Doctor Mitchell Low

Doctor Mitchell Low

Postdoctoral Research Fellow - Natural Products Research,
NICM Health Research Institute


Dr Low is an enthusiastic early career researcher who previously worked as NICMs TGA accredited Analytical testing laboratory's Commercial Laboratory Manager. Over the last eight years, he has acquired cross-disciplinary technical skills in pharmacology and analytical chemistry with his time at NICM. 

His research interest focus on the safety and efficacy of natural products.

This information has been contributed by Doctor Low.


  • PhD University of Western Sydney
  • BSc(Hons) University of Western Sydney


  • Medicinal plants
  • Pharmacokinetic and Bioavailability of Herbal Medicine

Organisational Unit (School / Division)

  • NICM Health Research Institute


Phone: (02) 9685 4778
Mobile: 0431067086
Location: J.1.69

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Chapters in Books

  • Bhuyan, D., Perera, S., Kaur, K., Alsherbiny, M., Low, M., Seto, S., Li, C. and Zhou, X. (2020), 'Synergistic effects of Chinese herbal medicine and biological networks', Approaching Complex Diseases: Network-Based Pharmacology and Systems Approach in Bio-Medicine, Springer 9783030328566.

Journal Articles

  • Zhou, X., Al-Khazaleh, A., Afzal, S., Kao, M., Muench, G., Wohlmuth, H., Leach, D., Low, M. and Li, C. (2023), '6-shogaol and 10-shogaol synergize curcumin in ameliorating proinflammatory mediators via the modulation of TLR4/TRAF6/MAPK and NFkB translocation', Biomolecules and Therapeutics, vol 31, no 1 , pp 27 - 39.
  • Zhou, X., Afzal, S., Wohlmuth, H., Muench, G., Leach, D., Low, M. and Li, C. (2022), 'Synergistic anti-inflammatory activity of ginger and turmeric extracts in inhibiting lipopolysaccharide and interferon-y-induced proinflammatory mediators', Molecules, vol 27, no 12 .
  • Zhou, X., Muench, G., Wohlmuth, H., Afzal, S., Kao, M., Al-Khazaleh, A., Low, M., Leach, D. and Li, C. (2022), 'Synergistic inhibition of pro-inflammatory pathways by ginger and turmeric extracts in RAW 264.7 cells', Frontiers in Pharmacology, vol 13 .
  • Hall, D., Sinclair, J., Bhuyan, D., Khoo, C., Li, C., Sarris, J. and Low, M. (2022), 'Quality control of cannabis inflorescence and oil products : response factors for the cost-efficient determination of ten cannabinoids by HPLC', Talanta Open, vol 5 .
  • Shahbaz, K., Chang, D., Zhou, X., Low, M., Seto, S. and Li, C. (2022), 'Crocins for ischemic stroke : a review of current evidence', Frontiers in Pharmacology, vol 13 .
  • Bhuyan, D., Alsherbiny, M., Low, M., Zhou, X., Kaur, K., Li, G. and Li, C. (2021), 'Broad-spectrum pharmacological activity of Australian propolis and metabolomic-driven identification of marker metabolites of propolis samples from three continents', Food and Function, vol 12, no 6 , pp 2498 - 2519.
  • Alsherbiny, M., Bhuyan, D., Low, M., Chang, D. and Li, C. (2021), 'Synergistic interactions of cannabidiol with chemotherapeutic drugs in MCF7 cells : mode of interaction and proteomics analysis of mechanisms', International Journal of Molecular Sciences, vol 22, no 18 .
  • Jarouche, M., Ibrahim, M., Pearson, J., Venkataya, B., Low, M. and Rowe, J. (2020), 'Stability of metronidazole free-base oral suspensions formulated with United States Pharmacopeia-grade metronidazole powder and commercial metronidazole tablets', International Journal of Pharmaceutical Compounding, vol 24, no 1 , pp 77 - 82.
  • Yeon, S., Seto, S., Chan, G., Low, M., Kait, H., Wang, N., Liu, J. and Chang, D. (2020), 'Endothelium-independent vasodilatory effect of Sailuotong (SLT) on rat isolated tail artery', Evidence-Based Complementary and Alternative Medicine, vol 2020 .
  • Kazzem, M., Sun, Y., Low, M., Seto, S., Chang, D., Lee, S., Suresh, H., Khoo, C., Bensoussan, A. and Kiat, H. (2019), 'Chromatographic analysis and anti-oxidative property of Naoxinqing tablet, a proprietary preparation of Diospyros kaki leaves', Molecules, vol 24, no 6 .
  • Jarouche, M., Suresh, H., Low, M., Lee, S., Xu, C. and Khoo, C. (2019), 'Quality control and variability assessment of an eight-herb formulation for hypertension using method validation and statistical analysis', Molecules, vol 24, no 8 .
  • Bhuyan, D., Alsherbiny, M., Perera, S., Low, M., Basu, A., Devi, O., Barooah, M., Li, C. and Papoutsis, K. (2019), 'The odyssey of bioactive compounds in avocado (Persea americana) and their health benefits', Antioxidants, vol 8, no 10 .
  • Suresh, H., Low, M., Jarouche, M., Zheng, G., Zhang, L., Lee, S., Pearson, J., Power, D., Singh, S., Li, C. and Khoo, C. (2018), 'The chemical and pharmacological variability of key bio-actives present in commercially available Angelica sinensis, Glycyrrhiza uralensis and Rhodiola rosea samples', Pharmaceutica Analytica Acta, vol 9, no 10 .
  • Zhou, X., Razmovski-Naumovski, V., Chang, D., Li, C., Kam, A., Low, M., Bensoussan, A. and Chan, K. (2016), 'Synergistic effects of Danshen (Salvia Miltiorrhiza Radix et Rhizoma) and Sanqi (Notoginseng Radix et Rhizoma) combination in inhibiting inflammation mediators in RAW264.7 cells', BioMed Research International, vol 2016 .
  • Raju, R., Gunawardena, D., Akhtar, M., Low, M., Reddell, P. and Muench, G. (2016), 'Anti-inflammatory chemical profiling of the Australian rainforest tree Alphitonia petriei (Rhamnaceae)', Molecules, vol 21, no 11 .
  • Low, M., Khoo, C., Muench, G., Govindaraghavan, S. and Sucher, N. (2015), 'An in vitro study of anti-inflammatory activity of standardised Andrographis paniculata extracts and pure andrographolide', BMC Complementary and Alternative Medicine, vol 15 .
  • Gunawardena, D., Shanmugam, K., Low, M., Bennett, L., Govindaraghavan, S., Head, R., Ooi, L. and Muench, G. (2014), 'Determination of anti-inflammatory activities of standardised preparations of plant- and mushroom-based foods', European Journal of Nutrition, vol 53, no 1 , pp 335 - 343.
  • Pearson, J., Lee, S., Suresh, H., Low, M., Nang, M., Singh, S., Lamin, F., Kazzem, M., Sullivan, S. and Khoo, C. (2014), 'The liquid chromatographic determination of chlorogenic and caffeic acids in Xu Duan (Dipsacus asperoides) raw herb', ISRN Analytical Chemistry, vol 2014 .

His current research projects are focused on;

- Medicinal Cannabis

-Synergistic drug interactions

-Understanding and improving the pharmacokinetics of natural products

His research lab skills include;

  • In-vitro anti-inflammatory assays
  • In-vitro cancer proliferation assays
  • In-vitro cardiovascular assays
  • In-vitro antioxidant assays
  • Synergetic combination studies
  • Bio-assay guided fractionation
  • Pharmacokinetics in-vivo and in-vitro
  • Analytical method development and validation

This information has been contributed by Doctor Low.

Current Projects

Title: Plant breeding study to develop high DMT Psychotria strains in Australia
  • Herbalistics Pty Ltd
Western Researchers: Mitchell Low
Years: 2023-04-10 - 2024-04-10
ID: P00028644
Title: Improving the analysis and pharmacological characterisation of phytomelatonin
  • Natural Health International (Australia) Pty Limited
Western Researchers: Mitchell Low, Chun Guang Li and Deep Bhuyan
Years: 2022-06-02 - 2025-06-02
ID: P00028025
Title: Investigation of fractions and sesquiterpenes in Viga mushroom juice
  • Morpheus Tex Pyt Ltd
Western Researchers: Mitchell Low and Chun Guang Li
Years: 2023-05-01 - 2023-10-31
ID: P00028742
Title: Future Food Systems [Via UNSW]
  • Department of Industry, Science and Resources (CRC)
Western Researchers: Ian Anderson, David Tissue, Zhonghua Chen, Oula Ghannoum, Chris Cazzonelli, Mitchell Low, Chun Guang Li and James Cook
Years: 2019-06-30 - 2029-06-01
ID: P00025995

Previous Projects

Title: Analysis of urine and blood samples for CBD PK study
  • Southern Cross University
Western Researchers: Mitchell Low and Chun Guang Li
Years: 2022-08-22 - 2022-12-16
ID: P00028365
Title: Anti-inflammatory activity of enriched ginger for sepsis
  • Evithe Ltd
Western Researchers: Mitchell Low and Chun Guang Li
Years: 2023-02-28 - 2023-08-28
ID: P00028560
Title: Marine oil anti-inflammatory synergy research
  • NatMed Research
Western Researchers: Mitchell Low and Sai Seto
Years: 2018-07-23 - 2021-05-22
ID: P00025331
Title: Orchard Manufacturing: Herbal Lab Testing
  • Orchard Manufacturing Co. Pty. Ltd.
Western Researchers: Mitchell Low
Years: 2018-08-15 - 2019-10-18
ID: P00025340
Title: Warner Bros Natural Remedies Research
  • Warner Bros. International Television Production Australia Pty Ltd
Western Researchers: Carolyn Ee, Natalie Connor, Dina Vadassery, Mitchell Low and Mike Armour
Years: 2018-10-29 - 2018-12-20
ID: P00025343
Title: Deer Velvet Extract Testing
  • Golds Power Herbs Pty Ltd
Western Researchers: Mitchell Low
Years: 2017-07-17 - 2017-09-17
ID: P00024182
Title: Alkaloid Testing
  • Chinawest Pty Ltd
Western Researchers: Mitchell Low
Years: 2017-09-01 - 2019-07-12
ID: P00024662
Title: Eucalypt bioactivity screening
  • Forico Pty Ltd
Western Researchers: Mitchell Low and Phoebe Zhou
Years: 2017-08-22 - 2019-04-15
ID: P00024575
Title: NICM- THC Research Program Development
  • Therapeutic Health Corporation (THC)
Western Researchers: Alan Bensoussan and Mitchell Low
Years: 2017-01-05 - 2018-09-10
ID: P00024330
Title: Antioxidant and anti-inflammatory investigation of natural products
  • Integria Healthcare (Australia) Pty Ltd
Western Researchers: Mitchell Low and Chun Guang Li
Years: 2023-05-01 - 2023-07-31
ID: P00028733
Title: An investigation of the entourage effect: Synergistic anti-inflammatory interactions between cannabinoids and terpenes in Cannabis
  • Cymra Life Sciences Ltd
Western Researchers: Mitchell Low, Deep Bhuyan, Justin Sinclair and Chun Guang Li
Years: 2020-06-29 - 2021-06-29
ID: P00026672
Title: Bioavailability and Efficacy study of Pharmako Biotechnologies "HydroCurc" curcumin using the CaCo2 cell culture model and the GFAP-IL6 mouse
  • Pharmako Biotechnologies Pty Ltd
  • Department of Industry, Innovation and Science (non ACRG)
Western Researchers: Gerald Muench, Mitchell Low, Ritesh Raju and Garry Niedermayer
Years: 2019-01-28 - 2020-12-19
ID: P00025524
Title: Development of a Natural Canine Dermatitis Treatment - IC
  • Troy Laboratories Australia Pty Ltd
  • Department of Industry, Science, Energy and Resources
Western Researchers: Mitchell Low, Deep Bhuyan and Chun Guang Li
Years: 2021-02-01 - 2023-04-30
ID: P00026946


Current Supervision

Thesis Title: An investigation of the vascular effects of a standardised Chinese herbals formula (Sailuotong) on cerebral vascular reactivity in normal and hypertensive rats for vascular dementia
Field of Research:
Thesis Title: Development and Evaluation of Polyherbal Formulation for the Treatment of Osteoarthritis
Field of Research:
Thesis Title: Chemical Characterisation and Study of Pharmacological and Biological Activity of the Chinese Herbs
Field of Research:

Previous Supervision

Thesis Title: Determination of Marker Compounds to Assess the Quality of Green Tea
Field of Research: Natural And Physical Sciences, N.e.c.

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