Doctor Sai Seto

Doctor Sai Seto

Adjunct Fellow,
NICM Health Research Institute

Biography

Dr. Sai Wang Seto completed his PhD in Cardiovascular Pharmacology at the Chinese University of Hong Kong in 2008. His thesis project focused on the evaluation of the modulatory effects of HMG CoA reductase inhibitor on the vascular reactivity. Sai received his postdoctoral training from the Department of Physiology of the Royal College of Surgeons in Ireland focusing on blood pressure regulation and vascular/smooth muscle physiology using both in vitro and in vivo models. Before joining the NICM, Sai worked as a Senior Scientist in the Queensland Research Centre for Peripheral Vascular Disease, James Cook University and was a recipient of the National Health and Medical Research Council Research Fellowship and National Heart Foundation Fellowship. 

This information has been contributed by Doctor Seto.

Qualifications

  • PhDPharm Chinese University of Hong Kong
  • BSc(Hons) University of Liverpool

Organisational Unit (School / Division)

  • NICM Health Research Institute

Contact

Email: S.Seto@westernsydney.edu.au
Phone: (02) 4620 3646

Mobile:
Location: 22.1.21B
CampbelltownWestmeadWestmead

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Teaching

Previous Teaching Areas

  • 400981 Clinical Pharmacology, 2015

Publications

Chapters in Books

  • Bhuyan, D., Perera, S., Kaur, K., Alsherbiny, M., Low, M., Seto, S., Li, C. and Zhou, X. (2020), 'Synergistic effects of Chinese herbal medicine and biological networks', Approaching Complex Diseases: Network-Based Pharmacology and Systems Approach in Bio-Medicine, Springer 9783030328566.
  • Chan, E., Seto, S., Yeung, T. and Chan, G. (2018), 'Chinese herbal medicine in the management of atherosclerosis-related chronic conditions in an aging population', Sustainable Health and Long-Term Care Solutions for an Aging Population, IGI Global 9781522526339.

Journal Articles

  • Kwok, C., Chow, F., Cheung, K., Zhang, X., Mok, D., Kwan, Y., Chan, G., Leung, G., Cheung, K., Lee, S., Wang, N., Li, J. and Seto, S. (2023), 'Medulla Tetrapanacis water extract alleviates inflammation and infection by regulating macrophage polarization through MAPK signaling pathway', Inflammopharmacology, .
  • Cao, H., Seto, S., Bhuyan, D., Chan, H. and Song, W. (2022), 'Effects of thrombin on the neurovascular unit in cerebral ischemia', Cellular and Molecular Neurobiology, vol 42, no 4 , pp 973 - 984.
  • Shahbaz, K., Chang, D., Zhou, X., Low, M., Seto, S. and Li, C. (2022), 'Crocins for ischemic stroke : a review of current evidence', Frontiers in Pharmacology, vol 13 .
  • Chan, G., Chan, E., Kwok, C., Leung, G., Lee, S. and Seto, S. (2022), 'The role of p53 in the alternation of vascular functions', Frontiers in Pharmacology, vol 13 .
  • Zheng, Y., Zhou, X., Chang, D., Bhuyan, D., Zhang, J., Yu, W., Jiang, X., Seto, S., Yeon, S., Li, J. and Li, C. (2021), 'A novel tri-culture model for neuroinflammation', Journal of Neurochemistry, vol 156, no 2 , pp 249 - 261.
  • Gong, G., Kam, H., Tse, Y., Giesy, J., Seto, S. and Lee, S. (2021), 'Forchlorfenuron (CPPU) causes disorganization of the cytoskeleton and dysfunction of human umbilical vein endothelial cells, and abnormal vascular development in zebrafish embryos', Environmental Pollution, vol 271 .
  • Wong, E., Li, R., Li, J., Li, R., Seto, S., Lee, S. and Leung, G. (2021), 'Relaxation effect of narirutin on rat mesenteric arteries via nitric oxide release and activation of voltage-gated potassium channels', European Journal of Pharmacology, vol 905 .
  • Ruan, J., Wang, L., Dai, J., Li, J., Wang, N. and Seto, S. (2021), 'Hydroxysafflor yellow a promotes angiogenesis in rat brain microvascu-lar endothelial cells injured by oxygen-glucose deprivation/reoxygena-tion(OGD/R) through SIRT1-HIF-1a-VEGFA signaling pathway', Current Neurovascular Research, vol 18, no 4 , pp 415 - 426.
  • Yeon, S., Seto, S., Chan, G., Low, M., Kait, H., Wang, N., Liu, J. and Chang, D. (2020), 'Endothelium-independent vasodilatory effect of Sailuotong (SLT) on rat isolated tail artery', Evidence-Based Complementary and Alternative Medicine, vol 2020 .
  • Nsengiyumva, V., Krishna, S., Moran, C., Moxon, J., Morton, S., Clarke, M., Seto, S. and Golledge, J. (2020), 'Vitamin D deficiency promotes large rupture-prone abdominal aortic aneurysms and cholecalciferol supplementation limits progression of aneurysms in a mouse model', Clinical Science, vol 134, no 18 , pp 2521 - 2534.
  • Moran, C., Seto, S., Biros, E., Krishna, S., Morton, S., Kleinschnitz, C., Panousis, C. and Golledge, J. (2020), 'Factor XII blockade inhibits aortic dilatation in angiotensin II-infused apolipoprotein E-deficient mice', Clinical Science, vol 134, no 9 , pp 1049 - 1061.
  • Kazzem, M., Sun, Y., Low, M., Seto, S., Chang, D., Lee, S., Suresh, H., Khoo, C., Bensoussan, A. and Kiat, H. (2019), 'Chromatographic analysis and anti-oxidative property of Naoxinqing tablet, a proprietary preparation of Diospyros kaki leaves', Molecules, vol 24, no 6 .
  • He, L., Shi, X., Seto, S., Chang, D., Wang, H., Zhang, S., Chen, W. and Wang, J. (2019), 'Using 3D-UPLC-DAD and a new method-verification by adding mixture standard compounds to determine the fingerprint and eight active components of Naoluoxintong decoction', Journal of Pharmaceutical and Biomedical Analysis, vol 169 , pp 60 - 69.
  • Wu, S., Wang, N., Li, J., Wang, G., Seto, S., Chang, D. and Liang, H. (2019), 'Ligustilide ameliorates the permeability of the blood-brain barrier model in vitro during oxygen-glucose deprivation injury through HIF/VEGF pathway', Journal of Cardiovascular Pharmacology, vol 73, no 5 , pp 316 - 325.
  • Seto, S., Chang, D., Kiat, H., Wang, N. and Bensoussan, A. (2018), 'Chinese herbal medicine as a potential treatment of abdominal aortic aneurysm', Frontiers in Cardiovascular Medicine, vol 5 .
  • Yang, G., Wang, N., Seto, S., Chang, D. and Liang, H. (2018), 'Hydroxysafflor yellow A protects brain microvascular endothelial cells against oxygen glucose deprivation/reoxygenation injury : involvement of inhibiting autophagy via class I PI3K/Akt/mTOR signaling pathway', Brain Research Bulletin, vol 140 , pp 243 - 257.
  • Wu, S., Wang, N., He, Q., Chang, G., Seto, S., Chang, D. and Liang, H. (2018), 'The establishment of the method of cell biochromatograpy and analysis of the active ingredients from TongQiaoHuoXue decoction acting on the neurocytes', Chemical and Pharmaceutical Bulletin, vol 66, no 10 , pp 983 - 991.
  • Seto, S., Chang, D., Ko, W., Zhou, X., Kiat, H., Bensoussan, A., Lee, S., Hoi, M., Steiner, G. and Liu, J. (2017), 'Sailuotong prevents hydrogen peroxide (H2O2)-induced injury in EA.hy926 cells', International Journal of Molecular Sciences, vol 18, no 1 .
  • Steiner, G., Mathersul, D., MacMillan, F., Camfield, D., Klupp, N., Seto, S., Huang, Y., Hohenberg, M. and Chang, D. (2017), 'A systematic review of intervention studies examining nutritional and herbal therapies for mild cognitive impairment and dementia using neuroimaging methods : study characteristics and intervention efficacy', Evidence-Based Complementary and Alternative Medicine, vol 2017 .
  • Moran, C., Seto, S., Krishna, S., Sharma, S., Jose, R., Biros, E., Wang, Y., Morton, S. and Golledge, J. (2017), 'Parenteral administration of factor Xa/IIa inhibitors limits experimental aortic aneurysm and atherosclerosis', Scientific Reports, vol 7 .
  • Steiner, G., Seto, S., Kwan, Y., Haskell-Ramsay, C. and Camfield, D. (2017), 'Complementary medicine for the modification of risk factors for cognitive impairment', Evidence-Based Complementary and Alternative Medicine, vol 2017 , pp 1 - 2.
  • Krishna, S., Seto, S., Jose, R., Li, J., Morton, S., Biros, E., Wang, Y., Nsengiyumva, V., Lindeman, J., Loots, G., Rush, C., Craig, J. and Golledge, J. (2017), 'Wnt signaling pathway inhibitor sclerostin inhibits angiotensin II-induced aortic aneurysm and atherosclerosis', Arteriosclerosis, Thrombosis, and Vascular Biology, vol 37, no 3 , pp 553 - 566.
  • Krishna, S., Seto, S., Jose, R., Li, J., Moxon, J., Clancy, P., Crossman, D., Norman, P., Emeto, T. and Golledge, J. (2017), 'High serum thrombospondin-1 concentration is associated with slower abdominal aortic aneurysm growth and deficiency of thrombospondin-1 promotes angiotensin II induced aortic aneurysm in mice', Clinical Science, vol 131, no 12 , pp 1261 - 1281.
  • Li, J., Zhang, J., Zou, L., Lee, S., Yang, C., Seto, S. and Leung, G. (2017), 'Pro-angiogenic effects of Ilexsaponin A1 on human umbilical vein endothelial cells in vitro and zebrafish in vivo', Phytomedicine, vol 36 , pp 229 - 237.
  • Zhou, X., Seto, S., Chang, D., Kiat, H., Razmovski-Naumovski, V., Chan, K. and Bensoussan, A. (2016), 'Synergistic effects of Chinese herbal medicine : a comprehensive review of methodology and current research', Frontiers in Pharmacology, vol 7 .
  • Seto, S., Chang, D., Jenkins, A., Bensoussan, A. and Kiat, H. (2016), 'Angiogenesis in ischemic stroke and angiogenic effects of Chinese herbal medicine', Journal of Clinical Medicine, vol 5, no 6 .
  • Tseng, H., Vong, C., Leung, G., Seto, S., Kwan, Y., Lee, S. and Hoi, M. (2016), 'Calycosin and formononetin induce endothelium-dependent vasodilation by the activation of large-conductance Ca2+-activated K+ channels (BKCa)', Evidence-Based Complementary and Alternative Medicine, vol 2016 .
  • Chang, D., Liu, J., Stalgis-Bilinski, K., Li, X., Steiner, G., Seto, S. and Bensoussan, A. (2016), 'Herbal medicine for the treatment of vascular dementia : an overview of scientific evidence', Evidence-Based Complementary and Alternative Medicine, vol 2016 .
  • Seto, S., Yang, G., Kiat, H., Bensoussan, A., Kwan, Y. and Chang, D. (2015), 'Diabetes Mellitus, cognitive impairment, and traditional Chinese medicine', International Journal of Endocrinology, vol 2015 .
  • Wang, Y., Emeto, T., Lee, J., Marshman, L., Moran, C., Seto, S. and Golledge, J. (2015), 'Mouse models of intracranial aneurysm', Brain Pathology, vol 25, no 3 , pp 237 - 247.
  • Krishna, S., Seto, S., Jose, R., Biros, E., Moran, C., Wang, Y., Clancy, P. and Golledge, J. (2015), 'A peptide antagonist of thrombospondin-1 promotes abdominal aortic aneurysm progression in the angiotensin II-infused apolipoprotein-E-deficient mouse', Arteriosclerosis, Thrombosis, and Vascular Biology, vol 35, no 2 , pp 389 - 398.
  • Moxon, J., Behl-Gilhotra, R., Morton, S., Krishna, S., Seto, S., Biros, E., Nataatmadja, M., West, M., Walker, P., Norman, P. and Golledge, J. (2015), 'Plasma low-density lipoprotein receptor-related protein 1 concentration is not associated with human abdominal aortic aneurysm presence', European Journal of Vascular and Endovascular Surgery, vol 50, no 4 , pp 466 - 473.
  • Seto, S., Kiat, H., Lee, S., Bensoussan, A., Sun, Y., Hoi, M. and Chang, D. (2015), 'Zebrafish models of cardiovascular diseases and their applications in herbal medicine research', European Journal of Pharmacology, vol 768 , pp 77 - 86.
  • Poon, C., Li, R., Seto, S., Kong, S., Ho, H., Hoi, M., Lee, S., Ngai, S., Chan, S., Leung, G. and Kwan, Y. (2015), 'In vitro vitamin K2 and 1a,25-dihydroxyvitamin D3 combination enhances osteoblasts anabolism of diabetic mice', European Journal of Pharmacology, vol 767 , pp 30 - 40.
  • Nsengiyumva, V., Fernando, M., Moxon, J., Krishna, S., Pinchbeck, J., Omer, S., Morris, D., Jones, R., Moran, C., Seto, S. and Golledge, J. (2015), 'The association of circulating 25-hydroxyvitamin D concentration with peripheral arterial disease : a meta-analysis of observational studies', Atherosclerosis, vol 243, no 2 , pp 645 - 651.
  • Nsengiyumva, V., Fernando, M., Moxon, J., Krishna, S., Pinchbeck, J., Omer, S., Morris, D., Jones, R., Moran, C., Seto, S. and Golledge, J. (2015), 'The association of circulating 25-hydroxyvitamin D concentration with peripheral arterial disease : a meta-analysis of observational studies', Atherosclerosis, vol 243, no 2 , pp 645 - 651.
  • Seto, S., Krishan, S., Moran, C., Liu, D. and Golledge, J. (2014), 'Aliskiren limits abdominal aortic aneurysm, ventricular hypertrophy and atherosclerosis in an apolipoprotein-E-deficient mouse model', Clinical Science, vol 127 , pp 123 - 134.
  • Emeto, T., Seto, S. and Golledge, J. (2014), 'Targets for medical therapy to limit abdominal aortic aneurysm progression', Current Drug Targets, vol 15, no 9 , pp 860 - 873.
  • Wang, Y., Seto, S. and Golledge, J. (2014), 'Angiotensin II, sympathetic nerve activity and chronic heart failure', Heart Failure Reviews, vol 19, no 2 , pp 187 - 198.
  • Clancy, P., Seto, S., Koblar, S. and Golledge, J. (2013), 'Role of the angiotensin converting enzyme 1/angiotensin II/angiotensin receptor 1 axis in interstitial collagenase expression in human carotid atheroma', Atherosclerosis, vol 229, no 2 , pp 331 - 337.
  • Seto, S., Au, A., Poon, C., Zhang, Q., Li, R., Yeung, J., Kong, S., Ngai, S., Wan, S., Ho, H., Lee, S., Hoi, M., Chan, S., Leung, G. and Kwan, Y. (2013), 'Acute simvastatin inhibits KATP channels of porcine coronary artery myocytes', PLoS One, vol 8, no 6 .
  • Seto, S., Krishna, S., Yu, H., Liu, D., Khosla, S. and Golledge, J. (2013), 'Impaired acetylcholine-induced endothelium-dependent aortic relaxation by caveolin-1 in angiotensin II-infused apolipoprotein-e (ApoE-/-) knockout mice', PLoS One, vol 8, no 3 .
  • Krishna, S., Seto, S., Moxon, J., Rush, C., Walker, P., Norman, P. and Golledge, J. (2012), 'Fenofibrate increases high-density lipoprotein and sphingosine 1 phosphate concentrations limiting abdominal aortic aneurysm progression in a mouse model', American Journal of Pathology, vol 181, no 2 , pp 706 - 718.
  • Kwok, C., Wong, C., Yau, M., Yu, P., Au, A., Poon, C., Seto, S., Lam, T., Kwan, Y. and Chan, S. (2010), 'Consumption of dried fruit of Crataegus pinnatifida (hawthorn) suppresses high-cholesterol diet-induced hypercholesterolemia in rats', Journal of Functional Foods, vol 2, no 3 , pp 179 - 186.
  • Seto, S., Lam, T., Or, P., Lee, W., Au, A., Poon, C., Li, R., Chan, S., Yeung, J., Leung, G., Lee, S., Ngai, S. and Kwan, Y. (2010), 'Folic acid consumption reduces resistin level and restores blunted acetylcholine-induced aortic relaxation in obese/diabetic mice', Journal of Nutritional Biochemistry, vol 21, no 9 , pp 872 - 880.
  • Seto, S., Bexis, S., McCormick, P. and Docherty, J. (2010), 'Actions of thalidomide in producing vascular relaxations', European Journal of Pharmacology, vol 644, no 1-3 , pp 113 - 119.
  • Poon, C., Seto, S., Au, A., Zhang, Q., Li, R., Lee, W., Leung, G., Kong, S., Yeung, J., Ngai, S., Ho, H., Lee, S., Chan, S. and Kwan, Y. (2010), 'Mitochondrial monoamine oxidase-A-mediated hydrogen peroxide generation enhances 5-hydroxytryptamine-induced contraction of rat basilar artery', British Journal of Pharmacology, vol 161, no 5 , pp 1086 - 1098.
  • Seto, S. and Docherty, J. (2010), 'Effects of T-type calcium channel blockers and thalidomide on contractions of rat vas deferens', British Journal of Pharmacology, vol 159, no 6 , pp 1211 - 1216.
  • Chan, E., Wong, C., Wan, C., Kwok, C., Wu, J., Ng, K., So, C., Au, A., Poon, C., Seto, S., Kwan, Y., Yu, P. and Chan, S. (2010), 'Evaluation of anti-oxidant capacity of root of Scutellaria baicalensis Georgi, in comparison with roots of Polygonum multiflorum Thunb and Panax ginseng CA Meyer', The American Journal of Chinese Medicine, vol 38, no 4 , pp 815 - 827.
  • Chu, K., Cheng, Q., Chen, C., Au, A., Seto, S., Tuo, Y., Motin, L., Kwan, Y. and Leung, P. (2010), 'Angiotensin II exerts glucose-dependent effects on Kv currents in mouse pancreatic ?-cells via angiotensin II type 2 receptors', American Journal of Physiology: Cell Physiology, vol 298, no 2 , pp 313 - 323.
  • Lam, T., Seto, S., Au, A., Poon, C., Li, R., Lam, H., Lau, W., Chan, S., Ngai, S., Leung, G., Lee, S., Tsui, S. and Kwan, Y. (2009), 'Folic acid supplementation modifies ?-adrenoceptor-mediated in vitro lipolysis of obese/diabetic (+db/+db) mice', Experimental Biology and Medicine, vol 234, no 9 , pp 1047 - 1055.
  • Seto, S., Lam, T., Tam, H., Au, A., Chan, S., Wu, J., Yu, P., Leung, G., Ngai, S., Yeung, J., Leung, P., Lee, S. and Kwan, Y. (2009), 'Novel hypoglycemic effects of Ganoderma lucidum water-extract in obese/diabetic (+db/+db) mice', Phytomedicine, vol 16, no 5 , pp 426 - 436.
  • Zhang, Y., Hu, G., Lin, H., Hong, S., Deng, Y., Tang, J., Seto, S., Kwan, Y., Waye, M., Wang, Y. and Lee, S. (2009), 'Radix Astragali extract promotes angiogenesis involving vascular endothelial growth factor receptor-related phosphatidylinositol 3-kinase/Akt-dependent pathway in human endothelial cells', Phytotherapy Research, vol 23, no 9 , pp 1205 - 1213.
  • Seto, S., Lam, H., Lau, W., Au, A., Lam, T., Chim, S., Ngai, S., Chan, S., Leung, T., Yeung, J., Kong, S., Leung, G., Lee, S. and Kwan, Y. (2009), 'Role of monoamine oxidases in the exaggerated 5-hydroxytryptamine-induced tension development of human isolated preeclamptic umbilical artery', European Journal of Pharmacology, vol 605, no 1-3 , pp 129 - 137.
  • Hong, S., Wan, J., Zhang, Y., Hu, G., Lin, H., Seto, S., Kwan, Y., Lin, Z., Wang, Y. and Lee, S. (2009), 'Angiogenic effect of saponin extract from Panax notoginseng on HUVECs in vitro and zebrafish in vivo', Phytotherapy Research, vol 23, no 5 , pp 677 - 686.
  • Li, R., Seto, S., Au, A., Kwan, Y., Chan, S., Lee, S., Tse, C. and Leung, G. (2009), 'Inhibitory effect of nonsteroidal anti-inflammatory drugs on adenosine transport in vascular smooth muscle cells', European Journal of Pharmacology, vol 612, no 1-3 , pp 15 - 20.
  • Zhang, M., Chen, S., Seto, S., Kwan, Y. and Chan, S. (2009), 'Correlation of antioxidative properties and vaso-relaxation effects of major active constituents of traditional Chinese medicines', Pharmaceutical Biology, vol 47, no 4 , pp 366 - 371.
  • Yang, C., Kwan, Y., Seto, S. and Leung, G. (2008), 'Inhibitory effects of epoxyeicosatrienoic acids on volume-activated chloride channels in rat mesenteric arterial smooth muscle', Prostaglandins and Other Lipid Mediators, vol 87, no 1-4 , pp 62 - 67.

Previous Projects

Title: Marine oil anti-inflammatory synergy research
Funder:
  • NatMed Research
Western Researchers: Mitchell Low and Sai Seto
Years: 2018-07-23 - 2021-05-22
ID: P00025331
Title: An investigation of the vascular effects of Sailuotong (SLT), a standardized Chinese herbal formula, for Vascular Dementia [via HKPolyTechUni]
Funder:
  • The Hong Kong Polytechnic University
Western Researchers: Sai Seto
Years: 2017-12-01 - 2018-12-01
ID: P00024515

Supervision

Current Supervision

Thesis Title: Pharmacological and Clinical Effects of a Standardised Herbal Extract, Nao Xin Qing (NXQ) for Ischaemic Stroke
Field of Research: Pharmacology; Traditional Chinese Medicine; Other Natural And Physical Sciences

Previous Supervision

Thesis Title: An Investigation Of The Vascular Effects of Sai-luo-tong (SLT), A Standardized Chinese Herbal Formula, For Vascular Dementia
Field of Research: Natural And Physical Sciences

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