatinib treatment efficacy in patients with advanced breast cancer', Journal of Clinical Oncology, vol 34, no 9 , pp 936 - 944.
  • Toh, J., de Souza, P., Lim, S., Singh, P., Chua, W., Ng, W. and Spring, K. (2016), 'The potential value of immunotherapy in colorectal cancers : review of the evidence for programmed death-1 (PD-1) inhibitor therapy', Clinical Colorectal Cancer, vol 15, no 4 , pp 285 - 291.
  • Ma, Y., Luk, A., Young, F., Lynch, D., Chua, W., Balakrishnar, B., de Souza, P. and Becker, T. (2016), 'Droplet digital PCR based androgen receptor variant 7 (AR-V7) detection from prostate cancer patient blood biopsies', International Journal of Molecular Sciences, vol 17, no 8 .
  • Ho, V., Chung, L., Revoltar, M., Lim, S., Tut, T., Abubakar, A., Henderson, C., Chua, W., Ng, W., Lee, M., de Souza, P., Morgan, M., Lee, S. and Shin, J. (2016), 'MRE11 and ATM expression levels predict rectal cancer survival and their association with radiotherapy response', PLoS One, vol 11, no 12 .
  • Revoltar, M., Shin, J., Lim, S., Tut, T., Dissanayake, I., Descallar, J., Ho, V., Chua, W., Ng, W., Lee, M., Henderson, C., de Souza, P., Morgan, M. and Lee, S. (2016), 'Early marker of DNA damage response, ATM, as a predictor of clinical outcome following radiotherapy in rectal cancer patients', Pathology, vol 48, no Supplement 1 , pp 153 - 153.
  • Scarano, W., de Souza, P. and Stenzel, M. (2015), 'Dual-drug delivery of curcumin and platinum drugs in polymeric micelles enhances the synergistic effects : a double act for the treatment of multidrug-resistant cancer', Biomaterials Science, vol 3, no 1 , pp 163 - 174.
  • Sengupta, S., Grimison, P., Hayne, D., Williams, S., Chambers, S., de Souza, P., Stockler, M., McJannett, M., Toner, G. and Davis, I. (2015), 'The Australian and New Zealand Urogenital and Prostate (ANZUP) Cancer Trials Group : a new co-operative cancer trials group in genitourinary oncology', BJU International, vol 115, no 6 , pp 856 - 858.
  • Ryan, C., Smith, M., Fizazi, K., Saad, F., Mulders, P., Sternberg, C., Miller, K., Logothetis, C., Shore, N., Small, E., Carles, J., Flaig, T., Taplin, M., Higano, C., de Souza, P., Bono, J., Griffin, T., Porre, P., Yu, M. and Park, Y. (2015), 'Abiraterone acetate plus prednisone versus placebo plus prednisone in chemotherapy-naive men with metastatic castration-resistant prostate cancer (COU-AA-302) : final overall survival analysis of a randomised, double-blind, placebo-controlled phase 3 study', The Lancet Oncology, vol 16, no 2 , pp 152 - 160.
  • Tognela, A., Spring, K., Becker, T., Caixeiro, N., Bray, V., Yip, P., Chua, W., Lim, S. and de Souza, P. (2015), 'Predictive and prognostic value of circulating tumor cell detection in lung cancer : a clinician's perspective', Critical Reviews in Oncology/Hematology, vol 93, no 2 , pp 90 - 102.
  • Lim, S., Spring, K., de Souza, P., MacKenzie, S. and Bokey, E. (2015), 'Circulating tumour cells and circulating nucleic acids as a measure of tumour dissemination in non-metastatic colorectal cancer surgery', European Journal of Surgical Oncology, vol 41, no 3 , pp 309 - 314.
  • Tut, T., Lim, S., Dissanayake, I., Descallar, J., Chua, W., Ng, W., de Souza, P., Shin, J. and Lee, S. (2015), 'Upregulated polo-like kinase 1 expression correlates with inferior survival outcomes in rectal cancer', PLoS One, vol 10, no 6 .
  • Hnit, S., Xie, C., Yao, M., Holst, J., Bensoussan, A., de Souza, P., Li, Z. and Dong, Q. (2015), 'p27Kip1 signaling : transcriptional and post-translational regulation', International Journal of Biochemistry & Cell Biology, vol 68 , pp 9 - 14.
  • Saad, F., Shore, N., Poppel, H., Rathkopf, D., Smith, M., Bono, J., Logothetis, C., de Souza, P., Fizazi, K. and et al, .. (2015), 'Impact of bone-targeted therapies in chemotherapy-naive metastatic castration-resistant prostate cancer patients treated with abiraterone acetate : post hoc analysis of study COU-AA-302', European Urology, vol 68, no 4 , pp 570 - 577.
  • Lim, S., Chua, W., Henderson, C., Ng, W., Shin, J., Chantrill, L., Asghari, R., Lee, S., Spring, K. and de Souza, P. (2015), 'Predictive and prognostic biomarkers for neoadjuvant chemoradiotherapy in locally advanced rectal cancer', Critical Reviews in Oncology/Hematology, vol 96, no 1 , pp 67 - 80.
  • Morris, M., Molina, A., Small, E., De Bono, J., Logothetis, C., Fizazi, K., de Souza, P., Kantoff, P., Higano, C., Li, J., Kheoh, T., Larson, S., Matheny, S., Naini, V., Burzykowski, T., Griffin, T., Scher, H. and Ryan, C. (2015), 'Radiographic progression-free survival as a response biomarker in metastatic castration-resistant prostate cancer : COU-AA-302 results', Journal of Clinical Oncology, vol 33, no 12 , pp 1356 - 1363.
  • Choueiri, T., Figueroa, D., Fay, A., Signoretti, S., Liu, Y., Gagnon, R., Deen, K., Carpenter, C., Benson, P., Ho, T., Pandite, L., de Souza, P., Powles, T. and Motzer, R. (2015), 'Correlation of PD-L1 tumor expression and treatment outcomes in patients with renal cell carcinoma receiving sunitinib or pazopanib : results from COMPARZ, a randomized controlled trial', Clinical Cancer Research, vol 21, no 5 , pp 1071 - 1077.
  • Becker, T., Caixeiro, N., Lim, S., Tognela, A., Kienzle, N., Scott, K., Spring, K. and de Souza, P. (2014), 'New frontiers in circulating tumour cell analysis : a reference guide for bimolecular profiling towards translational clinical use', International Journal of Cancer, .
  • Hovey, E., de Souza, P., Marx, G., Parente, P., Rapke, T., Hill, A., Bonaventura, A., Michele, A., Craft, P., Abdi, E. and Lloyd, A. (2014), 'Phase III, randomized, double-blind, placebo-controlled study of modafinil for fatigue in patients treated with docetaxel-based chemotherapy', Supportive Care in Cancer, vol 22, no 5 , pp 1233 - 1242.
  • Lim, S., Ardern-Holmes, S., McCowage, G. and de Souza, P. (2014), 'Systemic therapy in neurofibromatosis type 2', Cancer Treatment Reviews, vol 40, no 7 , pp 857 - 861.
  • Lim, S., Delaney, G., Descallar, J., Sayaloune, P., Papadatos, G. and de Souza, P. (2014), 'Outcomes of ethnic minority groups with node-positive, non-metastatic breast cancer in two tertiary referral centers in Sydney, Australia', PLoS One, vol 9, no 4 .
  • Callari, M., Aldrich-Wright, J., de Souza, P. and Stenzel, M. (2014), 'Polymers with platinum drugs and other macromolecular metal complexes for cancer treatment', Progress in Polymer Science, vol 39, no 9 , pp 1614 - 1643.
  • Mak, G., Chin, M., Nahar, N. and de Souza, P. (2014), 'Cutaneous metastasis of prostate carcinoma treated with radiotherapy : a case presentation', BMC Research Notes, vol 7, no 1 .
  • Caixeiro, N., Kienzle, N., Lim, S., Spring, K., Tognela, A., Scott, K., de Souza, P. and Becker, T. (2014), 'Circulating tumour cells : a bona fide cause of metastatic cancer', Cancer and Metastasis Reviews, vol 33, no 2-3 , pp 747 - 756.
  • Rathkopf, D., Smith, M., Bono, J., Logothetis, C., Shore, N., de Souza, P., Fizazi, K., Mulders, P., Mainwaring, P., Hainsworth, J., Beer, T., North, S., Fradet, Y., Poppel, H., Carles, J., Flaig, T., Efstathiou, E., Yu, E., Higano, C. and Taplin, M. (2014), 'Updated interim efficacy analysis and long-term safety of abiraterone acetate in metastatic castration-resistant prostate cancer patients without prior chemotherapy (COU-AA-302)', European Urology, vol 66, no 5 , pp 815 - 825.
  • Lim, S., Becker, T., Chua, W., Ng, W., de Souza, P. and Spring, K. (2014), 'Circulating tumour cells and the epithelial mesenchymal transition in colorectal cancer', Journal of Clinical Pathology, vol 67, no 10 , pp 848 - 853.
  • Sebaratnam, D., Martin, L., Venugopal, S., Mangos, G., Freiman, J., de Souza, P., Farnsworth, A., Cheung, K., Scolyer, R. and Murrell, D. (2014), 'Diffuse melanosis cutis in the setting of BRAFV 600E metastatic melanoma', International Journal of Dermatology, vol 53, no 11 , pp 1409 - 1411.
  • Lim, S., Chua, W., Cheng, C., Descallar, J., Ng, W., Solomon, M., Bokey, E., Wong, K., Lee, M., de Souza, P., Shin, J. and Lee, S. (2014), 'Effect of neoadjuvant chemoradiation on tumor-infiltrating/associated lymphocytes in locally advanced rectal cancers', Anticancer Research, vol 34, no 11 , pp 6505 - 6513.
  • Tse, B., Jovanovic, L., Nelson, C., de Souza, P., Power, C. and Russell, P. (2014), 'From bench to bedside : immunotherapy for prostate cancer', BioMed Research International, vol 2014, no 981434 .
  • Lim, S., Becker, T., Chua, W., Caixeiro, N., Ng, W., Kienzle, N., Tognela, A., Lumba, S., Rasko, J., de Souza, P. and Spring, K. (2014), 'Circulating tumour cells and circulating free nucleic acid as prognostic and predictive biomarkers in colorectal cancer', Cancer Letters, vol 346, no 1 , pp 24 - 33.
  • Fox, P., Hudson, M., Brown, C., Lord, S., Gebski, V., De Souza, P. and Lee, C. (2013), 'Markers of systemic inflammation predict survival in patients with advanced renal cell cancer', British Journal of Cancer, vol 109, no 1 , pp 147 - 153.
  • Weber, M., Smith, D., O'Connell, D., Patel, M., de Souza, P., Sitas, F. and Banks, E. (2013), 'Risk factors for erectile dysfunction in a cohort of 108477 Australian men', Medical Journal of Australia, vol 199, no 2 , pp 107 - 111.
  • Won, A., Gurney, H., Marx, G., de Souza, P. and Patel, M. (2013), 'Primary treatment of the prostate improves local palliation in men who ultimately develop castrate-resistant prostate cancer', BJU International, vol 112, no 4 , pp 250 - 255.
  • Yee, G., de Souza, P. and Khachigian, L. (2013), 'Current and potential treatments for cervical cancer', Current Cancer Drug Targets, vol 13, no 2 , pp 205 - 220.
  • Suttle, A., de Souza, P. and Arumugham, T. (2013), 'Bayesian methods for pharmacokinetic/ pharmacodynamic modeling of pazopanib-induced increases in blood pressure and transaminases', Journal of Clinical Pharmacology, vol 53, no 4 , pp 377 - 384.
  • Paz-Ares, L., Balint, B., Boer, R., Meerbeeck, J., Wierzbicki, R., de Souza, P., Galimi, F., Haddad, V., Sabin, T., Hei, Y., Pan, Y., Cottrell, S., Hsu, C. and RamLau, R. (2013), 'A randomized phase 2 study of paclitaxel and carboplatin with or without conatumumab for first-line treatment of advanced non-small-cell lung cancer', Journal of Thoracic Oncology, vol 8, no 3 , pp 329 - 337.
  • Scarano, W., Duong, H., Lu, H., de Souza, P. and Stenzel, M. (2013), 'Folate conjugation to polymeric micelles via boronic acid ester to deliver platinum drugs to ovarian cancer cell lines', Biomacromolecules, vol 14, no 4 , pp 962 - 975.
  • Motzer, R., Hutson, T., Cella, D., Reeves, J., Hawkins, R., Guo, J., Nathan, P., Staehler, M., de Souza, P., Merchan, J., Boleti, E., Fife, K., Jin, J., Jones, R., Uemura, H., De Giorgi, U., Harmenberg, U., Wang, J., Sternberg, C. and Choueiri, T. (2013), 'Pazopanib versus sunitinib in metastatic renal-cell carcinoma', New England Journal of Medicine, vol 369, no 8 , pp 722 - 731.
  • Kim, M., Li, M., Intong, L., Tran, K., Melbourne, W., Marucci, D., Bucci, J., de Souza, P., Mallesara, G. and Murrell, D. (2013), 'Use of cetuximab as an adjuvant agent to radiotherapy and surgery in recessive dystrophic epidermolysis bullosa with squamous cell carcinoma', British Journal of Dermatology, vol 169, no 1 , pp 208 - 210.
  • Ryan, C., Smith, M., De Bono, J., Molina, A., Logothetis, C., de Souza, P., Fizazi, K., Mainwaring, P., Piulats, J., Ng, S., Carles, J., Mulders, P., Basch, E., Small, E., Saad, F., Schrijvers, D., Poppel, H., Mukherjee, S., Suttmann, H. and Gerritsen, W. (2013), 'Abiraterone in metastatic prostate cancer without previous chemotherapy', New England Journal of Medicine, vol 368, no 2 , pp 138 - 148.
  • Lee, C., Marschner, I., Simes, R., Voysey, M., Egleston, B., Hudes, G. and De Souza, P. (2012), 'Increase in cholesterol predicts survival advantage in renal cell carcinoma patients treated with temsirolimus', Clinical Cancer Research, vol 18, no 11 , pp 3188 - 3196.
  • Huynh, V., Quek, J., De Souza, P. and Stenzel, M. (2012), 'Block copolymer micelles with pendant bifunctional chelator for platinum drugs : effect of spacer length on the viability of tumor cells', Biomacromolecules, vol 13, no 4 , pp 1010 - 1023.
  • Boyer, M., Horwood, K., Pavlakis, N., De Souza, P., Millward, M., Stein, B., Johnston, M., Abell, F. and Rischin, D. (2012), 'Efficacy of erlotinib in patients with advanced non-small cell lung cancer (NSCLC) : analysis of the Australian subpopulation of the TRUST study', Asia-Pacific Journal of Clinical Oncology, vol 8, no 3 , pp 248 - 254.
  • Cameron, B., Bennett, B., Li, H., Boyle, F., De Souza, P., Wilcken, N., Friedlander, M., Goldstein, D. and Lloyd, A. (2012), 'Post-cancer fatigue is not associated with altered cytokine production', Annals of Oncology, vol 23, no 11 , pp 2890 - 2895.
  • Goldstein, D., Bennett, B., Webber, K., Boyle, F., De Souza, P., Wilcken, N., Scott, E., Toppler, R., Murie, P., O'Malley, L., McCourt, J., Friedlander, M., Hickie, I. and Lloyd, A. (2012), 'Cancer-related fatigue in women with breast cancer : outcomes of a 5-year prospective cohort study', Journal of Clinical Oncology, vol 30, no 15 , pp 1805 - 1812.
  • Huynh, V., Binauld, S., De Souza, P. and Stenzel, M. (2012), 'Acid degradable cross-linked micelles for the delivery of cisplatin : a comparison with nondegradable cross-linker', Chemistry of Materials, vol 24, no 16 , pp 3197 - 3211.
  • Gu, W., Gaborieau, M., Huynh, V., de Souza, P. and Stenzel, M. (2011), 'Functionalization of microspheres with malonates using Michael Addition as a pathway to create a drug delivery system for platinum drugs for the treatment of liver cancer', Polymer, vol 52, no 26 , pp 5993 - 6002.
  • Li, S. and de Souza, P. (2011), 'Ras isoprenylation and pAkt inhibition by zoledronic acid and fluvastatin enhances paclitaxel activity in T24 bladder cancer cells', Cancers, vol 3, no 1 , pp 662 - 674.
  • Howes, J., de Souza, P., West, L., Huang, L. and Howes, L. (2011), 'Pharmacokinetics of phenoxodiol, a novel isoflavone, following intravenous administration to patients with advanced cancer', BMC Clinical Pharmacology, vol 11 .
  • Huynh, V., de Souza, P. and Stenzel, M. (2011), 'Polymeric micelles with pendant dicarboxylato chelating ligands prepared via a michael addition for cis -platinum drug delivery', Macromolecules, vol 44, no 20 , pp 7888 - 7900.
  • Metharom, E., Galettis, P., Manners, S., Jelinek, M., Liauw, W., De Souza, P., Hoskins, J. and Matthew, L. (2011), 'The pharmacological advantage of prolonged dose rate gemcitabine is restricted to patients with variant alleles of cytidine deaminase c.79A>C', Asia-Pacific Journal of clinical Oncology, vol 7, no 2011 , pp 65 - 75.
  • De Souza, P. and Saad, F. (2011), 'Bone health in prostate cancer', Expert Review of Endocrinology and Metabolism, vol 6, no 3 , pp 317 - 321.
  • Manners, S., Galettis, P. and De Souza, P. (2011), 'Conditions causing gemcitabine crystallization', Journal of oncology pharmacy practice, vol 17, no 4 , pp 395 - 399.
  • Huynh, V., Chen, G., de Souza, P. and Stenzel, M. (2011), 'Thiol-yne and thiol-ene "click" chemistry as a tool for a variety of platinum drug delivery carriers, from statistical copolymers to crosslinked micelles', Biomacromolecules, vol 12, no 5 , pp 1738 - 1751.
  • Xu, C., Bing, N., Ball, H., Rajgopalan, D., Sternberg, C., Hutson, T., De Souza, P. and Xue, G. (2010), 'Efficacy and Safety of Pazopanib in Patients With Metastatic Renal Cell Carcinoma', Journal of clinical oncology, vol 29, no 18 , pp 2557 - 2564.

Current Projects

Title: Blood based biomarkers in breast cancer
Funder:
  • Ingham Institute for Applied Medical Research
Western Researchers: Therese Becker and Paul De Souza
Years: 2017-03-06 - 2021-03-05
ID: P00023834

Previous Projects

Title: Veridex "CellSearch" machine for detection of circulating tumour cells
Funder:
  • Prostate Cancer Foundation of Australia (ACRG)
Western Researchers: Paul De Souza
Years: 2013-01-30 - 2013-12-31
ID: P00021071
Title: Biology of circulating tumour cells in patients with advanced ovarian cancer: Does epithelial to mesenchymal transition (EMT) contribute to chemoresistance?
Funder:
  • Australian Rotary Health (non ACRG)
  • South Western Sydney Local Health District
Western Researchers: Paul De Souza
Years: 2014-03-13 - 2017-09-12
ID: P00022233
Title: To Determine the Mechanism of Cell Cycle Re-entry by Quiescent Prostate Cancer Cells
Funder:
  • University of Western Sydney
Western Researchers: Qihan Dong and Paul De Souza
Years: 2012-11-15 - 2013-12-15
ID: P00021217
Title: Translational development of the anti-tropomyosin drug candidate Anisina [via Liverpool Hospital (SWSLHD)]
Funder:
  • Novogen Research Pty Ltd
Western Researchers: Paul De Souza
Years: 2015-02-19 - 2018-02-18
ID: P00023030
Title: Translational development of the Super Benzopyran drug candidate Cantrixil [via Liverpool Hospital (SWSLHD)]
Funder:
  • Novogen Research Pty Ltd
Western Researchers: Paul De Souza
Years: 2015-03-02 - 2018-03-01
ID: P00023031
Title: Molecular barcoding of tissue specimens: setting new benchmarks in biobanking quality assurance and quality control in NSW
Funder:
  • University of Western Sydney
  • Cancer Institute NSW
Western Researchers: Kevin Spring, Paul De Souza, Soon Lee and Tara Roberts
Years: 2015-07-01 - 2016-06-30
ID: P00022764
Title: A translational and pharmacokinetic study of a novel, orally-active, targeted treatment for hormone refractory prostate cancer
Funder:
  • Prostate Cancer Foundation of Australia (ACRG)
Western Researchers: Paul De Souza and Kieran Scott
Years: 2017-07-19 - 2018-12-31
ID: P00021763
Title: Evaluation of Chinese herbal medicine in preventing prostate cancer progression in patients under active surveillance
Funder:
  • University of Western Sydney
  • Actel Medicine International Pty Ltd
Western Researchers: Qihan Dong, Paul De Souza, Soon Lee and Alan Bensoussan
Years: 2016-03-29 - 2017-03-28
ID: P00022994
Title: Understanding the changes from tumour dormancy to metastasis: Development of prognostic tests and identification of potential therapeutic targets to prevent metastasis
Funder:
  • National Breast Cancer Foundation (ACGR)
Western Researchers: Therese Becker and Paul De Souza
Years: 2016-01-01 - 2017-12-31
ID: P00023038
Title: Noxopharm_Drug development
Funder:
  • Noxopharm Limited
Western Researchers: Paul De Souza
Years: 2017-04-13 - 2017-11-14
ID: P00024310
Title: A feasiblity study to examine the role of acupuncture to reduce symptoms of lymphoedema post-breast cancer treatment
Funder:
  • University of Western Sydney
Western Researchers: Caroline Smith and Paul De Souza
Years: 2012-03-02 - 2013-03-01
ID: P00020587
Title: An automated micromanipulator platform to capture viable single cells for culture and molecular analyses
Funder:
  • Cancer Institute NSW
Western Researchers: Paul De Souza, Therese Becker and Kevin Spring
Years: 2014-07-01 - 2015-06-30
ID: P00022222
Title: Centre for Oncology Education and Research Translation (CONCERT) [via UNSW]
Funder:
  • University of Western Sydney
  • Cancer Institute NSW
  • Cancer Institute NSW
  • University of Western Sydney
  • South Western Sydney Local Health District
Western Researchers: Paul De Souza, Soon Lee and Les Bokey
Years: 2014-06-06 - 2019-09-03
ID: P00021956
Title: Identification of circulating tumour cells and circulating tumour RNA in patients with brain cancer
Funder:
  • Ingham Institute for Applied Medical Research
Western Researchers: Therese Becker, Paul De Souza and Tara Roberts
Years: 2015-03-24 - 2019-03-23
ID: P00022750
Title: South West Sydney Translational Cancer Research Unit [via Ingham Institute for Applied Medical Research]
Funder:
  • Cancer Institute NSW
Western Researchers: Paul De Souza, Soon Lee and Les Bokey
Years: 2012-02-27 - 2013-02-26
ID: P00020939

Supervision

Current Supervision

Thesis Title: Assessment of the Impact of Dietary Factors in the Control of PSA in Men with Advanced Prostate Cancer
Field of Research:

Western Sydney University

Locked Bag 1797
Penrith NSW 2751

Tel: +61 2 9852 5222

ABN 53 014 069 881
CRICOS Provider No: 00917k

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