Doctor Mitchell Low

Doctor Mitchell Low

Postdoctoral Research Fellow - Natural Products Research,
NICM Health Research Institute

Biography

Dr Low is an enthusiastic early career researcher who previously worked as NICMs TGA accredited Analytical testing laboratory's Commercial Laboratory Manager. Over the last eight years, he has acquired cross-disciplinary technical skills in pharmacology and analytical chemistry with his time at NICM. 

His research interest focus on the safety and efficacy of natural products.

This information has been contributed by Doctor Low.

Qualifications

  • PhD University of Western Sydney
  • BSc(Hons) University of Western Sydney

Interests

  • Medicinal plants
  • Pharmacokinetic and Bioavailability of Herbal Medicine

Organisational Unit (School / Division)

  • NICM Health Research Institute

Contact

Email: Mitchell.Low@westernsydney.edu.au
Phone: (02) 9685 4778
Mobile: 0431067086
Location: J.1.69
Westmead

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Publications

Chapters in Books

  • Bhuyan, D., Perera, S., Kaur, K., Alsherbiny, M., Low, M., Seto, S., Li, C. and Zhou, X. (2020), 'Synergistic effects of Chinese herbal medicine and biological networks', Approaching Complex Diseases: Network-Based Pharmacology and Systems Approach in Bio-Medicine, Springer 9783030328566.

Journal Articles

  • Jarouche, M., Ibrahim, M., Pearson, J., Venkataya, B., Low, M. and Rowe, J. (2020), 'Stability of metronidazole free-base oral suspensions formulated with United States Pharmacopeia-grade metronidazole powder and commercial metronidazole tablets', International Journal of Pharmaceutical Compounding, vol 24, no 1 , pp 77 - 82.
  • Kazzem, M., Sun, Y., Low, M., Seto, S., Chang, D., Lee, S., Suresh, H., Khoo, C., Bensoussan, A. and Kiat, H. (2019), 'Chromatographic analysis and anti-oxidative property of Naoxinqing tablet, a proprietary preparation of Diospyros kaki leaves', Molecules, vol 24, no 6 .
  • Jarouche, M., Suresh, H., Low, M., Lee, S., Xu, C. and Khoo, C. (2019), 'Quality control and variability assessment of an eight-herb formulation for hypertension using method validation and statistical analysis', Molecules, vol 24, no 8 .
  • Bhuyan, D., Alsherbiny, M., Perera, S., Low, M., Basu, A., Devi, O., Barooah, M., Li, C. and Papoutsis, K. (2019), 'The odyssey of bioactive compounds in avocado (Persea americana) and their health benefits', Antioxidants, vol 8, no 10 .
  • Suresh, H., Low, M., Jarouche, M., Zheng, G., Zhang, L., Lee, S., Pearson, J., Power, D., Singh, S., Li, C. and Khoo, C. (2018), 'The chemical and pharmacological variability of key bio-actives present in commercially available Angelica sinensis, Glycyrrhiza uralensis and Rhodiola rosea samples', Pharmaceutica Analytica Acta, vol 9, no 10 .
  • Zhou, X., Razmovski-Naumovski, V., Chang, D., Li, C., Kam, A., Low, M., Bensoussan, A. and Chan, K. (2016), 'Synergistic effects of Danshen (Salvia Miltiorrhiza Radix et Rhizoma) and Sanqi (Notoginseng Radix et Rhizoma) combination in inhibiting inflammation mediators in RAW264.7 cells', BioMed Research International, vol 2016 .
  • Raju, R., Gunawardena, D., Akhtar, M., Low, M., Reddell, P. and Muench, G. (2016), 'Anti-inflammatory chemical profiling of the Australian rainforest tree Alphitonia petriei (Rhamnaceae)', Molecules, vol 21, no 11 .
  • Low, M., Khoo, C., Muench, G., Govindaraghavan, S. and Sucher, N. (2015), 'An in vitro study of anti-inflammatory activity of standardised Andrographis paniculata extracts and pure andrographolide', BMC Complementary and Alternative Medicine, vol 15 .
  • Gunawardena, D., Shanmugam, K., Low, M., Bennett, L., Govindaraghavan, S., Head, R., Ooi, L. and Muench, G. (2014), 'Determination of anti-inflammatory activities of standardised preparations of plant- and mushroom-based foods', European Journal of Nutrition, vol 53, no 1 , pp 335 - 343.
  • Pearson, J., Lee, S., Suresh, H., Low, M., Nang, M., Singh, S., Lamin, F., Kazzem, M., Sullivan, S. and Khoo, C. (2014), 'The liquid chromatographic determination of chlorogenic and caffeic acids in Xu Duan (Dipsacus asperoides) raw herb', ISRN Analytical Chemistry, vol 2014 .

His current research projects are focused on;

- Medicinal Cannabis

-Synergistic drug interactions

-Understanding and improving the pharmacokinetics of natural products

His research lab skills include;

  • In-vitro anti-inflammatory assays
  • In-vitro cancer proliferation assays
  • In-vitro cardiovascular assays
  • In-vitro antioxidant assays
  • Synergetic combination studies
  • Bio-assay guided fractionation
  • Pharmacokinetics in-vivo and in-vitro
  • Analytical method development and validation

This information has been contributed by Doctor Low.

Current Projects

Title: An investigation of the entourage effect: Synergistic anti-inflammatory interactions between cannabinoids and terpenes in Cannabis
Funder:
  • CYMRA Life
Western Researchers: Mitchell Low, Deep Bhuyan, Justin Sinclair and Chun Guang Li
Years: 2020-06-29 - 2021-06-29
ID: P00026672
Title: Bioavailability and Efficacy study of Pharmako Biotechnologies "HydroCurc" curcumin using the CaCo2 cell culture model and the GFAP-IL6 mouse
Funder:
  • Pharmako Biotechnologies Pty Ltd
  • Department of Industry, Innovation and Science (non ACRG)
Western Researchers: Gerald Muench, Mitchell Low, Ritesh Raju and Garry Niedermayer
Years: 2019-01-28 - 2020-12-19
ID: P00025524
Title: Future Food Systems [Via UNSW]
Funder:
  • Department of Industry, Innovation and Science (CRC)
Western Researchers: Ian Anderson, David Tissue, Priti Krishna, Zhonghua Chen, Oula Ghannoum, Chris Cazzonelli, Mitchell Low, Chun Guang Li, Donald Mcneill and James Cook
Years: 2019-06-30 - 2029-06-01
ID: P00025995

Previous Projects

Title: Marine oil anti-inflammatory synergy research
Funder:
  • Natmed Research
Western Researchers: Mitchell Low and Sai Seto
Years: 2018-07-23 - 2018-11-30
ID: P00025331
Title: Orchard Manufacturing: Herbal Lab Testing
Funder:
  • Orchard Manufacturing Co. Pty. Ltd.
Western Researchers: Mitchell Low
Years: 2018-08-15 - 2019-10-18
ID: P00025340
Title: Warner Bros Natural Remedies Research
Funder:
  • Warner Bros. International Television Production Australia Pty Ltd
Western Researchers: Carolyn Ee, Natalie Connor, Dina Vadassery, Mitchell Low and Mike Armour
Years: 2018-10-29 - 2018-12-20
ID: P00025343
Title: Deer Velvet Extract Testing
Funder:
  • Golds Power Herbs Pty Ltd
Western Researchers: Mitchell Low
Years: 2017-07-17 - 2017-09-17
ID: P00024182
Title: Alkaloid Testing
Funder:
  • Chinawest Pty Ltd
Western Researchers: Mitchell Low
Years: 2017-09-01 - 2019-07-12
ID: P00024662
Title: Eucalypt bioactivity screening
Funder:
  • Forico Pty Ltd
Western Researchers: Mitchell Low and Phoebe Zhou
Years: 2017-08-22 - 2019-04-15
ID: P00024575
Title: NICM- THC Research Program Development
Funder:
  • Therapeutic Health Corporation (THC)
Western Researchers: Alan Bensoussan and Mitchell Low
Years: 2017-01-05 - 2018-09-10
ID: P00024330

Supervision

Current Supervision

Thesis Title: An investigation of the vascular effects of a standardised Chinese herbals formula (Sailuotong) on cerebral vascular reactivity in normal and hypertensive rats for vascular dementia
Field of Research:
Thesis Title: Development and Evaluation of Polyherbal Formulation for the Treatment of Osteoarthritis
Field of Research:
Thesis Title: Chemical Characterisation and Study of Pharmacological and Biological Activity of the Chinese Herbs
Field of Research:

Previous Supervision

Thesis Title: Determination of Marker Compounds to Assess the Quality of Green Tea
Field of Research: Natural And Physical Sciences Not Elsewhere Classified

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