Professor Dennis Chang

Professor Dennis Chang

Director, NICM Health Research Institute,
NICM Health Research Institute

Professor,
Medical Sciences

Biography

Dennis Chang is a Professor of Pharmacology and lead of NICM's Healthy Hearts research program. His research interests include clinical and pharmacological studies of herbal medicine and other complementary medicine interventions at NICM Health Research Institute, Western Sydney University.

Professor Chang has led a numerous clinical trial projects evaluating the effect of herbal medicine, yoga and Tai Chi for the treatment of dementia, mild cognitive impairment, coronary heart disease, metabolic syndrome and type 2 diabetes.

He has also led multiple laboratory-based pharmacological studies to evaluate pharmacokinetic/bioavailability profiles and mechanisms of action underlying the neuro and cardiac-protective effects of herbal medicine using a range of in vitro and in vivo models.

Prof Chang's research has been published in a broad range of high-quality peer-reviewed journals such as Cochrane Systematic Review, Journal of Translational Medicine, Clinical Pharmacology and Therapeutics, and British Journal of Pharmacology. His research has attracted significant research funding support from various external funding agencies, governments and industry totalling over $6M.

As Associate Director of NICM Health Research Institute, Prof Chang also plays a leading role in the development of NICM's international partnership program, which has led to multiple substantial collaborations/partnerships with prestigious universities, research institutions and pharmaceutical/herbal medicine industry.

This information has been contributed by Professor Chang.

Qualifications

  • PhD University of Sydney
  • MSc University of Sydney

Organisational Unit (School / Division)

  • NICM Health Research Institute
  • Medical Sciences

Contact

Email: D.Chang@westernsydney.edu.au
Phone:
(02) 9685 4725
Mobile:
0404453682
Location: J.1.37
Westmead

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Teaching

Previous Teaching Areas

  • 400981 Clinical Pharmacology, 2020

Publications

Books

  • Dua, K., Nammi, S., Chang , D., Chellappan, D., Gupta, G. and Collet, T. (2021), 'Medicinal Plants for Lung Diseases: A Pharmacological and Immunological Perspective', : Springer 9789813368491.

Chapters in Books

  • Ayati, Z., Emami, S., Guillemin, G., Karamacoska, D. and Chang, D. (2021), '10 Persian herbal medicines used for brain health', Nutraceuticals in Brain Health and Beyond, Academic Press 9780128205938.
  • Ayati, Z., Chang, D. and Lake, J. (2020), 'Advances in treatment of mild cognitive impairment (MCI) and dementia : a review of promising non-pharmaceutical modalities', Frontiers in Clinical Drug Research - Dementia. Volume 1, Bentham Science Publishers 9789811410932.
  • Chang, D., Steiner, G., Ghosh, D. and Bensoussan, A. (2017), 'Vitamins and complementary therapies used to treat Alzheimer's Disease', Dementia, CRC Press 9781498703109.
  • Nammi, S., Sun, Y. and Chang, D. (2015), 'Effects of ginger on metabolic syndrome : a review of evidence', Clinical Aspects of Functional Foods and Nutraceuticals, CRC Press 9781466569102.
  • Chang, D., Colagiuri, B. and Luo, R. (2013), 'Chinese medicine used to treat dementia', Advances in Natural Medicines, Nutraceuticals and Neurocognition, CRC Press 9781439893609.
  • Doran, C., Chang, D., Kiat, H. and Bensoussan, A. (2012), 'Review of economic methods used in complementary medicine', Traditional, Complementary and Integrative Medicine : an International Reader, Palgrave 9780230232655.
  • Chang, D., Nammi, S. and Grant, S. (2012), 'Traditional understanding, modern science, and usage of herbal medicines for diabetes', Innovation in Healthy and Functional Foods, CRC Press 9781439862674.
  • Chang, D., Ghosh, D. and Bensoussan, A. (2010), 'Vitamins and complementary therapies used to treat Alzheimer's disease', Dementia, Hodder Education 9780340987278.
  • Liang, H. and Chang, D. (2010), 'Cancer Clinical Trials on Chinese Medicine', Supportive Cancer Care with Chinese Medicine, Springer Publishing 978904813555.
  • Chan, D., Ong, B. and Chang, D. (2006), 'Polypharmacy and Adverse Drug Reaction', Chan's Practical Geriatrics, BA Printing & Publishing Services 0646465961.

Journal Articles

  • Zheng, Y., Zhou, X., Chang, D., Bhuyan, D., Zhang, J., Yu, W., Jiang, X., Seto, S., Yeon, S., Li, J. and Li, C. (2021), 'A novel tri-culture model for neuroinflammation', Journal of Neurochemistry, vol 156, no 2 , pp 249 - 261.
  • Amarasekera, A., Chang, D., Schwarz, P. and Tan, T. (2021), 'Does vascular endothelial dysfunction play a role in physical frailty and sarcopenia? : a systematic review', Age and Ageing, vol 50, no 3 , pp 725 - 732.
  • Amarasekera, A., Chang, D., Schwarz, P. and Tan, T. (2021), 'Vascular endothelial dysfunction may be an early predictor of physical frailty and sarcopenia : a meta-analysis of available data from observational studies', Experimental Gerontology, vol 148 .
  • Amarasekera, A., Schwarz, P., Chang, D., Brakoulias, V. and Tan, T. (2021), 'Twin D-frail study protocol : does vitamin D link vascular endothelial dysfunction to sarcopenic frailty', Journal of Gerontology and Geriatric Medicine, vol 7, no 3 .
  • Yang, G., Sabag, A., Hao, W., Zhang, L., Jia, M., Dai, N., Zhang, H., Ayati, Z., Cheng, Y., Zhang, C., Zhang, X., Bu, F., Wen, M., Zhou, X., Liu, J., Wayne, P., Ee, C., Chang, D., Kiat, H., Hunter, J. and Bensoussan, A. (2021), 'Tai Chi for health and well-being : a bibliometric analysis of published clinical studies between 2010 and 2020', Complementary Therapies in Medicine, vol 60 .
  • Steiner, G., George, E., Metri, N., MacMillan, F., Dubois, S., Moyle, W., Hohenberg, M., Singh, K., Townsend, C., Chang, D., Bensoussan, A. and McBride, K. (2021), '[In Press] Use of complementary medicines and lifestyle approaches by people living with dementia : exploring experiences, motivations and attitudes', International Journal of Older People Nursing, .
  • Alsherbiny, M., Bhuyan, D., Radwan, I., Chang, D. and Li, C. (2021), 'Metabolomic identification of anticancer metabolites of Australian propolis and proteomic elucidation of its synergistic mechanisms with doxorubicin in the MCF7 cells', International Journal of Molecular Sciences, vol 22, no 15 .
  • Bilinski, K., Chang, D., Fahey, P. and Bensoussan, A. (2020), 'Effect of omega-3 supplementation on the omega-3 blood index and fatty acid biomarkers in healthy individuals', Advances in Integrative Medicine, vol 7 , pp 23 - 28.
  • Ayati, Z., Sarris, J., Chang, D., Emami, S. and Rahimi, R. (2020), 'Herbal medicines and phytochemicals for obsessive-compulsive disorder', Phytotherapy Research, vol 34, no 8 , pp 1889 - 1901.
  • Ee, C., Courten, B., Avard, N., de Manincor, M., Al-Dabbas, M., Hao, J., McBride, K., Dubois, S., White, R., Fleming, C., Egger, G., Blair, A., Stevens, J., MacMillan, F., Deed, G., Grant, S., Templeman, K. and Chang, D. (2020), 'Shared medical appointments and mindfulness for Type 2 diabetes : a mixed-methods feasibility study', Frontiers in Endocrinology, vol 11 .
  • Khodamoradi, K., Khosropanah, M., Ayati, Z., Chang, D., Nasli-Esfahani, E., Ayati, M. and Namazi, N. (2020), 'The effects of fenugreek on cardiometabolic risk factors in adults : a systematic review and meta-analysis', Complementary Therapies in Medicine, vol 52 .
  • Yeon, S., Seto, S., Chan, G., Low, M., Kait, H., Wang, N., Liu, J. and Chang, D. (2020), 'Endothelium-independent vasodilatory effect of Sailuotong (SLT) on rat isolated tail artery', Evidence-Based Complementary and Alternative Medicine, vol 2020 .
  • Ayati, Z., Yang, G., Ayati, M., Emami, S. and Chang, D. (2020), 'Saffron for mild cognitive impairment and dementia : a systematic review and meta-analysis of randomised clinical trials', BMC Complementary Medicine and Therapies, vol 20 .
  • Zhou, X., Li, C., Chang, D. and Bensoussan, A. (2019), 'Current status and major challenges to the safety and efficacy presented by Chinese herbal medicine', Medicines, vol 6, no 1 .
  • Zhou, X., Razmovski-Naumovski, V., Kam, A., Chang, D., Li, C., Chan, K. and Bensoussan, A. (2019), 'Synergistic study of a Danshen (Salvia Miltiorrhizae Radix et Rhizoma) and Sanqi (Notoginseng Radix et Rhizoma) combination on cell survival in EA.hy926 cells', BMC Complementary and Alternative Medicine, vol 19 .
  • Kazzem, M., Sun, Y., Low, M., Seto, S., Chang, D., Lee, S., Suresh, H., Khoo, C., Bensoussan, A. and Kiat, H. (2019), 'Chromatographic analysis and anti-oxidative property of Naoxinqing tablet, a proprietary preparation of Diospyros kaki leaves', Molecules, vol 24, no 6 .
  • Ali, M., Abd-Elsalam, W., El badawy, S., Taher, E., Fares, M., Torres, A., Chang, D. and Li, C. (2019), 'Ameliorative and protective effects of ginger and its main constituents against natural, chemical and radiation-induced toxicities : a comprehensive review', Food and Chemical Toxicology, vol 123 , pp 72 - 97.
  • He, L., Shi, X., Seto, S., Chang, D., Wang, H., Zhang, S., Chen, W. and Wang, J. (2019), 'Using 3D-UPLC-DAD and a new method-verification by adding mixture standard compounds to determine the fingerprint and eight active components of Naoluoxintong decoction', Journal of Pharmaceutical and Biomedical Analysis, vol 169 , pp 60 - 69.
  • Xue, B., Huang, J., Ma, B., Yang, B., Chang, D. and Liu, J. (2019), 'Astragaloside IV protects primary cerebral cortical neurons from oxygen and glucose deprivation/reoxygenation by activating the PKA/CREB pathway', Neuroscience, vol 404 , pp 326 - 337.
  • Sharman, M., Verdile, G., Shanmugam, K., Parenti, C., Singh, A., Watt, G., Karl, T., Chang, D., Li, C. and Muench, G. (2019), 'Targeting inflammatory pathways in Alzheimer's disease : a focus on natural products and phytomedicines', CNS Drugs, vol 33, no 5 , pp 457 - 480.
  • Cave, A., Chang, D., Muench, G. and Steiner, G. (2019), 'Efficacy of Cognition Support Formula? on cognitive function in older adults with subjective cognitive impairment : a protocol for a 26-week, randomised, double-blind, placebo-controlled trial', Trials, vol 20, no 1 .
  • Wu, S., Wang, N., Li, J., Wang, G., Seto, S., Chang, D. and Liang, H. (2019), 'Ligustilide ameliorates the permeability of the blood-brain barrier model in vitro during oxygen-glucose deprivation injury through HIF/VEGF pathway', Journal of Cardiovascular Pharmacology, vol 73, no 5 , pp 316 - 325.
  • Zhang, Y., Liu, J., Yao, M., Song, W., Zheng, Y., Xu, L., Sun, M., Yang, B., Bensoussan, A., Chang, D. and Li, H. (2019), 'Sailuotong capsule prevents the cerebral ischaemia-induced neuroinflammation and impairment of recognition memory through inhibition of LCN2 expression', Oxidative Medicine and Cellular Longevity, vol 2019 .
  • Ghelani, H., Razmovski-Naumovski, V., Inampudi, V., Chang, D. and Nammi, S. (2019), 'Atorvastatin improves hepatic lipid metabolism and protects renal damage in adenine-induced chronic kidney disease in Sprague-Dawley rats', BioMed Research International, vol 2019 .
  • Amarasekera, A. and Chang, D. (2019), 'Buddhist meditation for vascular function : a narrative review', Integrative Medicine Research, vol 8, no 4 , pp 252 - 256.
  • Jiang, Y., Liu, N., Zhu, S., Hu, X., Chang, D. and Liu, J. (2019), 'Elucidation of the mechanisms and molecular targets of Yiqi Shexue formula for treatment of primary immune thrombocytopenia based on network pharmacology', Frontiers in Pharmacology, vol 10 .
  • Ghelani, H., Razmovski-Naumovski, V., Chang, D. and Nammi, S. (2019), 'Chronic treatment of curcumin improves hepatic lipid metabolism and alleviates the renal damage in adenine-induced chronic kidney disease in Sprague-Dawley rats', BMC Nephrology, vol 20, no 1 .
  • Seto, S., Chang, D., Kiat, H., Wang, N. and Bensoussan, A. (2018), 'Chinese herbal medicine as a potential treatment of abdominal aortic aneurysm', Frontiers in Cardiovascular Medicine, vol 5 .
  • Zhao, A., Qiu, W., Mao, L., Ren, J., Xu, L., Yao, M., Stalgis-Bilinski, K., Chang, D. and Liu, J. (2018), 'The efficacy and safety of Jiedu Tongluo granules for treating post-stroke depression with qi deficiency and blood stasis syndrome : study protocol for a randomized controlled trial', Trials, vol 19, no 1 .
  • Zhang, Y., Liu, J., Yang, B., Zheng, Y., Yao, M., Sun, M., Xu, L., Lin, C., Chang, D. and Tian, F. (2018), 'Ginkgo biloba extract inhibits astrocytic lipocalin-2 expression and alleviates neuroinflammatory injury via the JAK2/STAT3 pathway after ischemic brain stroke', Frontiers in Pharmacology, vol 9 .
  • Li, L., Hasegawa, H., Inaba, N., Yoshioka, W., Chang, D., Liu, J. and Ichida, K. (2018), 'Diet-induced hyperhomocysteinemia impairs vasodilation in 5/6-nephrectomized rats', Amino Acids, vol 50, no 10 , pp 1485 - 1494.
  • Steiner, G., Bensoussan, A., Liu, J., Hohenberg, M. and Chang, D. (2018), 'Study protocol for a randomised, double-blind, placebo-controlled 12-week pilot phase II trial of Sailuotong (SLT) for cognitive function in older adults with mild cognitive impairment', Trials, vol 19 .
  • Yang, G., Wang, N., Seto, S., Chang, D. and Liang, H. (2018), 'Hydroxysafflor yellow A protects brain microvascular endothelial cells against oxygen glucose deprivation/reoxygenation injury : involvement of inhibiting autophagy via class I PI3K/Akt/mTOR signaling pathway', Brain Research Bulletin, vol 140 , pp 243 - 257.
  • Wu, S., Wang, N., He, Q., Chang, G., Seto, S., Chang, D. and Liang, H. (2018), 'The establishment of the method of cell biochromatograpy and analysis of the active ingredients from TongQiaoHuoXue decoction acting on the neurocytes', Chemical and Pharmaceutical Bulletin, vol 66, no 10 , pp 983 - 991.
  • Ma, B., Chen, J., Mu, Y., Xue, B., Zhao, A., Wang, D., Chang, D., Pan, Y. and Liu, J. (2018), 'Proteomic analysis of rat serum revealed the effects of chronic sleep deprivation on metabolic, cardiovascular and nervous system', PLoS One, vol 13, no 9 .
  • Seto, S., Chang, D., Ko, W., Zhou, X., Kiat, H., Bensoussan, A., Lee, S., Hoi, M., Steiner, G. and Liu, J. (2017), 'Sailuotong prevents hydrogen peroxide (H2O2)-induced injury in EA.hy926 cells', International Journal of Molecular Sciences, vol 18, no 1 .
  • Steiner, G., Mathersul, D., MacMillan, F., Camfield, D., Klupp, N., Seto, S., Huang, Y., Hohenberg, M. and Chang, D. (2017), 'A systematic review of intervention studies examining nutritional and herbal therapies for mild cognitive impairment and dementia using neuroimaging methods : study characteristics and intervention efficacy', Evidence-Based Complementary and Alternative Medicine, vol 2017 .
  • Yang, G., Li, W., Cao, H., Klupp, N., Liu, J., Bensoussan, A., Kiat, H. and Chang, D. (2017), 'Does Tai Chi improve psychological well-being and quality of life in patients with cardiovascular disease and/or cardiovascular risk factors? : a systematic review protocol', BMJ Open, vol 7 .
  • Gupta, R., Chang, D., Nammi, S., Bensoussan, A., Stalgis-Bilinski, K. and Roufogalis, B. (2017), 'Interactions between antidiabetic drugs and herbs : an overview of mechanisms of action and clinical implications', Diabetology and Metabolic Syndrome, vol 9, no 1 .
  • Zhou, X., Razmovski-Naumovski, V., Kam, A., Chang, D., Li, C., Bensoussan, A. and Chan, K. (2017), 'Synergistic effects of Danshen (Salvia Miltiorrhizae Radix et Rhizoma) and Sanqi (Notoginseng Radix et Rhizoma) combination in angiogenesis behavior in EAhy 926 cells', Medicines, vol 4, no 4 .
  • Steiner, G., Yeung, A., Liu, J., Camfield, D., De Blasio, F., Pipingas, A., Scholey, A., Stough, C. and Chang, D. (2016), 'The effect of Sailuotong (SLT) on neurocognitive and cardiovascular function in healthy adults : a randomised, double-blind, placebo controlled crossover pilot trial', BMC Complementary and Alternative Medicine, vol 16 , pp 1 - 13.
  • Li, D., Wang, J., Hou, J., Fu, J., Chang, D., Bensoussan, A. and Liu, J. (2016), 'Ginsenoside Rg1 protects starving H9c2 cells by dissociation of Bcl-2-Beclin1 complex', BMC Complementary and Alternative Medicine, vol 16, no 1 .
  • Zhou, X., Seto, S., Chang, D., Kiat, H., Razmovski-Naumovski, V., Chan, K. and Bensoussan, A. (2016), 'Synergistic effects of Chinese herbal medicine : a comprehensive review of methodology and current research', Frontiers in Pharmacology, vol 7 .
  • Klupp, N., Kiat, H., Bensoussan, A., Steiner, G. and Chang, D. (2016), 'A double-blind, randomised, placebo-controlled trial of Ganoderma lucidum for the treatment of cardiovascular risk factors of metabolic syndrome', Scientific Reports, vol 6 .
  • Seto, S., Chang, D., Jenkins, A., Bensoussan, A. and Kiat, H. (2016), 'Angiogenesis in ischemic stroke and angiogenic effects of Chinese herbal medicine', Journal of Clinical Medicine, vol 5, no 6 .
  • Zhou, X., Razmovski-Naumovski, V., Chang, D., Li, C., Kam, A., Low, M., Bensoussan, A. and Chan, K. (2016), 'Synergistic effects of Danshen (Salvia Miltiorrhiza Radix et Rhizoma) and Sanqi (Notoginseng Radix et Rhizoma) combination in inhibiting inflammation mediators in RAW264.7 cells', BioMed Research International, vol 2016 .
  • Chang, D., Liu, J., Stalgis-Bilinski, K., Li, X., Steiner, G., Seto, S. and Bensoussan, A. (2016), 'Herbal medicine for the treatment of vascular dementia : an overview of scientific evidence', Evidence-Based Complementary and Alternative Medicine, vol 2016 .
  • van der Kooy, F., Venkataya, B., Pearson, J., Torres, A., Li, C. and Chang, D. (2015), 'Sensitivity of NMR-based metabolomics in drug discovery from medicinal plants', European Journal of Medicinal Plants, vol 5, no 2 , pp 191 - 203.
  • Seto, S., Yang, G., Kiat, H., Bensoussan, A., Kwan, Y. and Chang, D. (2015), 'Diabetes Mellitus, cognitive impairment, and traditional Chinese medicine', International Journal of Endocrinology, vol 2015 .
  • Klupp, N., Chang, D., Hawke, F., Kiat, H., Cao, H., Grant, S. and Bensoussan, A. (2015), 'Ganoderma lucidum mushroom for the treatment of cardiovascular risk factors (Review)', Cochrane Database of Systematic Reviews, vol 2 .
  • Bensoussan, A., Lee, S., Murray, C., Bourchier, S., van der Kooy, F., Pearson, J., Liu, J., Chang, D. and Khoo, C. (2015), 'Choosing chemical markers for quality assurance of complex herbal medicines : development and application of the Herb MaRS criteria', Clinical Pharmacology and Therapeutics, vol 97, no 6 , pp 628 - 640.
  • Fan, X., Wang, J., Hou, J., Lin, C., Bensoussan, A., Chang, D., Liu, J. and Wang, B. (2015), 'Berberine alleviates ox-LDL induced inflammatory factors by up-regulation of autophagy via AMPK/mTOR signaling pathway', Journal of Translational Medicine, vol 13, no 1 .
  • Seto, S., Kiat, H., Lee, S., Bensoussan, A., Sun, Y., Hoi, M. and Chang, D. (2015), 'Zebrafish models of cardiovascular diseases and their applications in herbal medicine research', European Journal of Pharmacology, vol 768 , pp 77 - 86.
  • Yeung, A., Chang, D., Bensoussan, A. and Kiat, H. (2015), 'Yoga and cardiac rehabilitation : a brief review of evidence', Journal of Yoga & Physical Therapy, vol 5, no 4 .
  • Yao, M., Zhang, P., Song, W., Xu, L., Bensoussan, A., Chang, D. and Liu, J. (2014), 'Effect of Tongluo Qingnao injection on glutamate and GABA in cerebral microdialysis samples of ischemia/reperfusion rats', Chinese Journal of Experimental Traditional Medical Formulae, vol 20, no 12 , pp 136 - 140.
  • Zhang, Y., Lin, L., Ren, C., Lin, C., Liu, J., Chang, D. and Bensoussan, A. (2014), 'Pharmacokinetics and brain distribution of ginkgolides after administration of Sai-Luo-Tong', Modernization of Traditional Chinese Medicine and Materia Medica, vol 16, no 7 , pp 1458 - 1464.
  • Yeung, A., Kiat, H., Denniss, A., Cheema, B., Bensoussan, A., Machliss, B., Colagiuri, B. and Chang, D. (2014), 'Randomised controlled trial of a 12 week yoga intervention on negative affective states, cardiovascular and cognitive function in post-cardiac rehabilitation patients', BMC Complementary and Alternative Medicine, vol 14 .
  • Grant, S., Schnyer, R., Chang, D., Fahey, P. and Bensoussan, A. (2013), 'Interrater reliability of Chinese medicine diagnosis in people with prediabetes', Evidence-Based Complementary and Alternative Medicine, vol 2013 , pp 1 - 8.
  • Asamoah, S., Siegler, J., Chang, D., Scholey, A., Yeung, A. and Cheema, B. (2013), 'Effect of aerobic training on cognitive function and arterial stiffness in sedentary young adults : a pilot randomized controlled trial', Physiology Journal, vol 2013 , pp 1 - 9.
  • Tan, X., Tan, D., Brown, L., Yang, D., Zhu, L., Chen, Y., Chang, D. and Wang, D. (2013), 'Isolation and purification of four bioactive constituents from Alpinia officinarum Hance utilizing high-speed counter-current chromatography', Journal of Liquid Chromatography and Related Technologies, vol 36, no 10 , pp 1355 - 1365.
  • Grant, S., Chang, D., Liu, J., Wong, V., Kiat, H. and Bensoussan, A. (2013), 'Chinese herbal medicine for impaired glucose tolerance : a randomized placebo controlled trial', BMC Complementary and Alternative Medicine, vol 13, no 1 , pp 104 - 113.
  • Cheema, B., Houridis, A., Busch, L., Raschke-Cheema, V., Melville, G., Marshall, P., Chang, D., Machliss, B., Lonsdale, C., Bowman, J. and Colagiuri, B. (2013), 'Effect of an office worksite-based yoga program on heart rate variability : outcomes of a randomized controlled trial', BMC Complementary and Alternative Medicine, vol 13, no 82 , pp 1 - 10.
  • Cao, H., Wang, Y., Chang, D., Zhou, L. and Liu, J. (2013), 'Acupuncture for vascular mild cognitive impairment : a systematic review of randomised controlled trials', Acupuncture in Medicine, vol 31, no 4 , pp 368 - 374.
  • Jelinek, H., Huang, Z., Khandoker, A., Chang, D. and Kiat, H. (2013), 'Cardiac rehabilitation outcomes following a 6-week program of PCI and CABG patients', Frontiers in Physiology, vol 4 , pp 1 - 7.
  • Melville, G., Chang, D., Colagiuri, B., Marshall, P. and Cheema, B. (2012), 'Fifteen minutes of chair-based yoga postures or guided meditation performed in the office can elicit a relaxation response', Evidence-based Complementary and Alternative Medicine, vol 2012 .
  • Stough, C., Pase, M., Cropley, V., Myers, S., Nolidin, K., King, R., Camfield, D., Wesnes, K., Pipingas, A., Croft, K., Chang, D. and Scholey, A. (2012), 'A randomized controlled trial investigating the effect of Pycnogenol and Bacopa CDRI08 herbal medicines on cognitive, cardiovascular, and biochemical functioning in cognitively healthy elderly people : the Australian Research Council Longevity Intervention (ARCLI) study protocol (ANZCTR12611000487910)', Nutrition Journal, vol 11, no 11 , pp 1 - 9.
  • Grant, S., Bin, Y., Kiat, H. and Chang, D. (2012), 'The use of complementary and alternative medicine by people with cardiovascular disease : a systematic review', BMC Public Health, vol 12 , pp 1 - 9.
  • Cheema, B., Marshall, P., Chang, D., Colagiuri, B. and Machliss, B. (2011), 'Effect of an office worksite-based yoga program on heart rate variability : a randomized controlled trial [Study Protocol]', BMC Public Health, vol 11 .
  • Kiat, H., Bin, Y., Grant, S. and Chang, D. (2011), 'Complementary Medicine Use in Cardiovascular Disease: A Clinician's Viewpoint.', The Medical Journal of Australia, vol 195, no 11 , pp 654 - 656.
  • Gray, M., Chang, D., Zhang, Y., Liu, J. and Bensoussan, A. (2010), 'Development of liquid chromatography/mass spectrometry methods for the quantitative analysis of herbal medicine in biological fluids : a review', Biomedical Chromatography, vol 24, no 1 , pp 91 - 103.
  • Doran, C., Chang, D., Kiat, H. and Bensoussan, A. (2010), 'Review of methodological approaches to economic analysis of complementary medicine interventions', Journal of Alternative and Complementary Medicine, vol 16, no 5 , pp 591 - 595.
  • Grant, S., Bensoussan, A., Chang, D., Kiat, H., Klupp, N., Liu, J. and Li, X. (2009), 'Chinese herbal medicines for people with impaired glucose tolerance or impaired fasting blood glucose', Cochrane Database of Systematic Reviews, vol 4 , pp 1 - 106.
  • Grant, S., Bensoussan, A., Chang, D., Kiat, H., Klupp, N., Liu, J. and Li, X. (2009), 'Chinese herbal medicines for people with impaired glucose tolerance or impaired fasting blood glucose.', Cochrane database of systematic reviews (Online), , no 4 .
  • Klupp, N., Chang, D., Hawke, F., Kiat, H., Grant, S. and Bensoussan, A. (2008), 'Ganoderma lucidum for the treatment of cardiovascular risk factors', Cochrane Database of Systematic Reviews, , no 3 .
  • Wang, J., Liu, J., Chang, D. and Bensoussan, A. (2008), 'Pharmacokinetic study of detecting medicinal ingredients of traditional Chinese medicines in different extract base', World Science and Technology: Modernization of Traditional Chinese Medicine and Materia Medica, vol 10, no 6 , pp 32 - 36.
  • Grant, S., Bensoussan, A., Chang, D., Kiat, H., Klupp, N. and Liu, J. (2007), 'Chinese herbal medicines for people with impaired glucose tolerance or impaired fasting blood glucose dysmenorrhoea (protocol)', Cochrane Database of Systematic Reviews, vol 2007, no 3 , pp 1 - 17.
  • Liu, J. and Chang, D. (2006), 'Vascular Dementia', The Journal of Complementary Medicine, vol 5, no 2 , pp 14 - 20.
  • Mather, L., Duke, C., Ladd, L., Copeland, S., Gallagher, G. and Chang, D. (2004), 'Direct cardiac effects of coronary site-directed thiopental and its enantiomers', Anesthesiology, vol 101, no 2 , pp 354 - 364.
  • Mather, L., Ladd, L., Copeland, S. and Chang, D. (2004), 'Effects of imposed acid-base derangement on the cardiovasscular effects and pharmacokinetics of bupivacaine adn thiopental.', Anesthesioloy, vol 100, no 6 , pp 1457 - 1468.
  • Ladd, L., Chang, D., Wilson, K., Copeland, S., Plummer, J. and Mather, L. (2002), 'Effects of CNS site-directed carotid arterial infusions of bupivacaine, levobupivacaine, and ropivacaine in sheep', Anesthesiology, vol 97, no 2 , pp 418 - 428.
  • Chang, D., Ladd, L., Copeland, S., Iglesias, M., Plummer, J. and Mather, L. (2001), 'Direct cardiac effects of intracoronary bupivacaine, levobupivacaine and ropivacaine in the sheep', British Journal Of Pharmacology, vol 132, no 3 , pp 649 - 658.
  • Mather, L. and Chang, D. (2001), 'Cardiotoxicity with modern local anaesthetics: Is there a safer choice', Drugs, vol 61, no 3 , pp 333 - 342.

Conference Papers

  • Cheema, B., Houridis, A., Busch, L., Raschke-Cheema, V., Melville, G., Marshall, P., Chang, D., Machliss, B., Lonsdale, C., Bowman, J. and Colagiuri, B. (2012), 'Effect of an office worksite-based yoga program on heart rate variability : a randomized controlled trial', American College of Sports Medicine. Annual Meeting, San Francisco, Calif..
  • Melville, G., Chang, D., Colagiuri, B., Marshall, P. and Cheema, B. (2011), 'Fifteen minutes of chair-based yoga postures or guided meditation in the office can elicit psychological and physiological relaxation', Australian Conference of Science and Medicine in Sport, Perth, W.A..

Research Strengths

Prof Chang's research constitutes an original and significant contribution to knowledge in the areas of complementary medicine. He has established solid research profiles in pharmacological and clinical studies of herbal medicine used for neurodegenerative and cardiovascular diseases. He has been a chief investigator for a number of significant clinical trials of complementary medicine interventions for dementia, diabetes, metabolic syndrome and cardiac rehabilitation. Prof Chang has also led several pharmacological studies of herbal medicine including pharmacokinetic study/bioavailability of herbal medicine in humans and animals and in vitro herb-drug interaction study. He has also been involved in setting up/employing several in vivo animal models in the study of mechanisms of action of herbal medicine (e.g. zebrafish model for the study of angiogenesis neuroprotective effects; animal behaviour model for the study of memory and cognitive functions).

This information has been contributed by Professor Chang.

Previous Projects

Title: Development of analytical methodologies for quality assurance and bioavailability of Chinese herbal medicines
Funder:
  • University of Western Sydney
Western Researchers: Dennis Chang
Years: 2003-02-15 - 2004-02-24
ID: P0013690
Title: Establishment of a Patient Information Database to monitor and evaluate clinical practice in Traditional Chinese Medicine (TCM)
Funder:
  • University of Western Sydney
Western Researchers: Dennis Chang
Years: 2002-05-01 - 2003-08-30
ID: P0010172
Title: Collaboration on the development of validation methods for Chinese herbal medicines
Funder:
  • Department of Education, Science and Training
Western Researchers: Alan Bensoussan, Dennis Chang and Cheang Khoo
Years: 2003-06-23 - 2004-05-31
ID: P0013174
Title: Clinical Trial of a Chinese herbal medicine for Blood Pressure and Glycemic control - preliminary work
Funder:
  • Concord International Trading Pty Ltd
Western Researchers: Dennis Chang
Years: 2004-07-08 - 2004-11-24
ID: P0014394
Title: Creating scientifically validated and evidence based natural medicines: development of laboratories and clinical research capacity.
Funder:
  • University of Western Sydney
Western Researchers: Alan Bensoussan, Dennis Chang and Cheang Khoo
Years: 2005-10-05 - 2006-10-04
ID: P0014811
Title: Developing bioavailability methods in herbal medicine
Funder:
  • Department of Education, Science and Training
Western Researchers: Alan Bensoussan and Dennis Chang
Years: 2007-03-13 - 2007-08-31
ID: P0015147
Title: Creating scientifically validated and evidence-based natural medicines. Phase 2: Development of the herbal pharmacology laboratory
Funder:
  • University of Western Sydney
Western Researchers: Alan Bensoussan, Dennis Chang and Cheang Khoo
Years: 2006-09-01 - 2007-08-31
ID: P0015239
Title: An investigation into the neural substrates of cognitive deficits in Mild Cognitive Impairment, and the mechanisms of action of a novel treatment
Funder:
  • National Health and Medical Research Council (ACRG)
Western Researchers: Genevieve Steiner and Dennis Chang
Years: 2016-01-01 - 2020-09-30
ID: P00022655
Title: Establishment of a mass spectrometer facility for natural products and proteomics research and teaching at the College of Health and Science within the University of Western Sydney, Campbelltown campus
Funder:
  • University of Western Sydney
Western Researchers: Nikolaus Sucher, Jens Coorssen, Bill Price, Gerald Muench, Andrew Shalliker, Dennis Chang, Sabine Piller, Simon Myers, Colin Stack and Michelle Moffitt
Years: 2008-09-24 - 2010-09-15
ID: P00016326
Title: NICM-FIT BioCeuticals Omega 3 Pilot trial
Funder:
  • FIT-BioCeuticals Limited
Western Researchers: Dennis Chang, Alan Bensoussan and Kellie Stalgis-Bilinski
Years: 2016-07-15 - 2018-01-31
ID: P00024321
Title: Traditional Chinese Medicine Diagnosis for Pre-Diabetes & Development of a Chinese Medicine Assessment Measure
Funder:
  • Australian Acupuncture & Chinese Medicine Association Ltd
Western Researchers: Dennis Chang
Years: 2008-07-02 - 2009-02-28
ID: P00016505
Title: Quality assurance and bioavailability of a Chinese herbal proprietary formula
Funder:
  • AusIndustry - Dept Industry Science & Resources
Western Researchers: Alan Bensoussan, Cheang Khoo, Janice Aldrich-Wright, Andrew Shalliker, Kamali Kannangara, Dennis Chang and Mick Wilson
Years: 2002-12-16 - 2004-03-31
ID: P0010628
Title: Joint Chair in Traditional Chinese Medicine
Funder:
  • Department of State and Regional Development
Western Researchers: Alan Bensoussan and Dennis Chang
Years: 2008-06-01 - 2014-12-01
ID: P00016230
Title: NICM TCM Neuroprotective effects of Chinese Herbal Medicine
Funder:
  • Department of Health (non ACRG)
Western Researchers: Dennis Chang
Years: 2008-08-21 - 2011-10-18
ID: P00016474
Title: A randomized, controlled clinical trial of the effectiveness of Chinese herbal medicine (CHM) in the treatment of vascular dementia
Funder:
  • University of Western Sydney
Western Researchers: Dennis Chang and Alan Bensoussan
Years: 2004-02-16 - 2007-05-31
ID: P0011626
Title: A Randomized Placebo-Controlled Clinical Trial to Study the Therapeutic Effectiveness of a Chinese Herbal Medicine Formula Used for the Treatment of Vascular Dementia - No funding to UWS
Funder:
  • Xi Yuan Hospital
Western Researchers: Dennis Chang and Alan Bensoussan
Years: 2007-05-08 - 2007-12-31
ID: P0015675
Title: Evaluation of Clinical Efficacy of Chinese Herbal Medicine for the Management of Vascular Dementia
Funder:
  • University of Western Sydney
Western Researchers: Dennis Chang
Years: 2010-01-08 - 2011-01-07
ID: P00018031
Title: Traditional Medicine Internationalisation Platform
Funder:
  • University of Western Sydney
  • Department of Industry NSW
Western Researchers: Alan Bensoussan, Kelvin Chan and Dennis Chang
Years: 2011-06-30 - 2012-12-31
ID: P00020056

Supervision

Professor Chang is available to be a principal supervisor for doctoral projects

Current Supervision

Thesis Title: Effects of Tai Chi on Stress and Cardiovascular Function in People with Coronary Heart Disease and/or Hypertension
Field of Research: Traditional Chinese Medicine; Other Health
Thesis Title: Randomised Controlled Trial of a 12 Week Yoga Intervention On Negative Affective States, Cardiovascular and Cognitive Function in Post-Cardiac Rehabilitation Patients
Field of Research:
Thesis Title: Herbal Formulation in the Management of Osteoarthritis of the Knee
Field of Research:
Thesis Title: Pharmacological and Clinical Effects of a Standardised Herbal Extract, Nao Xin Qing (NXQ) for Ischaemic Stroke
Field of Research: Traditional Chinese Medicine; Other Natural And Physical Sciences; Pharmacology
Thesis Title: Molecular Neuroprotective and Anti-aging Effects of Herbal Medicines
Field of Research:
Thesis Title: Effectiveness of a herbal and nutritional supplement on cognitive function in older adults with subjective cognitive complaints
Field of Research:

Previous Supervision

Thesis Title: An Investigation Of The Vascular Effects of Sai-luo-tong (SLT), A Standardized Chinese Herbal Formula, For Vascular Dementia
Field of Research: Natural And Physical Sciences
Thesis Title: Effects of Tai Chi on Stress and Cardiovascular Function in People with Coronary Heart Disease and/or Hypertension
Field of Research: Traditional Chinese Medicine

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