
Professor Gerald Muench
Professor Pharmacology,
School of Medicine
Biography
Gerald Muench started work at the University of Würzburg, Germany in 1995 and was then appointed Lecturer in the Department of Child and Adolescent Psychiatry in 1999. In 2000, he joined the Interdisciplinary Center for Clinical Research at the University of Leipzig. He left in 2004 to take up a position as Senior Lecturer at James Cook University in Townsville.
In May 2008 Gerald was appointed as Associate Professor of Pharmacology in the School of Medicine at the University of Western Sydney, and he was promoted to Professor with effect from 1 January 2012.
His major project focus is on Alzheimer's disease with a special emphasis on carbonyl stress in age-related and neurodegenerative processes, and also looking at brain inflammation as a major progression factor in Alzheimer's disease, now widely accepted.
He is also looking to discover and identify novel anti-inflammatory and neuroprotective compounds from marine macroorganisms and tropical rainforest plants, a project started through James Cook University's "Enhancing life in the tropics".
Gerald has served on the editorial boards of six international scientific journals and has been a consultant with Aventis, Roche Diagnostics, Merz, ASTA Medica/Degussa and Blackmores.
His teaching philosophy is to show students how much fun the learning experience can be and define precisely what they need to know and understand when the standards are high.
Awards and Recognition:
Rene Schubert Prize of the "German Society for Aging Research" (Dt. Gesellschaft für Alternsforschung), 2003
Best Biomedical Project in the Business Plan Competition of the Bavarian State Government & McKinsey for Northern Bavaria, 1999
Senior Scientist Visiting Fellowship (Australian Academy of Science / DFG), Host: Prof. Robin Holliday, Division of Biomolecular Engineering, CSIRO; North Ryde, NSW, 1998
Prize for Brain Research in Gerontology, Universität Witten-Herdecke, Germany, 1997
University Prize of the "Jubilumsstiftung der Universität", University of Würzburg, Germany, 1996
Stifterverband der dt. Wissenschaft (German Association of Private Foundations) Research Associate Fellowship, 1995
DFG (German Research Council) Postdoctoral Fellowship (Garvan Institute, Sydney: Host: Professor J. Shine), 1993
University prize for the best PhD thesis of the faculty, 1991
This information has been contributed by Professor Muench.
Qualifications
- PhD Julius Maximilian University of Bavaria, Wurzburg
- MSc(Chem) Julius Maximilian University of Bavaria, Wurzburg
Professional Memberships
- Australian Neuroscience Society (1992 - 2022)
Interests
- Biochemistry
- Biotechnology
- Cell Biology
- Molecular Biology
- Molecular Genetics
- Pharmacology
Organisational Unit (School / Division)
- School of Medicine
Contact
Email: | G.Muench@westernsydney.edu.au |
---|---|
Phone: | (02) 4620 3814 |
Mobile: | 0410679928 |
Location: | 30.2.15 Campbelltown |
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Publications
Chapters in Books
- Sharman, M., Verdile, G., Shanmugam, K. and Muench, G. (2019), 'Inflammation in Alzheimer's disease, and prevention with antioxidants and phenolic compounds : what are the most promising candidates?', Neurodegeneration and Alzheimer's Disease: The Role of Diabetes, Genetics, Hormones, and Lifestyle, Wiley 9781119356783.
- Dhananjayan, K., Forbes, J. and Muench, G. (2018), 'Advanced glycation, diabetes, and dementia', Type 2 Diabetes and Dementia, Academic Press 9780128094549.
- Bennett, L., Nigro, J., Bird, M., Gyengesi, E., Macaulay, L. and Muench, G. (2015), 'Chronic inflammation and innate immunity in Alzheimer's Disease : role of diet', Diet and Nutrition in Dementia and Cognitive Decline, Elsevier 9780124078246.
- Ooi, L., Patel, M. and Muench, G. (2014), 'The thiol antioxidant lipoic acid and Alzheimer's disease', Systems Biology of Free Radicals and Antioxidants, Springer 9783642300172.
- Maczurek, A., Ooi, L., Patel, M. and Muench, G. (2013), 'Lipoic acid as an anti-inflammatory and neuroprotective tretment for Alzheimer's disease ', Advances in Natural Medicines, Nutraceuticals and Neurocognition, CRC press 9781439893609.
- Gunawardena, D., Govindaraghavan, S. and Muench, G. (2013), 'Anti-inflammatory properties of cinnamon polyphenols and their monomeric precursors ', Polyphenols in Human Health and Disease Volume 1, Academic Press 9780123984715.
Journal Articles
- Afzal, S., Raju, R., Or, K. and Muench, G. (2023), 'Identification of Nrf2 activators from the roots of Valeriana officinalis', Planta Medica, vol 89, no 1 , pp 30 - 45.
- Mathew, S., Zhang, K., Zhou, X., Muench, G., Bodkin, F., Li, F. and Raju, R. (2023), 'Myrtinols A-F : new anti-inflammatory peltogynoid flavonoid derivatives from the leaves of Australian Indigenous plant Backhousia myrtifolia', Molecules, vol 28, no 5 .
- Mathew, S., Raju, R., Zhou, X., Bodkin, F., Govindaraghavan, S. and Muench, G. (2023), 'A method and formula for the quantitative analysis of the total bioactivity of natural products', International Journal of Molecular Sciences, vol 24, no 7 .
- Raju, R., Mathew, S., Singh, A., Reddell, P. and Muench, G. (2022), 'Acronyols A and B, new anti-inflammatory prenylated phloroglucinols from the fruits of Acronychia crassipetala', Natural Product Research, vol 36, no 17 , pp 4364 - 4370.
- Raju, R., Mathew, S., Reddell, P. and Muench, G. (2022), '[In Press] Ternstroenol F : a new pentacyclic triterpenoid saponin isolated from the Australian rainforest plant Ternstroemia cherryi', Natural Product Research, .
- Asgarov, R., Sen, M., Mikhael, M., Karl, T., Gyengesi, E., Mahns, D., Malladi, C. and Muench, G. (2022), 'Characterisation of the mouse cerebellar proteome in the GFAP-IL6 model of chronic neuroinflammation', Cerebellum, vol 21, no 3 , pp 404 - 424.
- Zhou, X., Venigalla, M., Raju, R. and Muench, G. (2022), 'Pharmacological considerations for treating neuroinflammation with curcumin in Alzheimer's disease', Journal of Neural Transmission, vol 129, no 5-6 , pp 755 - 771.
- Zhou, X., Afzal, S., Wohlmuth, H., Muench, G., Leach, D., Low, M. and Li, C. (2022), 'Synergistic anti-inflammatory activity of ginger and turmeric extracts in inhibiting lipopolysaccharide and interferon-y-induced proinflammatory mediators', Molecules, vol 27, no 12 .
- Zhou, X., Muench, G., Wohlmuth, H., Afzal, S., Kao, M., Al-Khazaleh, A., Low, M., Leach, D. and Li, C. (2022), 'Synergistic inhibition of pro-inflammatory pathways by ginger and turmeric extracts in RAW 264.7 cells', Frontiers in Pharmacology, vol 13 .
- Raju, R., Gunawardena, D., Reddell, P. and Muench, G. (2022), 'Cryptocaryoic acids A - C : new phenyl alkyl acids isolated from the leaves of Australian rainforest plant Cryptocarya mackinnoniana', Fitoterapia, vol 162 .
- Mathew, S., Zhou, X., Muench, G., Bodkin, F., Wallis, M., Li, F. and Raju, R. (2022), 'Tristaenone A : a new anti-inflammatory compound isolated from the Australian Indigenous plant Tristaniopsis laurina', Molecules, vol 27, no 19 .
- Wang, C., Sun, Y., Liu, W., Liu, Y., Afzal, S., Grover, J., Chang, D., Muench, G., Li, C., Lin, S., Chen, J., Zhang, Y., Cheng, Z., Lin, Y., Zheng, Y., Huang, M. and Zhou, X. (2022), 'Protective effect of the curcumin-baicalein combination against macrovascular changes in diabetic angiopathy', Frontiers in Endocrinology, vol 13 .
- Singh, A., Raju, R. and Muench, G. (2021), 'Potential anti-neuroinflammatory compounds from Australian plants : a review', Neurochemistry International, vol 142 .
- Venigalla, M., Roberts, T., Raju, R., Mrad, M., Bodkin, F., Kopp, K., Doyle, K. and Muench, G. (2021), 'Identification of tetragocarbone C and sideroxylin as the most potent anti-inflammatory components of Syncarpia glomulifera', Fitoterapia, vol 150 .
- Raju, R., Cullen, J., Bruce, Z., Reddell, P. and Muench, G. (2021), 'Eupomatenes A - E : neolignans isolated from the leaves of Australian rainforest plant Eupomatia laurina', Fitoterapia, vol 153 .
- Zhou, X., Afzal, S., Zheng, Y., Muench, G. and Li, C. (2021), 'Synergistic protective effect of curcumin and resveratrol against oxidative stress in endothelial EAhy926 cells', Evidence-Based Complementary and Alternative Medicine, vol 2021 .
- Childs, R., Gamage, R., Muench, G. and Gyengesi, E. (2021), 'The effect of aging and chronic microglia activation on the morphology and numbers of the cerebellar Purkinje cells', Neuroscience Letters, vol 751 .
- Chesworth, R., Gamage, R., Ullah, F., Sonego, S., Millington, C., Fernandez, A., Liang, H., Karl, T., Muench, G., Niedermayer, G. and Gyengesi, E. (2021), 'Spatial memory and microglia activation in a mouse model of chronic neuroinflammation and the anti-inflammatory effects of apigenin', Frontiers in Neuroscience, vol 15 .
- Businaro, R., Vauzour, D., Sarris, J., Muench, G., Gyengesi, E., Brogelli, L. and Zuzarte, P. (2021), 'Therapeutic opportunities for food supplements in neurodegenerative disease and depression', Frontiers in Nutrition, vol 8 .
- Ullah, F., Asgarov, R., Venigalla, M., Liang, H., Niedermayer, G., Muench, G. and Gyengesi, E. (2020), 'Effects of a solid lipid curcumin particle formulation on chronic activation of microglia and astroglia in the GFAP-IL6 mouse model', Scientific Reports, vol 10, no 1 .
- Singh, A., Raju, R., Mrad, M., Reddell, P. and Muench, G. (2020), 'The reciprocal EC50 value as a convenient measure of the potency of a compound in bioactivity-guided purification of natural products', Fitoterapia, vol 143 .
- Raju, R., Singh, A., Gunawardena, D., Reddell, P. and Muench, G. (2020), 'Mulgravanols A and B, rare oxidized xanthenes and a new phloroglucinol isolated from the Australian rainforest plant Waterhousea mulgraveana (Myrtaceae)', Fitoterapia, vol 143 .
- Ullah, F., Liang, H., Niedermayer, G., Muench, G. and Gyengesi, E. (2020), 'Evaluation of phytosomal curcumin as an anti-inflammatory agent for chronic glial activation in the GFAP-IL6 mouse model', Frontiers in Neuroscience, vol 14 .
- Singh, A., Cullen, J., Bruce, Z., Reddell, P., Muench, G. and Raju, R. (2020), 'Ternstroenols A - E : undescribed pentacyclic triterpenoids from the Australian rainforest plant Ternstroemia cherryi', Phytochemistry, vol 176 .
- Zhou, X., Afzal, S., Muench, G., Razmovski-Naumovski, V. and Li, C. (2020), 'Combined effect of 2 nutraceuticals, curcumin and resveratrol on the activation of nuclear factor erythroid 2-related factor 2', Global Advances in Health and Medicine, vol 9 , pp 49 - 49.
- Raju, R., Singh, A., Bodkin, F. and Muench, G. (2019), 'Costatamins A - C, new 4-phenylcoumarins with anti-inflammatory activity from the Australian woodland tree Angophora costata (Myrtaceae)', Fitoterapia, vol 133 , pp 171 - 174.
- Raju, R., Singh, A., Gunawardena, D., Reddell, P. and Muench, G. (2019), 'Diarylheptanoids with anti-inflammatory activity from the rhizomes of Pleuranthodium racemigerum (Zingiberaceae)', Phytochemistry Letters, vol 30 , pp 10 - 13.
- Dhananjayan, K., Irrgang, F., Raju, R., Harman, D., Moran, C., Srikanth, V. and Muench, G. (2019), 'Determination of glyoxal and methylglyoxal in serum by UHPLC coupled with fluoresecence detection', Analytical Biochemistry, vol 573 , pp 51 - 66.
- Gunawardena, D., Raju, R. and Muench, G. (2019), 'Hydrogen peroxide mediates pro-inflammatory cell-to-cell signaling : a new therapeutic target for inflammation?', Neural Regeneration Research, vol 14, no 8 , pp 1430 - 1437.
- Gyengesi, E., Rangel, A., Ullah, F., Liang, H., Niedermayer, G., Asgarov, R., Venigalla, M., Gunawardena, D., Karl, T. and Muench, G. (2019), 'Chronic microglial activation in the GFAP-IL6 mouse contributes to age-dependent cerebellar volume loss and impairment in motor function', Frontiers in Neuroscience, vol 13 .
- Saedisomeolia, A., Makhdoomi Arzati, M., Abdolahi, M., Sedighiyan, M., Rangel, A., Muench, G., Zarezadeh, M., Jafarieh, A. and Mohammadzadeh Honarvar, N. (2019), 'Mechanisms of action of ginger in nuclear factor-kappaB signaling pathways in diabetes', Journal of Herbal Medicine, vol 16 .
- Sharman, M., Gyengesi, E., Liang, H., Chatterjee, P., Karl, T., Li, Q., Wenk, M., Halliwell, B., Martins, R. and Muench, G. (2019), 'Assessment of diets containing curcumin, epigallocatechin-3-gallate, docosahexaenoic acid and a-lipoic acid on amyloid load and inflammation in a male transgenic mouse model of Alzheimer's disease : are combinations more effective?', Neurobiology of Disease, vol 124 , pp 505 - 519.
- Shanmugalingam, R., Wang, X., Muench, G., Fulcher, I., Lee, G., Chau, K., Xu, B., Kumar, R., Hennessy, A. and Makris, A. (2019), 'A pharmacokinetic assessment of optimal dosing, preparation and chronotherapy of aspirin in pregnancy', American Journal of Obstetrics and Gynecology, vol 221, no 3 , pp 2551 - 2559.
- Hess, A., Kress, S., Rakete, S., Muench, G., Kornhuber, J., Pischetsrieder, M. and Muller, C. (2019), 'Influence of the fat/carbohydrate component of snack food on energy intake pattern and reinforcing properties in rodents', Behavioural Brain Research, vol 364 , pp 328 - 333.
- Kekesi, O., Liang, H., Muench, G., Morley, J., Gyengesi, E. and Buskila, Y. (2019), 'The differential impact of acute microglia activation on the excitability of cholinergic neurons in the mouse medial septum', Brain Structure and Function, vol 224, no 7 , pp 2297 - 2309.
- Sharman, M., Verdile, G., Shanmugam, K., Parenti, C., Singh, A., Watt, G., Karl, T., Chang, D., Li, C. and Muench, G. (2019), 'Targeting inflammatory pathways in Alzheimer's disease : a focus on natural products and phytomedicines', CNS Drugs, vol 33, no 5 , pp 457 - 480.
- Cave, A., Cave, A., Chang, D., Muench, G. and Steiner, G. (2019), 'Efficacy of Cognition Support Formula? on cognitive function in older adults with subjective cognitive impairment : a protocol for a 26-week, randomised, double-blind, placebo-controlled trial', Trials, vol 20, no 1 .
- Zaman, M., Johnson, A., Petersingham, G., Muench, G., Dong, Q. and Wu, M. (2019), 'Protein kinase CK2 is involved in zinc homeostasis in breast and prostate cancer cells', BioMetals, vol 32, no 6 , pp 861 - 873.
- Khan, M., Cazzonelli, C., Kurata, H., Li, C., Badsha, M., Muench, G. and Majid, A. (2019), 'Advancing herbal medicine through metabolic pathway analysis in plants and animals for routine pharmacological assessments', Advances in Integrative Medicine, vol 6, no Suppl. 1 , pp 106 - 107.
- Khan, M., Cazzonelli, C., Kurata, H., Badsha, M., Li, C., Muench, G. and Majid, A. (2019), 'Metabolic similarity of plant and human : implications for efficacy and regulatory compliance of herbal therapies', Australian Herbal Insight, vol 2, no 1 , pp 028 - 037.
- Purpura, M., Lowery, R., Wilson, J., Mannan, H., Muench, G. and Razmovski-Naumovski, V. (2018), 'Analysis of different innovative formulations of curcumin for improved relative oral bioavailability in human subjects', European Journal of Nutrition, vol 57, no 3 , pp 929 - 938.
- Gyengesi, E., Liang, H., Millington, C., Sonego, S., Sirijovski, D., Gunawardena, D., Dhananjayan, K., Venigalla, M., Niedermayer, G. and Muench, G. (2018), 'Investigation into the effects of Tenilsetam on markers of neuroinflammation in GFAP-IL6 mice', Pharmaceutical Research, vol 35, no 1 .
- Singh, A., Muench, G., Reddell, P., Radzieta, M., Jensen, S., Jensen, S. and Raju, R. (2018), 'A new anti-inflammatory phenolic monosaccharide from the Australian native rainforest plant Elaeocarpus eumundi', Natural Product Communications, vol 13, no 6 , pp 731 - 733.
- Raju, R., Singh, A., Reddell, P. and Muench, G. (2018), 'Anti-inflammatory activity of prenyl and geranyloxy furanocoumarins from Citrus garrawayi (Rutaceae)', Phytochemistry Letters, vol 27 , pp 197 - 202.
- Lamb, L., Alfonso, H., Norman, P., Davis, T., Forbes, J., Muench, G., Irrgang, F., Almeida, O., Golledge, J., Hankey, G., Flicker, L. and Yeap, B. (2018), 'Advanced glycation end products and esRAGE are associated with bone turnover and incidence of hip fracture in older men', Journal of Clinical Endocrinology and Metabolism, vol 103, no 11 , pp 4224 - 4231.
- Akhtar, M., Muench, G., Bodkin, F. and Raju, R. (2018), 'A new anti-inflammatory chromone from the leaves of Eucalyptus viminalis', Natural Product Communications, vol 13, no 10 , pp 1297 - 1301.
- Mohammadzadeh Honarvar, N., Saedisomeolia, A., Abdolahi, M., Shayeganrad, A., Taheri Sangsari, G., Hassanzadeh Rad, B. and Muench, G. (2017), 'Molecular anti-inflammatory mechanisms of retinoids and carotenoids in Alzheimer's disease : a review of current evidence', Journal of Molecular Neuroscience, vol 61, no 3 , pp 289 - 304.
- Ullah, F., Liang, H., Rangel, A., Gyengesi, E., Niedermayer, G. and Muench, G. (2017), 'High bioavailability curcumin : an anti-inflammatory and neurosupportive bioactive nutrient for neurodegenerative diseases characterized by chronic neuroinflammation', Archives of Toxicology, vol 91, no 4 , pp 1623 - 1634.
- Denzer-Lippmann, M., Bachlechner, S., Wielopolski, J., Fischer, M., Buettner, A., Doerfler, A., Schofl, C., Muench, G., Kornhuber, J. and Thurauf, N. (2017), 'The effects of a normal rate versus a slow intervalled rate of oral nutrient intake and intravenous low rate macronutrient application on psychophysical function : two pilot studies', Frontiers in Psychology, vol 8 .
- Dhananjayan, K., Gunawardena, D., Hearn, N., Sonntag, T., Moran, C., Gyengesi, E., Srikanth, V. and Muench, G. (2017), 'Activation of macrophages and microglia by interferon-Y and lipopolysaccharide increases methylglyoxal production : a new mechanism in the development of vascular complications and cognitive decline in type 2 diabetes mellitus?', Journal of Alzheimer's Disease, vol 59, no 2 , pp 467 - 479.
- Bachlechner, S., Denzer-Lippmann, M., Wielopolski, J., Fischer, M., Buettner, A., Doerfler, A., Schofl, C., Muench, G., Kornhuber, J. and Thurauf, N. (2017), 'The effects of different isocaloric oral nutrient solutions on psychophysical, metabolic, cognitive, and olfactory function in young male subjects', Frontiers in Psychology, vol 8 .
- Denzer, I., Muench, G., Pischetsrieder, M. and Friedland, K. (2016), 'S-allyl-l-cysteine and isoliquiritigenin improve mitochondrial function in cellular models of oxidative and nitrosative stress', Food Chemistry, vol 194 , pp 843 - 848.
- Denzer, I., Muench, G. and Friedland, K. (2016), 'Modulation of mitochondrial dysfunction in neurodegenerative diseases via activation of nuclear factor erythroid-2-related factor 2 by food-derived compounds', Pharmacological Research, vol 103 , pp 80 - 94.
- Johnson, A., Veljanoski, F., O'Doherty, P., Zaman, M., Petersingham, G., Bailey, T., Muench, G., Kersaitis, C. and Wu, M. (2016), 'Molecular insight into arsenic toxicity via the genome-wide deletion mutant screening of Saccharomces cerevisiae', Metallomics, vol 8, no 2 , pp 228 - 235.
- Steiner, N., Balez, R., Karunaweera, N., Lind, J., Muench, G. and Ooi, L. (2016), 'Neuroprotection of Neuro2a cells and the cytokine suppressive and anti-inflammatory mode of action of resveratrol in activated RAW264.7 macrophages and C8-B4 microglia', Neurochemistry International, vol 95 , pp 46 - 54.
- Jayne, T., Newman, M., Verdile, G., Sutherland, G., Muench, G., Musgrave, I., Moussavi Nik, S. and Lardelli, M. (2016), 'Evidence for and against a pathogenic role of reduced Y-secretase activity in familial Alzheimer's disease', Journal of Alzheimer's Disease, vol 52, no 3 , pp 781 - 799.
- Johnson, A., Veljanoski, F., O'Doherty, P., Zaman, M., Petersingham, G., Bailey, T., Muench, G., Kersaitis, C. and Wu, M. (2016), 'Revelation of molecular basis for chromium toxicity by phenotypes of Saccharomyces cerevisiae gene deletion mutants', Metallomics, vol 8, no 5 , pp 542 - 550.
- Moran, C., Tapp, R., Hughes, A., Magnussen, C., Blizzard, L., Phan, T., Beare, R., Witt, N., Venn, A., Muench, G., Amaratunge, B. and Srikanth, V. (2016), 'The association of Type 2 Diabetes Mellitus with cerebral gray matter volume is independent of retinal vascular architecture and retinopathy', Journal of Diabetes Research, vol 2016 .
- Moran, C., Tapp, R., Hughes, A., Magnussen, C., Blizzard, L., Phan, T., Beare, R., Witt, N., Venn, A., Muench, G., Amaratunge, B. and Srikanth, V. (2016), 'The association of Type 2 Diabetes Mellitus with cerebral gray matter volume is independent of retinal vascular architecture and retinopathy', Journal of Diabetes Research, vol 2016 .
- Balez, R., Steiner, N., Engel, M., Munoz, S., Lum, J., Wu, Y., Wang, D., Vallotton, P., Sachdev, P., O'Connor, M., Sidhu, K., Muench, G. and Ooi, L. (2016), 'Neuroprotective effects of apigenin against inflammation, neuronal excitability and apoptosis in an induced pluripotent stem cell model of Alzheimer's disease', Scientific Reports, vol 6 .
- Balez, R., Steiner, N., Engel, M., Munoz, S., Lum, J., Wu, Y., Wang, D., Vallotton, P., Sachdev, P., O'Connor, M., Sidhu, K., Muench, G. and Ooi, L. (2016), 'Neuroprotective effects of apigenin against inflammation, neuronal excitability and apoptosis in an induced pluripotent stem cell model of Alzheimer's disease', Scientific Reports, vol 6 .
- Venigalla, M., Sonego, S., Gyengesi, E., Sharman, M. and Muench, G. (2016), 'Novel promising therapeutics against chronic neuroinflammation and neurodegeneration in Alzheimer's disease', Neurochemistry International, vol 95 , pp 63 - 74.
- Raju, R., Gunawardena, D., Akhtar, M., Low, M., Reddell, P. and Muench, G. (2016), 'Anti-inflammatory chemical profiling of the Australian rainforest tree Alphitonia petriei (Rhamnaceae)', Molecules, vol 21, no 11 .
- Akhtar, M., Raju, R., Beattie, K., Bodkin, F. and Muench, G. (2016), 'Medicinal plants of the Australian Aboriginal Dharawal people exhibiting anti-inflammatory activity', Evidence-Based Complementary and Alternative Medicine, vol 2016 .
- Gunawardena, D., Karunaweera, N., Lee, S., van der Kooy, F., Harman, D., Raju, R., Bennett, L., Gyengesi, E., Sucher, N. and Muench, G. (2015), 'Anti-inflammatory activity of cinnamon (C. zeylanicum and C. cassia) extracts - identification of e-cinnamaldehyde and o-methoxy cinnamaldehyde as the most potent bioactive compounds', Food and Function, vol 6, no 3 , pp 910 - 919.
- Low, M., Khoo, C., Muench, G., Govindaraghavan, S. and Sucher, N. (2015), 'An in vitro study of anti-inflammatory activity of standardised Andrographis paniculata extracts and pure andrographolide', BMC Complementary and Alternative Medicine, vol 15 .
- Moran, C., Muench, G., Forbes, J., Beare, R., Blizzard, L., Venn, A., Phan, T., Chen, J. and Srikanth, V. (2015), 'Type 2 diabetes, skin autofluorescence, and brain atrophy', Diabetes, vol 64, no 1 , pp 279 - 283.
- Kuhla, A., Ludwig, S., Kuhla, B., Muench, G. and Vollmar, B. (2015), 'Advanced glycation end products are mitogenic signals and trigger cell cycle reentry of neurons in Alzheimer's disease brain', Neurobiology of Aging, vol 36, no 2 , pp 753 - 761.
- Karunaweera, N., Raju, R., Gyengesi, E. and Muench, G. (2015), 'Plant polyphenols as inhibitors of NF-KB induced cytokine production : a potential anti-inflammatory treatment for Alzheimer's disease?', Frontiers in Molecular Neuroscience, vol 8 .
- Venigalla, M., Sonego, S., Gyengesi, E. and Muench, G. (2015), 'Curcumin and apigenin : novel and promising therapeutics against chronic neuroinflammation in Alzheimer's disease', Neural Regeneration Research, vol 10, no 8 , pp 1181 - 1185.
- Venigalla, M., Sonego, S., Gyengesi, E. and Muench, G. (2015), 'Curcumin and apigenin : novel and promising therapeutics against chronic neuroinflammation in Alzheimer's disease', Neural Regeneration Research, vol 10, no 8 , pp 1181 - 1185.
- Gunawardena, D., Bennett, L., Shanmugam, K., King, K., Williams, R., Zabaras, D., Head, R., Ooi, L., Gyengesi, E. and Muench, G. (2014), 'Anti-inflammatory effects of five commercially available mushroom species determined in lipopolysaccharide and interferon-gamma activated murine macrophages', Food Chemistry, vol 148 , pp 92 - 96.
- Gunawardena, D., Shanmugam, K., Low, M., Bennett, L., Govindaraghavan, S., Head, R., Ooi, L. and Muench, G. (2014), 'Determination of anti-inflammatory activities of standardised preparations of plant- and mushroom-based foods', European Journal of Nutrition, vol 53, no 1 , pp 335 - 343.
- Payne, M., Wang, D., Sinclair, C., Kapsa, R., Quigley, A., Wallace, G., Razal, J., Baughman, R., Muench, G. and Vallotton, P. (2014), 'Automated quantification of neurite outgrowth orientation distributions on patterned surfaces', Journal of Neural Engineering, vol 11, no 046006 .
- Williams, R., Muench, G., Gyengesi, E. and Bennett, L. (2014), 'Bacopa monnieri (L.) exerts anti-inflammatory effects on cells of the innate immune system in vitro', Food and Function, vol 5, no 3 , pp 517 - 520.
- Millington, C., Sonego, S., Karunaweera, N., Rangel, A., Aldrich-Wright, J., Campbell, I., Gyengesi, E. and Muench, G. (2014), 'Chronic neuroinflammation in Alzheimer's disease : new perspectives on animal models and promising candidate drugs', BioMed Research International, vol 2014 .
- Apetz, N., Muench, G., Govindaraghavan, S. and Gyengesi, E. (2014), 'Natural compounds and plant extracts as therapeutics against chronic inflammation in Alzheimer's disease - a translational perspective', CNS & Neurological Disorders Drug Targets, vol 13, no 7 , pp 1175 - 1191.
- Steele, M., Fuller, S., Maczurek, A., Kersaitis, C., Ooi, L. and Muench, G. (2013), 'Chronic inflammation alters production and release of glutathione and related thiols in human U373 astroglial cells', Cell and Molecular Neurobiology, vol 33, no 1 , pp 19 - 30.
- Srikanth, V., Westcott, B., Forbes, J., Phan, T., Beare, R., Venn, A., Pearson, S., Greenaway, T., Parameswaran, V. and Muench, G. (2013), 'Methylglyoxal, cognitive function and cerebral atrophy in older people', Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, vol 68, no 1 , pp 68 - 73.
- Steele, M., Truong, J., Govindaraghavan, S., Ooi, L., Sucher, N. and Muench, G. (2013), 'Cytoprotective properties of traditional Chinese medicinal herbal extracts in hydrogen peroxide challenged human U373 astroglia cells', Neurochemistry International, vol 62, no 5 , pp 522 - 529.
- Ooi, L., Sidhu, K., Poljak, A., Sutherland, G., O'Connor, M., Sachdev, P. and Muench, G. (2013), 'Induced pluripotent stem cells as tools for disease modelling and drug discovery in Alzheimer's disease', Journal of Neural Transmission, vol 120, no 1 , pp 103 - 111.
- Rahman, S., Basilakis, J., Rahmadi, A., Lujic, S., Musgrave, I., Jorm, L., Hay, P. and Muench, G. (2013), 'Use of serotonergic antidepressants and St John's wort in older Australians : a population-based cohort study', Australasian Psychiatry, vol 21, no 3 , pp 262 - 266.
- Maczurek, A., Wild, R., Laurenti, D., Steele, M., Ooi, L. and Muench, G. (2013), 'Generation of hydrogen peroxide-resistant murine neuroblastoma cells : a target discovery platform for novel neuroprotective genes', Journal of Neural Transmission, vol 120, no 8 , pp 1171 - 1178.
- Sauer, T., Raithel, M., Kressel, J., Muench, G. and Pischetsrieder, M. (2013), 'Activation of the transcription factor Nrf2 in macrophages, Caco-2 cells and intact human gut tissue by Maillard reaction products and coffee', Amino Acids, vol 44, no 6 , pp 1427 - 1439.
- Jayasena, T., Poljak, A., Smythe, G., Braidy, N., Muench, G. and Sachdev, P. (2013), 'The role of polyphenols in the modulation of sirtuins and other pathways involved in Alzheimer's disease', Ageing Research Reviews, vol 12, no 4 , pp 867 - 883.
- Bennett, L., Kersaitis, C., Macaulay, S., Muench, G., Niedermayer, G., Nigro, J., Payne, M., Sheean, P., Vallotton, P., Zabaras, D. and Bird, M. (2013), 'Vitamin D2-Enriched Button Mushroom (Agaricus bisporus) Improves Memory in Both Wild Type and APPswe/PS1dE9 Transgenic Mice', PLoS One, vol 8, no 10 .
- Steele, M., Fuller, S., Patel, M., Kersaitis, C., Ooi, L. and Muench, G. (2013), 'Effect of Nrf2 activators on release of glutathione, cysteinylglycine and homocysteine by human U373 astroglial cells', Redox Biology, vol 1, no 1 , pp 441 - 445.
- Nguyen, N., Ooi, L., Piller, S. and Muench, G. (2013), 'Proenergetic effects of resveratrol in the murine neuronal cell line Neuro2a', Molecular Nutrition and Food Research, vol 57, no 11 , pp 1901 - 1907.
- Moran, C., Phan, T., Chen, J., Blizzard, L., Beare, R., Venn, A., Muench, G., Wood, A., Forbes, J., Greenaway, T., Pearson, S. and Srikanth, V. (2013), 'Brain atrophy in type 2 diabetes : regional distribution and influence on cognition', Diabetes Care, vol 36, no 12 , pp 4036 - 4042.
- Wild, R., Ooi, L., Srikanth, V. and Muench, G. (2012), 'A quick, convenient and economical method for the reliable determination of methylglyoxal in millimolar concentrations : the N-acetyl-L-cysteine assay', Analytical and Bioanalytical Chemistry, vol 403, no 9 , pp 2577 - 2581.
- Steele, M., Ooi, L. and Muench, G. (2012), 'Development of a high-performance liquid chromatography method for the simultaneous quantitation of glutathione and related thiols', Analytical Biochemistry, vol 429, no 1 , pp 45 - 52.
- Ravipati, A., Zhang, L., Koyyalamudi, S., Jeong, S., Reddy, N., Bartlett, J., Smith, P., Shanmugam, K., Muench, G., Wu, M., Satyanarayanan, M. and Vysetti, B. (2012), 'Antioxidant and anti-inflammatory activities of selected Chinese medicinal plants and their relation with antioxidant content', BMC Complementary and Alternative Medicine, vol 12 , pp 1 - 14.
- Muench, G., Westcott, B., Menini, T. and Gugliucci, A. (2012), 'Advanced glycation endproducts and their pathogenic roles in neurological disorders', Amino Acids, vol 42, no 4 , pp 1221 - 1236.
- Zhang, L., Ravipati, A., Koyyalamudi, S., Jeong, S., Reddy, N., Smith, P., Bartlett, J., Shanmugam, K., Muench, G. and Wu, M. (2011), 'Antioxidant and anti-inflammatory activities of selected medicinal plants containing phenolic and flavonoid compounds', Journal of Agricultural and Food Chemistry, vol 59, no 23 , pp 12361 - 12367.
- Sauer, T., Raithel, M., Kressel, J., Muscat, S., Muench, G. and Pischetsrieder, M. (2011), 'Nuclear translocation of NF-kB in intact human gut tissue upon stimulation with coffee and roasting products', Food and Function, vol 2, no 9 , pp 529 - 540.
- Rahmadi, A., Steiner, N. and Muench, G. (2011), 'Advanced glycation endproducts as gerontotoxins and biomarkers for carbonyl-based degenerative processes in Alzheimer's disease', Clinical Chemistry and Laboratory Medicine, vol 49, no 3 , pp 385 - 391.
- Krautwald, M., Leech, D., Horne, S., Steele, M., Forbes, J., Rahmadi, A., Griffith, R. and Muench, G. (2011), 'The advanced glycation end product-lowering agent ALT-711 Is a Low-Affinity inhibitor of thiamine Diphosphokinase', Rejuvenation Research, vol 14, no 4 , pp 383 - 391.
- Srikanth, V., Maczurek, A., Phan, T., Steele, M., Westcott, B., Juskiw, D. and Muench, G. (2011), 'Advanced glycation endproducts and their receptor RAGE in Alzheimer's disease', Neurolbiol Aging, vol 32, no 5 , pp 763 - 777.
- Vallotton, P., Sun, C., Lovell, D., Savelsbergh, M., Payne, M. and Muench, G. (2011), 'Identifying weak linear features with the "coalescing shortest path image transform"', Microscopy and Microanalysis, vol 17, no 6 , pp 911 - 914.
- Stutchbury, G. and Muench, G. (2010), 'Optimizing the generation of stable neuronal cell lines via pre-transfection restriction enzyme digestion of plasmid DNA', Cytotechnology, vol 62, no 3 , pp 189 - 194.
- Krautwald, M. and Muench, G. (2010), 'Advanced glycation end products as biomarkers and gerontotoxins - a basisto explore methylglyoxal-lowering agents for Alzheimer's disease?', Experimental Gerontology, vol 45, no 10 , pp 744 - 751.
- Hansen, E., Krautwald, M., Maczurek, A., Stutchbury, G., Fromm, P., Steele, M., Schulz, O., Garcia, O., Castillo, J., Korner, H. and Muench, G. (2010), 'A versatile high throughput screening system for the simultaneous identification of anti-inflammatory and neuroprotective compounds', Journal of Alzheimer's Disease, vol 19, no 2 , pp 451 - 464.
- Chandler, D., Woldu, A., Rahmadi, A., Shanmugam, K., Steiner, N., Wright, E., Benavente-Garcia, O., Schulz, O., Castillo, J. and Muench, G. (2010), 'Effects of plant-derived polyphenols on TNF-alpha and nitric oxide production induced by advanced glycation endproducts', Molecular Nutrition and Food Research, vol 54, no 2 , pp 141 - 150.
- Fuller, S., Steele, M. and Muench, G. (2010), 'Activated astroglia during chronic inflammation in Alzheimer's disease - do they neglect their neurosupportive roles?', Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, vol 690, no 1-2 , pp 40 - 49.
- Muscat, S., Pischetsrieder, M., Maczurek, A., Rothemund, S. and Muench, G. (2009), 'Cytotoxicity of Maillard reaction products determined with a peptide spot library', Mol Nutr Food Res, vol 53, no 8 , pp 1019 - 1029.
- Krautwald, M., Maxwell, P., Stuchbury, G., Holtum, J., Burnell, J. and Muench, G. (2009), 'The thiamine analogue and advanced glycation endproducts crosslink breaker ALT-711 does not interfere with transketolase activity', Open Longevity Science, vol 3, no 5 , pp 11 - 15.
- Hegele, J., Muench, G. and Pischetsrieder, M. (2009), 'Identification of hydrogen peroxide as a major cytotoxic component in Maillard reaction mixtures and coffee', Mol Nutr Food Res, vol 53, no 6 , pp 760 - 769.
- Fuller, S., Steele, M. and Muench, G. (2009), 'Activated astrocytes - a therapeutic target in Alzheimer's disease?', Expert Rev Neurotherapeutics, vol 9, no 11 , pp 1585 - 1594.
- Bigl, K., Gaunitz, F., Schmitt, A., Rothemund, S., Schliebs, R., Muench, G. and Arendt, T. (2008), 'Cytotoxicity of advanced glycation endproducts in human micro- and astroglial cell lines depends on the degree of protein glycation', Journal of Neural Transmission, vol 115, no 11 , pp 1545 - 1556.
- Maczurek, A., Hager, K., Kenklies, M., Sharman, M., Martins, R., Engel, J., Carlson, D. and Muench, G. (2008), 'Lipoic acid as an anti-inflammatory and neuroprotective treatment for Alzheimer's disease', Advanced Drug Delivery Reviews, vol 60, no 13-14 , pp 1463 - 1470.
- Shanmugam, K., Holmquist, L., Steele, M., Stuchbury, G., Berbaum, K., Schulz, O., Garcia, O., Castillo, J., Burnell, J., Rivas, V., Dobson, G. and Muench, G. (2008), 'Plant-derived polyphenols attenuate lipopolysaccharide-induced nitric oxide and tumour necrosis factor production in murine microglia and macrophages', Mol Nutr Food Res, vol 52, no 4 , pp 427 - 438.
- Shanmugam, K., Holmquist, L., Steele, M., Stuchbury, G., Berbaum, K., Schulz, O., Garcia, O., Castillo, J., Burnell, J., Rivas, V., Dobson, G. and Muench, G. (2008), 'Plant-derived polyphenols attenuate lipopolysaccharide-induced nitric oxide and tumour necrosis factor production in murine microglia and macrophages', Mol Nutr Food Res, vol 52, no 4 , pp 427 - 438.
- Berbaum, K., Shanmugam, K., Stuchbury, G., Wiede, F., Korner, H. and Muench, G. (2008), 'Induction of novel cytokines and chemokines by advanced glycation endproducts determined with a cytometric bead array', Cytokine, vol 41, no 3 , pp 198 - 203.
- Maczurek, A., Shanmugam, K. and Muench, G. (2008), 'Inflammation and the redox-sensitive AGE-RAGE pathway as a therapeutic target in Alzheimer's disease', Annals of the New York Academy of Sciences, vol 1126, no 0 , pp 147 - 151.
- Kuhla, B., Haase, C., Flach, K., Luth, H., Arendt, T. and Muench, G. (2007), 'Effect of pseudophosphorylation and cross-linking by lipid peroxidation and advanced glycation end product precursors on tau aggregation and filament formation', Journal of Biological Chemistry, vol 282, no 10 , pp 6984 - 6991.
- Holmquist, L., Stuchbury, G., Berbaum, K., Muscat, S., Young, S., Hager, K., Engel, J. and Muench, G. (2007), 'Lipoic acid as a novel treatment for Alzheimer's disease and related dementias', Pharmacology and Therapeutics, vol 113, no 1 , pp 154 - 164.
- de Arriba, S., Stuchbury, G., Yarin, J., Burnell, J., Loske, C. and Muench, G. (2007), 'Methylglyoxal impairs glucose metabolism and leads to energy depletion in neuronal cells-protection by carbonyl scavengers', Neurobiology of Aging, vol 28, no 7 , pp 1044 - 1050.
- Kuhla, B., Boeck, K., Schmidt, A., Ogunlade, V., Arendt, T., Muench, G. and Luth, H. (2007), 'Age- and stage-dependent glyoxalase I expression and its activity in normal and Alzheimer's disease brains', Neurobiology of Aging, vol 28, no 1 , pp 29 - 41.
- Schmidt, A., Kuhla, B., Bigl, K., Muench, G. and Arendt, T. (2007), 'Cell cycle related signaling in neuro2a cells proceeds via the receptor for advanced glycation end products', Journal of Neural Transmission, vol 114, no 11 , pp 1413 - 1424.
- Holmquist, L., Stuchbury, G., Steele, M. and Muench, G. (2007), 'Hydrogen peroxide is a true first messenger.', Journal of neural transmission. Supplementum, , no 72 , pp 39 - 41.
- Hager, K., Kenklies, M., Wenke, M., Fleischer, G., Engel, J. and Muench, G. (2007), '?-lipoic acid as a new treatment option for Alzheimer's disease- a follow-up analysis', Journal of neural transmission. Supplementum, vol 72 , pp 189 - 193.
- Steele, M., Stuchbury, G. and Muench, G. (2007), 'The molecular basis of the prevention of Alzheimer's disease through healthy nutrition', Experimental Gerontology, vol 42, no 40575 , pp 28 - 36.
- Bigl, K., Schmitt, A., Meiners, I., Muench, G. and Arendt, T. (2007), 'Comparison of results of the CellTiter Blue, the tetrazolium (3-[4,5-dimethylthioazol-2-yl]-2,5-diphenyl tetrazolium bromide), and the lactate dehydrogenase assay applied in brain cells after exposure to advanced glycation endproducts', Toxicology in Vitro, vol 21, no 5 , pp 962 - 971.
- Muscat, S., Pelka, J., Hegele, J., Weigle, B., Muench, G. and Pischetsrieder, M. (2007), 'Coffee and Maillard products activate NF-I?B in macrophages via H2O2 production', Molecular Nutrition and Food Research, vol 51, no 5 , pp 525 - 535.
- Kuhla, B., Boeck, K., Luth, H., Schmidt, A., Weigle, B., Schmitz, M., Ogunlade, V., Muench, G. and Arendt, T. (2006), 'Age-dependent changes of glyoxalase I expression in human brain', Neurobiology of Aging, vol 27, no 6 , pp 815 - 822.
- Kuhla, B., Luth, H., Haferburg, D., Weick, M., Reichenbach, A., Arendt, T. and Muench, G. (2006), 'Pathological effects of glyoxalase I inhibition in SH-SY5Y neuroblastoma cells', Journal of Neuroscience Research, vol 83, no 8 , pp 1591 - 1600.
- De Arriba, G., Krugel, U., Regenthal, R., Vissiennon, Z., Verdaguer, E., Lewerenz, A., Garcia-Jorda, E., Pallas, M., Camins, A., Muench, G., Nieber, K. and Allgaier, C. (2006), 'Carbonyl stress and NMDA receptor activation contribute to methylglyoxal neurotoxicity', Free Radical Biology and Medicine, vol 40, no 5 , pp 779 - 790.
- Langer, A., Poon, H., Muench, G., Lynn, B., Arendt, T. and Butterfield, D. (2006), 'Identification of AGE-modified proteins in SH-SY5Y and OLN-93 Cells', Neurotoxicity Research, vol 9, no 4 , pp 255 - 268.
- Huber, A., Stuchbury, G., Burkle, A., Burnell, J. and Muench, G. (2006), 'Neuroprotective therapies for Alzheimer's disease', Current Pharmaceutical Design, vol 12, no 6 , pp 705 - 717.
- Schmitt, A., Schmitt, J., Muench, G. and Gasic-Milencovic, J. (2005), 'Characterization of advanced glycation end products for biochemical studies: Side chain modifications and fluorescence characteristics', Analytical Biochemistry, vol 338, no 2 , pp 201 - 215.
- Ahmed, N., Ahmed, U., Thornalley, P., Hager, K., Fleischer, G. and Muench, G. (2005), 'Protein glycation, oxidation and nitration adduct residues and free adducts of cerebrospinal fluid in Alzheimer's disease and link to cognitive impairment', Journal of Neurochemistry, vol 92, no 2 , pp 255 - 263.
- Richter, T., Muench, G., Luth, H., Arendt, T., Kientsch-Engel, R., Stahl, P., Fengler, D. and Kuhla, B. (2005), 'Immunochemical crossreactivity of antibodies specific for "advanced glycation endproducts" with "advanced lipoxidation endproducts"', Neurobiology of Aging, vol 26, no 4 , pp 465 - 474.
- Stuchbury, G. and Muench, G. (2005), 'Alzheimer's associated inflammation, potential drug targets and future therapies', Journal of Neural Transmission, vol 112, no 3 , pp 429 - 453.
- Webster, J., Wilke, M., Stahl, P., Kientsch-Engel, R. and Muench, G. (2005), 'Maillard reaction products in food as pro-inflammatory and pro-arteriosclerotic factors of degenerative diseases [Maillardprodukte aus lebensmitteln als pro-entz??ndliche und pro-arteriosklerotische faktoren bei degenerativen erkrankungen]', Zeitschrift fur Gerontologie und Geriatrie, vol 38, no 5 , pp 347 - 353.
- Webster, J., Urban, C., Berbaum, K., Loske, C., Alpar, A., Gartner, U., De Arriba, S., Arendt, T. and Muench, G. (2005), 'The carbonyl scavengers aminoguanidine and tenilsetam protect against the neurotoxic effects of methylglyoxal', Neurotoxicity Research, vol 7, no 40575 , pp 95 - 101.
- Luth, H., Ogunlade, V., Kuhla, B., Kientsch-Engel, R., Stahl, P., Webster, J., Arendt, T. and Muench, G. (2005), 'Age- and stage-dependent accumulation of advanced glycation end products in intracellular deposits in normal and Alzheimer's disease brains', Cerebral Cortex, vol 15, no 2 , pp 211 - 220.
- Wihler, C., Schafer, S., Schmid, K., Deemer, E., Muench, G., Bleich, M., Busch, A., Dingermann, T., Somoza, V., Baynes, J. and Huber, J. (2005), 'Renal accumulation and clearance of advanced glycation end-products in type 2 diabetic nephropathy: Effect of angiotensin-converting enzyme and vasopeptidase inhibition', Diabetologia, vol 48, no 8 , pp 1645 - 1653.
- Schmitt, A., Meiners, I., Schmitt, J., Noller, J., Ihling, C., Muench, G., Sinz, A. and Nieber, K. (2005), 'Two analytical methods to study the interaction of AGEs with cell surface proteins', Journal of Biochemical and Biophysical Methods, vol 65, no 40604 , pp 121 - 136.
- Chen, F., Wollmer, M., Hoerndi, F., Muench, G., Kuhla, B., Rogaev, E., Tsolaki, M., Papassotiropoulos, A. and Gotz, J. (2004), 'Role for glyoxalase I in Alzheimer's disease', Proceedings of the National Academy of Sciences of the United States of America, vol 101, no 20 , pp 7687 - 7692.
- Robinson, S., Bishop, G., Lee, H. and Muench, G. (2004), 'Lessons from the AN 1792 Alzheimer vaccine: Lest we forget', Neurobiology of Aging, vol 25, no 5 , pp 609 - 615.
- Meiners, I., Hauschildt, S., Nieber, K. and Muench, G. (2004), 'Pentoxyphylline and propentophylline are inhibitors of TNF-I? release in monocytes activated by advanced glycation endproducts', Journal of Neural Transmission, vol 111, no 3 , pp 441 - 447.
- Kuhla, B., Loske, C., De Arriba, S., Schninzel, R., Huber, J. and Muench, G. (2004), 'Differential effects of "Advanced glycation endproducts" and I?-amyloid peptide on glucose utilization and ATP levels in the neuronal cell line SH-SY5Y', Journal of Neural Transmission, vol 111, no 3 , pp 427 - 439.
- Muench, G., Gasic-Milenkovic, J., Dukic-Stefanovic, S., Kuhla, B., Heinrich, K., Reiderer, P., Huttunen, H., Founds, H. and Sajithlal, G. (2003), 'Microglial activation induces cell death, inhibits neurite outgrowth and causes neurite retraction of differentiated neuroblastoma cells', Experimental Brain Research, vol 150, no 1 , pp 1 - 8.
- Dukic-Stefanovic, S., Gasic-Milenkovic, J., Deuther-Conrad, W. and Muench, G. (2003), 'Signal transduction pathways in mouse microglia N-11 cells activated by advanced glycation endproducts (AGEs)', Journal of Neurochemistry, vol 87, no 1 , pp 44 - 55.
- Muench, G., Apelt, J., Kientsch-Engel, R., Stahl, P., Luth, P. and Schliebs, R. (2003), 'Advanced glycation endproducts and pro-inflammatory cytokines in transgenic Tg2576 mice with amyloid plaque pathology', Journal of Neurochemistry, vol 86, no 2 , pp 283 - 289.
- Galler, A., Muller, G., Schinzel, R., Kratzsch, J., Kiess, W. and Muench, G. (2003), 'Impact of metabolic control and serum lipids on the concentration of advanced glycation end products in the serum of children and adolescents with type 1 diabetes, as determined by fluorescence spectroscopy and NI?-(carboxymethyl) lysine ELISA', Diabetes Care, vol 26, no 9 , pp 2609 - 2615.
- Robinson, S., Bishop, G. and Muench, G. (2003), 'Alzheimer vaccine: Amyloid-I? on trial', BioEssays, vol 25, no 3 , pp 283 - 288.
- Gasic-Milenkovic, J., Loske, C. and Muench, G. (2003), 'Advanced glycation endproducts cause lipid peroxidation in the human neuronal cell line SH-SY5Y', Journal of Alzheimer's Disease, vol 5, no 1 , pp 25 - 30.
- De Arriba, S., Loske, C., Meiners, I., Fleischer, G., Lobisch, M., Wessel, K., Tritschler, H., Schinzel, R. and Muench, G. (2003), 'Advanced Glycation Endproducts Induce Changes in Glucose Consumption, Lactate Production, and ATP Levels in SH-SY5Y Neuroblastoma Cells by a Redox-Sensitive Mechanism', Journal of Cerebral Blood Flow and Metabolism, vol 23, no 11 , pp 1307 - 1313.
- Gasic-Milenkovic, J., Dukic-Stefanovic, S., Deuther-Conrad, W., Gartner, U. and Muench, G. (2003), 'I?-Amyloid peptide potentiates inflammatory responses induced by lipopolysaccharide, interferon -I? and 'advanced glycation endproducts' in a murine microglia cell line', European Journal of Neuroscience, vol 17, no 4 , pp 813 - 821.
- Luth, H., Muench, G. and Arendt, T. (2002), 'Aberrant expression of NOS isoforms in Alzheimer's disease is structurally related to nitrotyrosine formation', Brain Research, vol 953, no 1-Feb , pp 135 - 143.
- Sajithlal, G., Huttunen, H., Rauvala, H. and Muench, G. (2002), 'Receptor for advanced glycation end products plays a more important role in cellular survival than in neurite outgrowth during retinoic acid-induced differentiation of neuroblastoma cells', Journal of Biological Chemistry, vol 277, no 9 , pp 6888 - 6897.
- Dukic-Stefanovic, S., Schicktanz, D., Wong, A., Palm, D., Riederer, P., Niwa, T., Schinzel, R. and Muench, G. (2002), 'Characterization of antibody affinities using an AGE-modified dipeptide spot library', Journal of Immunological Methods, vol 266, no 1-Feb , pp 45 - 52.
- Muench, G. and Robinson, S. (2002), 'Potential neurotoxic inflammatory responses to AI? vaccination in humans', Journal of Neural Transmission, vol 109, no 7-Aug , pp 1081 - 1087.
- Muench, G. and Robinson, S. (2002), 'Alzheimer's vaccine: A cure as dangerous as the disease?', Journal of Neural Transmission, vol 109, no 4 , pp 537 - 539.
- Wong, A., Luth, H., Deuther-Conrad, W., Dukic-Stefanovic, S., Gasic-Milenkovic, J., Arendt, T. and Muench, G. (2001), 'Advanced glycation endproducts co-localize with inducible nitric oxide synthase in Alzheimer's disease', Brain Research, vol 920, no 1-Feb , pp 32 - 40.
- Hager, K., Marahrens, A., Kenklies, M., Riederer, P. and Muench, G. (2001), 'Alpha-lipoic acid as a new treatment option for Azheimer type dementia', Archives of Gerontology and Geriatrics, vol 32, no 3 , pp 275 - 282.
- Deuther-Conrad, W., Loske, C., Schinzel, R., Dringen, R., Riederer, P. and Muench, G. (2001), 'Advanced glycation endproducts change glutathione redox status in SH-SY5Y human neuroblastoma cells by a hydrogen peroxide dependent mechanism', Neuroscience Letters, vol 312, no 1 , pp 29 - 32.
- Gasci-Milenkovic, J., Loske, C., Deuther-Conrad, W. and Muench, G. (2001), 'Protein "AGEing" - Cytotoxicity of a glycated protein increases with its degree of AGE-modification', Zeitschrift fur Gerontologie und Geriatrie, vol 34, no 6 , pp 457 - 460.
- Dukic-Stefanovic, S., Schinzel, R., Riederer, P. and Muench, G. (2001), 'AGES in the brain ageing: AGE-inhibitors as neuroprotective and anti-dementia drugs?', Biogerontology, vol 2, no 1 , pp 19 - 34.
- Wong, A., Dukic-Stefanovic, S., Gasic-Milenkovic, J., Schinzel, R., Wiesinger, H., Riederer, P. and Muench, G. (2001), 'Anti-inflammatory antioxidants attenuate the expression of inducible nitric oxide synthase mediated by advanced glycation endproducts in murine microglia', European Journal of Neuroscience, vol 14, no 12 , pp 1961 - 1967.
Conference Papers
- Liang, H., Sonego, S., Gyengesi, E., Rangel, A., Niedermayer, G., Karl, T. and Muench, G. (2017), 'Anti-inflammatory and neuroprotective effect of apigenin : studies in the GFAP-IL6 mouse model of chronic neuroinflammation', Oxygen Club of California. World Congress, Berlin, Germany.
- Payne, M., Muench, G. and Vallotton, P. (2013), 'A new GUI based toolbox to compare particle tracking approaches', International Symposium on Comnputational Models for Life Sciences, Sydney, N.S.W..
- Browne, C., Ratanapongleka, M., Muench, G., Parsons, C. and Morley, J. (2012), 'Alpha Lipoic Acid and noise induced hearing loss : a prevention and treatment trial', Association for Research in Otolaryngology Annual Midwinter Research Meeting, San Diego, Calif..
- Muench, G., Berbaum, K., Urban, C. and Schinzel, R. (2005), 'Proteins of Thermus thermophilus are resistant to glycation-induced protein precipitation: An evolutionary adaptation to life at extreme temperatures?', Annals of the New York Academy of Sciences, .
- Ahmed, N., Ahmed, U., Hager, K., Fleischer, G. and Muench, G. (2005), 'Protein glycation marker residues and free adducts of cerebrospinal fluid in Alzheimer's disease and a link to cognitive impairment', Annals of the New York Academy of Sciences, .
- Kuhla, B., Luth, H., Haferburg, D., Boeck, K., Arendt, T. and Muench, G. (2005), 'Methylglyoxal, glyoxal, and their detoxification in Alzheimer's disease', Annals of the New York Academy of Sciences, .
- Muench, G., Kuhla, B., Luth, H., Arendt, T. and Robinson, S. (2003), 'Anti-AGEing defences against Alzheimer's disease', Biochemical Society Transactions, .
- Muench, G., Gasic-Milenkovic, J. and Arendt, T. (2003), 'Effect of advanced glycation endproducts on cell cycle and their relevance for Alzheimer's disease', Journal of Neural Transmission, Supplement, .
- Muench, G., Deuther-Conrad, W. and Gasic-Milenkovic, J. (2002), 'Glycoxidative stress creates a vicious cycle of neurodegeneration in Alzheimer's disease - A target for neuroprotective treatment strategies?', Journal of Neural Transmission, Supplement, .
Current Projects
Title: | Identification and characterisation of new anti-inflammatory and neuroprotectant compounds and extracts from the Australian flora |
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Funder: |
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Western Researchers: | Gerald Muench |
Years: | 2014-02-15 - 2025-02-25 |
ID: | P00020996 |
Title: | Development of anti-inflammatory and antioxidant cellular extract combinations from Australian native plants via a synergistic approach |
Funder: |
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Western Researchers: | Phoebe Zhou, Gerald Muench and Dennis Chang |
Years: | 2022-12-01 - 2023-10-01 |
ID: | P00028398 |
Title: | In vivo evaluation of 'Meriva' curcumin phospholipid as anti-inflammatory drug in a mouse model of chronic neuroinflammation |
Funder: |
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Western Researchers: | Gerald Muench, Erika Gyengesi and David Harman |
Years: | 2016-03-31 - 2025-09-18 |
ID: | P00023016 |
Title: | Investigation of anti-inflammatory and neuroprotective activity of plant extracts for the treatment of Alzheimer's disease |
Funder: |
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Western Researchers: | Gerald Muench |
Years: | 2008-06-03 - 2024-07-30 |
ID: | P00016216 |
Title: | Stream 3 - Evaluation of novel therapeutic candidates |
Funder: |
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Western Researchers: | Michael O'Connor, Gerald Muench, Ritesh Raju, Tim Karl, Genevieve Steiner-Lim, Rose Chesworth Vieyra and Rossana Rosa Porto |
Years: | 2021-10-01 - 2025-12-31 |
ID: | P00027633 |
Title: | Stream 2 - New insights into disease mechanisms |
Funder: |
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Western Researchers: | Erika Gyengesi, Tara Roberts, Golo Ahlenstiel, Vincent Ho, Scott Read, Slade Jensen, Yossi Buskila, Ritesh Raju and Gerald Muench |
Years: | 2021-10-01 - 2025-12-31 |
ID: | P00027634 |
Title: | Evaluation of anti-inflammatories in restoring K+ homeostasis during neurodegeneration |
Funder: |
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Western Researchers: | Yossi Buskila, Erika Gyengesi, Rose Chesworth Vieyra and Gerald Muench |
Years: | 2022-04-01 - 2025-04-01 |
ID: | P00028081 |
Previous Projects
Title: | Effects of chronic inflammation on the cholinergic neurodegeneration and its therapeutic prevention by using highly bioavailable curcumin, as an anti-inflammatory agent |
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Funder: |
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Western Researchers: | Erika Gyengesi and Gerald Muench |
Years: | 2013-09-09 - 2015-01-09 |
ID: | P00021743 |
Title: | IDP Student Mobility Scholarship |
Funder: |
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Western Researchers: | Gerald Muench |
Years: | 2008-01-25 - 2010-12-31 |
ID: | P0016107 |
Title: | Identification of anti-inflammatory compounds from food and plant libraries as therapeutics for Alzheimer's Disease |
Funder: |
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Western Researchers: | Gerald Muench and Kirubakaran Shunmugam |
Years: | 2008-02-01 - 2011-12-31 |
ID: | P0016110 |
Title: | The role of central haemodynamics in Type 2 Diabetes Mellitus-related brain disease [via Monash Uni] |
Funder: |
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Western Researchers: | Gerald Muench |
Years: | 2014-03-28 - 2019-03-27 |
ID: | P00021871 |
Title: | Identification of anti-inflammatory compounds from white button mushrooms |
Funder: |
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Western Researchers: | Gerald Muench and Ritesh Raju |
Years: | 2014-07-22 - 2016-04-30 |
ID: | P00022214 |
Title: | Establishment of a mass spectrometer facility for natural products and proteomics research and teaching at the College of Health and Science within the University of Western Sydney, Campbelltown campus |
Funder: |
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Western Researchers: | Nikolaus Sucher, Jens Coorssen, Bill Price, Gerald Muench, Andrew Shalliker, Dennis Chang, Sabine Piller, Simon Myers, Colin Stack and Michelle Moffitt |
Years: | 2008-09-24 - 2010-09-15 |
ID: | P00016326 |
Title: | Identification of novel and potent Nrf2 activators from medicinal plants |
Funder: |
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Western Researchers: | Gerald Muench |
Years: | 2016-04-01 - 2021-05-31 |
ID: | P00023798 |
Title: | Investigating the architecture of rice starch at the nanoscale using complementary scattering methods to predict digestibility |
Funder: |
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Western Researchers: | Marion Gaborieau, Patrice Castignolles and Gerald Muench |
Years: | 2017-07-01 - 2019-06-30 |
ID: | P00024028 |
Title: | Mechanism of synergy of ingredients in natural products and functional foods |
Funder: |
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Western Researchers: | Chun Guang Li, Gerald Muench and Vijay Jayasena |
Years: | 2017-11-16 - 2021-05-15 |
ID: | P00023810 |
Title: | Activation of microglial cells by advanced glycation endproducts and beta-amyloid peptide via RAGE - a novel therapeutic target in Alzheimer's disease |
Funder: |
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Western Researchers: | Gerald Muench |
Years: | 2008-11-26 - 2012-12-31 |
ID: | P00016623 |
Title: | Reoxcyn Redox Concentration testing 2016 Extension (USD 41K) |
Funder: |
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Western Researchers: | Alejandra Rangel and Gerald Muench |
Years: | 2016-10-03 - 2017-07-17 |
ID: | P00024281 |
Title: | Reoxcyn Redox Concentration testing (USD $49K) Phase 1 |
Funder: |
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Western Researchers: | Gerald Muench |
Years: | 2015-11-11 - 2015-12-15 |
ID: | P00024282 |
Title: | A study of mechanisms of cognitive decline in Type 2 diabetes mellitus [via Monash University] |
Funder: |
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Western Researchers: | Gerald Muench |
Years: | 2009-06-11 - 2011-12-31 |
ID: | P00016232 |
Title: | Activation of glial cells by advanced glycation endproducts and beta-amyloid peptide via Rage - a novel therapeutic target in Alzheimer's disease |
Funder: |
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Western Researchers: | Gerald Muench |
Years: | 2008-04-29 - 2013-12-31 |
ID: | P00016143 |
Title: | Effect of Carnosine on pro-inflammatory signalling and toxicity of advanced glycation endproducts |
Funder: |
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Western Researchers: | Gerald Muench |
Years: | 2008-04-29 - 2022-06-30 |
ID: | P00016144 |
Title: | Identification of neuroprotective genes from a hydrogen-peroxide and glutamate resistant neuronal cell line - a novel approach to discover novel drug targets for neurodegenerative diseases |
Funder: |
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Western Researchers: | Gerald Muench |
Years: | 2008-07-08 - 2013-04-30 |
ID: | P00016284 |
Title: | Cell and Protein Analysis Unit |
Funder: |
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Western Researchers: | Simon Myers, Jens Coorssen, Sabine Piller, Annemarie Hennessy, Janice Aldrich-Wright, Soon Lee and Gerald Muench |
Years: | 2009-09-22 - 2010-09-21 |
ID: | P00017371 |
Title: | International Efforts in Translational Medicine |
Funder: |
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Western Researchers: | Jens Coorssen, Annemarie Hennessy, Bradley Frankum, Gerald Muench, Lind, Simon Myers and Soon Lee |
Years: | 2009-10-28 - 2010-10-27 |
ID: | P00017596 |
Title: | The neurosupportive role of astroglia - a novel drug target in Alzheimer's disease |
Funder: |
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Western Researchers: | Gerald Muench |
Years: | 2009-12-04 - 2011-12-30 |
ID: | P00017775 |
Title: | Understand and more accurately predict GI with techniques such as capillary electrophoresis and solid-state NMR spectroscopy |
Funder: |
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Western Researchers: | Marion Gaborieau, Patrice Castignolles and Gerald Muench |
Years: | 2017-02-01 - 2020-04-03 |
ID: | P00023894 |
Title: | Type 2 Diabetes Mellitus and Cognitive Decline - a longitudinal study of effects and mechanisms [via Monash Uni] |
Funder: |
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Western Researchers: | Gerald Muench |
Years: | 2010-01-01 - 2014-12-31 |
ID: | P00017003 |
Title: | Identification of anti-inflammatory and neuroprotective compounds from native Australian plants |
Funder: |
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Western Researchers: | Gerald Muench |
Years: | 2009-11-23 - 2012-03-31 |
ID: | P00017131 |
Title: | Anti-inflammatory and Neuroprotective effects of Lipoic acid (LA) in the treatment of Alzheimer's Disease |
Funder: |
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Western Researchers: | Gerald Muench |
Years: | 2009-05-14 - 2011-12-06 |
ID: | P00017177 |
Title: | A longitudinal population-based cohort study of brain ageing - The Tasmanian Study of Cognition and Gait [via Monash Uni] |
Funder: |
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Western Researchers: | Gerald Muench |
Years: | 2008-01-01 - 2013-01-01 |
ID: | P00016214 |
Title: | ALT-711 - a structural analog of thiamine (Vitamin B1) - a potential inhibitor of thiamine pyrophosphate synthesis? |
Funder: |
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Western Researchers: | Gerald Muench |
Years: | 2008-06-03 - 2011-12-31 |
ID: | P00016215 |
Title: | Development of image analysis to automate research in neurodegenerative diseases |
Funder: |
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Western Researchers: | Gerald Muench |
Years: | 2010-02-10 - 2013-05-09 |
ID: | P00018360 |
Title: | Investigation of anti-neuroinflammatory herbal combinations |
Funder: |
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Western Researchers: | Gerald Muench and Ritesh Raju |
Years: | 2021-01-04 - 2021-03-31 |
ID: | P00026877 |
Title: | Molecular characterization of the anti-inflammatory activity of Andrographis paniculata |
Funder: |
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Western Researchers: | Gerald Muench |
Years: | 2010-11-30 - 2012-12-12 |
ID: | P00019633 |
Title: | Screening for abdominal aortic aneurysms: long-term outcome and role of circulating markers of glycation [via UWA] |
Funder: |
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Western Researchers: | Gerald Muench |
Years: | 2011-01-01 - 2013-12-31 |
ID: | P00018593 |
Title: | Investigation of protective health benefits of selected varieties of mushroom in relation to Alzheimer's disease [via CSIRO] |
Funder: |
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Western Researchers: | Gerald Muench |
Years: | 2009-09-01 - 2011-12-31 |
ID: | P00017275 |
Title: | Glutathione delivery of astrocytes to Neurons as a target for therapeutic intervention in Alzheimer's disease |
Funder: |
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Western Researchers: | Gerald Muench and Megan Steele |
Years: | 2011-01-01 - 2013-12-31 |
ID: | P00018694 |
Title: | Bioavailability and Efficacy study of Pharmako Biotechnologies "HydroCurc" curcumin using the CaCo2 cell culture model and the GFAP-IL6 mouse |
Funder: |
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Western Researchers: | Gerald Muench, Mitchell Low, Ritesh Raju and Garry Niedermayer |
Years: | 2019-01-28 - 2020-12-19 |
ID: | P00025524 |
Supervision
Professor Muench is available to be a principal supervisor for doctoral projects
Current Supervision
Thesis Title: | Investigating the Anti-Inflammatory Activity of Selected Tropical Rainforest Plants |
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Field of Research: | |
Thesis Title: | Evaluation of Cognition Enhancing Effect of Natural Products |
Field of Research: | |
Thesis Title: | Inflammatory Pathology in Neurodegenerative Dementias |
Field of Research: | |
Thesis Title: | Use of a Behavioral Animal Testing Unit for the Evaluation of Cognition Enhancing Effects of Complementary and Alternative Medicines |
Field of Research: | |
Thesis Title: | Advanced Glycation End Products as Biomarkers for Cognitive Decline in Diabetic Patients |
Field of Research: | |
Thesis Title: | Encapsulated curcumin in nanoparticles - determination of curcumin and its metabolites in mice with brain inflammation |
Field of Research: | |
Thesis Title: | Australian Native Plants - A Source of Novel Anti-inflammatory Compounds |
Field of Research: | Pharmacology; Other Health; Other Natural And Physical Sciences; Organic Chemistry |
Thesis Title: | Identification of Novel Anti-Inflammatory Compounds from Plants as Potential Therapeutic for Chronic Neuroinflammatory Diseases |
Field of Research: | |
Thesis Title: | Effectiveness of a herbal and nutritional supplement on cognitive function in older adults with subjective cognitive complaints |
Field of Research: | |
Thesis Title: | Phytoequivalence of Standardized Andrographis Paniculata Extracts: An In-depth Study of Molecular Immunomodulatory Effects |
Field of Research: | |
Thesis Title: | Prevention of Inflammation and Neurodegeneration in Alzheimer's Disease by Antioxidant Combinations |
Field of Research: | |
Thesis Title: | Establishment of a High Content Co-Culture Screening Platform for the Discovery of Anti-Inflammatory Drugs in Alzheimer's Disease |
Field of Research: | Medical Science |
Thesis Title: | Prevention of neurodegeneration in Alzheimers disease by anti-inflammatory antioxidants |
Field of Research: | |
Thesis Title: | Identification of Novel Neuroprotective Genes - a Systems Biology Approach combining Genetic and Proteomic Analyses |
Field of Research: | |
Thesis Title: | Dicovery of anti-inflammatory and neuroprotective compounds from the Australian native flora |
Field of Research: | |
Thesis Title: | Isolation and Characterization of Plant Based Nrf2 Activating Compounds for the Treatment of Dementia |
Field of Research: | |
Thesis Title: | Identification of Anti-inflammatory and Neuroprotective Agents from Food and Plant Libraries |
Field of Research: | |
Thesis Title: | Identification of Molecular Targets of Anti-inflammatory Compounds |
Field of Research: | Medical Science |
Previous Supervision
Thesis Title: | Quality Control Methods for Herbal Medicine: A Multifaceted Approach |
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Field of Research: | Complementaty Therapies |
Thesis Title: | Development of a Novel Flurometric Method for the Detection of Methylglyoxal in Human Plasma |
Field of Research: | Pharmacology |
Thesis Title: | Identification of Neuroprotective Genes from Hydrogen Peroxide Resistant Neuron-like Cell Lines - An Innovative Approach to Discover Novel Drug Targets for Alzheimer's Disease |
Field of Research: | Medical Science |
Thesis Title: | Identification of Methyglyoxal-lowering Agents for the Treatment of Advanced Glycation End Products-related Diseases |
Field of Research: | General Medicine |
Thesis Title: | Effect of Proinflammatory Activation on the Neurosupportive Functions of Astrocytes |
Field of Research: | Medical Studies |
Thesis Title: | Effect of Glycated Proteins and Inhibitory Compounds Intervening with Age-Rage Pathway on Macrophages |
Field of Research: | General Medicine |
Thesis Title: | Neuroinflammation: Identifying approaches to protect neurons from inflammation-related death |
Field of Research: | Pharmacology; Biochemistry And Cell Biology |
Thesis Title: | Pulled through a Hedge Backwards: Improving the Quality of Life of People with Dementia through Dramatherapy |
Field of Research: | Performing Arts; Complementaty Therapies; Social Work |
Thesis Title: | Using Automated Image Analysis of Live Neurons to Screen for Natural Compounds Effective against Alzheimer's Disease |
Field of Research: | Biological Sciences, N.e.c.; Conceptual Modelling; Process And Resources Engineering, N.e.c. |
Thesis Title: | A study of the effects of chronic neuroinflammation on cognition and behaviour in the GFAP-IL6 transgenic mouse and investigation of the flavonoid apigenin as a neuroprotective agent |
Field of Research: | Medical Studies |
Thesis Title: | The effects of chronic neuroinflammation on cognition and behaviour in the GFAP-IL6 transgenic mouse and an investigation of the nootropic AGE inhibitor Tenilsetam. |
Field of Research: | Medical Science |
Thesis Title: | The Effects of Two Highly Bioavailable Curcumin Preparations on the Activation of Glial Cells and Chronic Neuroinflammation in GFAP-IL6 Mice |
Field of Research: | Pharmacology; Medical Studies, N.e.c.; Pharmacy |
Thesis Title: | The Therapeutic Potential of Phytocannabidiol cannabiodiol (CBD) for Alzheimer's Disease |
Field of Research: | Medical Studies, N.e.c. |