A Western Sydney University researcher is exploring
how genetic data can be used to create tailored treatment options for children with
Dr Quang Vinh Nguyen, from the MARCS Institute for
Brain, Behaviour and Development [and Senior Lecturer with the School of Computing,
Engineering and Mathematics], is researching how large amounts of genetic data
can be analysed to explore and guide better diagnosis and treatment options
that are safer, less toxic and more effective for kids with leukemia.
In Australia, more than 650 kids are diagnosed with
cancer each year, and around 215,000 children worldwide.
Through advancements in technology and research, Australia
now records an 83 per cent survival rate in the first five years post remission.
But Dr Nguyen said we should be aiming higher.
His research explores a unique approach that assesses
how genomic and biomedical data is interpreted to determine which cancer
patients were likely to respond poorly to a particular treatment and / or
He said it was intended that new patients who were
yet to be treated, could have their genetic and biological information compared
to a group of other patients' genetic data to develop a customized treatment
"The human genome is comprised of thousands of
genes containing information about individual patients and the biological
mechanisms of their diseases," he said.
"By comparing one patient's biological information
to a group of others who have already been treated and have a similar biology, we
can determine how a new patient might respond to similar treatment and develop
a personalized approach to their cancer treatment.
"This research will also allow medical
practitioners to make more informed decisions about treatment options overall."
The research is financially supported by the Cancer
Institute NSW and Oracle.
This work is one component of a collaborative
research study involving researchers at The Children's Hospital at Westmead
(lead by Associate Professor Daniel Catchpoole) and The University of
Technology Sydney (lead by Associate Professor Paul Kennedy).
 Children's Cancer, Australian Government, https://childrenscancer.canceraustralia.gov.au/about-childrens-cancer/statistics#reference
 WHO's International Agency for Research on
Cancer (IARC), https://www.iarc.fr/en/media-centre/pr/2016/pdfs/pr241_E.pdf
Data, Big Impact Grant — Stage 2 at Cancer Institute NSW (https://www.cancerinstitute.org.au/about-us/events/premiers-research-awards)
For more information, contact Farah Abdurahman on (02) 9772 6695 / 0427945 382 / F.Abdurahman@westernsydney.edu.au
17 February, 2017