Doctor Deep Bhuyan
Research Support Program Fellow - Healthy Ageing: Therapeutic Potential of Natural Products,
NICM Health Research Institute
Biography
Dr Bhuyan is a Research Support Program Fellow at NICM Health Research Institute, Western Sydney University. He joined NICM Health Research Institute as an ARC Postdoctoral Research Fellow in 2018. His current research is centred on understanding the role of gut microbial metabolites (aka postbiotics) in the occurrence, treatment and prognosis of cancer to define postbiotic-based therapeutic strategies. His research group is also investigating the complex synergistic interactions of natural bioactive compounds with standard drugs on specific biological targets and how these interactions can be utilised as therapeutic strategies against infectious (bacterial, fungal and viral) diseases and cancer.
In his PhD (Food Science, University of Newcastle, 2018), he investigated the anticancer (against pancreatic adenocarcinoma) and antimicrobial properties of phenolic compounds and antioxidants present in Australian eucalypts at the molecular level. He also taught microbiology at the University of Newcastle. He has published several Q1 journal articles, invited book chapters with national and international collaborators, presented his research at different national and international conferences and appeared in television interviews and media coverages in India and Australia. Since the completion of his MSc in Applied Microbiology in 2010, he has pursued many academic and industry-funded research projects in natural product/food chemistry, microbiology and pharmacology in India and Australia. Before coming to Australia, Dr Bhuyan worked as a Senior Research Fellow in probiotic food development at the Assam Agricultural University on a National Agricultural Innovation Project funded by the Indian Council of Agricultural Research.
As an Early Career Researcher, in addition to mentoring PhD and master’s students, he is actively engaged in science communication on social media (Facebook, YouTube and Twitter), news channels and through community outreach programs.
PhD Supervision:
Radwa Ahmed Mohamed Eladwy (Primary Supervisor)
Ahmad Al-Khazaleh (Primary Supervisor)
Dongzheng Liu (Co-supervisor)
Shayal A Devi (Co-supervisor)
Kirandeep Kaur (Co-supervisor)
Simi Singh (Co-supervisor)
Seungyeon Yeon (Co-supervisor)
MRes Supervision:
Kayla Jaye (Primary Supervisor)
Indeewarie Dissanayake Mudiyanselage (Primary Supervisor)
Karishma Gurung Pradhan (Co-supervisor)
Ava Murali (Co-supervisor; external; Macquarie University)
This information has been contributed by Doctor Bhuyan.
Qualifications
- PhD University of Newcastle (NSW)
- MSc Vellore Institute of Technology
- BSc Bangalore University
Professional Memberships
- NSW Cardiovascular Research Network, National Heart Foundation (2020)
- Australian Society of Medical Research (2015)
- Hunter Medical Research Institute (2014)
- Pharmacological Society of Singapore (2017)
- The Good Practice In Traditional Chinese Medicine Research Association (2019)
- Institute of Food Technologists, Chicago (2016)
- Pancreatic Cancer Research Group, School of Environmental and Life Sciences, University of Newcastle, Australia (2014)
- Defence Research and Development Organisation, Ministry of Defence, India (2010)
Awards
- 2020 Early Career Research Excellence Award, NICM Health Research Institute, Western Sydney University, Australia 2020-12-07
- 2010 Merit Certificate and Merit Scholarship for the best academic performance for the academic year 2009-2010, VIT University, India 2010-08-01
- 2009 Merit Certificate and Merit Scholarship for the best academic performance for the academic year 2008-2009, VIT University, India 2009-08-03
- 2011 Senior Research Fellowship, Indian Council of Agricultural Research, Assam Agricultural University, India 2011-08-02
- 2016 Research Higher Degree Conference Scholarship, The University of Newcastle, Australia 2016-07-16
- 2014 International Postgraduate Research Scholarship and Central Postgraduate Research Scholarship, The University of Newcastle, Australia 2014-03-03
- 2021 Research Support Program Fellow - Healthy Ageing 2021-07-26
- 2022 WSU Researcher Development Early Career Researcher Award 2021-09-30
Interests
- Cancer
- Microbiology
- Natural Gut Bacteria and Pathogens
Organisational Unit (School / Division)
- NICM Health Research Institute
Committees
- Review board member of Cancers, MDPI
- Review board member of Microorganisms, MDPI
- NHMRC Ideas Grant Review Panel
- NHMRC Ideas Grants Peer Review Working Committee
Contact
| Email: | D.Bhuyan@westernsydney.edu.au |
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| Phone: | (02) 9685 4778 |
| Mobile: | |
| Location: | J.1.STH Westmead |
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Publications
Chapters in Books
- Dissanayake, I., Jaye, K., Eladwy, R., Farrukh, S., Yasmin, S., Bhuyan, D. and Pandohee, J. (2023), 'Taxus wallichiana Zucc. : the Himalayan Yew', Immunity Boosting Medicinal Plants of the Western Himalayas, Springer 9789811995002.
- Bhuyan, D., Perera, S., Kaur, K., Alsherbiny, M., Low, M., Seto, S., Li, C. and Zhou, X. (2020), 'Synergistic effects of Chinese herbal medicine and biological networks', Approaching Complex Diseases: Network-Based Pharmacology and Systems Approach in Bio-Medicine, Springer 9783030328566.
- Bhuyan, D. and Basu, A. (2017), 'Phenolic compounds : potential health benefits and toxicity', Utilisation of Bioactive Compounds from Agricultural and Food Waste, CRC Press 9781498741316.
Journal Articles
- Eladwy, R., Vu, H., Shah, R., Li, C., Chang, D. and Bhuyan, D. (2023), 'The fight against the carcinogenic Epstein-Barr Virus : gut microbiota, natural medicines, and beyond', International Journal of Molecular Sciences, vol 24, no 2 .
- Cao, H., Seto, S., Bhuyan, D., Chan, H. and Song, W. (2022), 'Effects of thrombin on the neurovascular unit in cerebral ischemia', Cellular and Molecular Neurobiology, vol 42, no 4 , pp 973 - 984.
- AL Ubeed, H., Bhuyan, D., Alsherbiny, M., Basu, A. and Vuong, Q. (2022), 'A comprehensive review on the techniques for extraction of bioactive compounds from medicinal cannabis', Molecules, vol 27, no 3 .
- Jaye, K., Li, C., Chang, D. and Bhuyan, D. (2022), 'The role of key gut microbial metabolites in the development and treatment of cancer', Gut Microbes, vol 14, no 1 .
- Kumar, M., Chandran, D., Tomar, M., Bhuyan, D., Grasso, S., Almeida Sa, A., Carciofi, B., Radha, *., Dhumal, S., Singh, S., Senapathy, M., Changan, S., Dey, A., Pandiselvam, R., Mahato, D., Amarowicz, R., Rajalingam, S., Vishvanathan, M., Saleena, L. and Mekhemar, M. (2022), 'Valorization potential of tomato (Solanum lycopersicum L.) seed : nutraceutical quality, food properties, safety aspects, and application as a health-promoting ingredient in foods', Horticulturae, vol 8, no 3 .
- Kumar, M., Kapoor, S., Dhumal, S., Tkaczewska, J., Changan, S., Saurabh, V., Mekhemar, M., Radha, .., Rais, N., Satankar, V., Pandiselvam, R., Sayed, A., Senapathy, M., Anitha, T., Singh, S., Tomar, M., Dey, A., Zengin, G., Amarowicz, R. and Bhuyan, D. (2022), 'Guava (Psidium guajava L.) seed : a low-volume, high-value byproduct for human health and the food industry', Food Chemistry, vol 386 .
- Dissanayake, I., Zak, V., Kaur, K., Jaye, K., Ayati, Z., Chang, D., Li, C. and Bhuyan, D. (2022), '[In Press] Australian native fruits and vegetables : chemical composition, nutritional profile, bioactivity and potential valorization by industries', Critical Reviews in Food Science and Nutrition, .
- Kumari, N., Kumar, M., Radha, .., Lorenzo, J., Sharma, D., Puri, S., Pundir, A., Dhumal, S., Bhuyan, D., Jayanthy, G., Selim, S., Abdel-Wahab, B., Chandran, D., Anitha, T., Deshmukh, V., Pandiselvam, R., Dey, A., Senapathy, M. and Kennedy, J. (2022), 'Onion and garlic polysaccharides : a review on extraction, characterization, bioactivity, and modifications', International Journal of Biological Macromolecules, vol 219 , pp 1047 - 1061.
- Hall, D., Sinclair, J., Bhuyan, D., Khoo, C., Li, C., Sarris, J. and Low, M. (2022), 'Quality control of cannabis inflorescence and oil products : response factors for the cost-efficient determination of ten cannabinoids by HPLC', Talanta Open, vol 5 .
- Jaye, K., Chang, D., Li, C. and Bhuyan, D. (2022), 'Gut metabolites and breast cancer : the continuum of dysbiosis, breast cancer risk, and potential breast cancer therapy', International Journal of Molecular Sciences, vol 23, no 16 .
- Eladwy, R., Chang, D., Li, C. and Bhuyan, D. (2022), 'Anti-proliferative effects of gut microbial metabolites on human gastric adenocarcinoma cells and their potential synergy with dexamethasone', Journal for ImmunoTherapy of Cancer, vol 10, no Suppl. 1 , pp 37 - 38.
- Bhuyan, D., Dissanayake, I., Jaye, K. and Chang, D. (2022), 'Traditional and complementary medicine in Australia : clinical practice, research, education, and regulation', International Journal of Ayurveda Research, vol 3, no 1 , pp 16 - 29.
- Zheng, Y., Zhou, X., Chang, D., Bhuyan, D., Zhang, J., Yu, W., Jiang, X., Seto, S., Yeon, S., Li, J. and Li, C. (2021), 'A novel tri-culture model for neuroinflammation', Journal of Neurochemistry, vol 156, no 2 , pp 249 - 261.
- Bhuyan, D., Alsherbiny, M., Low, M., Zhou, X., Kaur, K., Li, G. and Li, C. (2021), 'Broad-spectrum pharmacological activity of Australian propolis and metabolomic-driven identification of marker metabolites of propolis samples from three continents', Food and Function, vol 12, no 6 , pp 2498 - 2519.
- Biswakarma, J., Rushworth, D., Srivastava, G., Singh, G., Kang, K., Das, S., Anantharaman, S., Aeppli, M., Popp, A. and Bhuyan, D. (2021), 'Organizational level responses to the COVID-19 outbreak : challenges, strategies and framework for academic institutions', Frontiers in Communication, vol 6 .
- Alsherbiny, M., Bhuyan, D., Radwan, I., Chang, D. and Li, C. (2021), 'Metabolomic identification of anticancer metabolites of Australian propolis and proteomic elucidation of its synergistic mechanisms with doxorubicin in the MCF7 cells', International Journal of Molecular Sciences, vol 22, no 15 .
- Jaye, K., Li, C. and Bhuyan, D. (2021), 'The complex interplay of gut microbiota with the five most common cancer types : from carcinogenesis to therapeutics to prognoses', Critical Reviews in Oncology/Hematology, vol 165 .
- Kumar, M., Tomar, M., Bhuyan, D., Punia, S., Grasso, S., Almeida Sa, A., Carciofi, B., Arrutia, F., Changan, S., Radha, .., Singh, S., Dhumal, S., Senapathy, M., Satankar, V., Anitha, T., Sharma, A., Pandiselvam, R., Amarowicz, R. and Mekhemar, M. (2021), 'Tomato (Solanum lycopersicum L.) seed : a review on bioactives and biomedical activities', Biomedicine and Pharmacotherapy, vol 142 .
- Rifai, Y., ., N., Tanggulungan, W., Rahman, L., ., S. and Bhuyan, D. (2021), 'Characterization and biological evaluation of solid dispersed nanoparticles of synthetic epoksilignan targeting pancreatic cancer cell as an anticancer agent', Journal of Biomedical Nanotechnology, vol 17, no 7 , pp 1453 - 1458.
- Alsherbiny, M., Bhuyan, D., Low, M., Chang, D. and Li, C. (2021), 'Synergistic interactions of cannabidiol with chemotherapeutic drugs in MCF7 cells : mode of interaction and proteomics analysis of mechanisms', International Journal of Molecular Sciences, vol 22, no 18 .
- Birling, Y., Nevitt, S., Bhuyan, D., Jia, M., Feng, F., Carlson, L., Pham, T., Liu, J., Ayati, Z., Nyiam, L., Yu, Z. and Fahey, P. (2021), 'Mind-body therapies for cancer patients living with depression, anxiety or insomnia (MIRACLE) : a systematic review with individual participant data network meta-analysis', Methods and Protocols, vol 4, no 4 .
- Alsherbiny, M., Radwan, I., Moustafa, N., Bhuyan, D., El-Waisi, M., Chang, D. and Li, C. (2021), '[In Press] Trustworthy deep neural network for inferring anticancer synergistic combinations', IEEE Journal of Biomedical and Health Informatics, .
- Miller, R., O?Neill, D., Bhuyan, D. and Martin, F. (2021), 'Sex differences in the attitudes of Australian and Indian heterosexual individuals toward gay men, lesbians, bisexual men and bisexual women', Journal of Bisexuality, vol 21, no 3 , pp 332 - 356.
- Papoutsis, K., Grasso, S., Menon, A., Brunton, N., Lyng, J., Jacquier, J. and Bhuyan, D. (2020), 'Recovery of ergosterol and vitamin D2 from mushroom waste : potential valorization by food and pharmaceutical industries', Trends in Food Science and Technology, vol 99 , pp 351 - 366.
- Bhuyan, D., Alsherbiny, M., Perera, S., Low, M., Basu, A., Devi, O., Barooah, M., Li, C. and Papoutsis, K. (2019), 'The odyssey of bioactive compounds in avocado (Persea americana) and their health benefits', Antioxidants, vol 8, no 10 .
- Bhuyan, D., Vuong, Q., Chalmers, A., Bowyer, M. and Scarlett, C. (2018), 'An array of bioactive compounds from Australian eucalypts and their relevance in pancreatic cancer therapeutics', Pancreas, vol 47, no 6 , pp 690 - 707.
- Bhuyan, D., Vuong, Q., Bond, D., Chalmers, A., Bowyer, M. and Scarlett, C. (2018), 'Eucalyptus microcorys leaf extract derived HPLC-fraction reduces the viability of MIA PaCa-2 cells by inducing apoptosis and arresting cell cycle', Biomedicine and Pharmacotherapy, vol 105 , pp 449 - 460.
- Bhuyan, D., Sakoff, J., Bond, D., Predebon, M., Vuong, Q., Chalmers, A., van Altena, I., Bowyer, M. and Scarlett, C. (2017), 'In vitro anticancer properties of selected Eucalyptus species', In Vitro Cellular and Developmental Biology: Animal, vol 53, no 7 , pp 604 - 615.
- Bhuyan, D., Vuong, Q., Chalmers, A., van Altena, I., Bowyer, M. and Scarlett, C. (2017), 'Phytochemical, antibacterial and antifungal properties of an aqueous extract of Eucalyptus microcorys leaves', South African Journal of Botany, vol 112 , pp 180 - 185.
- Bhuyan, D., Vuong, Q., Bond, D., Chalmers, A., van Altena, I., Bowyer, M. and Scarlett, C. (2017), 'Exploring the least studied Australian eucalypt genera : Corymbia and Angophora for phytochemicals with anticancer activity against pancreatic malignancies', Chemistry and Biodiversity, vol 14, no 3 .
- Bhuyan, D., Vuong, Q., Chalmers, A., Altena, I., Bowyer, M. and Scarlett, C. (2017), 'Development of the ultrasonic conditions as an advanced technique for extraction of phenolic compounds from Eucalyptus robusta', Separation Science and Technology, vol 52, no 1 , pp 100 - 112.
- Saberi, B., Thakur, R., Bhuyan, D., Vuong, Q., Chockchaisawasdee, S., Golding, J., Scarlett, C. and Stathopoulos, C. (2017), 'Development of edible blend films with good mechanical and barrier properties from pea starch and guar gum', Starch, vol 69, no 1-2 .
- Bhuyan, D., Vuong, Q., Chalmers, A., Altena, I., Bowyer, M. and Scarlett, C. (2016), 'Investigation of phytochemicals and antioxidant capacity of selected Eucalyptus species using conventional extraction', Chemical Papers, vol 70, no 5 , pp 567 - 575.
- Bhuyan, D., Vuong, Q., Chalmers, A., Altena, I., Bowyer, M. and Scarlett, C. (2015), 'Microwave-assisted extraction of Eucalyptus robusta leaf for the optimal yield of total phenolic compounds', Industrial Crops and Products, vol 69 , pp 290 - 299.
- Vuong, Q., Chalmers, A., Bhuyan, D., Bowyer, M. and Scarlett, C. (2015), 'Botanical, phytochemical, and anticancer properties of the Eucalyptus species', Chemistry and Biodiversity, vol 12, no 6 , pp 907 - 924.
- Vuong, Q., Nguyen, V., Thanh, D., Bhuyan, D., Goldsmith, C., Sadeqzadeh, E., Scarlett, C. and Bowyer, M. (2015), 'Optimization of ultrasound-assisted extraction conditions for euphol from the medicinal plant, Euphorbia tirucalli, using response surface methodology', Industrial Crops and Products, vol 63 , pp 197 - 202.
- Bhuyan, D., Barooah, M., Bora, S. and Singaravadivel, K. (2014), 'Biochemical and nutritional analysis of rice beer of North East India', Indian Journal of Traditional Knowledge, vol 13, no 1 , pp 142 - 148.
- Vuong, Q., Goldsmith, C., Dang, T., Nguyen, V., Bhuyan, D., Sadeqzadeh, E., Scarlett, C. and Bowyer, M. (2014), 'Optimisation of ultrasound-assisted extraction conditions for phenolic content and antioxidant capacity from Euphorbia tirucalli using response surface methodology', Antioxidants, vol 3, no 3 , pp 604 - 617.
- Sadeqzadeh, E., Vuong, Q., Goldsmith, C., Nguyen, V., Bhuyan, D., Dang, T., Chalmers, A., Altena, I., Gaston, T., Moltschaniwskyj, N., Bowyer, M., Thorne, R., Weidenhofer, J., Thuong, P., Nguyen, M. and Scarlett, C. (2014), 'A natural product drug discovery pipeline for novel pancreatic cancer therapies : a new cancer research hub for the Hunter region of NSW', Asia-Pacific Journal of Clinical Oncology, vol 10, no S10 , pp 18 - 18.
- Bhuyan, D. and Barooah, M. (2012), 'Evaluation of antifungal, antibacterial and antioxidant activities of Amphineuron extensus, Hedyotis diffusa and Vitex negundo', Journal of Cell and Tissue Research, vol 12, no 3 , pp 3343 - 3348.
- Bhuyan, D. and Das, J. (2012), 'Plant extracts as biofungicides : a review', Electronic Journal of Environmental Sciences, vol 5 , pp 49 - 54.
Conference Papers
- Dissanayake, I., Alsherbiny, M., Chang, D., Li, C. and Bhuyan, D. (2022), 'Growth inhibition of the MCF7 breast adenocarcinoma cells with Australian native currant (Acrotriche depressa) extracts and metabolomic Identification of key anticancer metabolites', World Congress on Polyphenols Applications, Valencia, Spain.
- Biswakarma, J., Rushworth, D., Srivastava, G., Kang, K., Singh, G., Das, S., Anantharaman, S., Aeppli, M., Popp, A. and Bhuyan, D. (2021), 'Academic institutions' responses to COVID-19 crisis', V.M. Goldschmidt Conference, online.
- Alsherbiny, M., Bhuyan, D., Radwan, I., Chang, D. and Li, C. (2021), 'Molecular mechanisms underlying synergistic interactions between Australian propolis and doxorubicin in MCF7 breast adenocarcinoma cells : multiomics study', EMBO-EMBL Symposium, Virtual.
- Kaur, K., Bhuyan, D., Li, C. and Li, F. (2020), 'Modification of curcumin and investigation of its bioactivity', Keystone Symposia: Advances in Cancer Immunotherapy, Online.
- Bhuyan, D. and Li, C. (2020), 'Antiviral compounds from plants : current trends and future directions', International e-Conference on Nutrients Acquisition by Plants and Plant Based Remedies against Viral Diseases, Assam, India.
- Bhuyan, D., Vuong, Q., Bond, D., Chalmers, A., Bowyer, M. and Scarlett, C. (2017), 'Aqueous Angophora floribunda extract as a source of phenolics and antioxidants with anti-pancreatic cancer and antimicrobial activity', International Conference on Scientific Frontiers in Natural Product Based Drugs, Singapore.
- Bhuyan, D., Vuong, Q., Chalmers, A., Bowyer , M. and Scarlett , C. (2017), 'Aqueous Eucalyptus microcorys extract derived HPLC fractions with antioxidant and anti-pancreatic cancer activity', Australian Society for Medical Research. Scientific Meeting, Newcastle, N.S.W..
- Bhuyan, D. (2016), 'Phytochemical, antibacterial and antifungal properties of an aqueous extract of Eucalyptus microcorys leaves', IFT Meeting, Chicago, Ill..
- Bond, D., Turner, A., Richmond, R., Sadeqzadeh, E., Vuong, Q., Bhuyan, D., Rifai, Y., Chalmers, A., van Altena, I., Gaston, T., Bowyer, M., Brzozowski, J., Jankowski, H., Weidenhofer, J., Sakoff, J., Thuong, P., Ha, D., Nguyen, M. and Scarlett, C. (2015), 'The search for novel treatment agents for pancreatic cancer : tales from the land and sea', Hunter Cancer Research Alliance. Symposium, New Lambton Heights, N.S.W..
- Bhuyan, D., Vuong, Q., Chalmers, A., Altena, I., Bowyer, M. and Scarlett, C. (2015), 'Optimisation of microwave-assisted extraction parameters for total phenolic content from Eucalyptus robusta using response surface methodology', International Journal of Food Science and Technology 50th Celebration Conference, Canterbury, N.Z..
- Barooah, M. and Bhuyan, D. (2013), 'Probiotic chocolate : future prospect', International Conference on Food Technology, Indian Institute of Crop Processing Technology.
- Das, J., Bhuyan, D., Policegoudra, R., Jha, D., Chattapadhyay, P. and Singh, L. (2011), 'Effect of plant extracts in controlling Sclerotinia sclerotiorum in French bean', National Symposium on Microorganisms and Plant Health, Guwahati, India.
Current Projects
| Title: | Improving the analysis and pharmacological characterisation of phytomelatonin |
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| Funder: |
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| Western Researchers: | Mitchell Low, Chun Guang Li and Deep Bhuyan |
| Years: | 2022-06-02 - 2025-06-02 |
| ID: | P00028025 |
Previous Projects
| Title: | An investigation of the entourage effect: Synergistic anti-inflammatory interactions between cannabinoids and terpenes in Cannabis |
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| Funder: |
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| Western Researchers: | Mitchell Low, Deep Bhuyan, Justin Sinclair and Chun Guang Li |
| Years: | 2020-06-29 - 2021-06-29 |
| ID: | P00026672 |
| Title: | Development of a Natural Canine Dermatitis Treatment - IC |
| Funder: |
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| Western Researchers: | Mitchell Low, Deep Bhuyan and Chun Guang Li |
| Years: | 2021-02-01 - 2023-04-30 |
| ID: | P00026946 |
Supervision
Current Supervision
| Thesis Title: | MRES International coursework |
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| Field of Research: | |
| Thesis Title: | Exploring the role of gut microbiota in the pharmacological effects of Cholesterol Health? on controlling blood cholesterol and the risk of metabolic syndrome |
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| Thesis Title: | Chemical Characterisation and Study of Pharmacological and Biological Activity of the Chinese Herbs |
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| Thesis Title: | Modification of Curcumin and Its Bioactivity - Anticancer, Antioxidant and Anti-inflammatory |
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Previous Supervision
| Thesis Title: | Antiviral Activity of Natural Products Against Epstein Barr Virus: Synergistic Study and Molecular Mechanisms Elucidation |
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| Field of Research: | |
| Thesis Title: | Natural Food Components Against HCoV229e |
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| Thesis Title: | Quality Standards and Pharmacological Effects and Clinical Trial of Australian Propolis |
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| Thesis Title: | Investigation of inorganic phosphate-induced vascular calcification in primary human aortic smooth muscle cells |
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