National Health and Medical Research Council (NHMRC) Funding Outcomes

NHMRC funding awarded for 2019

Congratulations to the following researchers on their NHMRC funding success:

Project Grants

Distinguished Professor Annemarie Hennessy and Professor Angela Makris
School of Medicine

siRNA in preeclampsia: Reversal of early onset preeclampsia with novel treatment of the placenta

Distinguished Professor Annemarie Hennessy; Professor Angela Makris

This study is designed to continue work on a cheap and cost effective rescue treatment for severe, early preeclampsia.

Total funding: $1,922,127

Postgraduate Scholarships

Amy Villarosa
School of Nursing and Midwifery

Development and implementation of the Children’s Healthy Eating and Weight Intervention (CHEWI) program for dental therapists in Australia

The aim of this project is to use an evidence-based approach to develop and implement a Children’s Healthy Eating and Weight Intervention (CHEWI) Program to capacity-build dental and oral health therapists to identify and manage childhood obesity.

Total funding: $88,502

Project Grants administered by other institutions

Dr Rose Chesworth
School of Medicine

Novel Nanotechnology for the Delivery of Amyloid and Tau aggregation Targeting siRNA for a potential Alzheimer’s Disease Therapy

Dr Bingyang Shi (Macquarie University); Dr Rose Chesworth (Western); Dr Amanda Wright (Macquarie University Hospital)

Alzheimer's disease is the most common form of dementia, leading to cognitive decline and death, yet there is no cure for this brain disease. Current treatments targeting amyloid-beta and tau pathology have had little success in clinical trials. The present proposal will use a new technology to target amyloid-beta and tau pathology - notably delivering glucose functionalised siRNA nanoparticles (GLU-NPs) which target this pathology. This project will examine the safety and utility of GLU-NPs for reducing amyloid burden and tau pathology in two well-established mouse models of Alzheimer's disease, as well as the potential for GLU-NPs to reverse behavioural impairment in these models.

Administering institution: Macquarie University

Total funding: $472,551

Professor Dafna Merom
School of Science and Health

WalkBack: Preventing recurrence of low back pain

Associate Professor Mark Hancock (Macquarie University); Professor Jane Latimer (University of Sydney); Associate Professor Chung-Wei Christine Lin (University of Sydney); Professor Dafna Merom (Western); Professor Maurits van Tulder (VU University Amsterdam)

Each year low back pain costs Australia around $9 billion with the direct costs of treatment being estimated at $4.8 billion annually. Much of these costs are for treatment of those who recovered from a previous episode of low back pain and are now suffering a recurrence. It is known that approximately 30% of people, recovered from low back pain, will suffer a recurrence in the subsequent year. To date the great majority of trials in the low back pain field evaluate treatments rather than prevention. Our study seeks to redress this, investigating a low cost, home-based walking and education program, delivered within a clinical setting, to prevent recurrences and associated disability.

Administering institution: Macquarie University

Total funding: $813,443

Professor Andrew Page
Translational Health Research Institute

Health service and medicine utilisation before suicide: optimising suicide prevention using population-based linkage of routinely collected data

Chief Investigators: Dr Kate Chitty (University of Sydney); Dr Jennifer Pilgrim (Monash University); Dr Andrea Schaffer (University of New South Wales); Dr Rose Cairns (University of Sydney)

Associate Investigator: Professor Andrew Page (Western)

Suicide in Australia is the leading cause of death for young people. Optimising suicide prevention lies in delivering the right interventions to the right people. Yet currently we lack crucial information - we do not know which individuals are likely to receive some of our most promising suicide interventions and therefore where to deliver them in the future. To gain this knowledge this project will examine the medicines dispensed and healthcare utilised prior to previous suicides in Australia.

Administering institution: University of Sydney

Total funding: $354,526

Boosting Dementia Research Grants administered by other institutions

Dr Genevieve Steiner
NICM Health Research Institute

Self-management and HeAlth Promotion in early-stage dementia with E-learning for carers - A randomised controlled trial

Chief Investigator: Professor Kaarin Anstey (University of New South Wales)

Associate Investigator: Dr Genevieve Steiner (Western)

This project will develop and validate a Self-management and HeAlth Promotion intervention for people with mild dementia, combined with E-learning resources for carers (SHAPE). The study will involve collaboration with research partners in Norway, the UK, Austria and Slovenia, as well as dementia advocates, carers and service users.

Administering institution: University of New South Wales

Total funding: $746,997