
Doctor Mitchell Low
Postdoctoral Research Fellow - Natural Products Research,
NICM Health Research Institute
Biography
Dr Low is an enthusiastic early career researcher who previously worked as NICMs TGA accredited Analytical testing laboratory's Commercial Laboratory Manager. Over the last eight years, he has acquired cross-disciplinary technical skills in pharmacology and analytical chemistry with his time at NICM.
His research interest focus on the safety and efficacy of natural products.
This information has been contributed by Doctor Low.
Qualifications
- PhD University of Western Sydney
- BSc(Hons) University of Western Sydney
Interests
- Medicinal plants
- Pharmacokinetic and Bioavailability of Herbal Medicine
Organisational Unit (School / Division)
- NICM Health Research Institute
Contact
Email: | Mitchell.Low@westernsydney.edu.au |
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Phone: | (02) 9685 4778 |
Mobile: | 0431067086 |
Location: | J.1.69 Westmead |
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Publications
Chapters in Books
- Bhuyan, D., Perera, S., Kaur, K., Alsherbiny, M., Low, M., Seto, S., Li, C. and Zhou, X. (2020), 'Synergistic effects of Chinese herbal medicine and biological networks', Approaching Complex Diseases: Network-Based Pharmacology and Systems Approach in Bio-Medicine, Springer 9783030328566.
Journal Articles
- Zhou, X., Al-Khazaleh, A., Afzal, S., Kao, M., Muench, G., Wohlmuth, H., Leach, D., Low, M. and Li, C. (2023), '6-shogaol and 10-shogaol synergize curcumin in ameliorating proinflammatory mediators via the modulation of TLR4/TRAF6/MAPK and NFkB translocation', Biomolecules and Therapeutics, vol 31, no 1 , pp 27 - 39.
- Zhou, X., Afzal, S., Wohlmuth, H., Muench, G., Leach, D., Low, M. and Li, C. (2022), 'Synergistic anti-inflammatory activity of ginger and turmeric extracts in inhibiting lipopolysaccharide and interferon-y-induced proinflammatory mediators', Molecules, vol 27, no 12 .
- Zhou, X., Muench, G., Wohlmuth, H., Afzal, S., Kao, M., Al-Khazaleh, A., Low, M., Leach, D. and Li, C. (2022), 'Synergistic inhibition of pro-inflammatory pathways by ginger and turmeric extracts in RAW 264.7 cells', Frontiers in Pharmacology, vol 13 .
- Hall, D., Sinclair, J., Bhuyan, D., Khoo, C., Li, C., Sarris, J. and Low, M. (2022), 'Quality control of cannabis inflorescence and oil products : response factors for the cost-efficient determination of ten cannabinoids by HPLC', Talanta Open, vol 5 .
- Shahbaz, K., Chang, D., Zhou, X., Low, M., Seto, S. and Li, C. (2022), 'Crocins for ischemic stroke : a review of current evidence', Frontiers in Pharmacology, vol 13 .
- Bhuyan, D., Alsherbiny, M., Low, M., Zhou, X., Kaur, K., Li, G. and Li, C. (2021), 'Broad-spectrum pharmacological activity of Australian propolis and metabolomic-driven identification of marker metabolites of propolis samples from three continents', Food and Function, vol 12, no 6 , pp 2498 - 2519.
- Alsherbiny, M., Bhuyan, D., Low, M., Chang, D. and Li, C. (2021), 'Synergistic interactions of cannabidiol with chemotherapeutic drugs in MCF7 cells : mode of interaction and proteomics analysis of mechanisms', International Journal of Molecular Sciences, vol 22, no 18 .
- Jarouche, M., Ibrahim, M., Pearson, J., Venkataya, B., Low, M. and Rowe, J. (2020), 'Stability of metronidazole free-base oral suspensions formulated with United States Pharmacopeia-grade metronidazole powder and commercial metronidazole tablets', International Journal of Pharmaceutical Compounding, vol 24, no 1 , pp 77 - 82.
- Yeon, S., Seto, S., Chan, G., Low, M., Kait, H., Wang, N., Liu, J. and Chang, D. (2020), 'Endothelium-independent vasodilatory effect of Sailuotong (SLT) on rat isolated tail artery', Evidence-Based Complementary and Alternative Medicine, vol 2020 .
- Kazzem, M., Sun, Y., Low, M., Seto, S., Chang, D., Lee, S., Suresh, H., Khoo, C., Bensoussan, A. and Kiat, H. (2019), 'Chromatographic analysis and anti-oxidative property of Naoxinqing tablet, a proprietary preparation of Diospyros kaki leaves', Molecules, vol 24, no 6 .
- Jarouche, M., Suresh, H., Low, M., Lee, S., Xu, C. and Khoo, C. (2019), 'Quality control and variability assessment of an eight-herb formulation for hypertension using method validation and statistical analysis', Molecules, vol 24, no 8 .
- Bhuyan, D., Alsherbiny, M., Perera, S., Low, M., Basu, A., Devi, O., Barooah, M., Li, C. and Papoutsis, K. (2019), 'The odyssey of bioactive compounds in avocado (Persea americana) and their health benefits', Antioxidants, vol 8, no 10 .
- Suresh, H., Low, M., Jarouche, M., Zheng, G., Zhang, L., Lee, S., Pearson, J., Power, D., Singh, S., Li, C. and Khoo, C. (2018), 'The chemical and pharmacological variability of key bio-actives present in commercially available Angelica sinensis, Glycyrrhiza uralensis and Rhodiola rosea samples', Pharmaceutica Analytica Acta, vol 9, no 10 .
- Zhou, X., Razmovski-Naumovski, V., Chang, D., Li, C., Kam, A., Low, M., Bensoussan, A. and Chan, K. (2016), 'Synergistic effects of Danshen (Salvia Miltiorrhiza Radix et Rhizoma) and Sanqi (Notoginseng Radix et Rhizoma) combination in inhibiting inflammation mediators in RAW264.7 cells', BioMed Research International, vol 2016 .
- Raju, R., Gunawardena, D., Akhtar, M., Low, M., Reddell, P. and Muench, G. (2016), 'Anti-inflammatory chemical profiling of the Australian rainforest tree Alphitonia petriei (Rhamnaceae)', Molecules, vol 21, no 11 .
- Low, M., Khoo, C., Muench, G., Govindaraghavan, S. and Sucher, N. (2015), 'An in vitro study of anti-inflammatory activity of standardised Andrographis paniculata extracts and pure andrographolide', BMC Complementary and Alternative Medicine, vol 15 .
- Gunawardena, D., Shanmugam, K., Low, M., Bennett, L., Govindaraghavan, S., Head, R., Ooi, L. and Muench, G. (2014), 'Determination of anti-inflammatory activities of standardised preparations of plant- and mushroom-based foods', European Journal of Nutrition, vol 53, no 1 , pp 335 - 343.
- Pearson, J., Lee, S., Suresh, H., Low, M., Nang, M., Singh, S., Lamin, F., Kazzem, M., Sullivan, S. and Khoo, C. (2014), 'The liquid chromatographic determination of chlorogenic and caffeic acids in Xu Duan (Dipsacus asperoides) raw herb', ISRN Analytical Chemistry, vol 2014 .
His current research projects are focused on;
- Medicinal Cannabis
-Synergistic drug interactions
-Understanding and improving the pharmacokinetics of natural products
His research lab skills include;
- In-vitro anti-inflammatory assays
- In-vitro cancer proliferation assays
- In-vitro cardiovascular assays
- In-vitro antioxidant assays
- Synergetic combination studies
- Bio-assay guided fractionation
- Pharmacokinetics in-vivo and in-vitro
- Analytical method development and validation
This information has been contributed by Doctor Low.
Current Projects
Title: | Plant breeding study to develop high DMT Psychotria strains in Australia |
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Funder: |
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Western Researchers: | Mitchell Low |
Years: | 2023-04-10 - 2024-04-10 |
ID: | P00028644 |
Title: | Improving the analysis and pharmacological characterisation of phytomelatonin |
Funder: |
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Western Researchers: | Mitchell Low, Chun Guang Li and Deep Bhuyan |
Years: | 2022-06-02 - 2025-06-02 |
ID: | P00028025 |
Title: | Investigation of fractions and sesquiterpenes in Viga mushroom juice |
Funder: |
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Western Researchers: | Mitchell Low and Chun Guang Li |
Years: | 2023-05-01 - 2023-10-31 |
ID: | P00028742 |
Title: | Future Food Systems [Via UNSW] |
Funder: |
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Western Researchers: | Ian Anderson, David Tissue, Zhonghua Chen, Oula Ghannoum, Chris Cazzonelli, Mitchell Low, Chun Guang Li and James Cook |
Years: | 2019-06-30 - 2029-06-01 |
ID: | P00025995 |
Previous Projects
Title: | Analysis of urine and blood samples for CBD PK study |
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Funder: |
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Western Researchers: | Mitchell Low and Chun Guang Li |
Years: | 2022-08-22 - 2022-12-16 |
ID: | P00028365 |
Title: | Anti-inflammatory activity of enriched ginger for sepsis |
Funder: |
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Western Researchers: | Mitchell Low and Chun Guang Li |
Years: | 2023-02-28 - 2023-08-28 |
ID: | P00028560 |
Title: | Marine oil anti-inflammatory synergy research |
Funder: |
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Western Researchers: | Mitchell Low and Sai Seto |
Years: | 2018-07-23 - 2021-05-22 |
ID: | P00025331 |
Title: | Orchard Manufacturing: Herbal Lab Testing |
Funder: |
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Western Researchers: | Mitchell Low |
Years: | 2018-08-15 - 2019-10-18 |
ID: | P00025340 |
Title: | Warner Bros Natural Remedies Research |
Funder: |
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Western Researchers: | Carolyn Ee, Natalie Connor, Dina Vadassery, Mitchell Low and Mike Armour |
Years: | 2018-10-29 - 2018-12-20 |
ID: | P00025343 |
Title: | Deer Velvet Extract Testing |
Funder: |
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Western Researchers: | Mitchell Low |
Years: | 2017-07-17 - 2017-09-17 |
ID: | P00024182 |
Title: | Alkaloid Testing |
Funder: |
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Western Researchers: | Mitchell Low |
Years: | 2017-09-01 - 2019-07-12 |
ID: | P00024662 |
Title: | Eucalypt bioactivity screening |
Funder: |
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Western Researchers: | Mitchell Low and Phoebe Zhou |
Years: | 2017-08-22 - 2019-04-15 |
ID: | P00024575 |
Title: | NICM- THC Research Program Development |
Funder: |
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Western Researchers: | Alan Bensoussan and Mitchell Low |
Years: | 2017-01-05 - 2018-09-10 |
ID: | P00024330 |
Title: | Antioxidant and anti-inflammatory investigation of natural products |
Funder: |
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Western Researchers: | Mitchell Low and Chun Guang Li |
Years: | 2023-05-01 - 2023-07-31 |
ID: | P00028733 |
Title: | An investigation of the entourage effect: Synergistic anti-inflammatory interactions between cannabinoids and terpenes in Cannabis |
Funder: |
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Western Researchers: | Mitchell Low, Deep Bhuyan, Justin Sinclair and Chun Guang Li |
Years: | 2020-06-29 - 2021-06-29 |
ID: | P00026672 |
Title: | Bioavailability and Efficacy study of Pharmako Biotechnologies "HydroCurc" curcumin using the CaCo2 cell culture model and the GFAP-IL6 mouse |
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Western Researchers: | Gerald Muench, Mitchell Low, Ritesh Raju and Garry Niedermayer |
Years: | 2019-01-28 - 2020-12-19 |
ID: | P00025524 |
Title: | Development of a Natural Canine Dermatitis Treatment - IC |
Funder: |
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Western Researchers: | Mitchell Low, Deep Bhuyan and Chun Guang Li |
Years: | 2021-02-01 - 2023-04-30 |
ID: | P00026946 |
Supervision
Current Supervision
Thesis Title: | An investigation of the vascular effects of a standardised Chinese herbals formula (Sailuotong) on cerebral vascular reactivity in normal and hypertensive rats for vascular dementia |
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Field of Research: | |
Thesis Title: | Development and Evaluation of Polyherbal Formulation for the Treatment of Osteoarthritis |
Field of Research: | |
Thesis Title: | Chemical Characterisation and Study of Pharmacological and Biological Activity of the Chinese Herbs |
Field of Research: |
Previous Supervision
Thesis Title: | Determination of Marker Compounds to Assess the Quality of Green Tea |
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Field of Research: | Natural And Physical Sciences, N.e.c. |