Doctor Gabriel Perrone

Doctor Gabriel Perrone

Senior Lecturer - Human Genetics,
Life Sciences

Biography

Qualifications

  • PhD University of New South Wales

Organisational Unit (School / Division)

  • Life Sciences

Contact

Email: G.Perrone@westernsydney.edu.au
Phone: (02) 4620 3286
Mobile:
Location: 21.1.27
Campbelltown

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Publications

Journal Articles

  • Dawes, I. and Perrone, G. (2020), 'Stress and ageing in yeast', FEMS Yeast Research, vol 20, no 1 .
  • Houang, J., Perrone, G., Pedrinazzi, C., Longo, L., Mawad, D., Boughton, P., Ruys, A. and Lauto, A. (2019), 'Genetic tolerance to rose bengal photodynamic therapy and antifungal clinical application for onychomycosis', Advanced Therapeutics, vol 2, no 2 .
  • Houang, J., Perrone, G., Mawad, D., Boughton, P., Ruys, A. and Lauto, A. (2018), 'Light treatments of nail fungal infections', Journal of Biophotonics, vol 11, no 3 .
  • Johnson, A., Zaman, M., Veljanoski, F., Phrakaysone, A., Li, S., O'Doherty, P., Petersingham, G., Perrone, G., Molloy, M. and Wu, M. (2017), 'Unravelling the role of protein kinase CK2 in metal toxicity using gene deletion mutants', Metallomics, vol 9, no 3 , pp 301 - 308.
  • El-Khoury, M., Ligot, R., Mahoney, S., Stack, C., Perrone, G. and Morton, C. (2017), 'The in vitro effects of interferon-gamma, alone or in combination with amphotericin B, tested against the pathogenic fungi Candida albicans and Aspergillus fumigatus', BMC Research Notes, vol 10, no 1 .
  • Serhan, G., Stack, C., Perrone, G. and Morton, O. (2014), 'The polyene antifungals, amphotericin B and nystatin, cause cell death in Saccharomyces cerevisiae by a distinct mechanism to amphibian-derived antimicrobial peptides', Annals of Clinical Microbiology and Antimicrobials, vol 13, no 18 .
  • Nair, S., Traini, M., Dawes, I. and Perrone, G. (2014), 'Genome-wide analysis of Saccharomyces cerevisiae identifies cellular processes affecting intracellular aggregation of Alzheimer's amyloid-?42 : importance of lipid homeostasis', Molecular Biology of the Cell, vol 25, no 15 , pp 2235 - 2249.
  • Ayer, A., Sanwald, J., Pillay, B., Meyer, A., Perrone, G. and Dawes, I. (2013), 'Distinct redox regulation in sub-cellular compartments in response to various stress conditions in Saccharomyces cerevisiae', PLoS One, vol 8, no 6 .
  • Jarolim, S., Ayer, A., Pillay, B., Gee, A., Phrakaysone, A., Perrone, G., Breitenbach, M. and Dawes, I. (2013), 'Saccharomyces cerevisiae genes involved in survival of heat shock', G3: Genes, Genomes, Genetics, vol 3, no 12 , pp 2321 - 2333.
  • Breitenbach, M., Ralser, M., Perrone, G., Iglseder, B., Rinnerthaler, M. and Dawes, I. (2013), 'Oxidative stress and neurodegeneration : the yeast model system', Frontiers in Bioscience, vol 18, no 3 , pp 1174 - 1193.
  • Tun, N., O'Doherty, P., Perrone, G., Bailey, T., Kersaitis, C. and Wu, M. (2013), 'Disulfide stress-induced aluminium toxicity : molecular insights through genome-wide screening of Saccharomyces cerevisiae', Metallomics, vol 5, no 8 , pp 1068 - 1075.
  • Ayer, A., Fellermeier, S., Fife, C., Li, S., Smits, G., Meyer, A., Dawes, I. and Perrone, G. (2012), 'A Genome-wide screen in yeast identifies specific oxidative stress genes required for the maintenance of sub-cellular redox homeostasis', PLoS One, vol 7, no 9 .
  • Park, D., Chiu, J., Perrone, G., Dilda, P. and Hogg, P. (2012), 'The tumour metabolism inhibitors GSAO and PENAO react with cysteines 57 and 257 of mitochondrial adenine nucleotide translocase', Cancer Cell International, vol 12, no 11 , pp 1 - 6.
  • Ayer, A., Tan, S., Grant, C., Meyer, A., Dawes, I. and Perrone, G. (2010), 'The critical role of glutathione in maintenance of the mitochondrial genome', Free Radicals in Biology and Medicine, vol 49, no 12 , pp 1956 - 1968.
  • Greetham, D., Vickerstaff, J., Shenton, D., Perrone, G., Dawes, I. and Grant, C. (2010), 'Thioredoxins function as deglutathionylase enzymes in the yeast Saccharomyces cerevisiae', BMC Biochemistry, vol 11, no 1 .
  • Tan, S., Greetham, D., Raeth, S., Grant, C., Dawes, C. and Perrone, G. (2010), 'The thioredoxin-thioredoxin reductase system can function in vivo as an alternative system to reduce oxidized glutathione in Saccharomyces cerevisiae', Journal of Biological Chemistry, vol 285, no 9 , pp 6118 - 6126.
  • Thorsen, M., Perrone, G., Kristiansson, E., Traini, M., Dawes, I., Nerman, O. and Tamas, M. (2009), 'Genetic basis of arsenite and cadmium tolerance in Saccharomyces cerevisiae', BMC Genomics, vol 10 .
  • Tan, S., Mariati, M., Dawes, I. and Perrone, G. (2009), 'Cu, Zn superoxide dismutase and NADP(H) homeostasis are required for tolerance of endoplasmic reticulum stress in Saccharomyces cerevisiae', Molecular Biology of the Cell, vol 20, no 5 , pp 1493 - 1408.
  • Ng, C., Tan, S., Perrone, G., Thorpe, G., Higgins, V. and Dawes, I. (2008), 'Adaptation to hydrogen peroxide in Saccharomyces cerevisiae : the role of NADPH-generating systems and the SKN7 transcription factor', Free Radical Biology and Medicine, vol 44, no 6 , pp 1131 - 1145.
  • Herst, P., Perrone, G., Dawes, I., Bircham, P. and Berridge, M. (2008), 'Plasma membrane electron transport in Saccharomyces cerevisiae depends on the presence of mitochondrial respiratory subunits', FEMS Yeast Research, vol 8, no 6 , pp 897 - 905.
  • Perrone, G., Tan, S. and Dawes, I. (2008), 'Reactive oxygen species and yeast apoptosis', BBA-Molecular Cell Research, vol 1783, no 7 , pp 1354 - 1368.
  • Dilda, P., Perrone, G., Philp, A., Lock, R., Dawes, I. and Hogg, P. (2008), 'Insight into the selectivity of arsenic trioxide for acute promyelocytic leukemia cells by characterizing Saccharomyces cerevisiae deletion strains that are sensitive or resistant to the metalloid', The International Journal of Biochemistry Cell Biology, vol 40, no 5 , pp 1016 - 1029.
  • Perrone, G., Grant, C. and Dawes, I. (2005), 'Genetic and environmental factors influencing glutathione homeostasis in Saccharomyces cerevisiae.', Molecular Biology of the Cell, vol 16, no 1 , pp 218 - 230.
  • Temple, M., Perrone, G. and Dawes, I. (2005), 'Complex cellular responses to reactive oxygen species', Trends in Cell Biology, vol 15, no 6 , pp 319 - 326.
  • Heeren, G., Jarolim, S., Laun, P., Rinnerthaler, M., Stolze, K., Perrone, G., Kolwein, S., Nohl, H., Dawes, I. and Breitenbach, M. (2004), 'The role of respiration, reactive oxygen species and oxidative stress in mother cell-specific ageing of yeast strains defective in the RAS signalling pathway.', FEMS Yeast Research, vol 5 , pp 157 - 167.
  • Shenton, D., Perrone, G., Quinn, K., Dawes, I. and Grant, C. (2002), 'Regulation of protein S-thiolation by glutaredoxin 5 in the yeast Saccharomyces cerevisiae', Journal of Biological Chemistry, vol 277 , pp 16853 - 16859.
  • Wheeler, G., Quinn, K., Perrone, G., Dawes, I. and Grany, C. (2002), 'Glutathione regulates the expression of gamma-glutamylcysteine synthetase via the Met4 transcription factor', Molecular Microbiology, vol 46, no 2 , pp 545 - 546.

Conference Papers

  • Houang, J., Perrone, G., Pedrinazzi, C., Longo, L., Mawad, D., Boughton, P., Ruys, A. and Lauto, A. (2019), 'A genome-wide screen for tolerance to rose bengal photodynamic therapy and its use in onychomycosis treatment', SPIE BIOS: Photonic Diagnosis and Treatment of Infections and Inflammatory Diseases, San Francisco, Calif..

Previous Projects

Title: Genomic approach to investigate the impact of exogenous glutathione on yeast cells
Funder:
  • Australian Wine Research Institute
  • University of Western Sydney
Western Researchers: Gabriel Perrone
Years: 2016-10-15 - 2017-10-14
ID: P00023602
Title: Global mechanisms affecting heat stress survival and their implications for cell ageing
Funder:
  • University of Western Sydney
Western Researchers: Gabriel Perrone
Years: 2012-03-02 - 2013-03-01
ID: P00020579

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